Authors: Aureliano Bombarely, Boyce Thompson Institute LycoCyc: Solanum lycopersicum Cellular Overview Lukas Mueller, Boyce Thompson Institute a xenobiotic a xenobiotic a xenobiotic a xenobiotic + a xenobiotic a xenobiotic H phosphonate 2+ an a xenobiotic a xenobiotic ABC a xenobiotic a xenobiotic a xenobiotic ABC a xenobiotic Cd a xenobiotic a xenobiotic a xenobiotic ABC a xenobiotic ABC a xenobiotic a xenobiotic a xenobiotic oligopeptide a xenobiotic a xenobiotic Cd 2+ a xenobiotic sucrose a xenobiotic transporter transporter transporter transporter sucrose H + a xenobiotic a xenobiotic C family C family C family C family a xenobiotic a xenobiotic ABC a xenobiotic a xenobiotic a xenobiotic a xenobiotic a xenobiotic Macrolide ABC a xenobiotic sucrose H(+)-ATPase H + member 4/ member 8/ a xenobiotic member 10/ member 10/ Cu 2+ H + transporter ABC export ATP- ABC transporter 4//H(\+)- ABC /Multidrug ABC ABC ABC /Multidrug ABC Cadmium- ABC ABC ABC /Multidrug ABC /Multidrug ABC ABC ABC Sucrose C family transporter ABC binding/ transporter B family Sucrose transporting transporter ABC resistance transporter transporter transporter resistance transporter transporting Cadmium/zinc- ABC transporter transporter transporter resistance transporter resistance transporter transporter transporter transport ABC transporter member 2/ I family transporter permease B family member transport Sucrose ATP synthase atpase plant/ MATE efflux ABC C family transporter protein ABC C family C family C family protein ABC C family ATPase// transporting transporter C family B family C family protein ABC C family protein ABC C family ABC C family C family protein ABC C family member /Multidrug ABC ABC ABC member 11, ABC ABC family protein/ protein member 9//Lipid A ABC protein// transport epsilon chain, fungi plasma ATP synthase family protein/ transporter member 12/ B family transporter member 10/ member 10/ member 8/ transporter member 10/ Probable ATPase 3// G family member 10/ member ABC member 14/ transporter member 3/ transporter member 3/ transporter member 12/ member 10/ Copper SUC3// ATP synthase transporter 12//Cystic fibrosis resistance transporter transporter transporter chloroplastic// transporter transporter /Lipid A MacB//RNA- 19//ABC export ATP- transporter Sucrose protein mitochondrial// membrane subunit beta /multidrug C family /Multidrug member 1// family// /Multidrug /Multidrug /Multidrug family// /multidrug cadmium/zinc- Potassium- member 14// /Multidrug 15//Lipid A transporter /Multidrug family// /multidrug family// /Multidrug C family /Multidrug /multidrug transporting sucrose subunit beta C family transmembrane ABC C family C family B family Cobalt import C family C family export ATP- directed DNA transporter- binding/ B family transporter/ SUC4// ATP synthase type, putative/ chloroplastic resistance member 14/ resistance ATP binding multidrug resistance resistance resistance multidrug resistance transporting transporting ABC-2 type resistance export ATP- family protein resistance multidrug resistance multidrug resistance member 12/ resistance resistance ATPase 2 transporter member 9 conductance transporter member 9 member 5 member 6 ATP-binding member 14 member 14 binding/ polymerase like protein// permease member 2 /sucrose- sucrose epsilon subunit 1 /Plasma pump, putative /ATMRP10 protein ABC cassette resistance- protein ABC protein ABC protein ABC resistance- protein ABC ATPase ATPase transporter protein ABC binding/ protein ABC resistance- protein ABC resistance- protein ABC /ATMRP13 protein ABC protein ABC 2//sucrose regulator ATP- protein CbiO 2/ permease (reverse ATP binding protein proton transporter membrane transporter subfamily B1 associated transporter transporter transporter associated transporter HMA1, B chain family protein transporter permease transporter associated transporter associated transporter transporter transporter transporter- H + binding and /non-intrinsic protein msbA transcriptase) cassette msbA//MDR- symporter 2 ATPase 2 H + family protein 2, family family family protein 1, family chloroplastic family protein msbA a xenobiotic family protein 1, family protein 1, family family family Cu 2+ like protein a xenobiotic permease a xenobiotic a xenobiotic a xenobiotic ABC protein 14 a xenobiotic a xenobiotic -related subfamily B19 like ABC a xenobiotic H + (Fragment) a xenobiotic a xenobiotic 6 (mrp2, 3 (mrp1, 3 (mrp1, 3 (mrp1, a xenobiotic a xenobiotic protein family protein transporter sucrose-6- a xenobiotic 6), abc- 3), abc- Cd 2+ a xenobiotic 3), abc- 3), abc- transoprter, transoprter, 2+ a xenobiotic transoprter, transoprter, sucrose-6- phosphate a xenobiotic a xenobiotic a xenobiotic a xenobiotic a xenobiotic Cd a xenobiotic a xenobiotic a xenobiotic a xenobiotic a xenobiotic a xenobiotic a xenobiotic sucrose-6- putative putative a xenobiotic putative putative phosphate H + an phosphate a xenobiotic oligopeptide a xenobiotic phosphonate AMINO ACIDS DEGRADATION FATTY ACID AND LIPID BIOSYNTHESIS AROMATIC COMPOUNDS DEGRADATION a xenobiotic a xenobiotic a xenobiotic a xenobiotic xyloglucan SECONDARY METABOLITES BIOSYNTHESIS valine degradation I dCMP dCMP β dTDP α a monocarboxylic a [protein]- uridine all-t actinorhodin biosynthesis methylthiopropionate chlorogenic acid biosynthesis I α-amyrin lipid-independent phytate biosynthesis cinnamate esters apigenin glycosides biosynthesis phenylpropanoid betaxanthin β-carotene avenacin biosynthesis superpathway of fatty acid biosynthesis II (plant) superpathway of glycolysis, pyruvate GLYCOLYSIS lysine degradation II leucine methionine degradation isoleucine phenylalanine degradation III L-cysteine superpathway of purines degradation in plants -D-glucose lactose oligosaccharide oxalate an aryl aldehyde m7G(5')pppAm -glucan a phenyl acetate hypoglycin biosynthesis sanguinarine and simple coumarins biosynthesis superpathway of lipid-dependent phytate biosynthesis superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside) calystegine canavanine biosynthesis antheraxanthin and flavonoid biosynthesis chlorogenic acid biosynthesis II hyperforin biosynthesis geraniol methylquercetin biosynthesis volatile cinnamoic ester biosynthesis cholesterol biosynthesis sphingomyelin metabolism stearate biosynthesis cis-vaccenate triacylglycerol biosynthesis ACETYL-COA BIOSYNTHESIS leucine degradation I threonine acid amide L-histidine dip biosynthesis biosynthesis biosynthesis biosynthesis, biosynthesis biosynthesis phospholipid biosynthesis II dehydrogenase, TCA, and glyoxylate bypass degradation III I (to homocysteine) degradation II degradation II Deoxycytidylate Uridylate kinase: Nucleoside macarpine biosynthesis biosynthesis violaxanthin biosynthesis and geranial III (via desmosterol) I (animals) biosynthesis glycolysis III degradation III uridine cytidine malonyl-CoA β-D-glucose- delphinidin-3-O initial reactions (via dopamine) (S)-2,3- deaminase: Solyc08g077300.2 Beta-galactosidase: diphosphate kinase: oxalate oxidase: aldehyde oxidase: mRNAadenosine glucan water amidase: Histidine kinase: arylesterase: D-myo-inositol D-myo-inositol 1 3,7-di- acetyl-CoA β L-valine (to methylglyoxal) xylose isomerase: Alpha-xylosidase: kinase I, putative: 4-coumarate 1,2-dihydroxy-3-keto- 4-coumaroyl-CoA (S)-2,3- N-methyl-∆ - 4-coumarate 4-coumaroyl-CoA H + biosynthesis apigenin dihydroxyacetone sn-glycerol- -D-glucose- superpathway of acetyl-CoA biosynthesis L-lysine Solyc03g093750.1 Solyc11g068600.1 dikinase: Solyc12g039070.1 L-threonine (S)-reticuline 6-phosphate (1,3,4)-trisphosphate (1,4,5)-trisphosphate -β-D-glucoside homoserine zeaxanthin trans-cinnamate a quercetin trans-cinnamate methylcinnamate trans-lycopene epoxysqualene all-trans-farnesyl a ceramide palmitate L-leucine L-leucine L-methionine L-isoleucine L-phenylalanine adenosine- Solyc03g111350.2 [+ 2 isozymes] Solyc07g006650.2 Solyc12g049370.1 Solyc04g007160.1 Solyc01g088210.2 methylase: Solyc03g118690.2 Solyc12g099670.1 Solyc10g005880.2 5-methylthiopentene epoxysqualene Inositol-3-phosphate pyrrolinium cation methylquercetagetin phosphate a palmitoleoyl-[acp] 3-phosphate 6-phosphate β-D-glucose L-cysteine [+ 3 isozymes] [+ 14 isozymes] Solyc05g005020.2 [+ 16 isozymes] geranyl-diphosphate L-phenylalanine L-dopa Acetyl-coenzyme diphosphate a [pyruvate L-threonine tryptophan 5'-phosphate [+ 7 isozymes] [+ 9 isozymes] Solyc08g066730.2 [+ 8 isozymes] [+ 13 isozymes] Reticuline oxidase precursor, Acireductone beta-amyrin synthase: myo-inositol polyphosphate 5- 4-coumarate-coa ligase: UDP-glucose Lycopene beta-cyclase Glycerol-3- Glycerol-3- glucose-6- Branched-chain- lysine-ketoglutarate dUMP dCDP [+ 9 isozymes] threonine 4-coumarate-coa ligase: Hydroxycinnamoyl- Hydroxycinnamoyl- anthocyanin 5-O- Zeaxanthin lupeol synthase: Cycloartenol A carboxylase long-chain-fatty- Hexokinase: dehydrogenase Branched-chain- Methionine aminotransferase: hyoscyamine dioxygenase: synthase: Solyc05g051850.2 Inositol- Inositol- kinase||polyphosphate Solyc03g005090.2 Hydroxycinnamoyl- Hydroxycinnamoyl- quercetin 3-O- O-methyltransferase: 1: Solyc04g040190.1 farnesyl-diphosphate sphingomyelin phosphate citrate amino-acid reductase||saccharopine L-threonine 3- Branched-chain- Branched-chain- tyrosine transaminase: Cystathionine AMP deaminase: D-fructose allolactose D-xylose H O CO [phospho-α-glucan] acetate a phenol deaminase: putative: Solyc02g069690.1 Solyc03g005090.2 CoA shikimate/quinate CoA shikimate/quinate kinase: glucosyltransferase: epoxidase, glucosyltransferase: phenylalanine Aromatic L-amino Solyc07g042630.2 Synthase: carboxyl