Program and Speakers 8:30 Breakfast and registration 9:15 Opening remarks Aviv Regev, Broad Institute, Harvard University 9:25 Keynote address Hopi Hoekstra, Harvard University The genetic basis of parental behavior in wild mice Session 1: Microbial adaptation and evolution 10:00 Jeff Gore, Massachusetts Institute of Technology Cooperation, cheating and collapse of microbial populations 10:20 Chris Sassetti, University of Massachusetts Medical School Combinatorial genetics to understand tuberculosis Gene Circuits pathogenesis 10:40 Martin Polz, Massachusetts Institute of Technology Identifying bacterial populations as gene flow units Monday, March 14, 2016 11:00 Break 8:30 a.m. – 5:30 p.m. Session 2: Chromatin: Folding and function Broad Institute, Cambridge 11:40 Cigall Kadoch, Dana Farber Cancer Institute BAF complex structure and function in cancer Organizers 12:00 Christina Leslie, Memorial Sloan Kettering Cancer Aviv Regev Center Decoding epigenomic programs in cellular Broad Institute of MIT and Harvard and differentiation Director, Cell Circuits Program and Klarman Cell Observatory 12:20 Leonid Mirny, Massachusetts Institute of Technology Physics of genome folding 12:40 Lunch (provided) Brian Plosky Session 3: Variation and adaptation Deputy Editor, Molecular Cell 1:40 Daniel MacArthur, Massachusetts General Hospital Using large-scale databases of human genetic variation to understand gene function Christine Cosma Scientific Editor,Cell Host & Microbe 2:00 Aswin Sekar, Broad Institute, Harvard University Schizophrenia risk from complex variation of and Current Biology complement component 4 2:20 Elinor Karlsson, University of Massachusetts Medical Quincey Justman School Scientific Editor,Cell Systems Natural selection and cholera resistance in Bangladesh To register, go to: 2:40 Michael Desai, Harvard University Evolutionary dynamics in lab yeast http://www.cell.com/lablinks 3:00 Break Registration is FREE (space is limited) Session 4: Insights from Engineering 3:30 Ahmad (Mo) Khalil, Boston University Naturally-inspired engineering of biological systems This free one-day meeting, co-sponsored by 3:50 Ed Boyden, Massachusetts Institute of Technology the NHGRI CEGS Center for Cell Circuits at Tools for mapping and controlling complex biological systems the Broad Institute and Cell Press, will bring together leaders of diverse fields. Fundamental 4:10 Caroline Uhler, Massachusetts Institute of Technology Packing models of chromosomes and their expression questions about gene regulation will be 4:30 Keynote address addressed as well as the engineering and Will Greenleaf, Stanford University evolution of gene circuits. Short-format Single-cell open chromatin landscapes provide a window during differentiation talks will promote discussion and provide an excellent opportunity for local labs to Sponsored by interact. www.cell.com.