Journal of Oncology Tumor Angiogenesis Guest Editors: Arkadiusz Dudek, Kalpna Gupta, Sundaram Ramakrishnan, and Debabrata Mukhopadhyay Tumor Angiogenesis Journal of Oncology Tumor Angiogenesis Guest Editors: Arkadiusz Dudek, Kalpna Gupta, Sundaram Ramakrishnan, and Debabrata Mukhopadhyay Copyright © 2010 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in volume 2010 of “Journal of Oncology.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Journal of Oncology Editorial Board Thomas E. Adrian, UAE Andreas H. Jacobs, Germany Dirk Rades, Germany Massimo Aglietta, Italy Ismail Jatoi, USA Zvi Ram, Israel Bruce Baguley, New Zealand G. Kaspers, The Netherlands Dirk Reinhardt, Germany David Ball, Australia Michael J. Kerin, Ireland Paul G. Richardson, USA A. J. M. Balm, The Netherlands Turker¨ Kilic¸, Turkey Michel Rigaud, France Frederic G. Barr, USA Timothy J. Kinsella, USA Jorg¨ Ritter, Germany Søren M. Bentzen, USA Jorg¨ Kleeff,Germany Mack Roach, USA Rolf Bjerkvig, Norway George O. Klein, Sweden BerndF.M.Romeike,Germany Peter McLaren Black, USA Mark J. Krasna, USA Volker Rudat, Germany Susana M. Campos, USA Masatoshi Kudo, Japan Thomas J. Rutherford, USA Michael A. Carducci, USA Robert Langley, USA Aysegula A. Sahin, USA Stefano Cascinu, Italy Charles F. Levenback, USA Giovanni Scambia, Italy Soonmee Cha, USA Allan Lipton, USA P. Magnus Schneider, Switzerland Susan Chang, USA Jay S. Loeffler, USA Peter E. Schwartz, USA Thomas R. Chauncey, USA Dario Marchetti, USA Jalid Sehouli, Germany Dennis S. Chi, USA Maurie M. Markman, USA Edgar Selzer, Austria Edward A. Copelan, USA Shahla Masood, USA Francis Seow-Choen, Singapore Richard Crevenna, Austria Keisuke Masuyama, Japan Dong M. Shin, USA Massimo Cristofanilli, USA Ian E. McCutcheon, USA Jean F. Simpson, USA Christos Dervenis, Greece Minesh Mehta, USA Keshav K. Singh, USA Andreas Dietz, Germany Sofia D. Merajver, USA Judith A. Smith, USA Frederick E. Domann, USA Bradley J. Monk, USA Lawrence J. Solin, USA Avraham Eisbruch, USA Yoshihiro Moriya, Japan Luis Souhami, Canada Joann G. Elmore, USA Satoru Motoyama, Japan Alphonse G. Taghian, USA Thomas J. Fahey, USA JamesL.Mulshine,USA Hiromitsu Takeyama, Japan Dominic Fan, USA Arya Nabavi, Germany Nelson Teng, USA Phillip G. Febbo, USA Patrick Neven, Belgium C. H. J. Terhaard, The Netherlands Douglas L. Fraker, USA Felix Niggli, Switzerland Douglas S. Tyler, USA Henry S. Friedman, USA Patrizia Olmi, Italy Raul A. Urrutia, USA Hani Gabra, UK Jan I. Olofsson, Norway Vincenzo Valentini, Italy Cicek Gercel-Taylor, USA Jens Overgaard, Denmark Daniel Vallbohmer,¨ Germany William J. Gradishar, USA Richard T. Penson, USA M. W. M. van den Brekel, The Netherlands Robert M. Hermann, Germany Joseph M. Piepmeier, USA G. A. M. S. Van Dongen, The Netherlands Mario Hermsen, Spain Rob Pieters, The Netherlands John R. van Nagell, USA Fred H. Hochberg, USA M. Steven Piver, USA Bruno Vincenzi, Italy William J. Hoskins, USA Alfredo Quinones-Hinojosa, USA Dennis D. Weisenburger, USA Toshiyuki Ishiwata, Japan JanetS.Rader,USA Jochen A. Werner, Germany Contents Tumor Angiogenesis, Arkadiusz Dudek, Kalpna Gupta, Sundaram Ramakrishnan, and Debabrata Mukhopadhyay Volume 2010, Article ID 761671, 2 pages Tumor Angiogenesis: Insights and Innovations, Fernando Nussenbaum and Ira M. Herman Volume 2010, Article ID 132641, 24 pages Extracellular Matrix Proteins and Tumor Angiogenesis,N.E.Campbell,L.Kellenberger,J.Greenaway, R. A. Moorehead, N. M. Linnerth-Petrik, and J. Petrik Volume 2010, Article ID 586905, 13 pages Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis, Birgit Mosch, Bettina Reissenweber, Christin Neuber, and Jens Pietzsch Volume 2010, Article ID 135285, 12 pages Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation, Michael C. Schmid and Judith A. Varner Volume 2010, Article ID 201026, 10 pages Sympathetic Neurotransmitters and Tumor Angiogenesis—Link between Stress and Cancer Progression, Jason Tilan and Joanna Kitlinska Volume 2010, Article ID 539706, 6 pages IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis, Andrew J. Sanders, Xiaoxia Guo, Malcolm D. Mason, and Wen G. Jiang Volume 2010, Article ID 817375, 5 pages An Active Form of Sphingosine Kinase-1 Is Released in the Extracellular Medium as Component of Membrane Vesicles Shed by Two Human Tumor Cell Lines, Salvatrice Rigogliuso, Chiara Donati, Donata Cassara,` Simona Taverna, Monica Salamone, Paola Bruni, and Maria Letizia Vittorelli Volume 2010, Article ID 509329, 10 pages Hsp90 as a Gatekeeper of Tumor Angiogenesis: Clinical Promise and Potential Pitfalls,J.E.Bohonowych, U. Gopal, and J. S. Isaacs Volume 2010, Article ID 412985, 17 pages The Role of Ets Factors in Tumor Angiogenesis, Peter Oettgen Volume 2010, Article ID 767384, 6 pages Molecular Mechanisms of Resistance to Tumour Anti-Angiogenic Strategies,RenaudGrepin´ and Gilles Pages` Volume 2010, Article ID 835680, 8 pages Molecular and Clinical Aspects of Targeting the VEGF Pathway in Tumors, Grzegorz Korpanty, Laura A. Sullivan, Elizabeth Smyth, Desmond N. Carney, and Rolf A. Brekken Volume 2010, Article ID 652320, 12 pages TGF-β Superfamily Receptors—Targets for Antiangiogenic Therapy?, Jasmin Otten, Carsten Bokemeyer, and Walter Fiedler Volume 2010, Article ID 317068, 10 pages Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound,YoucefM.Rustum, Karoly´ Toth,´ Mukund Seshadri, Arindam Sen, Farukh A. Durrani, Emily Stott, Carl D. Morrison, Shousong Cao, and Arup Bhattacharya Volume 2010, Article ID 396286, 13 pages Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy, Han-Chung Wu and De-Kuan Chang Volume 2010, Article ID 723798, 8 pages Angiogenesis Inhibition in Prostate Cancer: Current Uses and Future Promises, Jeanny B. Aragon-Ching, Ravi A. Madan, and William L. Dahut Volume 2010, Article ID 361836, 7 pages CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer Cells, Minghuan Yu, Richard Berk, and Mary Ann Kosir Volume 2010, Article ID 939407, 10 pages Immunomodulatory Agents with Antivascular Activity in the Treatment of Non-Small Cell Lung Cancer: Focus on TLR9 Agonists, IMiDs and NGR-TNF, Angelo Corti, Monica Giovannini, Carmen Belli, and Eugenio Villa Volume 2010, Article ID 732680, 8 pages Angiogenesis: From Chronic Liver Inflammation to Hepatocellular Carcinoma, Paloma Sanz-Cameno, Mar´ıa Trapero-Marugan,´ Mar´ıa Chaparro, Evan Anthony Jones, and Ricardo Moreno-Otero Volume 2010, Article ID 272170, 7 pages Angiogenesis and Lymphangiogenesis of Gastric Cancer, Yasuhiko Kitadai Volume 2010, Article ID 468725, 8 pages Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides, Christina Coleman, Danielle Levine, Raj Kishore, Gangjian Qin, Tina Thorne, Erin Lambers, Sharath P. Sasi, Mina Yaar, Barbara A. Gilchrest, and David A. Goukassian Volume 2010, Article ID 928628, 14 pages Molecular Therapeutic Targets for Glioma Angiogenesis, Shingo Takano, Toshiharu Yamashita, and Osamu Ohneda Volume 2010, Article ID 351908, 11 pages Progress on Antiangiogenic Therapy for Patients with Malignant Glioma,ManmeetS.Ahluwaliaand Candece L. Gladson Volume 2010, Article ID 689018, 14 pages Antiangiogenic Therapy and Mechanisms of Tumor Resistance in Malignant Glioma, Ruman Rahman, Stuart Smith, Cheryl Rahman, and Richard Grundy Volume 2010, Article ID 251231, 16 pages Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer, Thomas N. Seyfried and Purna Mukherjee Volume 2010, Article ID 961243, 8 pages Role of Angiopoietin-2 in Regulating Growth and Vascularity of Astrocytomas, Gelareh Zadeh, Keyvan Koushan, Qian Baoping, Patrick Shannon, and Abhijit Guha Volume 2010, Article ID 659231, 7 pages Vascular Endothelial Growth Factor-Related Pathways in Hemato-Lymphoid Malignancies, Michael Medinger, Natalie Fischer, and Alexandar Tzankov Volume 2010, Article ID 729725, 13 pages Hindawi Publishing Corporation Journal of Oncology Volume 2010, Article ID 761671, 2 pages doi:10.1155/2010/761671 Editorial Tumor Angiogenesis Arkadiusz Dudek,1 Kalpna Gupta,1 Sundaram Ramakrishnan,2 and Debabrata Mukhopadhyay3 1 Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA 2 Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA 3 Department of Biochemistry and Molecular Biology, Tumor Angiogenesis, Vascular Biology and Nanotechnology Laboratory, Mayo Clinic Foundation, Rochester, MN, USA Correspondence should be addressed to Arkadiusz Dudek, [email protected] Received 30 August 2010; Accepted 30 August 2010 Copyright © 2010 Arkadiusz Dudek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In a seminal New England Journal of Medicine article, pub- and result in resumption of tumor dormancy. The fourth lished 40 years ago, Folkman proposed the concept that assumption was that antiangiogenic cancer therapy could angiogenesis could be a target for cancer therapy [1]. This be