DE98F5489 3 ^ f xO REPORT 97-09 September 1997 6th Workshop on Heavy-Charged Particles in Biology and Medicine Baveno September 29, 30 and October 1,1997 Book of Abstracts G. Kraft, K. Langbein Gesellschaft fur Schwerionenforschung mbH PlanckstraBe 1 • D-64291 Darmstadt • Germany Postfach 11 05 52 • D-64220 Darmstadt • Germany 6th Workshop on Heavy-Charged Particles in Biology and Medicine Baveno Sept. 29, 30 and October 1, 1997 Book of Abstracts Editors: G. Kraft & K. Langbein PREFACE The idea to organize this meeting in the lovely landscape of northern Italy was bom two years ago when we thought that the heavy-ion therapy at GSI would have already started then with patient treatment and that for the TERA project the first building would be under construction. However, we have been too optimistic and we have not yet reached these goals. Heavy-ion therapy at GSI is close to start. All necessary tests have been performed and the test protocols are submitted to the government. The installation of a novel control and safety system, that fulfills the laws for the application of beams in therapy, took much more effort than anticipated. Also the dosimetry of a scanned carbon beam turned finally out to be more difficult than predicted by the specialists. In addition, inverse treatment planning including the dependence of RBE on the particle spectrum and the tissues’ radiosensitivity is a complex and tedious task, again taking more time than suggested before. In order to cover at least some of these aspects in greater detail we decided to change the topics of our workshop so that treatment planning and dosimetry are found to be more extended than before. But the basic radiobiology like DNA damage, cell inactivation and mutation are still essential parts of the program. An independent session of modelling, however, disappeared simply by asking the modellers to calculate with their approach the specific case of the inactivation by a particle beam penetrating a water like tissue and to compare it with measurements. Since only a few responses came they are now integrated in the treatment planning session. Finally, I hope that the session of clinical results, new techniques and future projects will provide strong motivations for the work still to be done in the future. 6th Workshop on Heavy-Charged Particles in Biology and Medicine Baveno, Sept 29, 30 and October 1 Introduction L. Skarsgard Radiobiology with Heavy Charged Particles: A (Cancer Research Center, Historical Review Canada) A DNA Damage and Repair K. Prise, B. Rydberg (Chair) Oral Presentations 1. Kevin Prise A Study of DNA Fragmentation Patterns in Cells (Mount Vernon Hospital, Irradiated with Charged Particles: Evidence for non- Northwood, UK) random Distributions 2. Bjorn Rydberg (LBNL Berkeley, USA) 3. Gisela Taucher-Scholz Track-Structure Effects on Biological Targets: DNA (GSI, Darmstadt, Germany) Double-Strand Break Induction and Rejoining 4. Mauro Belli DNA Damage Induction and Processing after (INFN, Rome, Italy) Irradiation with Different Light Ions 5. Kai Rothkamm Heavy-Ion-Induced DNA Double-Strand-Breaks in (Univers, Giefien, Germany) Yeast and Man: Differences and Similarities 6. Bernd Dusemund Structural and Quantitative Aspects of Radical (Univers. d. Saarlandes, Formation after Heavy-Ion Bombardment Germany) 7. Zengquan Wei Carbon-lon-induced DNA Double-Strand Breaks in (Chin. Aca. of Sc. Lanzhou, Melanophore B16 China) Posters 8. Erik Hoglund Initial DNA Fragmentaion Induced by Radiation of (Uppsala Univers., Sweden) Different Linear Energy Transfer 9. Daniela Keller Double-Strand Break Induction along a Particle Track: (GSI, Darmstadt, Germany) Visualization of Different Fragment Sizes 10 Wolfgang Schonert Investigation of Radiation Induced DNA Breaks Using (GSI, Darmstadt, Germany) Scanning Tunneling Microscopy 11 Barbara Weiland Free Radicals from DNA after Irradiation with Heavy (Uni. des Saarlandes, Ions or X-Rays: a Highfield EPR Study at 8.7T and 245 Homburg, Germany) Ghz 12 Anne-Kathrin Hoffmann Heavy-Ion-Induced Damage to DNA Constituents: (Uni. des Saarlandes, Product Formation Homburg, Germany) Space Research (Chair Walter Schimmerling) Oral Presentations Walter Schimmerling Radiation in Space (NASA, Washington, USA) Thomas Streibel Cross Sections and Kinematics of Proton nduced (Univers. Siegen, Germany) Fragmentation of Carbon Manfred Schafer Inactivation Probalility as a Function of the Distance (DLR Cologne, Germany) from the Particle’s Path Measured with Spores of Bacillus Subtilis and Using an Image Analyzing System Mutation and Chromosome Aberration S. Ritter (Chair) Oral Presentations Sylvia Ritter Particle-Induced Chromosome Aberration and (GSI, Darmstadt, Germany) Mutations:an Overview Marco Durante Heavy-Ion-Induced Chromosomal Aberrations (Univers. Federico „Neapel II", Analyzed by Fluorescence in Situ Hybridization Italy) Karin Fussel Comparison of RBE for Inactivation and Chromosomal (GSI, Darmstadt, Germany) Damage of High-Energy Carbon Ions Jurgen Kiefer Mutations Induced by Heavy-Ions: Cross Sections, (Strahlenzentrum,Univers. RBE and Molecular Patterns GieGen, Germany) Fumio Yatagai Analysis of Mutations in the Human HPRT Gene (Inst. Rhys. Chem.Res., Induced by Heavy-Ion Irradiation Saitama, Japan) Hermann Rink HPRT Mutations in V79 Cells: Type of Lesions (Univers. Bonn, Germany) Dependent on LET Shigemitsu Tano Structural Changes of DNA in Heavy-Ion-Induced (Jap. Atom. Energ. Res. Inst, Mutants on Arabidopsis Takasaki, Japan) Posters Robert Katz Track Theory Estimates of Single Particle Traversals of (Univers. of Nebraska, USA) Cell Nuclei Paul Schmidt Molecular Spectra of Heavy-Ion-Induced Mutations (Strahlenzentrum,Univers. Gielien, Germany) Cell and Tissue Radiobiology K. Ando (Chair) Oral Presentations Koichi Ando Mouse Skin Damages Caused by Fractionated (Nat. Inst. Rad. Science, Chiba, Irradiation with Carbon Ions Japan) Jurgen Debus Conformal Radiotherapy with Volume-Scanned Carbon (Univers. Heidelberg, Ions - Relative Biological Effectiveness in the Rat Germany) Spinal Cord Claudia Fournier Human Fibroblasts as a Model for Healthy Tissue in (GSI, Darmstadt, Germany) Radiotherapy 4. Hiroshi Watanabe Influence of Penetration Controlled Irradiation with (Jap. Atom. Res. Energ. Inst. , Charged Particles on Tobacco Pollen Takasaki, Japan) 5. L. Distel First Biological Experiments at the Vertical Proton (Univers. Erlangen-Nurnberg, Beam Germany) 6. Milos Lokajicek Inactivation Mechanism of Different Radiation Kinds, (Academy of Science, Prague, Shapes of Survival Curves and Deviations from LQ Czech Republic) Model 7. D. Choudhary Effect of 45 MeV 7Li and 68 MeV 160 Charged (Jawaharlal Nehru Univers., Particles on Biological Membranes New Dehli, India) Posters 8. Martin Moosburger Status of the Vertical Beam Facility at the Munich (Ludwig-Max.-Univers. Tandem Accelerator Munchen, germany) 9. Mayank Srivastava Effects of 45 MeV and 68 MeV Charged Particles on (Jawaharlal Nehru Univers., Microsomal Mem bra nee Fluidity New Dehli, India) 10 A. Touati Experimental Determination of the Contribution of (Univers. Paris 7 and 6, Carbon K-lonizations to the RBE for Cell Inactivation France) by Ultrasoft X-Rays 11 Gianfranco Gross! Survival of Human Cells Exposed to Acute and (Inst Sup. San. and INFN, Fractionated Doses of Low-Energy Protons Roma, Italy) 12 Daniel Zukowski Cellular Response of V79 Spheroids Exposed to High (Uni Mainz, Germany) Energy Carbon Ions 13 Mirjam Fritsch First Experiments at a Vertical Proton Beam (Uni Erlangen, Germany) E Treatment Planning I: The Role of Clinical RBEs A. Kellerer (Chair) Oral Presentations 1. A.Kellerer (Introduction) Accounting for Radiation Quality in Heavy Ion Therapy (LMU, Munich, Germany) 2. Michael Scholz Estimation of Clinical RBE for Carbon Therapy (GSI, Darmstadt, Germany) 3. Alessandro Campa RBE evaluation of Therapeutic Proton Beams in (Inst Sup. San. and INFN, Computer Simulations Roma, Italy) 4. Andrea Ottolenghi Analysis of a Slowing down 150 MeV Proton Beam in (Uni. Milano, INFN, Italy) Water: Physical Characteristics and Effectiveness in Inducing DNA Clustered Damage 5. Robert Katz Treatment Planning Problems with Range Modulated (Univers. of Nebraska, USA) Heavy Ion Beams Posters 6. Nina Tilly The Contribution by Inelastic Nuclear Interactions to (Uni. Stockholm, Sweden) the RBE of Protons p Treatment Planning II: Dose Optimization and Inverse Planning M. Benassi (Chair) Oral Presentations 1. Oliver Jake I Treatment Planning for Heavy Ion Irradiation I (DKFZ, Heidelberg, Germany) 2. Michael Kramer Treatment Planning for Heavy Ion Irradiation II (GSI, Darmstadt, Germany) 3. Yoshihisa Takada SOBP Formation by Two-Dimensional Array of Cone (Uni. Tsukuba, Japan) Filter 4- Uli Weber Bragg-Peak Widening Using a Ripple Filter (GSI, Darmstadt, Germany) 5. Enzo Menapace The Role of Nuclear Constants for Applications (ENEA, Bologna, Italy) Related to the Proton Radiotherapy 6. Dieter Schardt Nuclear Fragmentation of 270 MeV/u 12 C Ions in (GSI, Darmstadt, Germany) Water 7. Ivan Petrovic SRNA: A Monte Carlo Code for Proton Transport (Vinca, INS, Belgrade, Simulation Yugoslavia) Poster 8. Angela Mitaroff Investigation of Treatment Planning Using Biological (GSI, Darmstadt, Germany) and Thermoluminescence Detectors G Dosimetry Kanai/Goitein (Chair) Oral Presentations 1. Tatsuaki Kanai Three-Year Experiences of Heavy-Ion Dosimetry at (Chiba, Japan) HIMAC 2. Adolf Coray Monitoring the Dose Delivery for the Spot Scanning at (PSI, Villingen, Switzerland) PSI 3. S. Onori Recent Developments