Drugs that affect Bowel/Bladder Control The purpose of this list is to give examples -Aluminum Hydroxide Protriptyline - Propoxyphene of drugs that can affect incontinence. It is -Calcium Carbonate - Trimipramine - Nalbuphine not a comprehensive list. -Calcium Carbonate and Magnesia -Calcium Carbonate, Magnesia, and MAO Antidepressants NSAIDS Blood pressure/Heart Simethicone - Amoxapine -Urinary retention in elderly and or arthritic Anti-hypertensives -Calcium and Magnesium Carbonates - Bupropion patients (on large doses) (Postural hypotension leads and functional -Magaldrate - Citalopram Oral urinary incontinence). -Magaldrate and Simethicone - Fluoxetine - Diclofenac -Magnesium Carbonate and Sodium - Fluvoxamine - Diflunisal ACE inhibitors Bicarbonate - Mirtazapine - Etodolac - Benazepril -Magnesium Hydroxide - Nefazadone - Fenoprofen - Captopril - Paroxetine - Floctafenine - Enalapril Laxatives - Sertraline - Ibuprofen - Fosinopril (Diarrhea, intestinal cramping, fecal - Trazodone - Indomethacin - Lisinopril incontinence) - Venlafaxine - Ketoprofen - Quinapril - Polycarbophil - Meclofenamate - Ramipril - Psyllium; Hydrophilic Mucilloid and Senna Anti-psychotics - Mefenamic Acid - Lactulose (Constipation, confusion, sedation, rigidity - Nabumetone ACE II inhibitors (ARB’s) - Polyethylene glycol 3350 and immobility leading to overflow and - Naproxen - Candesartan - Magnesium Citrate functional urinary incontinence). - Oxaprozin - Eprosartan - Magnesium Hydroxide (Milk of magnesia) - Piroxicam - Irbesartan - Magnesium Sulfate - Chlorpromazine - Sulindac - Losartan - Sodium Phosphate - Clozapine* - Tenoxicam - Telmisartan - Milk of Magnesia & Mineral Oil - Fluphenazine - Tiaprofenic Acid - Valsartan - Mineral Oil - Haloperidol -Tolmetin - Bisacodyl - Loxapine Alpha Adreneurgics - Cascara Sagrada; and Aloe; and - Olanzapine* Other - Clonidine Bisacodyl - Perphenazine - Castor Oil - Pimozide Anticholinergic/ Antispasmodic/ Anti- Diuretics - Senna - Quetiapine* emetics (Diruresis causes overflow incontinence) - Sennosides - Risperidone* (Constipation and urinary retention leading - Acetazolamide - Bisacodyl and Docusate - Thioridazine to overflow and functional urinary - Amiloride - Casanthranol and Docusate - Trifluoperazine incontinence) - Bumetanide - Danthron and Docusate *atypicals - Benztropine - Chlorthalidone - Sennosides and Docusate - Oxybutynin - Hydrochlorothiazide - Docusate Sedative/Hypnotic/ Barbiturate - Procyclidine indapamide (Can cause excessive sedation and - Scopolamine - Metolazone Mood/Behaviour: decreased mobility in elderly people - Tolterodine - Spironolactone Antidepressant predisposing them to functional urinary - Trihexyphenidyl (Constipation, especially in elderly. incontinence. Not commonly used in long Calcium Channel Blockers Contributes to overflow and functional term care.) 1st Generation Antihistamines (Constipation, diarrhea) urinary incontinence. Problems with - Butabarbital - Chorpheniramine - Amlodipine urination and loss of bladder control. - Dephenhydramine - Diltiazem Monoamine oxidase inhibitors (MAO’s) can Pain; Analgesics - Dimenhydrinate - Felodipine cause urinary retention.) Narcotic - Hydroxyxine - Nifedipine Constipation and confusion leading to - Verapamil Tricyclic antidepressants overflow and functional urinary Cholinergic - Amitriptyline incontinence. (Cause urge incontinence due to bladder Digestion/Excretion: - Clomipramine - Codeine relaxation. Not commonly used in long Antacids with aluminum - Desipramine - Hydrocodone term care). (laxative effect, can cause diarrhea or - Doxepin - Hydromorphone - Bethanechol loose stools) - Imipramine - Levorphanol - Maprotiline (tetracyclic) Anti-Parkinson agents -Various Alumina compounds - Meperidine - Nortriptyline - Morphine (Constipation, diarrhea) - Oxycodone - Levadopa - Pentazocine - Carbadopa - Pergolide Sources: AHCPR . 2006. Urinary Incontinence. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat6.section.10079 .; Brigham & Women’s Hospital. 2004, Urinary incontinence http://www.brighamandwomens.org/medical/HandbookArticles/Urinaryincontinence.pdf .; The Hartford Institute for Geriatric Nursing. 2001. Urinary incontinence. http://www.hartfordign.org/publications/trythis/issue11.pdf .; IC-5 Continence Project, 2005, http://www.hospitalreport.ca/projects/QI_projects/IC5.html . Rehabilitation Nursing Foundation. 2002. Constipation. www.rehabnurse.org .; RNAO. 2005, Preventing Constipation; Prompting Continence. http://www.rnao.org/bestpractices . ; Royal Women’s Hospital . 2005. Urinary incontinence, http://www.rwh.org.au/rwhcpg/womenshealth.cfm?doc_id=3661 . ; Singapore Ministry of Health . 2003, http://www.moh.gov.sg/cmaweb/attachments/publication/Nursing_Management_of_Patients_with_Urinary_Incontinence_1-2003.pdf . U.S. National Library of Medicine and U.S. National Institute of Health . 2006. Drugs, supplements. < http://www.nlm.nih.gov/medlineplus/druginformation.html >. 18 .