DUSP3 rabbit monoclonal antibody with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases Catalog Number: H00001845-K show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular Regulatory Status: For research use only (RUO) localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a Product Description: Rabbit monoclonal antibody region that contains the BRCA1 locus which confers raised against a human DUSP3 peptide using ARM susceptibility to breast and ovarian cancer. Although Technology. DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in Immunogen: A synthetic peptide of human DUSP3 is sporadic tumors was negative, leading to the conclusion used for rabbit immunization. that this gene is not BRCA1. [provided by RefSeq] Customer or Abnova will decide on the preferred peptide sequence. Host: Rabbit Reactivity: Human Applications: ELISA, WB-Tr (See our web site product page for detailed applications information) Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols Purification: Protein A Isotype: IgG Storage Buffer: In 1x PBS, pH 7.4 Storage Instruction: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 1845 Gene Symbol: DUSP3 Gene Alias: VHR Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated Page 1/1 Powered by TCPDF (www.tcpdf.org).