PATIENTS CAN FEEL COMPLETELY SAFE Possible Side Effects EnBrace HR SSRI’s SNRI’s Weight Gain No! Yes Yes Loss of Libido, difficulty achieving erections, No! Yes Yes inability to reach orgasm Increased thoughts of suicide and No! Yes Yes aggression in adolescents & adults Drowsiness or Confusion No! Yes Yes Nervousness & Agitation No! Yes Yes Adapted from: Consumer Reports Best Buy Drugs. Using antidepressants to treat depression: comparing efficacy, safety and price. 2012 Drug antidepressant risks in pregnancy Reference Included In Pocket EnBraceHR.com EnBraceHR.com 985-629-5990 Andy Farah MD, Chief of Psychiatry, Women’s Mental Health and Addiction UNC Addiction and Health Mental Women’s Psychiatry, of Chief MD, Farah Andy therapeutic benefits in the Rx prenatal market” prenatal Rx the in benefits therapeutic Polymorphic patient, EnBrace HR offers proven expanded expanded proven offers HR EnBrace patient, Polymorphic We Look Forward To Speaking With You! With Speaking To Forward Look We congenital and other birth defects, even in the MTHFR MTHFR the in even defects, birth other and congenital Your EnBrace HR Prescription. HR EnBrace Your and its positive impact in the prevention of neural tube, tube, neural of prevention the in impact positive its and Our Friendly Customer Service Team Is Here To Help You Obtain Obtain You Help To Here Is Team Service Customer Friendly Our treatment of depression before, during and after pregnancy pregnancy after and during before, depression of treatment you determine the most cost effective way to receive your prescription. your receive to way effective cost most the determine you clinical effectiveness and safety for the prevention and prevention the for safety and effectiveness clinical A customer care representative from our Reimbursement Department will be reaching out to help help to out reaching be will Department Reimbursement our from representative care customer A “Given the demonstrated the “Given THE PATIENT: THE With Clinical Proof Clinical With Reimbursement Department who will help determine the most cost effective option for your patient. your for option effective cost most the determine help will who Department Reimbursement easy to use fax form on EnBraceHR.com or by calling 985.629.5990. Please fax the form to our our to form the fax Please 985.629.5990. calling by or EnBraceHR.com on form fax use to easy The Patient’s Mail Order Prescription Plan May Be A Cost Effective Option. You will find our our find will You Option. Effective Cost A Be May Plan Prescription Order Mail Patient’s The 1-24 THE PROVIDER: THE Offers 3 Major Therapeutic Benefits Therapeutic Major 3 Offers FILLING THE PRESCRIPTION THE FILLING FOR FREE 30 DAY TRIAL BOTTLE CALL 985-629-5990 CALL BOTTLE TRIAL DAY 30 FREE FOR NEWS FLASH NEWS Prenatal Vitamin Gel Cap Gel Vitamin Prenatal BEFORE DURING AFTER DURING BEFORE Rx All Natural, Unique, Bioactive Bioactive Unique, Natural, All Rx SMALL GEL CAP GEL SMALL PRESCRIPTION ONLY PRESCRIPTION WHEN TO USE EnBRACE HR EnBRACE USE TO WHEN Insurance, Medicaid Coverage Medicaid Insurance, With Rx Only Rx Now You Can You Now CASEIN FREE CASEIN You Want To Help To Want You CALCIUM FREE CALCIUM CAP GEL SMALL PRESCRIPTION ONLY PRESCRIPTION DYE FREE DYE Concerns GLUTEN FREE GLUTEN She Has Has She References: 1. Freeman et al., A prenatal supplement with methylfolate for the treatment and prevention of depression in women trying to conceive EnBrace HR Small Gel Cap and during pregnancy, Annals of Clinical Psychiatry, Feb. 2019 2. Farah et.al, Correlation of Clinical Response with Homocysteine Reduction During Therapy With Reduced B Vitamins in Patients With MDD Who Are Positive for MTHFR C677T or A1298C Polymorphism, Journal of Clinical Psychiatry, May 2016 Ingredients 3. MRC Vitamin Group, Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study, Lancet, 1991 4. Czeizel et al., Periconceptional Folic Acid and Multivitamin Supplementation for the Prevention of Neural Tube Defects and Other Con- genital Abnormalities, Clinical and Molecular Teratology, 2008 Rx, All Natural, Unique, Bioactive Prenatal Vitamin Gel Cap 5. FDA, 21 CFR-101.79- Health Claims: Folate and neural tube defects, CFR Text. 2019 6. Kirk E et al., Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study, BMJ, 2004 7. Ufriend et al., The C677T polymorphism of the methelenetetrahydrofolate reductase gene and idiopathic recurrent miscarriage, Obstet- L-Methylfolate Magnesium 5.53mg rics & Gynecology, April 2002 8. MTHFR Living, Preparing for Pregnancy with MTHFR Mutations, Jan. 2014 Folinic Acid 2.5mg 9. Garilli, Bianca ND, MTHFR Mutation: A Missing Piece in the Chronic Disease Puzzle, Huffington Post, Summer, 2012 10. Wald et al, Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate, Folic Acid 1mg Public Health Reviews, 2018 11. Farah et al., The Prevalence and Role of MTHFR Polymorphism in Opiate Dependency, Journal of Addiction and Therapies, Feb. 2018 12. El-Hadidy et al., Methylene tetra hydrofolate reductase C677T Gene Polymorphism in Heroin Dependence, Addiction Research & B12 (Methylcobalamin) 25mcg Therapy, 2015 13. Mararwa et al., Prenatal exposure to SSRIs and SNRIs and risk for pulmonary hypertension of the newborn: a systemic review, me- B12 (Adenosylcobalamin) 25mcg ta-analysis, AJOG, 2018 14. Chambers et al., SSRI and Risk of Persistent Pulmonary Hypertension of the Newborn, The New England Journal of Medicine, 2011 Intrinsic Factor (B12 Vitamin Bioenhancer) 25mg 15. Kieviet et al., Use of antidepressants during pregnancy in The Netherlands: observational study into post-partum interventions, BMC Pregnancy & Childbirth, 2017 B6 (Pyridoxal-5-Phosphate) 25mcg 16. MGH Center for Women’s Health, womensmentalhealth.org, SSRIs and Poor Neonatal Adaptation: How Long do Symptoms Last, 2015 B1 (Thiamine Pyrophosphate) 25mcg 17. Liu et al., Antidepressant Use During Pregnancy and Psychiatric Disorders in Offsprings, BMJ, 2017 18. Lugo-Candelas et al., Association Between Brain Structure and Connectivity in Infants and Exposure to SSRIs During Pregnancy, JAMA B2 (Flavin Adenine Dinucleotide) 25mcg Pediatrics, 2018 19. Berard et al., Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women, BMJ, 2016 B3 (Nicotinamide Adenine Dinucleotide) 25mcg 20. WebMD www.webmd.com, pregnancy-and-antidepressants, 2018 21. FDA A Appendix NIH, Antidepressant Drug Labels for Pregnant and Postpartum Women, 2014 PS-Omega-3 (Phosphatidylserine, EPA, DHA) 23mg 22. EnBrace HR PI, FDS Daily Med, Dec. 2018 23. Turgal et al. MTHFR Polymorphisms and Pregnancy Outcome, PMC 6138472, Sept. 2018 Magnesium Ascorbate 24mg 24. Duprey Robert P. MTHFR Gene Polymorphism positive treatment-resistant depression, Neuropsychiatry 2019 Magnesium L-Threonate 1mg Iron (Ferrous Glycine Cysteinate) 13.6mg Zinc Ascorbate 1mg Betaine 500mcg Citric Acid Monohydrate 1.83mg Sodium Citrate 3.67mg CoQ10 500mcg Bioperine (B Vitamin Bioenhancer) 25mg “EnBrace HR contains 5.53 mg. of L-Methylfolate Magnesium and small quantities of other folate derivatives (1mg. folic acid and 2.5mg of folinic acid) optimal for a depressed population with high rates of MTHFR polymorphism that affect folic acid metabolism and high risk of neural tube defects and other birth defects.” EnBraceHR.com Freeman M. et al: A prenatal Supplement with Methylfolate for the Treatment and Prevention of Depression in Women Trying to Conceive and During Pregnancy, Annals of Clinical Psychiatry, February 2019. EnBrace HR Small Gel Cap Offers 3 Major Therapeutic Benefits With Clinical Proof 1. Clinically Proven to Prevent and Treat Depression Before, During and after Pregnancy. 1,2 2. Negates the Risk of MTHFR and Other Polymorphisms for Adverse Pregnancy Outcomes. 6,7,8,9,11, 23, 24 3. Provides the Most Folate Protection for the Prevention of NTDs and Other Birth Defects. 3,4,5 EnBraceHR.com EnBraceHR.com A PrenatalEnBrace SupplementA Prenatal Supplement HRwith MethylfolateFor withThe Methylfolate forTreatment the Treatment for the andand Treatment and Prevention ofPrevention Depression of inDepression Women Trying in Women to Conceive Trying toand Conceive During Pregnancyand During Pregnancy Marlene P. Freeman,Marlene MDPrevention1,, P. Gina Freeman, Savella, MD BS1,1, GinaTaylor of Savella, Church, Depression BS BS1, 1Taylor, Lina GoezChurch,-Mogoll BS1, óLinainn, MD, GoezWomen MSc-Mogoll1,2, Alexandraón, MD, Trying MScZ. Sosinsky,1,2, Alexandra BS 1to, Olivia Z. Sosinsky,Conceive B. Noe 1BS, BS,1, Olivia Anjali B. Kaimal Noe 1,3 BS,, Anjali Kaimal3, andMD MAS,During Lee S. Cohen,MD MAS,Pregnancy MD 1Lee S. Cohen, MD1 1Massachusetts General1Massachusetts Hospital, Psychiatry General Department,Hospital, Psychiatry Center Department,for Women’s CenterMental for Health, Women’s Boston, Mental MA; Health, 2Harvard Boston, T.H. Chan MA; School 2Harvard of Public T.H. Chan Health, School Department of Public Health,of Epidemiology, Department of Epidemiology, Marlene P. Freeman,Boston, MA; 3Obstetrics MDBoston, Department,et MA; al, 3Obstetrics Annals Massachusetts Department, of General Clinical Massachusetts Hospital, Boston, Psychiatry,General MA Hospital, Boston, February MA 2019 Abstract Abstract Results Results Results (Cont.) Results (Cont.) Background: Women often seekBackgroundalternativesFIGURE: Womento standardoften antidepressantsseek alternatives 2.fortomajor standardMADRSdepressiveantidepressantsdisorder