Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information Handbook of Advanced Cancer Care Patients with advanced cancer increasingly receive end-of-life care from a variety of nonspecialist physicians and nurses. These professionals need to be able to assess the original diagnosis and the appropriateness of patient referral, set a treatment or palliation program, and recognize and plan for the clinical problems associated with specific primary tumors. However, there is no comprehensive source of information available to them at a level between specialist oncology texts and nursing texts. Toremedy this, two eminent physicians from one of the world’s foremost cancer centers have drawn together a remarkable team to provide a handbook which covers the full range of problems nonspecialists will encounter. This highly accessible text covers general principles in oncology, the primary tumors one by one, and management of specific symptoms and syndromes. It will be invaluable to primary care physicians, surgeons, non-oncology subspecialists, nurses, therapists, and trainees. Dr Michael J. Fisch is Assistant Professor of Medicine at the University of Texas M.D. Anderson Cancer Center. Dr Eduardo BrueraisProfessorandChairoftheDepartmentofPalliativeCareandRehabilitation Medicine at the University of Texas M.D. Anderson Cancer Center. © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information Handbook of Advanced Cancer Care edited by Michael J. Fisch and Eduardo Bruera © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information University Printing House, Cambridge CB2 8BS, United Kingdom One Liberty Plaza, 20th Floor, New York, NY 10006, USA 477 Williamstown Road, Port Melbourne, VIC 3207, Australia 314-321, 3rd Floor, Plot 3, Splendor Forum, Jasola District Centre, New Delhi - 110025, India 103 Penang Road, #05-06/07, Visioncrest Commercial, Singapore 238467 Cambridge University Press is part of the University of Cambridge. It furthers the University’s mission by disseminating knowledge in the pursuit of education, learning and research at the highest international levels of excellence. www.cambridge.org Information on this title: www.cambridge.org/9780521010436 © Cambridge University Press 2003 This publication is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 2003 A catalogue record for this publication is available from the British Library Library of Congress Cataloging in Publication data Handbook of advanced cancer care / [edited by] Michael J. Fisch, Eduardo D. Bruera. p. cm. Includes bibliographical references and index. ISBN 0 521 01043 8 (pbk.) 1. Cancer – Palliative treatment – Handbooks, manuals, etc. 2. Terminal care – Handbooks, manuals, etc. 3. Cancer – Nursing – Handbooks, manuals, etc. I. Bruera, Eduardo. II. Fisch, Michael J., 1964– RC271.P33 C356 2003 616.99´406 – dc21 2002073305 ISBN 978-0-521-01043-6 Paperback Cambridge University Press has no responsibility for the persistence or accuracy of URLs for external or third-party internet websites referred to in this publication, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. Every effort has been made in preparing this book to provide accurate and up-to-date information which is in accord with accepted standards and practice at the time of publication. Although case histories are drawn from actual cases, every effort has been made to disguise the identities of the individuals involved. Nevertheless, the authors, editors and publishers can make no warranties that the information contained herein is totally free from error, not least because clinical standards are constantly changing through research and regulation. The authors, editors and publishers therefore disclaim all liability for direct or consequential damages resulting from the use of material contained in this book. Readers are strongly advised to pay careful attention to information provided by the manufacturer of any drugs or equipment that they plan to use. © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information To our spouses and children whose love and sacrifice allow us the privilege to care for patients and families with advanced cancer Susan, Amanda, and Ryan Fisch Maria, Ed, Sophia, and Sabastian Bruera © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information Contents List of contributors page xii Preface xix Acknowledgements xxi Part I General concepts in oncology 1 Principles of diagnosis and staging 3 John J. Kavanagh 2 Principles of palliative chemotherapy 12 Michael Fisch 3 Principles of palliative surgery 22 Barry W. Feig 4 Radiotherapy for palliation of symptoms 27 Carlos Centeno and Carmen Gonzalez´ 5 ABCs of clinical trials 40 J. Lynn Palmer 6 Principles of cancer rehabilitation 45 Ki Y. Shin 7 Principles of palliative nursing 51 Nessa Coyle 8 Ethics of decision making towards the end of life 58 Christopher K. Daugherty 9 Breaking bad news 70 Walter F. Baile and Robert Buckman vii © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information viii Contents 10 The use of complementary/alternative medicine 88 Mary Ann Richardson 11 Understanding “hospice” 96 Vincent Hsieh and Jane Ingham 12 Practical aspects of home care 108 Anna Wreath Taube 13 Cultural differences in advanced cancer care 113 Juan M. N´unez-Olarte˜ 14 Implementing social services 117 A. Marlene Lockey 15 Pastoral care 123 Derek B. Murray 16 Bereavement 126 Stephen D. King Part II Primary tumors 17 Lung cancer 137 Suzie Whelen and Thomas J. Smith 18 Breast cancer 150 Kathy D. Miller 19 Colorectal cancer 162 Charles D. Blanke 20 Prostate cancer 171 Christopher Sweeney 21 Pancreatic and hepatobiliary cancer 178 Edward H. Lin and James L. Abbruzzese 22 Anal cancer 190 Rob Glynne-Jones 23 Esophageal and gastric cancer 197 Stephen A. Bernard 24 Head and neckcancer 207 Merrill S. Kies and Roy S. Herbst © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information ix Contents 25 Kidney cancer 217 Lori Wood 26 Bladder cancer 223 Heather-Jane Au and S. North 27 Ovarian cancer 229 Diane C. Bodurka 28 Gynecologic malignancies: endometrial and cervical carcinoma 235 William Paul Irvin, Jr. 29 Testicular cancer 247 David B. Solit and Pamela N. Munster 30 Unknown primary site cancer 254 Renato Lenzi 31 Mesothelioma 262 Ralph Zinner 32 Adult soft tissue sarcoma 267 Alan Sandler and Laura McClure-Barnes 33 Osteosarcoma and Ewing’s sarcoma 271 Sharon Soule and David Seitz 34 Melanoma 277 Mark Harries and Tim Eisen 35 Primary brain tumors 289 Paul M. DesRosiers and Robert D. Timmerman 36 Thyroid and adrenal cancer 294 Rae Zyn H. Brana and Douglas B. Evans 37 HIV-related cancer 300 Julia Ladd Smith 38 Hodgkin’s and non-Hodgkin’s lymphoma 308 Craig R. Nichols 39 Leukemia, myelodysplastic syndrome and myeloproliferative disorder 317 Larry D. Cripe and Cheryl Rutledge 40 Multiple myeloma 331 Letha E. Mills © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information x Contents Part III Management of specific symptoms and syndromes 41 Assessment of pain 341 Larry Driver 42 Drugs for managing cancer pain 347 Barry A. Eagel 43 Difficult pain management problems 355 Robin L. Fainsinger 44 Dyspnea 362 Sam H. Ahmedzai and Silvia Paz 45 Loss of appetite and weight 369 Aminah Jatoi and Charles L. Loprinzi 46 Fatigue 374 Hans Neuenschwander 47 Depression and anxiety 382 Michael Fisch 48 Delirium 390 Peter G. Lawlor 49 Constipation 397 Florian Strasser 50 Palliation of fever and sweats: the heat is on! 408 Donna S. Zhukovsky 51 Bleeding in advanced cancer patients 416 Isabelle Mancini and J. J. Body 52 Thrombosis 420 Lukas Radbruch 53 Hypercalcemia of malignancy 426 Paul W. Walker 54 Lymphedema 433 Mabel Caban 55 Wound care of the advanced cancer patient 439 Kathryn G. Froiland © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information xi Contents 56 Infections in patients with advanced cancer 444 Rudolph M. Navari 57 Urogenital complications 450 Romano T. DeMarco and Richard S. Foster 58 Brain metastases 454 Doreen Oneschuk 59 Bowel obstruction 460 Carla Ripamonti 60 Bone metastases 469 Carlos Centeno and Alvaro Sanz 61 Meningeal cancer 477 Neil A. Hagen 62 Pleural and pericardial effusions 481 Michael J. Boyer 63 Superior vena cava syndrome 488 Paul Read and Maria Kelly 64 Chronic nausea 491 Ahmed Elsayem and Michael Fisch Index 500 © in this web service Cambridge University Press www.cambridge.org Cambridge University Press 978-0-521-01043-6 — Handbook of Advanced Cancer Care Edited by Michael J. Fisch , Eduardo Bruera Frontmatter More Information Contributors James L. Abbruzzese Charles D. Blanke Department of Medical Oncology, OHSU-Hem/Medical Oncology Division GI Oncology (Box 426) Oregon Health & Science University U.T.