NYMU - HD 2013 5th Bilateral Symposium National Yang-Ming University and Heidelberg University 5. – 6. October 2012 National Yang-Ming University, Taipei, Taiwan 1 NYMU - HD 2013 2 NYMU - HD 2013 3 Sessions Molecular Biophysics Drug Development Spectroscopy Technique Nano Medicine Speakers Shy Arkin , Jerusalem, IL Hidekatsu Iha , Oita, JP Plenary Lecture Arthur Chiou , Taipei Fu-Jen Kao , Taipei Harald zur Hausen Christoph Cremer , Mainz, DE Bernd König, Jülich, DE Rainer Fink , Heidelberg, DE Jung-Hsin Lin , Taipei Nobel Laureate in Wolfgang Fischer , Taipei Alex Ma , Taipei Medicine 2008 Eric Freed , Klaus Strebel , NIH/NCI, Frederick, MD, USA NIH, Bethesda, USA Stephen Hashmi , Heidelberg, DE Bing Sun , Dieter Heermann , Heidelberg, DE Pasteur Institute, Shanghai Andreas Herrmann , Berlin, DE Peter Tieleman , Calgary, CA Yi-Tsau Huang , Taipei Chin-Tien Wang , Taipei Sponsors: Lin Meng-Han by Design National Yang-Ming University For registration email: [email protected] National Science Council Taiwan http://www.ym.edu.tw/~wfischer/international_vmp_conf/ Biophysical Society of R.O.C. National Yang-Ming University, Taipei, Taiwan Viral Membrane Proteins - Taipei 2012 Symposium on Viral Membrane Proteins National Yang-Ming University 5. – 6. October 2012 Taipei, Taiwan 1 Viral Membrane Proteins - Taipei 2012 Schedule: Thursday, 4 th of October 2012 Morning Arrival Evening 18:00 – 18:30 Registration DAAD, Taipei 101 18:30 – 18:50 Welcome and Introduction Dr. Michael Zickerick, German Institute Taipei, Director General Dr. Stefanie Eschenlohr, DAAD Information Centre Taipei, Director Prof. Dr. Wolfgang Fischer, National Yang-Ming University, Taipei 18:50 – 19:45 Lecture Prof. Harald zur Hausen, DKFZ, Heidelberg, DE Cancer prevention by vaccination. 19:45 German Buffet Dinner Friday, 5 th of October 2012 8:15 Hotel Shuttle Bus to National Yang-Ming University (NYMU) 8:30 – 9:00 Registration Opening 9:00 – 9:10 President Liang, National Yang-Ming University Director General Dr. Michael Zickerick, German Institute Taipei 9: 10 – 10:00 Prof. Harald zur Hausen, DKFZ, DE, Nobel Laureate 2008 The search for infectious causes of human cancers. 10:00 – 10:25 Alex Ma, Taipei The future Influenza vaccine: monoglycosylated hemagglutinin. 10:25 – 10:50 Shy Arkin, Jerusalem, IL How do aminoadamantanes block the influenza M2 channel and how does resistance develop? 2 Viral Membrane Proteins - Taipei 2012 10:50 – 11:00 Coffee Break 11:00 – 11:25 Peter Tieleman, Calgary, CN Simulation studies on the role of the M2 proteins in viral budding. 11:25 – 11:50 Andreas Herrmann, Berlin, DE Influenza virus binds to its host cell through multiple dynamic interactions – A single virus force spectroscopy and force probe MD simulation study. 11:50 – 12:15 Klaus Strebel, Bethesda, USA Functional Characterization of HIV-1 Vpu. 12:15 – 12:40 Wolfgang Fischer, Taipei Multi scale simulations on the assembly of viral channel forming proteins. 12:40 – 14:00 Lunch Break 14:00 – 14:25 Eric Freed, Frederick, USA HIV-1 assembly and release. 14:25 – 14:50 Bernd König, Jülich, D Interaction of HIV-1 VpU and human CD4. 14:50 – 15:15 Bing Sun, Shanghai . ORF4a protein of HCoV-229E forms an ion channel functionally analogous to the SARS-CoV 3a protein . 15:15 – 15:40 Chin-Tien Wang, Taipei Identifying SARS-CoV membrane protein amino acid residues linked to virus-like particle assembly. 15:40 – 16:00 Coffe Break 16:00 – 16:25 Dieter Heermann, Heidelberg, DE A topological similarity measure for proteins. 16:25 – 16:50 Jung-Hsin Lin, Taipei An anatomy of membrane protein dynamics. 16:50 – 17:15 Yi-Tsau Huang, Taipei Bioactivity study of herbs against hepatic fibrogenesis induced by hepatocyte apoptotic bodies. 18:00 – 19:30 Dinner at Escargot, NYMU 3 Viral Membrane Proteins - Taipei 2012 Saturday, 6 th of October 2012 8:15 Hotel Shuttle Bus to NYMU 9:00 – 9:10 Opening 9:10 – 9:35 Stephen Hashmi, Heidelberg, DE The organic side of gold, palladium and platinum. 9:35 – 10:00 Rainer Fink, Heidelberg, DE The ryanodin-receptor - a potential target for VMPs? 10:00 – 10:25 Fu-Jen Kao, Taipei Long working distance fluorescence lifetime imaging with stimulated emission and electronic time delay. 10:25 – 10:45 Coffee Break 10:45 – 11:10 Christoph Cremer, Mainz, DE Far field fluorescence microscopy of viral proteins at molecular optical resolution. 11:10 – 11:35 Hidekatsu Iha, Oita, JP Application of the novel lectin microarray system for the diagnosis of ATL pathogenesis. 11:35 – 12:00 Arthur Chiou, Taipei Optical tweezers based bio-micro-rheology. 12:00 – 12:15 Closing Remarks 12:15 – 14:00 Lunch Break Afternoon Tour: National Palace Museum, Taipei Evening Dinner 4 Viral Membrane Proteins - Taipei 2012 Participants: Keynote Speaker Prof. Dr. Harald zur Hausen Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280 DO 02.049 69120 Heidelberg, Germany T. +49 6221 42 4804 F. +49 6221 42 4808 E-Mail: [email protected] Speakers Prof. Dr. Isaiah Arkin Vice President Institute of Life Sciences Department of Biological Chemistry The Hebrew University, Givat-Ram Jerusalem, 91904, Israel Tel./Fax: +972 – (0)2 – 6584329 Email: [email protected] Prof. Dr. Arthur Chiou Dean of International Affairs, NYMU Director, Biophotonics and Medical Imaging Research Center Institute of Biophotoncis School of Biomedical Science and Engineering National Yang-Ming University 155, Sec. 2, Li-Nong St. Taipei 112, Taiwan Tel.: +886 2 2826 Email: [email protected] 5 Viral Membrane Proteins - Taipei 2012 Prof. Dr. Christoph Cremer Institute of Molecular Biology gGmbH (IMB) Ackermannweg 4 55128 Mainz, Germany Applied Optics & Information Processing, Kirchhoff Institute for Physics, and Institute for Pharmacy and Molecular Biotechnology Heidelberg University Im Neuenheimer Feld 227 D-69120 Heidelberg , Germany Tel.: +49 6221 549252 (Secretary: -54-9271) Fax: +49 6221 549112 Email: [email protected] Prof. Dr. Rainer Fink Medicinal Biophysics Institute for Physiology und Pathophysiology Heidelberg University Im Neuenheimer Feld 326 D-69120 Heidelberg, Germany Tel.: +49 6221 54 4065 or 4084 Fax: +49 6221 54 4123 Email: [email protected] Prof. Dr. Wolfgang B. Fischer Institute of Biophotonics School of Biomedical Science and Engineering National Yang-Ming University 155, Sec. 2, Li-Nong St. Taipei 112 Tel.: +886 2 2826 7394 Fax: +886 2 2823 5460 Email: [email protected] Prof. Dr. Eric O. Freed Head, Virus-Cell Interaction Section HIV Drug Resistance Program National Cancer Institute Frederick National Laboratory for Cancer Research P.O. Box B, Building 535, Room 110 Frederick, MD 21702-1201, USA Tel.: +1 301-846-6223 (office); +1 301-846-6483 (lab) Fax: +1 301-846-6777 E-mail : [email protected] 6 Viral Membrane Proteins - Taipei 2012 Prof. Dr. A. Stephen K. Hashmi Dean of Faculty of Chemistry and Geo-Sciences Organisch-Chemisches Institut Heidelberg University Im Neuenheimer Feld 270 D-69120 Heidelberg, Germany Tel.: +49(0)6221-54 8413 Fax: +49(0)6221-54 4205 Email: [email protected] Prof. Dr. Dieter W. Heermann Institut für Theoretische Physik Philosophenweg 19 Heidelberg University D-69120 Heidelberg, Germany Tel.: +49 6221 549 431 Fax: +49 6221 549 331 Email: [email protected] Prof. Dr. Andreas Herrmann Department of Biology, Lab Molecular Biophysics Humboldt-University Berlin, Invalidenstr. 42, 10115 Berlin, Germany Tel.: +49 030-2093-8830 Fax: +49 030-2093-8585 Email: [email protected] Prof. Dr. Yi-Tsau Huang Director National Research Institute of Chinese Medicine 155, Sec. 2, Li-Nong St. Taipei 112, Taiwan Tel.: +886 2 2820 3101 Fax: +886 2 2823 30488 Email: [email protected] Prof. Dr. Hidekatsu Iha Department of Microbiology Oita University Faculty of Medicine 1-1 Idaiga-oka, Hasama Yufu 879-5593, Oita, Japan. Tel.: +81-97-586-6224 Fax: +81-97-586-5719 Email: [email protected] 7 Viral Membrane Proteins - Taipei 2012 Prof. Dr. Fu-Jen Kao Institute of Biophotonics School of Biomedical Science and Engineering 155, Sec. 2, Li-Nong St. Taipei 112, Taiwan Tel.: +886 2 2826 7394 Fax: +886 2 2823 5460 Email: [email protected] Dr. Bernd W. König Institute of Complex Systems: Strukturbiochemie (ICS-6) Wilhelm-Johnen-Straße 52425 Jülich, Germany Telefon: +49 2461 61-5385 Fax: +49 2461 61-8766 E-Mail: [email protected] Prof. Dr. Jung-Hsin Lin Research Center for Applied Sciences Academia Sinica 128 Sec. 2, Academia Rd., Nankang, Taipei 11529 Tel: + 886-2-27898000 ext 63 Email: [email protected] Prof. Dr. Alex Che Ma Genomics Research Center Academia Sinica 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan Tel.: +886-2-27871233 Email: [email protected] Prof. Dr. Bing Sun Co-Director Laboratory of Molecular Virology Chinese Academy of Science Institute Pasteur of Shanghai 225 South Chongqing Road Shanghai 200025 Tel.: +86 (0)21-63851927 Fax: +86 (0) 21-63843571 Email: [email protected] 8 Viral Membrane Proteins - Taipei 2012 Prof . Dr. Klaus Strebel Chief, Viral Biochemistry Section Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases National Institute of Health Building 4 Center Drive MSC Room 312 0460, Bethesda, MD 20892-0460 Tel.: +1 301-496-3132 Fax: +1 301-402-0226 Email: [email protected] Prof. Dr. Peter Tieleman Dept. of Biological Sciences, BIOL 415 University of Calgary 2500 University Dr. NW Calgary, Alberta Canada, T2N 1N4 Tel: +1 (403) 220-2966 Fax: +1 (403) 289-9311 Email: [email protected] Prof. Dr. Chin-Tien Wang Institute of Clinical Medicine National Yang Ming University, and Department of Medical Research and Education Taipei Veterans General Hospital 201, Sec, 2, Shih-Pai Road, Beitou Taipei 112, Taiwan Tel.: +886-2-28712121 ext.2684 Fax: +886-2-28742279 Email: [email protected] 9 Viral Membrane Proteins - Taipei 2012 Abstracts: 10 Viral Membrane Proteins - Taipei 2012 How do aminoadamantanes block the influenza M2 channel and how does resistance develop? Isaiah Arkin Institute of Life Sciences Department of Biological Chemistry The Hebrew University, Givat-Ram Jerusalem, 91904, Israel Email: [email protected] The interactions between channels and their cognate blockers are at the heart of numerous biomedical phenomena.