US 201203 01400A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0301400 A1 Williams et al. (43) Pub. Date: Nov. 29, 2012 (54) MEDITOPES AND MEDITOPE-BINDING (30) Foreign Application Priority Data ANTIBODIES AND USES THEREOF Oct. 10, 2011 (US) ................. PCT/US2011/055656 (76) Inventors: John C. Williams, Monrovia, CA (US); David A. Horne, Duarte, CA Publication Classification (US); Yuelong Ma, Duarte, CA (51) Int. Cl. (US); Heng Wei Chang, Foster C07K 6/8 (2006.01) City, CA (US); Joshua Michael C07K 7/08 (2006.01) Donaldson, Lumberton, NJ (US); C07K L/4 (2006.01) Cindy Zer, Duarte, CA (US); A 6LX 39/395 (2006.01) Krzysztof Bzymek, Pasadena, CA A61R 49/00 (2006.01) (US); Kendra Nicole Avery, CI2N 5/071 (2010.01) Pasadena, CA (US); Jun Xie, C07K 7/06 (2006.01) Duarte, CA (US) C07K 2/00 (2006.01) (21) Appl. No.: 13/443,804 (52) U.S. Cl. ....... 424/9.1; 530/387.9; 530/330,530/329; 530/328; 530/327: 530/326; 530/321; 424/139.1; (22) Filed: Apr. 10, 2012 424/178.1; 435/331 Related U.S. Application Data (57) ABSTRACT (63) Continuation-in-part of application No. 13/270.207, Antibodies and meditopes that bind to the antibodies are filed on Oct. 10, 2011. provided, as well as complexes, compositions and combina (60) Provisional application No. 61/391,558, filed on Oct. tions containing the meditopes and antibodies, and methods 8, 2010, provisional application No. 61/597,708, filed of producing, using, testing, and screening the same, includ on Feb. 10, 2012. ing therapeutic and diagnostic methods and uses. Patent Application Publication Nov. 29, 2012 Sheet 1 of 79 US 2012/0301400 A1 figure i Patent Application Publication Nov. 29, 2012 Sheet 2 of 79 US 2012/0301400 A1 *igi: 3. A. :::::::::: 8. 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