Supplemental Digital Content 1 Search strategy (first conducted on January 17, 2014; second retrieval on November 5, 2014) Cochrane Central Register of Controlled Trials and MEDLINE via OVID 1. exp chronic pain/ 2. Pain Management/ 3. Pain Measurement/ 4. pain*.mp. 5. 1 or 2 or 3 or 4 11. exp neoplasms/ 12. (neoplas* or cancer* or tumor* or tumour* or carcinoma* or malignan* or oncolog* or metasta* or sarcoma* or adenocarcinoma* or choriocarcinoma* or leukemia* or leukaemia*).mp. 13. 11 or 12 14. exp Anticonvulsants/ or exp Antidepressive Agents/ 15. (anticonvulsant* or antiepilept* or antidepressant* or anti-convulsant* or anti-epilept* or anti-depressant*).mp. 16. (acetazolamide or carbamazepine or clonazepam or divalproex or ethosuximide or ethotoin or felbamate or fosphenytoin or gabapentin or lacosamide or lamotrigine or levetiracetam or methsuximide or oxcarbazepine or phenobarbital or phenobarbitone or phenytoin or pregabalin or primidone or tiagabine or topiramate or trimethadione or valproate or valproic or vigabatrin or zonisamide).mp. 17. (agomelatine or amesergide or amineptine or amitriptyline or amoxapine or aripiprazole or benactyzine or brofaromine or bupropion or butriptyline or chlorimipramine or cianopramine or citalopram or clomipramine or clorgyline or clovoxamine or demexiptiline or desipramine or desvenlafaxine or dibenzepin or dimetacrine tartrate or dosulepin or dothiepin or doxepin or duloxetine or escitalopram or etoperidone or femoxetine or fezolamine fumarate or fluoxetine or fluvoxamine or ifoxetine or imipramine or iprindole or iproniazid phosphate or isocarboxazid or levoprotiline or lofepramine or l-tryptophan or maprotiline or medifoxamide or melitracen or metapramine fumarate or mianserin or milnacipran or minaprine or mirtazapine or moclobemide or nefazodone or nialamide or nomifensine maleate or nortriptyline or opipramol or oxaprotiline or oxitriptan or Pamelor or paroxetine or phenelzine or pirlindole or propizepine or protriptyline or quinupramine or reboxetine or rolipram or rubidium chloride or selegiline or sertraline or setiptiline or sibutramine or sulpiride or teniloxazine or tianeptine sodium or tofenacin or toloxatone or tranylcypromine or trazodone or trimipramine or tryptophan or venlafaxine or vilazodone or viloxazine or viqualine or zimeldine).mp. 18. 14 or 15 or 16 or 17 19. randomized controlled trial.pt. 20. controlled clinical trial.pt. 21. randomized.ab. 22. placebo.ab. 23. drug therapy.fs. 24. randomly.ab. 25. trial.ab. 26. groups.ab. 27. or/19-26 28. exp animals/ not humans.sh. 29. 27 not 28 30. 5 and 10 and 13 and 18 and 29 EMBASE via OVID 1. exp pain/ 2. Pain Management/ 3. Pain Measurement/ 4. pain*.mp. 5. 1 or 2 or 3 or 4 6. exp neuralgia/ 7. (Neuropath* or neuralgi* or neurodynia or radiculopathy or causalgia or plexopath*).mp. 8. ((neur* or nerv*) adj6 (compress* or damage* or injur*)).mp. 9. (pain* adj10 (central or peripher* or nerv* or neur* or complex or mix* or deafferentation or intractab*)).mp. 10. 6 or 7 or 8 or 9 11. exp neoplasms/ 12. (neoplas* or cancer* or tumor* or tumour* or carcinoma* or malignan* or oncolog* or metasta* or sarcoma* or adenocarcinoma* or choriocarcinoma* or leukemia* or leukaemia*).mp. 13. 11 or 12 14. exp Anticonvulsants/ or exp Antidepressive Agents/ 15. (anticonvulsant* or antiepilept* or antidepressant* or anti-convulsant* or anti-epilept* or anti-depressant*).mp. 16. (acetazolamide or carbamazepine or clonazepam or divalproex or ethosuximide or ethotoin or felbamate or fosphenytoin or gabapentin or lacosamide or lamotrigine or levetiracetam or methsuximide or oxcarbazepine or phenobarbital or phenobarbitone or phenytoin or pregabalin or primidone or tiagabine or topiramate or trimethadione or valproate or valproic or vigabatrin or zonisamide).mp. 17. (agomelatine or amesergide or amineptine or amitriptyline or amoxapine or aripiprazole or benactyzine or brofaromine or bupropion or butriptyline or chlorimipramine or cianopramine or citalopram or clomipramine or clorgyline or clovoxamine or demexiptiline or desipramine or desvenlafaxine or dibenzepin or dimetacrine tartrate or dosulepin or dothiepin or doxepin or duloxetine or escitalopram or etoperidone or femoxetine or fezolamine fumarate or fluoxetine or fluvoxamine or ifoxetine or imipramine or iprindole or iproniazid phosphate or isocarboxazid or levoprotiline or lofepramine or l-tryptophan or maprotiline or medifoxamide or melitracen or metapramine fumarate or mianserin or milnacipran or minaprine or mirtazapine or moclobemide or nefazodone or nialamide or nomifensine maleate or nortriptyline or opipramol or oxaprotiline or oxitriptan or Pamelor or paroxetine or phenelzine or pirlindole or propizepine or protriptyline or quinupramine or reboxetine or rolipram or rubidium chloride or selegiline or sertraline or setiptiline or sibutramine or sulpiride or teniloxazine or tianeptine sodium or tofenacin or toloxatone or tranylcypromine or trazodone or trimipramine or tryptophan or venlafaxine or vilazodone or viloxazine or viqualine or zimeldine).mp. 18. 14 or 15 or 16 or 17 19. crossover procedure/ 20. double-blind procedure/ 21. randomized controlled trial/ 22. single-blind procedure/ 23. (random* OR factorial* OR crossover* OR (cross adj1 over*) OR placebo* OR (doubl* adj1 blind*) OR (singl* adj1 blind*) OR assign* OR allocat* OR volunteer*).ab,ti. 24. 19 or 20 or 21 or 22 or 23 25. 5 and 10 and 13 and 18 and 24 .