FEBSSysBio2007: Program version 09/03/2007 10:18:00, page 2 FEBSSysBio2007: Program version 09/03/2007 10:18:00, page 4 P-L02 Adriano Henney [Main lecture hall] (plenary) 11:20 am - 11:40 am 2nd FEBS Advanced Lecture Course on How does systems biology work in and for industry? (results) Systems Biology: Sunday March 11: Symposium on Principles Saturday March 10: Opening (co-organized with AstraZeneca) P-L03 Johan Paulsson [Main lecture hall] (plenary) 11:40am-12:00 noon From Molecules to Life Sunday March 11: 8h30-23h00 Towards a coherent stochastic theory for cellular kinetics (results) Gosau, Austria, EU, March 10-16, 2007 Saturday March 10: 18h00-24h00 8h30 – 12h30: Main lecture hall in 1 Chair’s Resumé and students posing issues; General discussion 12:00 noon–12:30 am Main lecture hall (also the music and the dinner) 10h20-11h05: Main lecture hall in 1, plus Yellow room, plus Gosau room [Main lecture hall] 16h30-18h05: Main lecture hall split in 3, Course Registration & Hotel Check-In 11:00 am - 6:00 pm Lunch & Afternoon Break 12:30 am - 4:30 pm plus Yellow room, plus Gosau room Welcome Reception 5:30 pm - 6:15 pm 18h20 – 19h25: Main lecture hall in 1 Official Course Opening 6:15 pm - 6:25 pm Coffee & Tea 4:00 pm - 4:30 pm 21h00- 23h00: Poster hall Hans Westerhoff and Karl Kuchler Breakfast 7:00 - 8:30 am Sunday’s lack Board Teaching / Computer practicals (parallel) 4:30 pm – 6:05 pm Opening session Chair: Hans V. Westerhoff 6:25 pm - 10:30 pm Scientific Program Session 1-Sunday (parallel) 4:30 pm – 5:15 pm AstraZeneca Opening Lecture BB-01 Frank J. Bruggeman & Hans V. Westerhoff [Main lecture hall-A] 4:30 pm – 5:15 pm Table of Contents rinciples of Systems Biology Lectures 8:30 am - 12:30 pm Chair: Edda Klipp Hierarchical regulation analysis of cellular adaptive responses Scientific Program........................................................................................................................................... 1 OL-01 Leroy Hood 6:30 pm – 7:30 pm (black board teaching) Saturday March 10: Opening (co-organized with AstraZeneca)......................................................................2 Chairs introduction 8:30 am -8:35 am Systems Biollogy and Systems Medicine Sunday March 11: Symposium on Principles................................................................................................. 3 BB-02 Edda Klipp [Main lecture hall-B] 4:30 pm – 5:15 pm Monday March 12: Symposium on Yeast (with YSBN) ................................................................................... 9 Tuesday March 13: Symposium Mammalian (with NucSys)......................................................................... 14 P-L01 Jan-Hendrik S. Hofmeyr [Main lecture hall] (plenary) 8:35 am - 9:20 am Introduction to dynamic modeling of biochemical networks Wednesday March 14: Symposium Towards Life ......................................................................................... 15 Welcome Dinner 7:30 pm – 8:30 pm (black board teaching) Thursday March 15: Symposium Tools & Methods (with BioSim) ................................................................. 20 The Regulatory Design of Cellular Processes: Friday March 16: The day after ..................................................................................................................... 22 BB-03 Hans Meinhardt [Main lecture hall-C] 4:30 pm – 5:15 pm Index: participants and topics........................................................................................................................ 22 Musical intermezzo Principles of Supply and Demand (didactic lecture) Model of biological pattern formation (black board teaching) Frits Kamp and Jelena Petronievic 8:15 pm – 8:45 pm P-L02 Adriano Henney [Main lecture hall] (plenary) 9:20 am - 9:40 am Hommage to Reinhart Heinrich How does systems biology work in and for industry? (methodology) BB-04 Guy Shinar [Gosau room] 4:30 pm – 5:15 pm A Mechanism for Robust Biochemical Concentrations – 1 (black board teaching) Reinhart Heinrich Memorial Lecture P-L03 Johan Paulsson [Main lecture hall] (plenary) 9:40 am - 10:00 am CP-01 Ursula Kummer [Yellow room] 4:30 pm – 5:15 pm OL-02 Hans Meinhardt 8:45pm-9:45pm Towards a coherent stochastic theory for cellular kinetics (methodology) CoPaSi (computer practical ) Making Systems Biiollogy work -Models of biologiical pattern formatiion: from ellementary steps to the organiizatiion of embryoniic axes Coffee & Refreshment Break 10:00 am - 10:20 am Opening discussion and drinks 9:45 – 10:30 pm Coffee & Refreshment Break 5:15 pm – 5:20 pm Tutorials corresponding to lectures (3 in parallel) 10:20 am – 11:05 am Black board Session 2 - Sunday (parallel) 5:20 pm – 6:05 pm Jan-Hendrik S. Hofmeyr [Main lecture hall] Bar 10:30– :00 am BB-05 Jeroen Jeneson [Main lecture hall-A] 5:20 pm – 6:05 pm Adriano Henney [Yellow room] Physiological modeling (black board teaching) Johan Paulsson [Gosau room] BB-06 Uwe Sauer [Main lecture hall-B] 5:20 pm – 6:05 pm Metabolomics and Flux analysis (black board teaching) Coffee & Refreshment Break 11:05 am-11:20 am BB-07 Johannes P. Schlöder [Main lecture hall-C] 5:20 pm – 6:05 pm Program 3 FEBSSysBio2007: Program version 09/03/2007 10:18:00, page 6 FEBSSysBio2007: Program version 09/03/2007 10:18:00, page 8 Differential Equation Models: Parameter Estimation and P-P10 Inferring the starch-regulating gene network in Arabidopsis thaliana M-P07 Human osteoblasts as a model to study Peroxisome Proliferator-Activated Receptor T-P19 Workshop: PottersWheel – MATLAB toolbox for model creation, analysis, multi- experiment Optimum Experimental Design (Black Board Teaching) Papapit Ingkasuwan, Stijn Meganck, Supapon Cheevadhanarak, Supatcharee Netrphan, Asawin Gamma (PPARG) signaling during differentiation and proliferation using integrative fitting and experimental design Meechai, Sukon Prasitwattanaseree, Jeerayut Chaijaruwanich, Morakot Tanticharoen & Sakarindr systems-biology approaches Thomas Maiwald, Marcel Schilling, Ursula Klingmüller & Jens Timmer CP-02 Jacky L. Snoep [Yellow room] 5:20 pm – 6:05 pm Bhumiratana Claudia Bruedigam, Marco Eijken, Alexey Kolodkin, Katja Rybakova, Marijke Koedam, Frank T-P22 Modeling and simulation of fructo-oligosaccharides production P-P13 A systems-biological approach to nuclear receptor signalling by PPARs: from model to Bruggeman, Hans Westerhoff, Huib Pols & Hans van Leeuwen Orlando Rocha, Ana Domingues, Clarisse Nobre, Duarte Torres, Lígia Rodrigues, José Teixeira, Tools for Systems Biologists: using JWS Online for integration experiment M-P10 Setting the framework for large scale system biology: The integration of human protein Isabel Rocha & Eugénio Ferreira and storage of data and models (Computer Practicals) Alexey Kolodkin, Katja Rybakova, Claudia Bruedigam, Marco Eijken, Frank Bruggeman, Hans van interactome T-P25 Stochastic and modular approach in cellular modeling Leeuwen, Barbara Bakker & Hans V. Westerhoff Matthias E. Futschik, Gautam Chaurasia, Erich Wanker & Hanspeter Herzel Egils Stalidzans P-P16 Transcriptional regulation evolves around conserved and metabolically related genes CP-03 Igor Goryanin and Anatoly Sorokin [Gosau room] 5:20 pm – 6:05 pm M-P13 Gene expression profiling in Vitamin D3 treated MC3T3-E1 mouse osteoblasts. T-P28 Connectivity matrix method and atom mapping matrices Kiran Raosaheb Patil, Prashant M Bapat, Ana Paula Oliveira & Jens Nielsen Carsten Kriebitzsch, Lieve Verlinden, Guy Eelen, Roger Bouillon & Mieke Verstuyf Jun Ohta Edinburgh Pathway Editor (Computer Practicals) P-P19 Underground metabolic routes in E. coli M-P16 Dynamic modeling of dual negative feedback regulation of TGFbeta-SMAD signaling in T-P29 No abstract Naomi Siew, Yizhak Pilpel & Dan S. Tawfik Shu Ye 2+ primary hepatocytes Coffee & Refreshment Break P-P22 Modeling Ca -calmodulin-dependent selective target activation Peter J. Nickel, Thomas Maiwald, Stefan Legewie, Patricio Godoy, Sebastian Bohl, Thomas Frahm, Najl Valeyev, Nikolai Kotov, Ian Postlethwaite & Declan Bates Steven Dooley, Hanspeter Herzel, Jens Timmer & Ursula Klingmüller 6:05 pm – 6:20 pm P-P25 no abstract M-P19 Analysis of murine models with tissue-specific nuclear receptor deficiency using systems Ion Petre biology approaches Sunday: rinciples of Systems Biology Short Talks and discussion (plenary) 6:20 pm – 7:05 pm P-P26 Central carbohydrate metabolism of the archaeon Sulfolobus solfataricus Pedro Rocha, Heiner Schrewe & Chris Bunce Bettina Siebers & Christa Schleper M-P22 Erythroid progenitor cell development elucidated by a dynamic pathway model of MAP- P-P27 Adaptive response of a gene network to environmental changes by fitness-induced attractor kinase signaling P-S01 Naomi Siew [Main lecture hall] (plenary) 6:20 pm -6:35 pm selection Marcel Schilling, Thomas Maiwald, Jens Timmer & Ursula Klingmüller Tetsuya Yomo, Akiko Kashiwagi, Kunihiko Kaneko& Itaru Urabe M-P25 A mathematical model of Smad nucleocytoplasmic shuttling Shedding Light on the ORFan Puzzle (short talk) P-P28 Mathematical modeling of metabolic networks: From topology to dynamics of metabolic Alexander Tournier, Bernhard Schmierer, Paul A. Bates & Caroline S. Hill pathways P-S02 Tetsuya Yomo [Main lecture hall] (plenary) 6:35 pm- 6:50 pm Ralf Steuer Towards Life: Principles and studies of simpler systems (Sunday posters) Adaptive response of a gene network to environmental changes by Yeast Systems Biology (Sunday posters) L-P01 Regulation at the RNA level fitness-induced attractor selection (short talk) Y-P01 Robustness analysis of HOG pathway related