Windows of CROSSWORD PUZZLES Susceptibility UNIVERSITY OF for learning about Breast Cincinnati Dept of Env Hlth phytochemicals Cancer in food Risk Wikipedia has a provided considerable information about phytochemicals commonly found in Chinese medicines and as puported pharmacological benefits. This puzzle is a difficult, but interesting look at many of those chemicals. Windows of Across CLUES Susceptibility Breast Cancer 1. The main sweet-tasting compound from liquorice root 30–50 times as sweet as sucrose but important in treating chronic viral hepatitis and like glabridin is a Risk phytoextrogen, 2. Naturally occurring flavinol found in grapes berries peas nuts onions and some teas and may lower risk for prostate and pncreatic cancer and help with heart disease, 3. This flavonoid is found in parsley artichoke basil celery and other plants and binds well to the estrogen receptor blocking cell proliferation, 4. From the barberry plant genus name Berber comes this chemical which appears to reduce growth of several types of tumors including breast cancer cells, 5. Common pigment in red fruits and vegetables and is the colorant in its namesake carrots and in pumpkins and yams and is a precursor to vitamin A, 6. A acid as a component of all plants since it is part of lignan but named from the stimulant alkyolid in coffee which is an antioxidant and has immunomodulatory and anticancer properties, 7. This compound also called indian basil oil is a para-allylphenol occurs in some of the betel leaf oils and possesses strongly antiseptic and antifungal properties and the methy chavicol form may be psychidelic, 8. A natural carotenoid pigment found in flowers egg yolks orange rind papaya apples and others which sounds like something superman would be harmed by, 9. Naturally occurring anthraquinone and is a purgative and has a similarly - substitute the I for an e named commercial product as it is found in rhubarb other plants roots used in Chinese medicine with potential benefit for those with diabetes and inhibitory effects on angiogenic and metastasis regulatory processes make emodin a sensible candidate as a specific blocker of tumor-associated events, 10. Currently being investigated as a tea which might increase the effectiveness of some antibiotics against some Staph aureus bacteria resistent to many antibiotics, 11. The major polyphenol catechin in green tea but not black tea and various studies in laboratory animals suggest it is antiinflammatory good for diabetes and the prostate and leukemia but more work is needed, 12. This compound is extracted from bay leaf and clove and nutmeg and cinnamon and is used as an antiscptic and anesthetic, 13. A steroid found in the guggul plant was thought to reduce cholesterol but is still found in many supplements, 14. Name is a combination of dark purple indigo and rubin and it is present in Chinese medicinals and studied as an inhibitor of mitosis and cell signaling pathway during some developmental processes, 15. This acid onverts glucose into energy and is an essential cofactor of four mitochondrial enzyme complexes and is found in almost all foods but slightly more so in kidney heart liver spinach broccoli and yeast extract, 16. From the word lycopersicum referring to the tomato species this is a bright red carotene and carotenoid pigment and phytochemical found in tomatoes and other red fruits and vegetables such as red carrots and red bell peppers watermelons gac and papayas but not strawberries or cherries and may prevent of some types of cancers, 17. This is the acid form of phytate which is plant fiber which can have different nutritional benefits or ill effects depending upon many factors such as a individual intestinal microbiome, 18. A compounds found in Norway spruce and grapes passion fruit and white tea and is a metabolite of resveratrol and displays antioxidant and anticancer properties, 19. This pungent compound in black pepper can inhibit some metabolizing enzymes allowing variation in drug responses and it is 8 on culinary heat scale list, 20. Derived from the Plumbago plant this compound is regarded as a toxin a genotoxin and a mutagen but it is these same features that give it cell cycle and anticancer drug importance and a long list of impressive bioactive effects, 21. Pentacyclic triterpene acid found in prunes as well as apples basil bilberries cranberries elder flowers peppermint rosemary lavender oregano thyme and hawthorn and is used in cosmetics but also decreases proliferation in some cancer cell types and induces apoptosis, 22. Antioxidant found in wine and grapes that has limited success in lengthening lifespan of normal weight experimental animals, 23. Thymoquinone has antiepileptic effects in children with refractory seizures and has antioxidant effects and protective effects for heart liver and kidney damage in animal studies as well as having possible anticancer effects and it comes from the seed of black cumin or if from the flowering plant is used as a spice, 24. A bioactive flavinoid in different types of teas which is an antiinflammatory and is being investigated as a possible chemical to potentiate some kinds of chemotherpy regimens, 25. Derived from the Zingiber zerumbet Smith plant from which it gets its name may be antiinflammtory and is purported suppress free radical formation and cancer cell proliferation, . Down 1. Like glabridin this coumpond is obtained from liquorice root and is effective in the treatment of peptic ulcer and is expectorant and antitussive, 2. Found in mangos with antimicrobial andidiabetic and antioxidant effects, 3. From the allium family this compound is only in garlic only after it is crushed or extracted and it has anti-fungal and antibacterial properties, 4. Compound isolated from pink Lapacho trees and is in phase II clinical trials as anticancer drug therapy alone or in combination with others but was deemed ineffective at this time, 5. A naturally occurring acid found in the burch tree genus name and namesake Betula and has antiretroviral antimalarial and anti-inflammatory properties possible anticancer use in inhibititing topoisomerase, 6. Five ring triterpene acid produced by plants of the genus Boswellia which shows promise in careful doses as an antiinflammatory, 7. A plant polyphenol from Toxicodendron that contains the allergen of poison ivy but some extracts have antitumor antioxidant bloodpressure lowering and antifibrogenic effects, 8. this is an irritant and causes a burning sensation but is used medicinally as a dermal treatment for pain and neuralgia and also a clinically proven nasal spray for allergies, 9. This compound is named after the a biologist Carolus Linneaus but is extracted from Rosemary plants with possible health benefits of cancer prevention antioxidants antiinflammatory protection, 10. This compound exhibits antioxidant antiinflammatory anticancer and insecticidal qualities and it is a also tripterine with 5 rings and belongs in the family of quinone methides, 11. The principal curcuminoid of the popular Indian spice turmeric which is a member of the ginger family but which has neither supported nor refuted in its health benefits, 12. Named for two benzine rings and a methane group this compound shows some promise along with curcumin for its potential to block carcinogen-induced mammary tumors, 13. Extracted from the tubers of Dioscorea wild yam and used for the commercial synthesis of cortisone pregnenolone progesterone and other steroid products, 14. Also called evodia used in Chinese medicine and is anti-alergic anticancer and is thought to inhibit proliferation of breast cancer cells, 15. A phytoestrogen and a natural chemical isoflavone that is found in soybeans fava beans and common in supplements behaving like an antioxidant and antihelmintic, Windows of Susceptibility 16. An alcohol found in fresh ginger root and a relative of capsasin and Breast piperine and that is a pungent yellow oil a heat designation of 8 cdifferent Cancer kinds of chilies, 17. An xenoestrogen isoflavone found in the licorice root species Risk Glycyrrhiza glabra and used in cosmetics to reduce melanogenesis and inflammation In laboratory animals and may help with colitis and colon inflammation, 18. This is a diterpene found in some types of coffee beans with anti-inflammatory and anti- angiogenic activities, 19. Naturally occurring terpene found in plants with a spicy scent like lavender coriander rosa palma and bay leaf and it is used is soaps and perfumes, 20. Found in mangos and acacia and in dandelion coffee Lupeol has a complex pharmacology in humans displaying antiprotozoal antimicrobial antiinflammatory antitumor and chemopreventive properties, 21. Luteus meaning yellow is the root word for this xanthophyll and one of 600 known naturally occurring carotenoids and high in green leafy vegetables such as spinach kale and yellow carrots and there is epidemiological evidence that increased consumption of this compound and zeaxanthin lowers the risk of cataract development, 22. Occurs naturally in chinchona bark and coffee beans is a polyol with many OH groups and from which tamiflu for influenza virus was developed, 23. Sulforaphane is an isothiocyanate organosulfur compound which exhibits anticancer and antimicrobial properties in experimental models and it is obtained from cruciferous vegetables such as broccoli Brussels sprouts or cabbages, 24. From the sativa plant and chinese pharmacopia this compound is also called chia and is currently in phase III clinical trials for bioactive effects and relevant to breast cancer chemotherapy, 25. Called vitamin E and in all of its forms it functions as an antioxidant just like the tocotrienol its antioxidant activity due to the ability to donate a hydrogen atom from the hydroxyl group to free radicals in the body, 26. Like tocopherol this compound is part of vitamin E family of essential nutrients for the body and conprises four tocotrienols either alpha beta gamma or delta) and only slightly different than tocopherol in the unsaturated side chain having three double bonds, 27.