I Dangerous Liaisons translating cancer biology into better patients management 56th Annual Meeting of the Italian Cancer Society Ferrara, 11-13 September 2014 Università degli Studi di Ferrara II 1 th Annual Meeting of the 56 Italian Cancer Society Dangerous Liaisons translating cancer biology into better patients management CONGRESS VENUE Università degli Studi di Ferrara - Via Luigi Borsari, 46 - 44121 Ferrara OPENING CEREMONY VENUE Azienda Ospedaliero Universitaria di Ferrara Arcispedale Sant’Anna - Via Aldo Moro, 8 - 44124 Cona – Ferrara SIC SECRETARIAT Società Italiana di Cancerologia Via G. Venezian, 1 - 20133 Milan, Italy Phone +39 02 2666895 - Fax +39 02 2664342 E-mail: [email protected] www.cancerologia.it ORGANIZING SECRETARIAT C.S.C. S.r.l. Via L.S. Gualtieri, 11 - 06123 Perugia Tel+390755730617 - Fax +390755730619 www.csccongressi.it 2 With the auspices of 2 3 With the auspices of COMUNE DI FERRARA Città Patrimonio dell’Umanità 3 4 56th Dangerous Liaisons translating cancer biology into better patients management Committee SIC SCIENTIFIC BOARD President Silvia Giordano (Candiolo Cancer Institute - FPO, IRCCS, University of Turin, Candiolo, Italy) President Elect Gabriella Sozzi (IRCCS National Cancer Institute, Milan, Italy) Board Rita Falcioni (Regina Elena National Cancer Institute, Rome, Italy) Davide Melisi (University of Verona, Italy) Nicola Normanno (National Cancer Institute “G. Pascale”, Naples, Italy) Massimo Santoro (“Federico II” University, Naples, Italy) Elda Tagliabue (IRCCS National Cancer Institute, Milan, Italy) Giulia Taraboletti (“Mario Negri” Institute for Pharmacological Research, Bergamo, Italy) Giuseppe Viglietto (University of Magna Græcia, Catanzaro, Italy) Members under 35 Marco Macagno (University of Turin, Italy) Selena Ventura (Orthopaedic Rizzoli Institute, Bologna, Italy) Past President Riccardo Dolcetti (CRO-IRCCS, National Cancer Institute, Aviano, Pordenone, Italy) SCIENTIFIC AND ORGANIZING COMMITTEE Scientific Coordinator Massimo Negrini (University of Ferrara, Italy) Local Scientific Committee Silvano Capitani, (University of Ferrara, Italy) Giorgio Cavallesco, (University Hospital of Ferrara, Italy) Antonio Cuneo, (University Hospital of Ferrara, Italy) Francesco Di Virgilio, (University of Ferrara, Italy) Antonio Frassoldati, (University Hospital of Ferrara) Giovanni Lanza, (University Hospital of Ferrara, Italy) Alberto Liboni, (University Hospital of Ferrara, Italy) Paolo Pinton, (University of Ferrara, Italy) Silvia Sabbioni, (University of Ferrara, Italy) Mauro Tognon, (University of Ferrara, Italy) Stefano Volinia, (University of Ferrara, Italy) 4 5 Facult y Reuven Agami Cancer Institute - Amsterdam, The Netherlands Mattia Boeri IRCCS National Cancer Institute - Milan, Italy James Brenton Cancer Research UK Cambridge Institute - University of Cambridge, UK George Adrian Calin MD Anderson Cancer Center - University of Texas, Houston, Texas, USA Silvano Capitani University of Ferrara, Italy Carlo M. Croce Ohio State University - Columbus, Ohio, USA Ruggero De Maria Regina Elena National Cancer Institute - Rome, Italy Pier Paolo Di Fiore IFOM-IEO Campus - Milan, Italy Francesco Di Virgilio University of Ferrara, Italy Janine Erler BRIC-Biotech Research & Innovation Centre - University of Copenhagen, Denmark Rita Falcioni Regina Elena National Cancer Institute - Rome, Italy Brunangelo Falini University of Perugia, Italy Antonio Frassoldati University Hospital of Ferrara Gaia Cristina Ghedini IRCCS National Cancer Institute - Milan, Italy Christopher Heeschen Spanish National Cancer Research (CNIO) - Madrid, Spain Enrico Iaccino University Magna Graecia - Catanzaro, Italy Marilena Iorio IRCCS National Cancer Institute - Milan, Italy Simon Joosse University Medical Center- Hamburg, Eppendorf , Germany Guido Kroemer INSERM, Institut Gustave Roussy - Villejuif, France Marco Macagno University of Turin, Italy Valerie Matarese UpTo infotechnologies - Vidor, Italy Alberto Mantovani University of Milan, Italy Davide Melisi University of Verona, Italy Andrea Morandi University of Florence, Italy Massimo Negrini University of Ferrara, Italy Clara Nervi University La Sapienza - Rome, Italy Nicola Normanno National Cancer Institute “G. Pascale” - Naples, Italy Pier Paolo Pandolfi Beth Israel Deaconess Medical Center - Boston, Massachussets, USA Pier Giuseppe Pelicci IFOM-IEO Campus - Milan, Italy Paolo Pinton University of Ferrara, Italy Ymera Pignochino Institute for Cancer Research and Treatment - Candiolo, Turin, Italy Vito Pistoia Gaslini Children’s Hospital - Genoa, Italy Valeria Poli University of Turin, Italy Sabina Sangaletti IRCCS National Cancer Institute - Milan, Italy Gabriella Sozzi IRCCS National Cancer Institute - Milan, Italy Elda Tagliabue IRCCS National Cancer Institute - Milan, Italy Giulia Taraboletti “Mario Negri” Institute for Pharmacological Research - Bergamo, Italy Giampaolo Tortora University of Verona, Italy Giuseppe Viglietto University of Magna Græcia - Catanzaro, Italy Selena Ventura Orthopaedic Rizzoli Institute - Bologna, Italy Stefano Volinia University of Ferrara, Italy 5 6 Programme at a glance Thursday September 11th - AULA MAGNA - OSPEDALE CONA 10.00 - 13.00 Pre-Meeting SIC young investigators 14.00 - 14.30 Welcome Opening 14.30 - 15.15 Opening Lecture 15.15 - 18.30 Session 1: Cancer Microenvironment and Inflammation 19.00 - 19.15 Bus Transfer 19.15 - 22.00 Welcome Cocktail Friday September 12th - POLO CHIMICO BIO MEDICO (Mammut) 08.00 Registration and poster hanging 08.30 - 10.30 Session 2: Non Coding RNAs and Epigenetics 10.30 - 11.00 Coffee Break 11.00 - 13.00 Poster Viewing with Authors 13.00 - 14.00 Light Lunch 14.00 - 15.30 Poster Discussion (4 parallel sessions) 15.30 - 16.45 Session 3a: Cancer Stem Cells 16.45 - 17.15 Coffee Break 17.15 - 18.00 Session 3b: Cancer Stem Cells 18.15 - 19.15 SIC General Assembly 20.15 Social Dinner Saturday September 13th - POLO CHIMICO BIO MEDICO (Mammut) 08.30 - 09.15 Plenary Lecture 09.15 - 11.30 Session 4: “Translational” Therapy 11.30 - 12.30 Award Ceremony 12.30 - 13.30 Light Lunch 13.30 - 14.15 Giorgio Prodi Lecture 14.15 - 15.45 Session 5: Translational Diagnostics: NGS, Circulating Cells\Nucleic Acids 15.45 - 16.30 Closing Lecture 16.30 - 17.00 Closing Remarks 6 7 Thursday September 11th Scientific Programme Venue: AULA MAGNA - OSPEDALE CONA 10.00 - 13.00 PRE-MEETING SIC YOUNG INVESTIGATORS Chairs: Marco Macagno (Turin, Italy), Selena Ventura (Bologna, Italy) “Writing Grant Proposals: three techniques to present your idea with clarity and conviction” Valerie Matarese Ph.D. (Vidor, TV) Meeting of SIC young investigators 14.00 - 14.30 WELCOME OPENING 14.30 - 15.15 OPENING LECTURE Causes and Consequences of microRNA Dysregulation in Cancer Carlo M. Croce (Columbus, Ohio, USA) 15.15 - 18.30 Session 1: CANCER MICROENVIRONMENT AND INFLAMMATION Chairs: Francesco Di Virgilio (Ferrara, Italy), Andrea Morandi (Florence, Italy) 15.15 - 15.45 Immunosuppressive microenvironnment in neuroblastoma Vito Pistoia (Genoa, Italy) 15.45 - 16.00 New players and targets in tumor vasculature V 9 Ugo Cavallaro (IEO, Istituto Europeo di Oncologia, Milan, Italy), Elena Magrini, Fabrizio Bianchi, Andrea Doni, Francesca Angiolini, Alessandra Villa, Massimiliano Mazzone 16.00 - 16.30 The transcritpion factor STAT3 at the crossroad between cancer and inflammation Valeria Poli (Turin, Italy) 16.30 - 16.45 Stable modulation of the glycolytic phenotype of tumor cells by anti-VEGF therapy V 17 Stefano Indraccolo (Istituto Oncologico Veneto, IRCCS, Padua, Italy), Matteo Curtarello, Elisabetta Zulato, Giorgia Nardo, Silvia Valtorta, Giulia Guzzo, Elisabetta Rossi, Giovanni Esposito, Aichi Msaki, Andrea Rasola, Luca Persano, Francesco Ciccarese, Roberta Bertorelle, Sergio Todde, Mario Plebani, Henrike Schroer, Stefan Walenta, Wolfgang Mueller- Klieser, Alberto Amadori, Rosa Maria Moresco 16.45 - 17.15 The extracellular matrix at the interface between immunity and cancer Sabina Sangaletti (Milan, Italy) 17.15 - 17.45 Matrix remodelling during cancer progression Janine Erler (Copenhagen, Denmark) 17.45 - 18.30 PLENARY LECTURE Molecular pathways linking inflammation and cancer Alberto Mantovani (Milan, Italy) 19.00 - 19.15 BUS TRANSFER 19.15 - 22.00 Welcome Cocktail 7 8 Friday September 12th Scientific Programme Venue: POLO CHIMICO BIO MEDICO (Mammut) 08.00 REGISTRATION AND POSTER HANGING 08.30 - 10.30 Session 2: NON CODING RNAS AND EPIGENETICS Chairs: Massimo Negrini (Ferrara, Italy), Stefano Volinia (Ferrara, Italy) 08.30 - 09.00 About Noam Chomsky, DNA patterns, Non-codingRNAs and Cancer patients George A. Calin (Houston, Texas, USA) 09.00 - 09.15 Targeting aberrant HDAC4 activity in multiple myeloma (MM) through a miR-29b- based therapeutic strategy R 2 Nicola Amodio (Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy), Marzia Leotta, Eugenio Morelli, Maria Angelica Stamato, Lavinia Raimondi, Anna Maria Gullà, Maria Teresa Di Martino, Teresa Calimeri, Marco Rossi, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tassone 09.15 - 09.45 EnhancerRNAs at the service of p53 Reuven Agami (Amsterdam, The Netherlands) 09.45 - 10.00 Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction R 9 Orazio Fortunato (Fondazione IRCCS Istituto Nazionale dei Tumori, Tumor Genomics Unit, Milan), Mattia Boeri, Massimo Moro, Carla Verri, Mavis Mensah, Davide Conte, Luca Roz, Ugo Pastorino, Gabriella Sozzi 10.00 -