Programme Wednesday 09 October 2013 14:00 - 16:45 Arrival and registration ATC Foyer 16:45 - 17:00 Welcome ATC Auditorium 17:00 - 20:15 Session 1: The diversity of non-coding RNAs Chair: Elisa Izaurralde ATC Auditorium 17:00 - 17:30 Central roles of bacterial RNAs in regulating 1 metabolism Gisela Storz NICHD, NIH, United States of America 17:30 - 18:00 RNA: protein interactions 2 Nikolaus Rajewsky Max Delbrück Center for Molecular Medicine, Germany 18:00 - 18:15 Natural RNA circles function as efficient miRNA 3 sponges Thomas Hansen Aarhus University, Denmark 18:15 - 18:45 Coffee Break ATC Foyer 18:45 - 19:15 The human genome as the zip file extraordinaire 4 John Mattick Garvan Institute of Medical Research, Australia 19:15 - 19:45 RNA silencing and epigenetics in plants 5 David Baulcombe University of Cambridge, United Kingdom 19:45 - 20:00 Cross-talking noncoding RNAs confer central 6 nervous system specificity to Spinocerebellar Ataxia 7 pathology Ana Marques University of Oxford, United Kingdom EMBO|EMBL Symposium The Non-Coding Genome 20:00 - 20:15 A long non coding RNA regulates chromatin mediated 7 modulation of alternative splicing Reini Luco IGH-CNRS, France 20:15 - 23:00 Dinner Canteen Page 6 Programme Thursday 10 October 2013 09:00 - 12:15 Session 2: miRNA function and mechanisms Chair: David P. Bartel ATC Auditorium 09:00 - 09:30 The roles of long noncoding RNA in epigenetic 8 regulation Jeannie Lee Massachusetts General Hospital, United States of America 09:30 - 10:00 3’ end modifications in the MicroRNA pathway 9 V. Narry Kim Institute for Basic Science and Seoul National University, Korea 10:00 - 10:15 Dicer activity and microRNA maturation are regulated by 10 stress signaling in neurodegeneration Eran Hornstein Weizmann Institute of Science, Israel 10:15 - 10:45 Coffee Break ATC Foyer 10:45 - 11:15 Mechanisms and regulation of miRNA-mediated 11 repression in mammalian cells Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Switzerland 11:15 - 11:45 Using ribosome footprinting to characterize the coding 12 potential on the genome Antonio Giraldez Yale University, United States of America 11:45 - 12:00 Quantitative evaluation of the relationship of miRNA and 13 target abundance in liver: Implications for disease Remy Denzler ETH Zürich, Switzerland Page 7 EMBO|EMBL Symposium The Non-Coding Genome 12:00 - 12:15 Specific inhibition of miR-124 function improves spatial 14 and working memory capacity in mice Josephine Malmevik Lund University, Sweden 12:15 - 12:30 Functional high-throughput screening identifies 15 microRNAs regulating Salmonella infection Ana Eulalio Institute for Molecular Infection Biology, University of Würzburg, Germany 12:30 - 14:00 Lunch ATC Foyer 14:00 - 17:15 Session 3: Non-coding RNAs in prokaryotes Chair: Gisela Storz ATC Auditorium 14:00 - 14:30 DNA-guided DNA interference by prokaryotic 16 Argonaute John van der Oost Wageningen University, The Netherlands 14:30 - 15:00 RNA-programmed genome defense and genomic 17 engineering Jennifer Doudna University of California, Berkeley, United States of America 15:00 - 15:30 Small RNA: from bacteria to metazoan germline 18 Alexei Aravin California Institute of Technology, United States of America 15:30 - 16:00 Coffee Break ATC Foyer 16:00 - 16:30 Bacterial sRNAs regulating transcription factors: 19 mechanistic aspects and regulatory properties Gerhart Wagner Uppsala University, Sweden Page 8 Programme 16:30 - 17:00 The RNA complement of pathogen and host revealed by 20 Dual RNA-seq Jörg Vogel Institute for Molecular Infection Biology, University of Würzburg, Germany 17:00 - 17:15 Targeted decay of small RNA GlmZ by RNase E 21 adaptor protein RapZ and inhibition by sRNA mimicry GlmY Yvonne Göpel University of Göttingen, Germany 17:15 - 20:00 Poster Session (Even numbers) ATC Helix 20:00 - 23:00 Dinner Canteen Page 9 EMBO|EMBL Symposium The Non-Coding Genome Friday 11 October 2013 09:00 - 12:15 Session 4: siRNAs and piRNAs: Biogenesis and function Chair: V. Narry Kim ATC Auditorium 09:00 - 09:30 Production and functions of PIWI-interacting RNAs in 22 Drosophila Mikiko Siomi Graduate School of Science, University of Tokyo, Japan 09:30 - 09:45 Social RNA: Interspecies small RNA-mediated 23 communication in nematodes Peter Sarkies University of Cambridge, United Kingdom 09:45 - 10:00 A small RNA-triggered nuclear activity by targeting a large 24 chromosomal region in human cells Nicole Darricarrère Yale University, United States of America 10:00 - 10:15 Plants encode a general siRNA suppressor that is induced 25 and suppressed by viruses Nahid Shamandi IJPB, France 10:15 - 10:45 Coffee Break ATC Foyer 10:45 - 11:15 The involvement of chromatin in the Drosophila piRNA 26 pathway Julius Brennecke Institute of Molecular Biotechnology, Austria 11:15 - 11:30 PRDE-1, a novel piRNA biogenesis factor, reveals 27 separate functions for two classes of piRNAs in C. elegans Eva-Maria Weick The Wellcome Trust/CRUK Gurdon Instititute, United Kingdom Page 10 Programme 11:30 - 11:45 Identification of C. elegans piRNA biogenesis factors 28 through a genome wide RNAi screen Sho Goh Cold Spring Harbor Laboratory, United States of America 11:45 - 12:00 Imaging the dynamic nature of the piRNA pathway in living 29 cells Maike Laussmann EMBL, Germany 12:00 - 12:15 Transcriptome-wide identification and characterization of 30 coding and non-coding targets of human DND1 Markus Hafner The Rockefeller University, United States of America 12:15 - 14:00 Lunch ATC Foyer 14:00 - 17:15 Session 5: Transcriptional gene silencing Chair: John L. Rinn ATC Auditorium 14:00 - 14:30 Biogenesis and function of linc-MD1 in muscle 31 differentiation Irene Bozzoni Sapienza - University of Rome, Italy 14:30 - 15:30 Epigenetic genome control by heterochromatin and RNAi 32 machinery Shiv Grewal NIH, National Cancer Institute, United States of America 15:00 - 15:15 Identification of a new RNA-based epigenetic mechanism 33 involved in heterochromatic gene silencing and sexual differentiation control in fission yeast Leila Todeschini Université Joseph Fourier, Institut Albert Bonniot, France 15:15 - 15:45 Coffee Break ATC Foyer Page 11 EMBO|EMBL Symposium The Non-Coding Genome 15:45 - 16:15 Non-coding RNA activity in the fission yeast nucleus 34 Marc Bühler Friedrich Miescher Institute for Biomedical Research, Switzerland 16:15 - 16:45 X-chromosome inactivation: a paradigm of epigenetic 35 regulation via non-coding RNA Edith Heard Institut Curie, France 16:45 - 17:00 Interactions between JARID2 and noncoding RNAs 36 regulate PRC2 recruitment to chromatin Roberto Bonasio HHMI / NYU School of Medicine, United States of America 17:00 - 17:15 The lincRNA PINT connects the p53 pathway with 37 epigenetic silencing by PRC2 Maite Huarte CIMA, University of Navarra, Spain 17:15 - 20:00 Poster Session (Odd numbers) ATC Helix 20:00 - 22:00 Conference Dinner Canteen 22:00 - 00:30 Party ATC Foyer Page 12 Programme Saturday 12 October 2013 09:00 - 12:15 Session 6: Structures and mechanisms Chair: Jennifer Doudna ATC Auditorium 09:00 - 09:30 Structure-function studies of cytosolic DNA sensors 38 governing the interferon response Dinshaw Patel Memorial Sloan-Kettering Cancer Center, United States of America 09:30 - 10:00 Structural insight into the interaction of GW182 proteins 39 with deadenylase complexes Elisa Izaurralde MPI for Developmental Biology, Germany 10:00 - 10:15 lin-42 functions as a capacitor of microRNA expression 40 Roberto Perales Cold Spring Harbor Laboratory, United States of America 10:15 - 10:45 Coffee Break ATC Foyer 10:45 - 11:15 MicroRNAs and their regulatory effects 41 David P. Bartel HHMI/MIT/Whitehead Institute, United States of America 11:15 - 11:45 Antiviral RNAi in mammals 42 Olivier Voinnet ETH Zürich, Switzerland 11:45 - 12:00 The long non-coding RNA Paupar regulates the 43 expression of both local and distal neuronal genes Keith Vance University of Oxford, United Kingdom 12:00 - 12:15 Structural analysis of Stc1: insights into the coupling of 44 RNAi and chromatin modification Elizabeth Bayne University of Edinburgh, United Kingdom EMBO|EMBL Symposium The Non-Coding Genome 12:15 - 14:00 Lunch Canteen 14:00 - 17:15 Session 7: Long Non-coding RNAs, Chair: Jörg Vogel ATC Auditorium 14:00 - 14:30 Genome regulation by long noncoding RNAs 45 Howard Chang Stanford University, United States of America 14:30 - 15:00 Noncoding RNA targets chromatin modifying enzmes to 46 regulatory gene sequences Ingrid Grummt DKFZ, Germany 15:00 - 15:15 Common and distinct features of short translated ORFs in 47 lincRNAs and 5'UTRs Igor Ulitsky Weizmann Institute of Science, Israel 15:15 - 15:45 Coffee Break ATC Foyer 15:45 - 16:15 Functional intronic long noncoding RNAs 48 Ling-Ling Chen Shanghai Institutes for Biological Sciences, CAS, China 16:15 - 16:45 Multiple knockout mouse models reveal lincRNAs are 49 required for life and brain development John L. Rinn Harvard University, United States of America 16:45 - 17:00 The cryptic lncRNA XUTs coexist with RNAi in yeast 50 species Maxime Wery Institut Curie, France 17:00 - 17:15 Concluding remarks and poster prize announcement ATC Auditorium Page 14 .