58th ASMS Conference on Mass Spectrometry and Allied Topics May 23 – 27, 2010 Salt Lake City, Utah Front cover Front th 58 ASMS CONFERENCE ON MASS SPECTROMETRY AND ALLIED TOPICS MAY 23 - 27, 2010 SALT LAKE CITY, UTAH TABLE OF CONTENTS General Information ........................................................................... 2 Hotels and Transportation .................................................................. 4 ASMS Board of Directors .................................................................. 5 Interest Groups and Committees ........................................................ 6 Awards ............................................................................................... 7 Research Awards ................................................................................ 8 Convention Center Floor Plans .......................................................... 9 ASMS Corporate Members .............................................................. 12 Program Acknowledgements ........................................................... 16 Program Overview - Sunday, Monday, Tuesday ............................. 17 Program Overview - Wednesday, Thursday..................................... 18 Workshops ....................................................................................... 19 Title information in the following sections is provided by authors. The complete abstract database is available through the ASMS web page: http://www.asms.org Sunday ............................................................................................. 22 Monday Morning ............................................................................. 22 Monday Afternoon ........................................................................... 25 Tuesday Morning ............................................................................. 27 Tuesday Afternoon ........................................................................... 30 Wednesday Morning ........................................................................ 32 Wednesday Afternoon ...................................................................... 35 Thursday Morning ............................................................................ 37 Thursday Afternoon ......................................................................... 40 Special Posters ................................................................................. 43 Monday Posters ................................................................................ 43 Tuesday Posters ............................................................................... 73 Wednesday Posters ........................................................................ 104 Thursday Posters ............................................................................ 135 Author Index .................................................................................. 165 SPONSORS ASMS gratefully acknowledges the support of the following companies. Major Sponsor Agilent Technologies Student Travel Elsevier Science Sponsors st 1 Detect SGE Analytical Science IDEX Health & Science Shimadzu New Objective, Inc. Thermo Scientific Omni International Waters Corporation Zef Scientific, Inc. 58th ASMS Conference on Mass Spectrometry 1 GENERAL INFORMATION th Welcome to the 58 ASMS Conference on Mass Spectrometry and POSTERS AND EXHIBIT BOOTHS are in Exhibit Halls ABCDE. The Allied Topics. Conference program activities, exhibit booths and Hall is open: Corporate Member hospitality suites are located in the Salt Palace Sunday Reception: 7:45 - 9:30 pm Convention Center. Monday through Wednesday: 7:30 am – 8:00 pm Thursday: 7:30 am - 3:30 pm REGISTRATION is open 10:00 am – 8:00 pm on Sunday, 7:30 am – 5:00 pm on Monday through Thursday. POSTER SET-UP. Posters are located in Exhibit Hall ABCDE. SUNDAY TUTORIAL LECTURES. The Tutorial session is 5:00 – 6:30 Posters must be set up 8:00 - 8:30 am on the day scheduled and pm, Sunday in Hall 4. removed 7:30 to 8:00 pm. Thursday posters must be removed by 5:00 pm, Collision-Induced Dissociation: How 3:30 pm. Refer to the poster numbers in this final program for Does It Really Work and What It Can (or Can't) board assignments. Authors are expected to supply pushpins to Tell You mount their posters. Poster titles begin on page 43. Peter B. Armentrout POSTER SCHEDULE. The poster sessions are 10:30 am – 2:30 pm, University of Utah Monday through Thursday. Authors are encouraged to attend their posters between 10:30 am and 2:30 pm on their scheduled day. Authors should take a lunch break as follows: 11:45 am – 12:15 pm ............ Lunch break for odd-numbered posters 5:45 pm, The Role of Mass Spectrometry in 12:15 – 12:45 pm ................ Lunch break for even-numbered posters Drug Discovery and Development Walter A. Korfmacher Authors should wear a “presenter badge.” Presenter badges are Merck Research Laboratories available at the poster supply counter located at the entrance to the poster hall. Presenters should also use the cards provided to indicate when they will return if they leave their posters. WORKSHOPS. Workshops are 5:45 – 7:00 pm on Monday, Tuesday, and Wednesday. See pages 19 to 21 for schedule. Complimentary PLENARY SESSIONS. Plenary Sessions are in Hall 4. Sunday, 6:45 – 7:00 pm, Conference Opening snacks and beverages are offered for those attending workshops. 7:00 – 7:45 pm Refreshments are near the workshop session rooms. Systems Medicine and Emerging Technologies: EXHIBIT BOOTHS. The poster-exhibit hall is open 7:30 am – 8:00 Catalyzing the Transformation from Reactive to pm for poster viewing and the Internet Café. Companies may attend Proactive (P4) Medicine their booths 9:00 am – 5:00 pm; however attendance is required as Leroy Hood follows: Institute for Systems Biology Sunday Reception: 7:45 – 9:30 p Monday through Thursday: 10:30 am – 2:30 pm Monday, 4:45 – 5:30 pm, Marvin L. Vestal, Award Lecture LUNCH. There are concessions in the poster-exhibit hall. In Tuesday, 4:45 – 5:30 pm, David C. Muddiman, Award Lecture addition there are restaurants outside the convention center. For suggestions and reservations, visit the Salt Lake City Restaurant Thursday, 4:45 – 5:30 pm Counter near the entrance to the poster-exhibit hall. Molecular Approaches to Understanding DINNER, 7:00 - 8:00 PM. Take this hour for a breath of fresh Human Uniqueness mountain air before the opening of hospitality suites at 8:00 pm. For Svante Pääbo suggestions and reservations, visit the Salt Lake City Restaurant Max Planck Institute for Evolutionary Counter near the entrance to the poster-exhibit hall. Anthropology INTERNET ACCESS. Free wireless access is provided in the Poster- Exhibit Hall. ORAL SESSION LOCATIONS CONFERENCE PROCEEDINGS. The conference proceedings will be "A" Sessions (MOA, TOA, WOA, ThOA), Ballroom HJ published online after the conference. Visit www.asms.org after "B" Sessions (MOB, TOB, WOB, ThOB), Ballroom ACE June 30 to view and download the Proceedings. "C" Sessions (MOC, TOC, WOC, ThOC), Ballroom BDF "D" Sessions (MOD, TOD, WOD, ThOD), Room 155 WEB BROADCASTING OF SESSIONS. Tutorial lectures, plenary "E" Sessions (MOE, TOE, WOE, ThOE), Exhibit Hall 2 sessions, and oral sessions will be web cast. Your last name and the "F" Sessions (MOF, TOF, WOF, ThOF), Exhibit Hall 3 User ID on the back of your name badge must be entered to view "G" Sessions (MOG, TOG, WOG, ThOG), Exhibit Hall 4 presentations. All presentations will be available until July 30. Web casting of presentations does not constitute publication and in no ORAL PRESENTATIONS. Only LCD computer projectors are used for way jeopardizes the rights of authors to publish material that has oral sessions. The ASMS PC computers are running Office 2007. been presented. To access the presentations, go to www.asms.org. Speakers are required to present from the ASMS computers. CORPORATE HOSPITALITY SUITES. See pages 9 and 11 for maps. SPEAKER PREPARATION. Speakers must go to the speaker room at Hospitality suites may be open 8:00 – 11:30 pm, Monday through least one day prior to their talks to load presentations on the ASMS Wednesday. Suites are located in the convention center. Suite computers. The speaker room is Ballroom G. The room is open opening hours may vary. Please check at company exhibit booth. with a technician present: Sunday: 10:00 am - 8:00 pm Monday through Wednesday: 7:30 am - 5:00 pm 2 58th ASMS Conference on Mass Spectrometry GENERAL INFORMATION SOCIAL ACTVITIES EMPLOYMENT CENTER. The Employment Center is located in • WELCOME MIXER, SUNDAY, 7:45 - 9:30 PM, Poster-Exhibit Poster-Exhibit Hall and is open to all conference registrants. Hall ABCDE. Conference name badge is required. Candidates must supply at least 20 resumés. Employers and candidates may use the center to search the database of candidates • GUEST REGISTRATION. Guest registration includes Sunday and positions. There are poster boards to advertise positions and evening mixer and name badge. There will be a staffed messages. There are booths available for conducting interviews. hospitality counter in the entrance to the poster-exhibit hall Interview spaces must be reserved one day in advance. where guests may meet one another and plan excursions. Sunday: 7:45 – 9:30 pm Cost for guest registration: $10. Monday – Wednesday: 8:30 am - 5:00 pm • FAREWELL TOAST, 5:30 - 6:00 PM, THURSDAY, Hall 4. Thursday: 8:30 am – 2:30 pm The conference concludes on Thursday with a farewell MEDIA EVENTS toast in Hall 4 immediately