ITI HUMAN IMMUNE MONITORING TECHNOLOGY AND BIOINFORMATICS CONFERENCE – MARCH 30-31, 2018 Speakers Bios Robert Michael Angelo, MD, PhD Mike Angelo is an assistant professor of Pathology and Member of the Child Heath Research Institute and Cancer Institute at Stanford. He received his BS in Physics at the University of Mississippi. From 2002-2010, he was enrolled at Duke University in the Medical Scientist Training Program where he completed an MD and a PhD with an emphasis in biochemistry and electrical engineering. His experience in systems development led to a broader interest in clinical diagnostics, and ultimately a residency in clinical pathology at University of California San Francisco (2010- 2013). During that time, he became interested in developing novel methods for immunohistochemical multiplexing using mass spectrometry, which led him to the Nolan Lab at Stanford University. He developed a completely new method for simultaneous imaging of up to 100 metal-labeled antibodies within a single tissue section using multiplexed ion beam imaging (MIBI). Dr. Angelo is interested in optimizing this and other mass reporter based technologies further with the goal of identifying new transcriptional and translational signatures in solid tissue malignancies that can be used to improve clinical diagnosis and treatment. https://med.stanford.edu/profiles/robert-angelo Nima Aghaeepour, PhD Dr. Aghaeepour completed his undergraduate studies Computer Science at the University of Tehran were he helped create a soccer team of robots. His graduate research at University of British Columbia with Ryan Brinkman and Holger Hoos focused on bioinformatics analysis of single cell data. He established the first objective benchmark for evaluation of algorithms that could automatically identify cell-types (and, eventually, correlate them with clinical outcomes), namely the Flow Cytometry: Critical Assessment of Population Identification Methods (Flow- CAP). As a postdoc with Garry Nolan (Stanford), and now an independent faculty member, he is interested in the intersection of data sciences, immunology, and clinical phenotyping. https://nalab.stanford.edu Sean C. Bendall, PhD Sean C. Bendall is an Assistant Professor in the Department of Pathology at Stanford University, School of Medicine. His research specialty is the development and application of single-cell proteomic tools for the investigation of human systems. This includes pioneering single cell CyTOF mass cytometry and multiplexed ion beam imaging (MIBI). Sean’s work in mass cytometry analysis has gone on to provide an unparalleled granularity of understanding in multiple facets of human hematopoiesis and immunology. His lab work ranges from unravelling the nature of ‘healthy and dysfunctional’ human hematopoietic immune cell biology to investigating the phenotypic landscape of cognitive decline in the human brain using single cell proteomic analysis. His work has been recognized by numerous awards including the Damon Runyon Cancer Research Foundation “Breakthrough Scientist” Award, the International Society for the Advancement of Cytometry President’s Award of Excellence, and the NIH Common Fund “New Innovator” Award. https://profiles.stanford.edu/sean-bendall Catherine Blish, MD, PhD Catherine Blish, MD, PhD, FIDSA is an Associate Professor of Medicine and Immunology at the Stanford University School of Medicine. As an undergraduate she studied biochemistry at the University of California, Davis, before completing her MD and PhD at the University of Washington. She completed residency in internal medicine and fellowship training in infectious diseases at the University of Washington and the Fred Hutchinson Cancer Research Center. She joined the Stanford faculty in in 2011, where her research is dedicated to learning how to harness the immune system to prevent and cure diseases. Her lab is perhaps best known for redefining our understanding of the diversity of human natural killer (NK) cells, a critical first line of defense against viruses and tumors. Her lab continues to explore how human natural killer cells sense and respond to a diverse array of pathogens, including HIV, dengue virus, and influenza. She divides her time between research, clinical practice in infectious diseases, teaching, and her role as an Associate Director of the Stanford Medical Scientist Training Program. She has received numerous awards for research and mentoring, including the Stanford Immunology Outstanding Faculty Mentor Award, the Beckman Young Investigator Award, the McCormick Faculty Award, the Baxter Faculty Scholar, the Doris Duke Charitable Foundation Clinical Scientist Development Award, the Tashia and John Morgridge Faculty Scholar in Pediatric Translational Medicine, the NIH Director’s New Innovator Award, and the NIDA Avant-Garde Award for HIV/AIDS Research. She is an elected a member of the American Society for Clinical Investigation and an Investigator of the Chan Zuckerberg Biohub. https://sites.stanford.edu/blishlab/ Scott D. Boyd, MD, PhD Dr. Boyd is an Associate Professor in the Department of Pathology at Stanford University. The Boyd laboratory develops high-throughput DNA sequencing and single-cell experiments together with data analysis methodology to study lymphocyte populations in human immune responses to infection and vaccination, as well as in immunological disorders such as food allergy and immunodeficiency. Many of the laboratory’s projects analyze the gene rearrangements encoding antibodies and T cell receptors that form the basis of immunological specificity and memory in health and disease. Dr. Boyd received bachelor's degrees in Biochemistry at the University of Manitoba, and English Literature at Oxford University, where he was a Rhodes Scholar. He obtained his M.D. from Harvard Medical School and Ph.D. from MIT, followed by pathology residency, a hematopathology fellowship, and postdoctoral research work, at Stanford University. http://med.stanford.edu/scottboydlab.html Petter Brodin, MD, PhD Dr Brodin grew up in Stockholm, Sweden and graduated from a joint M.D and Ph.D program at the Karolinska Institute. After completing his clinical internship and pediatric residency at the Karolinska University Hospital, he joined the Mark Davis laboratory at Stanford University as a postdoctoral fellow. During this time the Davis lab was involved in several systems-immunology analyses in human cohort and Brodin contributed in particular to an analysis of immune system variation in healthy human twins in order to assess the influences of heritable and non-heritable factors. After this, Brodin was recruited back to the Karolinska Institute to lead his own research group, and also establish a Mass cytometry facility at the newly opened Science for life laboratory, a national center for life science technology funded by the Swedish government. Brodin now divides his time between clinical work at the Karolinska University Children’s Hospital with research aiming to understand human immune system variation in general, and the shaping of human immune systems early in life in particular. https://ki.se/en/people/pebrod Atul Butte, MD, PhD Atul Butte, MD, PhD is the Priscilla Chan and Mark Zuckerberg Distinguished Professor and inaugural Director of the Institute for Computational Health Sciences (ichs.ucsf.edu) at the University of California, San Francisco (UCSF). Dr. Butte is also the Executive Director for Clinical Informatics across the six University of California Medical Schools and Medical Centers. Dr. Butte has authored over 200 publications, with research repeatedly featured in the New York Times, Wall Street Journal, and Wired Magazine. Dr. Butte was elected into the National Academy of Medicine in 2015, and in 2013, he was recognized by the Obama Administration as a White House Champion of Change in Open Science for promoting science through publicly available data. Other recent awards include the 2014 E. Mead Johnson Award for Research in Pediatrics, 2013 induction into the American Society for Clinical Investigation, and the 2011 National Human Genome Research Institute Genomic Advance of the Month. Dr. Butte is a principal investigator of three major programs: (1) the California Initiative to Advance Precision Medicine, implementing Governor Brown’s vision to promote precision medicine in California; (2) ImmPort, the clinical and molecular data repository for the National Institute of Allergy and Infectious Diseases; and (3) the California Precision Medicine Consortium, helping recruit tens of thousands of participants into President Obama's AllofUs Precision Medicine Initiative. Dr. Butte trained in Computer Science at Brown University, worked as a software engineer at Apple and Microsoft, received his MD at Brown University, trained in Pediatrics and Pediatric Endocrinology at Children's Hospital Boston, then received his PhD from Harvard Medical School and MIT. Dr. Butte is also a founder of three investor-backed data-driven companies: Personalis, providing medical genome sequencing services, Carmenta (acquired by Progenity), discovering diagnostics for pregnancy complications, and NuMedii, finding new uses for drugs through open molecular data. http://buttelab.ucsf.edu/ Arup K. Chakraborty, PhD Arup K. Chakraborty is the Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering at MIT. He was the founding Director of MIT’s Institute for Medical Engineering and Science from February 2012 to January 2018. He is also