Anti-NSUN2 (aa 425-475) polyclonal antibody (DPABH-05753) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Immunogen Synthetic peptide corresponding to a region within amino acids 425-475 of Human NSUN2 (NP_060225.4). Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB, IP Format Liquid Size 100 μg Buffer Constituent: 99% Tris citrate/phosphate. Note: pH 7-8 Preservative 0.09% Sodium Azide Storage Store at 2-8°C. GENE INFORMATION Gene Name NSUN2 NOP2/Sun domain family, member 2 [ Homo sapiens ] Official Symbol NSUN2 Synonyms NSUN2; NOP2/Sun domain family, member 2; NOL1/NOP2/Sun domain family 2; NOL1/NOP2/Sun domain family, member 2; tRNA (cytosine(34)-C(5))-methyltransferase; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved FLJ20303; Misu; Myc induced SUN domain containing protein; TRM4; tRNA methyltransferase 4 homolog (S. cerevisiae); hTrm4; NOL1/NOP2/Sun domain family 2; tRNA methyltransferase 4 homolog; substrate of AIM1/Aurora kinase B; 5-methycytoisine methyltransferase; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; Myc- induced SUN-domain-containing protein; myc-induced SUN domain-containing protein; tRNA (cytosine-5-)-methyltransferase NSUN2; MISU; SAKI; Entrez Gene ID 54888 Protein Refseq NP_001180384 UniProt ID Q08J23 Chromosome Location 5p15.32 Pathway Aurora B signaling; Function methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity; tRNA binding; transferase activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.