Fostering Innovation at MGH Poster Session Abstracts 67th Annual Meeting of the MGH Scientific Advisory Committee Celebration of Science The MGH Research Institute: Meeting the Challenges that Lie Ahead April 2 & 3, 2014 Simches Auditorium 185 Cambridge Street, 3rd Floor Management Management ECOR Administrative Offices | 50 Staniford Street, 10th Floor | Boston, MA 02114 | [email protected] Fostering Mainstay Mainstay Innovation of MGH of MGH at MGH Management Innovation Management Innovation Welcome elcome to the 67th Annual Meeting of the MGH Scientific Advisory Committee (SAC) on April 2nd and 3rd, 2014. Dr. Richard Lifton has graciously agreed to W chair our SAC meeting again this year. As in past years, we will begin our two-day SAC meeting with a Celebration of Science at MGH. Our poster session begins at 11:00 am on Wednesday, April 2, followed by an afternoon Research Symposium from 2:00 pm to 5:00 pm. The outstanding MGH researchers who will be presenting their work in our Symposium this year are the 2014 Howard Goodman Award recipient Filip Swirski, PhD and the 2014 Martin Basic and Clinical Research Prize recipients, Jayaraj Rajagopal, MD, and Stephanie Seminara, MD. We are honored to have as our keynote speaker, Richard O. Hynes, PhD, from MIT. We will close the first day with a Reception for invited guests at the Russell Museum. On Thursday, April 3, Dr. Kingston will open the SAC meeting with an ECOR Report. After this report, Anne Klibanski, MD, Partners Chief Academic Officer, will give a presentation on the Integration of MGH Research to the Partners Enterprise. We will next turn our attention to department presentations by the Chiefs of Neurology (Merit E. Cudkowicz, MD, MSc) and Surgery (Keith Lillemoe, MD), who will describe some of the remarkable research being conducted across MGH. Over the past year and a half, the hospital has conducted a rigorous Strategic Planning Initiative. Harry W. Orf, PhD, Senior VP for Research will close the morning session with an overview of the Research Strategic Plan with his presentation on the MGH Research Institute. Our afternoon sessions will include three focused discussions on the main components of the Research Institute. The initiatives we will explore are: 1. Clinical Research Reorganization—presented by Jerrold F. Rosenbaum, MD 2. Translational Research Center—presented by Mason W. Freeman, MD 3. Life Registry—presented by Susan A. Slaugenhaupt, PhD Experience has reaffirmed that we get the most helpful advice and perspective from SAC via open discussion of key issues. This year we have made a concerted effort to shorten presentations to allow more time for discussion with the SAC members. Also on Thursday, SAC members will again have the opportunity to meet with small groups of MGH investigators in unstructured, informal conversations during breakfast. To maximize the time for discussion during the day, the annual MGH Research Administration Executive Report and Financials for FY13 will be provided in these printed materials in advance of the meeting. Dr. Kingston plans to highlight some of this information in his annual ECOR Report and there will be an opportunity for SAC members to ask questions about the written report. We look forward to an engaging and stimulating two days of discussion and appreciate your participation. Peter L. Slavin, MD Robert E. Kingston, PhD Harry W. Orf, PhD President Chair, EXecUtive Committee Senior Vice President ON Research for Research SAC 2014 Executive Committee on RESEARCH 1 Agenda: Day One, Wednesday, April 2, 2014 Annual Celebration of Science at MGH 11:00 am–1:45 pm SAC 2014 Poster Session (light lunch available) Wyndham,15th Floor 2:00–5:00 pm Scientific Presentations Simches 3.110 WELCOME Peter L. Slavin, MD, President, Massachusetts General Hospital OpENING COMMENTS AND INTRODUCTIONS Robert E. Kingston, PhD, Chair, Executive Committee On Research (ECOR) 2014 MGH RESEARCH SCHOLARS Robert E. Kingston, PhD 2:15–2:45 pm 2014 Martin Prize for Basic Research Dedifferentiation of Committed Epithelial Cells Into Stem Cells in Vivo Jayaraj Rajagopal, MD 2:45–3:15 pm 2014 Martin Prize for Clinical Research Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination Stephanie B. Seminara, MD 3:15–3:45 pm 2014 Goodman Award The Role of IRA B Cells in Sepsis Filip K. Swirski, PhD 3:45–4:00 pm Break 4:00–5:00 pm Keynote INTRODUCTION Peter L. Slavin, MD Platelets and Extracellular Matrix—Under-appreciated Key Players in Metastasis Richard O. Hynes, PhD, Daniel K. Ludwig Professor for Cancer Research Investigator, Howard Hughes Medical Institute Massachusetts Institute of Technology 5:00–7:00 pm Reception (for invited guests) Russell Museum 2 Executive Committee on RESEARCH SAC 2014 Agenda: Day Two, Thursday, April 3, 2014 Annual Celebration of Science at MGH 8:00–9:00 am BREAKFAST SERI 2nd Floor SAC Members with small groups of MGH Faculty 9:00–9:15 am WELCOME AND OpENING COMMENTS Simches 3.110 Peter L. Slavin, MD, President, Massachusetts General Hospital 9:15–9:40 am ECOR REPORT 2013 Robert E. Kingston, PhD, Chair, Executive Committee On Research (ECOR) 9:40–10:00 am INTEGRATION OF MGH RESEARCH TO THE PARTNERS ENTERPRISE Anne Klibanski, MD, Partners Chief Academic Officer 10:00–11:30 am DEPARTMENT REPORTS 10:00–10:40 am Neurology, Merit E. Cudkowicz, MD, MSc 10:40–10:50 am Break 10:50–11:30 am Surgery, Keith D. Lillemoe, MD The MGH Research Institute: Meeting the Challenges that Lie Ahead 11:30 am–12:00 pm OVERALL ORGANIZATION: THE RESEARCH INSTITUTE Harry W. Orf, PhD, Sr. Vice President for Research 12:00–1:30 pm Lunch SERI 2nd Floor SAC Members with ECOR and Hospital Leadership Simches 3.120 ECOR Members & Speakers 1:30–1:40pm CLINICAL RESEARCH REORGANIZATION, Jerrold F. Rosenbaum, MD Simches 3.110 1:40–2:00 pm Discussion 2:00–2:10 pm TRANSLATIONAL RESEARCH CENTER, Mason W. Freeman, MD 2:10–2:30 pm Discussion 2:30–2:40 pm LIFE REGISTRY, Susan A. Slaugenhaupt, PhD 2:40–3:00 pm Discussion 3:00–3:15 pm Break 3:15–3:45 pm EXECUTIVE SEssION (SAC members only) Simches 3.120 3:45–4:15 pm DEBRIEFING (SAC members and MGH Leadership) Simches 3.120 SAC 2014 Executive Committee on RESEARCH 3 Goodman & Martin Award Winners Howard M. Goodman Fellowship 2014 The Fellowship honors Howard M. Goodman, founder of the MGH Department of Molecular Biology in 1982 and Chief of that Department until 2004. Dr. Goodman’s guiding principle was that great science should not be encumbered by the continual need to convince the world concerning the merit of an individual scientific vision. He believed in choosing scientists of demonstrated excellence and giving them the resources to pursue their goals with vigor, a model that was resoundingly successful. Each year a Goodman Fellow is chosen from the MGH community to honor that legacy and to support the pursuit of excellence by young scientists of uncommon passion and ability. The Role of IRA B Cells in Sepsis Filip Swirski, PhD Assistant Professor Center for Systems Biology Martin Research Prize 2014 for Basic and Clinical Research The Martin Research Prizes were established to honor Joseph B. Martin, MD, PhD, who was Dean of Harvard Medical School from July 1997 to July 2007. Prior to becoming Dean, Dr. Martin was Chief of the Neurology Service at MGH. Each year, ECOR awards two $100,000 Martin Research Prizes to recognize outstanding research papers published by MGH investigators in Basic research and Clinical research. BASIC RESEARCH Dedifferentiation of Committed Epithelial Cells Into Stem Cells in Vivo Jayaraj Rajagopal, MD Assistant Professor Center for Regenerative Medicine CLINICAL RESEARCH Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination Stephanie Seminara, MD Associate Professor Reproductive Endocrine 4 Executive Committee on RESEARCH SAC 2014 Keynote Speakers Profile:Keynote MGH SpeakerScholars Richard O. Hynes, PhD, FRS Richard Hynes was educated at Cambridge University (BA, MA) and MIT (PhD). He is the Daniel K. Ludwig Professor for Cancer Research at the Koch Institute and Department of Biology at MIT, Investigator of the Howard Hughes Medical Institute and Senior Associate Member of the Broad Institute. He was formerly Associate Head and then Head of the Biology Department and was Director of the MIT Cancer Center for 10 years. He is a Fellow of the Royal Society (FRS) of London and a Member of the US National Academy of Sciences, the Institute of Medicine and the American Academy of Arts and Sciences. Dr. Hynes was born in Nairobi, Kenya and grew up in Liverpool, England. He did his undergraduate work at Trinity College in Cambridge, UK, and his PhD at MIT with Paul Gross, separating different cell types from early sea urchin embryos and studying the complexity of their RNA sequences. He then returned to the UK as a postdoctoral fellow at the Imperial Cancer Research Fund in London. By investigating the molecular changes on cell surfaces that distinguish cancer cells from normal cells, he discovered fibronectin, a cell adhesion protein present on normal cells that was noticeably absent on cancer cells. Dr. Hynes then went back to become an Assistant Professor in the Cancer Center and Biology Department at MIT in 1975, where he continued to work out the biology of fibronectin, the discovery of which set into motion a string of studies that has helped to establish cell adhesion as its own field of investigation. He showed that the extracellular matrix was connected across the membrane to the actin cytoskeleton. Dr. Hynes’s studies also contributed to the discovery and subsequent cloning of integrins, a family of protein receptors that gives cells their stickiness by binding with fibronectin and other cell adhesion molecules.