Henry Ford Health System Henry Ford Health System Scholarly Commons Center for Health Policy and Health Services Center for Health Policy and Health Services Research Articles Research 4-1-2017 Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium Maggie CY Ng Mariaelisa Graff Yingchang Lu FAnneollow E. this Justice and additional works at: https://scholarlycommons.henryford.com/chphsr_articles Poorva Mudgal Recommended Citation Ng MC, Graff M, Lu Y, Justice AE, Mudgal P, Liu C, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, BrSeeody next JA, page Cade for BE, additional Dimitrov L,authors Duan Q, Guo X, Lange LA, Nalls M, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen W, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Allison MA, Ambrosone CB, Bandera E, Bartz T, Berndt S, Bernstein L, Blot W, Bottinger E, Carpten J, Chanock S, Chen Y, Conti D, Cooper R, Fornage M, Freedman B, Garcia M, Goodman P, Hsu Y, Hu J, Huff C, Ingles S, John E, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press M, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick D, Stanford J, Stevens V, Stram A, Strom S, Vaidya D, Witte J, Yao J, Zhu X, Ziegler R, Zonderman A, Adeyemo A, Ambs S, Cushman M, Faul J, Hakonarson H, Levin AM, Nathanson K, Ware E, Weir D, Zhao W, Zhi D, Arnett D, Grant S, Kardia S, Oloapde O, Rao D, Rotimi C, Sale M, Williams KL, Zemel B, Becker D, Borecki I, Evans M, Harris T, Hirschhorn J, Li Y, Patel S, Psaty B, Rotter J, Wilson J, Bowden D, Cupples L, Haiman C, Loos R, North K. Discovery and fine- mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet 2017; 13(4):1006719-1006719. This Article is brought to you for free and open access by the Center for Health Policy and Health Services Research at Henry Ford Health System Scholarly Commons. It has been accepted for inclusion in Center for Health Policy and Health Services Research Articles by an authorized administrator of Henry Ford Health System Scholarly Commons. Authors Maggie CY Ng, Mariaelisa Graff, Yingchang Lu, Anne E. Justice, Poorva Mudgal, Ching-Ti Liu, Kristin Young, Lisa R. Yanek, Mary F. Feitosa, Mary K. Wojczynski, Kristin Rand, Jennifer A. Brody, Brian E. Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, Leslie A. Lange, Michael Nalls, Hayrettin Okut, Salman M. Tajuddin, Bamidele O. Tayo, Sailaja Vedantam, Jonathan P. Bradfield, Guanjie Chen, ei-MinW Chen, Alessandra Chesi, Marguerite R. Irvin, Badri Padhukasahasram, Jennifer A. Smith, Wei Zheng, Matthew A. Allison, Christine B. Ambrosone, Elisa V Bandera, Traci M Bartz, Sonja I Berndt, Leslie Bernstein, William J Blot, Erwin P Bottinger, John Carpten, Stephen J Chanock, Yii-Der Ida Chen, David V Conti, Richard S Cooper, Myriam Fornage, Barry I Freedman, Melissa Garcia, Phyllis J Goodman, Yu-Han H Hsu, Jennifer Hu, Chad D Huff, Sue A Ingles, Esther M John, Rick Kittles, Eric Klein, Jin Li, Barbara McKnight, Uma Nayak, Barbara Nemesure, Adesola Ogunniyi, Andrew Olshan, Michael F Press, Rebecca Rohde, Benjamin A. Rybicki, Babatunde Salako, Maureen Sanderson, Yaming Shao, David S Siscovick, Janet L Stanford, Victoria L Stevens, Alex Stram, Sara S Strom, Dhananjay Vaidya, John S Witte, Jie Yao, Xiaofeng Zhu, Regina G Ziegler, Alan B Zonderman, Adebowale Adeyemo, Stefan Ambs, Mary Cushman, Jessica D Faul, Hakon Hakonarson, Albert M. Levin, Katherine L Nathanson, Erin B Ware, David R Weir, Wei Zhao, Degui Zhi, Donna K Arnett, Struan F A Grant, Sharon L R Kardia, Olufunmilayo I Oloapde, D C Rao, Charles N Rotimi, Michele M Sale, Keoki L. Williams, Babette S Zemel, Diane M Becker, Ingrid B Borecki, Michele K Evans, Tamara B Harris, Joel N Hirschhorn, Yun Li, Sanjay R Patel, Bruce M Psaty, Jerome I Rotter, James G Wilson, Donald W Bowden, L Adrienne Cupples, Christopher A Haiman, Ruth J F Loos, and Kari E North This article is available at Henry Ford Health System Scholarly Commons: https://scholarlycommons.henryford.com/ chphsr_articles/167 RESEARCH ARTICLE Discovery and fine-mapping of adiposity loci using high density imputation of genome- wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium Maggie C. Y. Ng1,2☯, Mariaelisa Graff3☯, Yingchang Lu4, Anne E. Justice3, Poorva Mudgal2, a1111111111 Ching-Ti Liu5, Kristin Young3, Lisa R. Yanek6, Mary F. Feitosa7, Mary K. Wojczynski7, a1111111111 Kristin Rand8, Jennifer A. Brody9, Brian E. Cade10,11, Latchezar Dimitrov1, Qing Duan12, a1111111111 Xiuqing Guo13, Leslie A. Lange12, Michael A. Nalls14,15, Hayrettin Okut2, Salman a1111111111 M. Tajuddin16, Bamidele O. Tayo17, Sailaja Vedantam18,19, Jonathan P. Bradfield20, a1111111111 Guanjie Chen21, Wei-Min Chen22, Alessandra Chesi23, Marguerite R. Irvin24, Badri Padhukasahasram25, Jennifer A. Smith26, Wei Zheng27, Matthew A. Allison28, Christine B. Ambrosone29, Elisa V. Bandera30, Traci M. Bartz31, Sonja I. Berndt32, Leslie Bernstein33, William J. Blot34, Erwin P. Bottinger4, John Carpten35, Stephen J. Chanock32, Yii-Der Ida Chen13, David V. Conti8, Richard S. Cooper17, Myriam Fornage36, Barry I. Freedman37, Melissa Garcia16, Phyllis J. Goodman38, Yu-Han H. Hsu18,19,39, OPEN ACCESS Jennifer Hu40,41, Chad D. Huff42, Sue A. Ingles8,43, Esther M. John44,45, Rick Kittles46, Citation: Ng MCY, Graff M, Lu Y, Justice AE, Eric Klein47, Jin Li48, Barbara McKnight49, Uma Nayak50, Barbara Nemesure51, Mudgal P, Liu C-T, et al. (2017) Discovery and fine- Adesola Ogunniyi52, Andrew Olshan3,53, Michael F. Press54, Rebecca Rohde3, Benjamin mapping of adiposity loci using high density A. Rybicki55, Babatunde Salako52, Maureen Sanderson56, Yaming Shao3, David imputation of genome-wide association studies in S. Siscovick57, Janet L. Stanford58,59, Victoria L. Stevens60, Alex Stram8, Sara S. Strom42, individuals of African ancestry: African Ancestry Dhananjay Vaidya6,61, John S. Witte62,63, Jie Yao13, Xiaofeng Zhu64, Regina G. Ziegler65, Anthropometry Genetics Consortium. PLoS Genet Alan B. Zonderman16, Adebowale Adeyemo21, Stefan Ambs66, Mary Cushman67, Jessica 13(4): e1006719. https://doi.org/10.1371/journal. D. Faul68, Hakon Hakonarson20,69, Albert M. Levin55, Katherine L. Nathanson70, Erin pgen.1006719 B. Ware26,68, David R. Weir68, Wei Zhao26, Degui Zhi71, The Bone Mineral Density in Childhood Study (BMDCS) Group¶, Donna K. Arnett72, Struan F. A. Grant20,23,69,73, Sharon Editor: Gregory P. Copenhaver, The University of L. R. Kardia26, Olufunmilayo I. Oloapde74, D. C. Rao75, Charles N. Rotimi21, Michele North Carolina at Chapel Hill, UNITED STATES M. Sale22, L. Keoki Williams25,76, Babette S. Zemel69,77, Diane M. Becker6, Ingrid Received: December 8, 2016 B. Borecki7,78, Michele K. Evans16, Tamara B. Harris16, Joel N. Hirschhorn18,19,79, Yun Li12,80,81, Sanjay R. Patel82, Bruce M. Psaty83,84, Jerome I. Rotter13,85, James Accepted: March 29, 2017 G. Wilson86, Donald W. Bowden1,2,87, L. Adrienne Cupples5,88, Christopher 8,43³ 4,89³ 3³ Published: April 21, 2017 A. Haiman *, Ruth J. F. Loos *, Kari E. North * Copyright: This is an open access article, free of all 1 Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston- copyright, and may be freely reproduced, Salem, NC, United States of America, 2 Center for Diabetes Research, Wake Forest School of Medicine, distributed, transmitted, modified, built upon, or Winston-Salem, NC, United States of America, 3 Department of Epidemiology, University of North Carolina, otherwise used by anyone for any lawful purpose. Chapel Hill, NC, United States of America, 4 The Charles Bronfman Institute for Personalized Medicine, Icachn School of Medicine at Mount Sinai, New York, NY, United States of America, 5 Department of The work is made available under the Creative Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, 6 Department Commons CC0 public domain dedication. of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America, Data Availability Statement: All relevant data are 7 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, within the paper and its Supporting Information St. Louis MO, United States of America, 8 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America, 9 Cardiovascular Health files. Summary association statistics from meta- Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States of America, analyses are available from dbGAP at accession 10 Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of number phs000930. America, 11 Harvard Medical School, Boston, MA, United States of America, 12 Department of Genetics, Funding: AABC-MEC: The MEC and genotyping of University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America, 13 Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor- samples for the GWAS of breast and prostate UCLA Medical Center, Torrance, CA, United States of America, 14 Laboratory of Neurogenetics, National cancer was supported by National Institutes of