COURSE SCHEDULE: Biochemistry/Chemistry 945: Seminar—Chemical Biology (Advanced) Blackwell — Spring 2018 Wednesdays @ 4:35 pm, Room 8335 Chemistry Discussion Date Speaker Paper CBI-relevant Seminars Facilitator Jan Introduction Blackwell None Paula Hammond – Jan 29/30 24 Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma Jan Marc Currie patients; Wargo, Science, 2018, 359, 97–103; Herman Sintim - Jan 26 31 Chevrette Commentary: Jobin Science, 2018, 359, 32–34 Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Benjamin Feb 7 Lynn Enhanced mRNA Delivery Ortiz Hammond, Angew Chem Int Ed, 2017, 56, 13709–13712 Acoustic reporter genes for noninvasive imaging of microorganisms in Feb Emily Cai mammalian hosts 14 Ehlerding Shapiro, Nature, 2018, 553, 86–90 Akt3 is a privileged first responder in isozyme-specific electrophile response Feb Mark Klein Denu Aye, Nature Chem Bio, 2017, 13, 333–338; 21 Commentary: Weerapana, Nature Chem Bio, 2017, 13, 244–245 Programmable base editing of A•T to G•C in genomic DNA without DNA Feb Rebeca Brunold cleavage Yimon Aye - Feb 27 28 Fernandez Liu, Nature, 2017, 551, 464–471 Tim Multidimensional chemical control of CRISPR-Cas9 Mar 7 Jin Tiambeng Shoulders & Choudhary, Nature Chem Bio, 2017, 13, 9–11 An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Mar Trisha Ge Cells Matt Shoulders – Mar 13 14 Tucholski Krogan, Cell, 2017, 169, 350–360 A semi-synthetic organism that stores and retrieves increased genetic Mar Joseph Blackwell information 21 Vasquez Romesburg, Nature, 2017, 551, 644–647 Spring Break Commensal bacteria make GPCR ligands that mimic human signalling Kayleigh Apr 4 Blackwell molecules Nyffeler Brady, Nature, 2017, 549, 48–53 Apr Stephanie Synthesis of d-Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars Tang 11 Blaszczyk Myers, Angew Chem Int Ed, 2016, 55, 523-527 Selective killing of Helicobacter pylori with pH-responsive helix–coil Apr Korbin Blackwell conformation transitionable antimicrobial polypeptides Andy Myers – Apr 17 18 West Cheng, PNAS, 2017, 114, 12675–12680 Apr Nathan Identifying Functional Cysteine Residues in the Mitochondria Katherine Grimes – Apr 19; Pagliarini 25 Murray Weerapana, ACS Chem Bio, 2017, 12, 947–957 Adam Urbach April 24 Enantioselective Hydrogen Atom Transfer: Discovery of Catalytic Promiscuity in Flavin-Dependent ‘Ene’-Reductases Kevin Hyster, J Am Chem Soc, 2017, 159, 11313–11316 May 2 Weix Garcia Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light Hyster, Nature, 2016, 540, 414–417 .