THE THIRD EUROPEAN-AMERICAN SCHOOL IN FORENSIC GENETICS AND MAYO CLINIC COURSE IN ADVANCED MOLECULAR AND CELLULAR MEDICINE Editors Dragan Primorac Ivana Erceg Ivkošiæ Ante Ivko{i} Stanimir Vuk-Pavloviæ Moses Schanfield Prepress and printed by Studio Hrg, Zagreb Zagreb, September 2003 Copyright 200 3 Video and/or audiotaping of any session is not permited without prior approval from the speakers and from the Scientific Commi ttee of The Third European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine 2 September 1-5, 2003, Zagreb, Croatia THE THIRD EUROPEAN-AMERICAN SCHOOL IN FORENSIC GENETICS AND MAYO CLINIC COURSE IN ADVANCED MOLECULAR AND CELLULAR MEDICINE TABLE OF CONTENTS Welcome . 4 Committees and Boards . 5 Scientific Program Information . 7 General Information . 9 Invited speakers . 12 Calendar of Events (The Third European - American School in Forensic Genetics) . 14 Calendar of Events (Mayo Clinic Course in Advanced Molecular and Cellular Medicine) . 23 Abstracts (The Third European - American School in Forensic Genetics) . 32 Abstracts (Mayo Clinic Course in Advanced Molecular and Cellular Medicine) . 68 Author Index . 126 Key Word Index . 132 Notes . 138 Acknowledgments . 142 September 1-5, 2003, Zagreb, Croatia 3 THE THIRD EUROPEAN-AMERICAN SCHOOL IN FORENSIC GENETICS AND MAYO CLINIC COURSE IN ADVANCED MOLECULAR AND CELLULAR MEDICINE Dear Colleagues, Welcome to The Third European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine, Zagreb, Croatia, September 1- 5, 2003. The event will provide an opportunity for exchange of the latest information and technology in clinical and forensic genetics as well as cutting-edge advances in cellular and molecular medicine. The first program in Split in 1997 and the second in Dubrovnik in 2001 were highly successful with the cumulative attendance of more than 800 participants from 62 countries. The program in Zagreb will feature plenary lectures by leaders in the field and poster presentations by participants. Programs in forensic medicine and in cellular and molecular medicine will run in parallel with the introductory and closing sessions held jointly. The Cellular and Molecular Medicine program is co-organized with the Mayo Clinic, Rochester, Minnesota, USA and University of Zagreb Program in Advanced Medical Education and chaired by Mayo's Dr. Stanimir Vuk-Pavlovi}. Special hands-on workshops will be offered by our sponsors Applied Biosystems and Roche Molecular Systems. We are pleased that the Croatian Society of Human Genetics has decided to hold its Third Congress in conjunction with our program on September 3-4, 2003. Many plenary talks and selected papers will be published in the Croatian Medical Journal, a publication listed in all major scientific indexes. The attendance of the conference will be accredited by the Croatian Medical Chamber with fifteen credit points. Furthermore, we are happy to offer two Young Investigator Awards (a plaque and US$500 each). The social program will include a welcome reception for all participants at the Hotel Opera on the 17 th floor. A one-day tour after the course will include the visit to the famed Plitvice Lakes National Park, a magical world of lakes, forests and waterfalls, which is under UNESCO protection. The Croatian capital Zagreb has nine hundred years of documented history with abundant traces of the many civilizations and cultures that have influenced the region. Today it is a city of distinct Central European flavor. Wherever you find yourself in Zagreb, you will be surrounded by historic buildings, concert halls, parks, restaurants, bars, nightclubs and shops. We are looking forward to sharing this unique scientific and social experience with you. Sincerely yours, Program Chairs Moses Schanfield, Ph.D. Dragan Primorac, M.D., Ph.D. Mayo Clinic Course Chair Stanimir Vuk-Pavloviæ, Ph.D. 4 September 1-5, 2003, Zagreb, Croatia THE THIRD EUROPEAN-AMERICAN SCHOOL IN FORENSIC GENETICS AND MAYO CLINIC COURSE IN ADVANCED MOLECULAR AND CELLULAR MEDICINE CONFERENCE ORGANIZERS Program Chairs Moses Schanfield , George Washington University, Washington, DC, USA Dragan Primorac , Split University School of Medicine, Osijek University School of Medicine and Polyclinic Holy Spirit II, Zagreb, Croatia Chair, Mayo Clinic Course in Advanced Molecular and Cellular Medicine Stanimir Vuk-Pavloviæ , Mayo Clinic, Rochester, MN, USA Chair, The Third Croatian Congress in Human Genetics (September 3 - 5, 2003) Ana Stavljeniæ-Rukavina , Zagreb University School of Medicine and Clinical Hospital, Zagreb, Croatia Institutions Clinical Hospital Split , Croatia Croatian Society of Human Genetics , Croatia General Hospital Holy Spirit , Croatia International Commission for Missing Persons , USA Mayo Clinic , USA Polyclinic Holy Spirit II , Croatia Split University School of Medicine , Croatia University of Zagreb , Croatia Standing Committee of the Mayo Clinic-University of Zagreb Program in Advanced Medical Education Nada Èikeš , Clinical Hospital Center, Zagreb, Croatia Nijaz Hadžiæ , Clinical Hospital Center, Zagreb, Croatia John La Forgia , Mayo Clinic, Rochester, MN, USA Thomas McDonald , Mayo Clinic, Rochester, MN, USA Dragan Primorac , Split University School of Medicine, Osijek University School of Medicine and Polyclinic Holy Spirit II, Zagreb, Croatia Stanimir Vuk-Pavloviæ , Mayo Clinic, Rochester, MN, USA Mark Wilhelm , Mayo Clinic, Rochester, MN, USA Scientific Advisory Committee Frederick Bieber , Harvard Medical School, Boston, MA, USA Bruce Budowle , Federal Bureau of Investigation, Washington, DC, USA Francis Glorieux , McGill University, Shriners Hospital for Children, Montreal, QC, Canada Mitchell Holland , The Bode Technology Group, Inc., Springfield, VA, USA Edwine Huffine , International Commission on Missing Persons, USA Henry Lee , Connecticut State Police, Meriden, CT, USA September 1-5, 2003, Zagreb, Croatia 5 THE THIRD EUROPEAN-AMERICAN SCHOOL IN FORENSIC GENETICS AND MAYO CLINIC COURSE IN ADVANCED MOLECULAR AND CELLULAR MEDICINE Slobodan Macura , Mayo Clinic, Rochester, MN, USA Timothy Palmbach , Connecticut State Police, Meriden, CT, USA Thomas Parsons , Armed Forces DNA Identification Laboratory, Rockville, MD, USA Walter Parson , Institute of Legal Medicine, Innsbruck, Austria Pier Franco Pignatti , Institute of Biology and Genetics University of Verona, Italy Jeffrey Platt , Mayo Clinic, Rochester, MN, USA Raj Puri , Food and Drug Administration, Bethesda, MD, USA David Rowe , University of Connecticut, School of Medicine, Farmington, USA Stephen Russell , Mayo Clinic, Rochester, MN, USA John Ryan , Myriad Genetic Laboratories, Inc., Salt Lake City, UT, USA David I. Smith , Mayo Clinic, Rochester, MN, USA Petros Tsipouras , University of Connecticut, School of Medicine, Farmington, USA Richard Weinshilboum , Mayo Clinic, Rochester, MN, USA Patrick Willems , Synergene, Mechelen, Belgium Local Organizing Committee: Chairperson: Paola Mariani Members: Šimun Anðelinoviæ, Ivo Bariæ, Ingeborg Barišiæ, Floriana Buliæ-Jakus, Ivana Erceg Ivkošiæ, Aleksandra Fuèiæ, Stjepko Gamulin, Ante Ivkošiæ, Sendi Kuret, Dalibor Marijanoviæ, Krešimir Paveliæ, Damir Primorac, Jadranka Sertiæ, Vedrana Škaro, Ana Stavljeniæ-Rukavina, Elizabeta Topiæ, Renata Zadro, Ljiljana Zergollern Èupak Conference secretariat: Ivana Erceg Ivkošiæ, Ljubica Grbiæ, Ante Ivkošiæ, Marko Maduniæ, Ivana Mikaèiæ, Petra Rožman Congress Service: Studio Hrg d.o.o. Hrvatske bratske zajednice 4, Zagreb, Croatia Tel.fax: +385 1 6110 449, 6110 450, 6110 452 e-mail: studiohrg @studiohrg.hr http://www.studiohrg.hr 6 September 1-5, 2003, Zagreb, Croatia THE THIRD EUROPEAN-AMERICAN SCHOOL IN FORENSIC GENETICS AND MAYO CLINIC COURSE IN ADVANCED MOLECULAR AND CELLULAR MEDICINE Scientific Program Information Cancellations and Refunds Notice of cancellation has to be made in writing by registered letter or fax to the Conference Office. The policy for refunding registration fees is as follows: Written cancellation received: - before July 30, 2003 75% refund - after July 30, 2003 no refund The date of the postmark or fax ID was the basis for considering refunds. Refunds will be made after the conference. Certificate of Attendance Confirmations of attendance will be issued at the registration desk. The Third European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine Awards The members of the scientific board will review all submitted abstracts and 2 selected authors will receive European-American Intensive Course Investigator Award. Recipients of the award will recieve a check of US$500 as well as a special certificate. Credits The Third European-American School in Forensic Genetics and Mayo Clinic Course in Advanced Molecular and Cellular Medicine, Zagreb, Croatia, has been approved for 15 (participants) or 20 (lecturers) points by the Croatian Medical Chamber. Sponsor Exhibition opening hours Monday, September 1, 2003 12:05 p.m. - 03:00 p.m. Tuesday, September 2, 2003 12:05 p.m. - 02:30 p.m. Wednesday, September 3, 2003 12:05 p.m. - 03:00 p.m. Language The official language of the conference is English (no simultaneous translation). Poster Sessions All posters are on display on Tuesday and Wednesday, September 2 and 3, 2003, 12:05 p.m. - 3:00 p.m. Poster Mounting Tuesday, September 2, 2003 08:30 a.m. - 11:30 a.m. Poster Removal Thursday, September 4, 2003 08:00 a.m. - 02:00 p.m. September 1-5, 2003, Zagreb, Croatia 7 THE