Inhibitors Product Data Sheet Moroxydine hydrochloride • Agonists Cat. No.: HY-B0420A CAS No.: 3160-91-6 Molecular Formula: C₆H₁₄ClN₅O • Molecular Weight: 207.66 Screening Libraries Target: Influenza Virus Pathway: Anti-infection Storage: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month SOLVENT & SOLUBILITY In Vitro H2O : ≥ 100 mg/mL (481.56 mM) DMSO : 50 mg/mL (240.78 mM; Need ultrasonic) * "≥" means soluble, but saturation unknown. Mass Solvent 1 mg 5 mg 10 mg Concentration Preparing 1 mM 4.8156 mL 24.0778 mL 48.1556 mL Stock Solutions 5 mM 0.9631 mL 4.8156 mL 9.6311 mL 10 mM 0.4816 mL 2.4078 mL 4.8156 mL Please refer to the solubility information to select the appropriate solvent. In Vivo 1. Add each solvent one by one: PBS Solubility: 100 mg/mL (481.56 mM); Clear solution; Need ultrasonic 2. Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (12.04 mM); Clear solution 3. Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (12.04 mM); Clear solution 4. Add each solvent one by one: 10% DMSO >> 90% corn oil Solubility: ≥ 2.5 mg/mL (12.04 mM); Clear solution BIOLOGICAL ACTIVITY Description Moroxydine hydrochloride (ABOB hydrochloride) is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.Target: Influenza VirusMoroxydine hydrochloride (ABOB hydrochloride) is an antiviral drug that was originally developed in the 1950s as an influenza treatment. It has potential applications against a number of RNA and Page 1 of 2 www.MedChemExpress.com DNA viruses [1]. Structurally moroxydine is a heterocyclic biguanidine. Moroxydine was reported in March 2014 that three kindergartens in two provinces of China had been found to be secretly dosing their students with moroxydine hydrochloride to try to prevent them from becoming ill. The kindergartens are paid only for the days that pupils attend and wanted to ensure that they maximised their earnings [2]. REFERENCES [1]. Sheppard, S., Moroxydine: the story of a mislaid antiviral. Acta Derm Venereol Suppl (Stockh), 1994. 183: p. 1-9. [2]. Moore, Malcolm. "China: All children to be given drug tests after schools caught medicating pupils". The Age. Retrieved 2014-03-20. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 609-228-6898 Fax: 609-228-5909 E-mail: [email protected] Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA Page 2 of 2 www.MedChemExpress.com.