CURRICULUM VITAE REUBEN KAPUR, PH.D. Freida and Albrecht Kipp Chair Professor of Pediatrics Director, Program in Hematologic Malignancies and Stem Cell Biology Professor of Biochemistry & Molecular Biology, Medical & Molecular Genetics, Microbiology & Immunology Chairman, Biomedical Research Committee Herman B Wells Center for Pediatric Research Indiana University School of Medicine Cancer Research Institute 1044 W. Walnut Street, Room 168 Indianapolis, IN 46202 Phone: 317-274-4658 Fax: 317-274-8679 Email: [email protected] http://www.wellscenter.iupui.edu/researchers/reuben-kapur http://www.cancer.iu.edu/research/members/member_bio.php?id=1250 PROFILE Dr. Kapur is the Director of the Hematologic Malignancies and Stem Cell Biology Research Program within the Herman B Wells Center for Pediatric Research at Indiana University School of Medicine. The group consists of six members including Drs. Mervin Yoder (endothelial cell biology and stem cell development), Nadia Carlesso (Notch signaling in stem cells and leukemogenesis), Rebecca Chan (SHP2 mutations in JMML), Mingjiang Xu (ASLX1 and TET2 mutations in leukemogenesis) and Yan Liu (Bmi1 signaling in stem cells and leukemogenesis). The group regularly interacts with other stem cell biologists on campus including Drs. Hal Broxmeyer (stem cell biology), Louis Pelus (stem cell homing and mobilization) and Edward Srour (hematopoietic microenvironment). Dr. Kapur is a principal investigator at the Wells Center focusing on understanding the molecular mechanisms of adhesion/migration and growth control in normal and leukemic stem/progenitor cells. He received his undergraduate degrees from Christ Church College (in Physics, Chemistry and Mathematics) and Washington State University (in Microbiology and Immunology). He obtained his Ph.D. from the University of Arizona, majoring in Microbiology and Immunology and minoring in Molecular and Cellular biology. He completed his post-doctoral fellowship under the supervision of Dr. David A. Williams at the Herman B Wells Center in the area of hematopoietic stem cell biology as a Howard Hughes Fellow and joined the pediatric faculty as an Assistant Professor in 2001. He was promoted to full Professor in 2010. Dr. Kapur has distinguished himself as an outstanding scientist in the area of Hematologic Malignancies and Hematopoietic Stem and Progenitor Cell Biology and has established a national and international reputation in this field. He has served on several important committees such as the American Society of Hematology (ASH), the International Society for Experimental Hematology (ISEH), and the National Institutes of Health (NIH) Hematopoiesis Study Section. Dr. Kapur continues Reuben Kapur, Ph.D. - CV 07152013 1 to publish in prestigious journals and holds multiple National Institutes of Health research grants in hematopoietic stem cell biology and leukemia. RESEARCH FOCUS Major focus of Dr. Kapur’s lab is to understand the signaling pathways involved in regulating normal and abnormal hematopoiesis. In adults, bone marrow (BM) is the major site for the continuous production of mature blood cells. Mature blood cells arise from hematopoietic stem cells (HSC) within the bone marrow cavity. While the regulation of HSCs is an extremely popular area of investigation, how it occurs remains an enigma. It is thought that part of the process involves self-renewal, differentiation and apoptosis or senescence. Although the precise mechanisms by which these fates are determined is still unclear, several molecules have been implicated in these processes, including components of the BM microenvironment. The BM microenvironment consists of extracellular matrix proteins as well as cells such as osteoblasts and stromal cells which contribute to hematopoietic stem/progenitor (HSC/P) cell fate by anchoring these cells in the BM cavity and delivering adhesive signals as well as signals in the form of soluble ligands, including cytokines and chemokines. These signals induce intracellular activation of both the positive regulators of HSC/P cell growth, self-renewal and differentiation as well as negative signals. Some of these pathways, such as those initiated by stem cell factor (SCF), the ligand for KIT, stromal cell derived factor-1 (SDF-1), and thrombopoietin (TPO), induce the activation of phosphatidylinositol-3 kinase (PI3K), Src kinase (SFK) and focal adhesion kinase (FAK). How PI3K and its downstream targets including members of Rho family GTPases including ROCK and Rap1 contribute to HSC/P regulation is a major area of ongoing research in Kapur's lab. Kapur lab is also interested in understanding the mechanisms of oxidative as well as ribosomal stress and has recently identified an essential role for FAK and ROCK kinases in this process. In the context of leukemogenesis, Kapur lab is interested in understanding the role of oncogenic forms of KIT and FLT3 receptors in regulating myeloproliferative neoplasms as well as acute myeloid leukemia, with the intent of defining novel therapeutic targets in these diseases. EDUCATION UNDERGRADUATE: 1982-1985 Christ Church College, B.S. Physics, Chemistry & Mathematics 1985-1989 Washington State University, B.S. (Cum Laude), Microbiology & Immunology GRADUATE: 1989-1994 University of Arizona, Ph.D. Microbiology & Immunology w/Minor in Molecular and Cellular Biology POSTDOCTORAL: 1994-1997 Howard Hughes Fellow, Howard Hughes Medical Institute, Indiana University School of Medicine, Indianapolis, IN 1997-1998 Leukemia Research Foundation Fellow, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN Reuben Kapur, Ph.D. - CV 07152013 2 1998-1999 National Research Service Award (NIH/NRSA Fellow), Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN ACADEMIC APPOINTMENTS 1999-2002 Adjunct Graduate Faculty, Department of Life Sciences, School of Graduate Studies, Indiana State University, Terre Haute, IN 1999-2001 Assistant Scientist, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 2001-2006 Assistant Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 2001-2006 Associate Member, Cancer Research Center, Indiana University School of Medicine, Indianapolis, IN 2003-2006 Assistant Professor of Molecular Biology and Biochemistry, Indiana University School of Medicine, Indianapolis, IN 2006-present Member, Cancer Research Center, Indiana University School of Medicine, Indianapolis, IN 2007-2010 Associate Professor of Pediatrics, Herman B Wells Center for Pediatrics, Indiana University School of Medicine, Indianapolis, IN 2007-2010 Associate Professor of Molecular Biology and Biochemistry, Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 2007-2010 Associate Professor of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 2009-present Director, Hematologic Malignancies and Stem Cell Biology Program, Herman B Wells Center for Pediatric Research, IU School of Medicine, Indianapolis, IN 2010-present Professor of Pediatrics, Herman B Wells Center for Pediatrics, Indiana University School of Medicine, Indianapolis, IN 2010-present Professor of Molecular Biology and Biochemistry, Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 2010-present Professor of Genetics, Indiana University School of Medicine, Indianapolis, IN 2010-present Professor of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 2010-present Freida and Albrecht Kipp Professor of Pediatrics, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 2013 Chairman, Biomedical Research Committee, Indiana University School of Medicine, Indianapolis, IN HONORS AND AWARDS 1989 Cum Laude, Washington State University 1989-1990 Graduate Academic Fellowship, University of Arizona 1991-1992 Outstanding Instructor, University of Arizona 1994-1997 Howard Hughes Postdoctoral Fellowship, Indiana University School of Medicine 1997-1998 Leukemia Research Foundation Fellowship, Indiana University School of Medicine 1998-1999 NIH Postdoctoral Fellowship (NRSA), Indiana University School of Medicine 2000-2002 Junior Faculty Scholar Award, American Society of Hematology (ASH) 2001 Travel Award, American Society of Hematology, Orlando, FL. Reuben Kapur, Ph.D. - CV 07152013 3 2008 Prestigious External Award Recognition, 2008 IUPUI Chancellor’s Honors Convocation, Indianapolis, IN 2008 Invited faculty of 1000 Medicine 2013 Chairman, Biomedical Research Committee (BRC), Indiana University School of Medicine, Indianapolis, IN 2013 Nominated, Vice President, International Society for Experimental Hematology TEACHING ASSIGNMENTS 1990-1994 Assistant Instructor, Microbiology and Immunology, University of Arizona UNDERGRADUATE SUMMER STUDENTS AND MEDICAL STUDENTS: 1990-1993 J. LoCascio, Selectide, Inc., Biotech firm 1990-1993 T. D. Camenisch, Assistant Professor, University of Arizona 1990-1994 J. Keifer, Graduate Student, University of Texas 1990-1992 A. Acevedo, Medical Student, University of Arizona 1995 J. Uffman, First Year Resident, University of Arizona 1996 K. Schindler, Graduate Student, University of Colorado 1995-1998 R. Maze, Patent Lawyer, Washington, DC 1995 D. McMillin, Undergraduate Student, Indiana University 1998 G. Chen, Residency, Vanderbilt University 1999-2010 Taught over 300 students in