THE UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE TUCSON DEPARTMENT OF SURGERY Core Faculty Biographical Sketches 2017 I. DIVISION OF CARDIOTHORACIC SURGERY • David Bull, MD (Professor of Surgery, with tenure; new Division Chief of CT Surgery) • Mary Jane Barth, MD (Clinical Associate Professor of Surgery) • Kenneth Fox, MD, (Clinical Assistant Professor of Surgery, clinical track) • Toshinobu Kazui, MD, PhD (Assistant Professor of Surgery, clinical track) • Zain Khalpey, MD, PhD (Associate Professor of Surgery, tenure track) • Samuel Kim, MD (Assistant Professor of Surgery, tenure track) • Scott Lick, MD (Professor of Surgery, with tenure) • Young-Wook Won, PhD (Assistant Professor of Surgery, tenure track) II. DIVISION OF GENERAL SURGERY • Taylor S. Riall, MD, PhD, FACS (Acting Chair and Division Chief - Professor - Tenured) • Amanda Arrington, MD, FACS (Assistant Professor – Non-Tenure Clinical Scholar Track) • Iman Ghaderi, MD, MSc, FRCSC, FACS (Assistant Professor - Non-Tenure Clinical Scholar Track) • Vinod Gollapalli MD (Clinical Instructor) • Marlon A. Guerrero, MD, FACS (Section Chief, Associate Professor - Tenured) • Robert C. Harland, MD, FACS (Professor - Tenured) • Tun Jie, MD, MS, FACS (Associate Professor - Non-Tenure Clinical Scholar Track) • Ethan E. Larson, MD (Assistant Professor - Non-Tenure Clinical Scholar Track) • James H. McClenathan, MD, FACS (Professor - Non-Tenure Clinical Scholar Track) • Lilah F. Morris-Wiseman, MD, FACS (Assistant Professor – Non-Tenure Clinical Scholar Track) • David D. Neal, MD, FACS (Associate Professor - Non-Tenure Clinical Scholar Track) • Leigh A. Neumayer, MD, MS, FACS (Professor - Tenured) • Valentine N. Nfonsam, MD, MS, FACS (Associate Professor - Tenured) • Rebecca K. Viscusi, MD, FACS (Assistant Professor - Non-Tenure Educator Scholar Track) • Amy L. Waer, MD, FACS (Professor - Non-Tenure Educator Scholar Track) • James A. Warneke, MD, FACS (Associate Professor - Tenure) III. DIVISION OF NEUROSURGERY • G. Michael Lemole Jr., MD (Division Chief – Professor, Surgery - Tenured) • Travis M. Dumont MD (Assistant Professor, Surgery - Tenure Track) • R. John Hurlbert MD (Professor, Surgery - Tenure Track) • Willard S. Kasoff MD (Assistant Professor, Surgery - Tenure Track) • Martin E. Weinand MD (Professor, Surgery - Tenured) 1 Core Faculty Biographical Sketches (cont.) 2017 IV. DIVISION OF TRUAMA, CRITICAL CARE, BURN AND EMERGENCY SURGERY • Terence O’Keeffe MB, ChB, MSPH, FACS (Interim Chief - Associate Professor - Tenured) • Randall S. Friese MD, FACS, FCCM (Professor - Tenured) • Lynn M. Gries MD (Assistant Professor - Non-Tenure Clinical Scholar Track) • Arpana Jain MD (Assistant Professor - Non-Tenure Clinical Scholar Track) • Bellal A. Joseph MD, FACS (Associate Professor - Tenured) • Narong Kulvatunyou MD, FACS (Associate Professor - Non-Tenured Clinical Scholar Track) • Andrew L. Tang MD, FACS (Associate Professor - Tenured) • Gary A. Vercruysse MD, FACS (Associate Professor - Tenure Track) • El Rasheid Zakaria PhD (Research Assistant Professor) V. DIVISION OF UROLOGY • Benjamin R. Lee, MD (Division Chief - Professor - Tenured) • Ken Batai, PhD (Research Assistant Professor – Non-tenure track) • Joel T. Funk, MD, FACS (Assistant Professor - Non-Tenure Clinical Scholar Track) • Matthew B. Gretzer, MD, FACS (Associate Professor - Non-Tenure Clinical Scholar Track) • Marty Schiff, MD (Professor Emeritus) • Christian O. Twiss, MD, FACS (Associate Professor - Non-Tenure Clinical Scholar Track) VI. DIVISION OF VASCULAR AND ENDOVASCULAR SURGERY • Wei Zhou, MD, FACS (Chief - Professor - Tenured) • Eric Espensen DPM, DABMSP (Assistant Professor - Non-Tenure Clinical Scholar Track) • Kay R. Goshima MD, FACS (Associate Professor - Non-Tenure Clinical Scholar Track) • Jennifer L. Pappalardo DPM (Assistant Professor - Non-Tenure Clinical Scholar Track) • Tze-Woei Tan MBBS (Assistant Professor - Tenure Track) • Craig Weinkauf, MD (Assistant Professor – Tenure Track, starting Fall 2017) • Marlys H. Witte MD (Professor - Tenured) VII. RESEARCH & EDUCATION • Allan Hamilton MD, FACS (Professor) • Ronald Heimark PhD (Professor) • Robert Johnson PhD (Research Professor) • Klearchos Papas PhD (Professor) • Wiliams Adamas-Rappaport MD, FACS (Professor) 2 I. DIVISION OF CARDIOTHORACIC SURGERY DAVID BULL BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Bull, David A. eRA COMMONS USER NAME: DAVID_BULL POSITION TITLE: Professor of Surgery, Division of Cardio-Thoracic Surgery, University of Arizona School of Medicine EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.) DEGREE INSTITUTION AND LOCATION Date FIELD OF STUDY (if applicable) University of California Berkeley, Berkeley, CA B.A. 1981 Biochemistry University of California San Francisco, San Francisco, CA M.D. 1985 Medicine University of California San Francisco, San Francisco, CA Intern 1986 General Surgery University of California San Francisco, San Francisco, CA Resident 1987 General Surgery University of Arizona Health Science Center, Tucson, AZ Resident 1989 General Surgery University of Arizona Health Science Center, Tucson, AZ Chief Resident 1990 General Surgery University of Arizona Health Science Center, Tucson, AZ Fellow 1992 Vascular Surgery University of Utah School of Medicine, Salt Lake City, UT Fellow 1994 Cardiothoracic Surgery A. Personal Statement With this application, we propose to develop a biological affinity-driven rapamycin delivery vehicle for T-cells- targeted immunosuppression. We will have developed a bi-functional recombinant fusion protein containing a CD80 domain that targets CTLA4 expressed on activated T-cells and the rapamycin-binding domain (RBD) derived from FKBP12. In this CD80-RBD fusion protein, the RBD incorporates rapamycin analogues through biological affinity binding that does not require the creation of chemical bonds. This targeted delivery of rapamycin by the CD80-RBD fusion protein provides a means for the recipient’s T-cell-focused combined immunosuppression to effectively reduce the incidence of grafts rejection and minimize the adverse effects of the immunosuppressive agents. As a Cardio-Thoracic surgeon with a history of published research and prior NIH funding in the fields of drug delivery systems, I have the skill set and experience to conduct and oversee the proposed studies as the principle investigator. Perhaps more importantly, having been intimately involved in developing and bringing together all of the elements that this project requires, I have the ability and the expertise in navigating through any unexpected challenges or unforeseen problems which may occur during the course of our project. The successful completion of our proposed Specific Aims will advance the development of a new platform for targeted delivery of immunosuppressive agents. 3 DAVID BULL B. Positions and Honors Positions and Employment 1994 – 2001 Assistant Professor of Surgery, University of Utah Division of Cardiothoracic Surgery, Salt Lake City, UT 1994 – Present Chief, Salt Lake City VA Medical Center, Cardiac Transplantation, Salt Lake City, UT 1994 – Present Surgical Co-Director, Salt Lake VA Medical Center, UTAH Cardiac Transplant Program, Salt Lake City, UT 2001 – Present Chief, Salt Lake VA Medical Center, Cardiothoracic Surgery, Salt Lake City, UT 2001 – 2006 Associate Professor of Surgery, University of Utah Division of Cardiothoracic Surgery, Salt Lake City, UT 2006 – 2016 Professor of Surgery, University of Utah Division of Cardiothoracic Surgery, Salt Lake City, UT 2009 – 2016 Division Chief, University of Utah Division of Cardiothoracic Surgery, Salt Lake City, UT 2017-Present Professor of Surgery, University of Arizona Division of Cardiothoracic Surgery, Tucson, AZ 2017-Present Division Chief, University of Arizona Division of Cardiothoracic Surgery, Tucson, AZ Honors 1980 Frank Gerbode Research Scholar 1981 Phi Beta Kappa, Achievement Award for College Scientists 1991 Who's Who Among Rising Young Americans 2002 J. Maxwell Chamberlain Memorial Paper, Society for Thoracic Surgery 2003 – 2017 America's Top Physicians, Consumers' Research Council of America 2003 – 2017 America's Top Surgeons, Consumers' Research Council of America 2004 – 2017 Good Housekeeping's Top Heart Specialists 2004 – 2017 America's Top Doctors 2009 – 2017 America’s Top Doctors for Cancer 4 DAVID BULL C. Contributions to Science My publications have been focused on clinically translatable research in the fields of cell therapy, stem cell biology, gene therapy for cancer, biopolymer carriers, and ischemia-inducible gene therapy systems. 1. Clinical Transplantation a. Kumpati GS, Patel AN, Bull DA. Thrombosis of a descending thoracic aortic endovascular stent graft in a patient with factor V Leiden: case report. Journal of cardiothoracic surgery. 2014; 9:47. PubMed [journal]PMID: 24618347 PMCID: PMC3984718 b. Wozniak CJ, Baird BC, Stehlik J, Drakos SG, Bull DA, Patel AN, Selzman CH. Improved survival in heart transplant patients living at high altitude. The Journal of thoracic and cardiovascular surgery. 2012; 143(3):735-741.e1. PubMed [journal]PMID: 22169457 c. Healy AH, Mason NO, Hammond ME, Reid BB, Clayson SE, Drakos SG, Kfoury AG, Patel AN, Bull DA, Budge D, Alharethi RA, Bader FM, Gilbert EM, Stehlik J, Selzman CH. Allograft rejection