NATIONAL CENTRE FOR INFORMATION AND DOCUMENTATION ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ ADVANCES IN BULGARIAN SCIENCE Annual ○○○○○ 2011 SOFIA Advances in Bulgarian Science ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ Published by National Centre for Information and Documentation 52 A, G. M. Dimitrov Blvd. 1125 Sofia, Bulgaria Phone: +359 2 817 38 62 http: www.nacid.bg e-mail: [email protected] Editorial board: Kamen Velev Vanya Grashkina, Yana Panova, Lyubov Racheva, Milen Angelov, Katia Stoilova, Lyudmila Velkova Disclaimer The articles are published as provided by their authors, without additional editing. ISSN: 1312-6164 © National Centre for Information and Documentation 2005 - Publisher © PrePress by Svetoslav G. Marinov Ltd., Sofia, Bulgaria © Printing by Milena Print Ltd., Sofia, Bulgaria © Cover design by Svetoslav G. Marinov Ltd., Sofia, Bulgaria 2 ○○○○○ Advances in Bulgarian Science ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ CONTENTS ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ NATIONAL SCIENTIFIC PROGRAMMES WITH EUROPEAN DIMENSIONS 5 Prognostic Models for Assessment of Risk of Central Sleep Apnoea in Patients with Chronic Heart Failure. Effects from the Non-Invasive Ventilation 5 Psychophysical and Electrophysiological Approaches in Search of New Evidence for Separate S-OFF Pathway in Human Visual System. Investigations with Healthy Volunteers and Patients with Glaucoma 13 Concerning Genetic Variability and Usable Isozyme Markers for Characterization of A. Mellifera L. Populations and B. Mori L. Breeds in Bulgaria 20 Immunomodulatory Effects of Selected Lactobacillus Strains Against Inflammation in Human Intestines 28 Immobilization of Trichosporon Cutaneum R57 Cells onto SiO /HPC 2 Hybrid Materials and Removal of Mn 2+ Ions 33 Inverse Field Source Problems in Biomagnetics 38 An Integral Solution for Telemedicine and Hospital Information System 47 ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ BULGARIAN ADDED VALUE TO ERA 54 The Genomic Research Center a Long Story Told in Short 54 Molecular Photonics Laboratory for Ultrafast Science and Technology at Sofia University St. Kliment Ohridski 64 ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ MADE IN BULGARIA WITH EUROPEAN SUPPORT 70 Sensor Effector Boot Module for a New Technology Spinal Patients Rehabilitation 70 Libraries with PLC Programming Modules 76 Prototype GIS for Analysis and Protection of the Bulgarian Archaeological Heritage ArchGIS 85 ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ EQUAL IN EUROPEAN RESEARCH AREA 92 BULGARIAN VIPs 92 AWARDS 97 ARTICLES 101 ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ EVENTS 105 ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ ○○○○○ 3 Advances in Bulgarian Science ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ NACID National Centre for Information and Documentation MAIN OBJECTIVES NACID is: Ø The leading institution in the national information infrastructure in Bulgaria in the sphere of education, science and innovations. Ø National information center for academic recognition and mobility (ENIC-NARIC center for Bulgaria). Ø Contact point to the Directive 2005/36/ÅC on the recognition of professional qualifications and delegated coordinator for Bulgaria in Internal Market Information (IMI) system. PRIMARY FIELDS OF ACTIVITIES: Ø Processing and dissemination of bibliographic and reference data and analytical information in support of the policy in the sphere of education, science, technology and innovations. Ø Building and maintaining specialized databases. Ø Maintaining national stock and DB of dissertations, deposited manuscripts and other scientific publications in Bulgaria. Ø Organizing application of ENIC-NARIC network decisions in the field of academic recognition. Ø Realizing information assistance in procedures for academic and professional recognition. Ø Performing activities resulting from the functions of ENIC-NARIC center. Ø Furnishing citizens and contact points in the rest of the member states with information in connection with recognition of professional qualifications and rights for practicing regulated professions in conformity with the Directive 2005/36/ÅC. Ø Performing functions of institutional contact point of the EUs Seventh Framework Programme. INFORMATION PRODUCTS AND SERVICES q NACID offers a wide range of information products: subject profiles, paper reviews, subject bibliographic and reference information. q NACID offers a great variety of information services through its own databases and resources, as well as through information brokerage to external databases. Online access is provided to NACIDs own databases grouped in two basic information blocks: Bulgarian Science Databases Science and Industry Databases Ø SIRENA, R&D reports and dissertations; Ø Partnership for Innovation and Development; Ø Scientific and Technical Publications in Bulgaria; Ø Knowledge for Innovations and Development . Ø Register of the Scientific Degrees and Titles; Information brokerage and servicing from external databases gives access to over 1200 databases of the leading information centers, including STN International Germany, DIALOG USA, EBSCO, etc. q Library Services Central Research and Technical Library (CRTL) with library information complex in pedagogics is one of the largest Bulgarian libraries and main supplier of information in the field of science, education, pedagogics, engineer- ing, technology and economy with more than 4 million registered items, including books, periodicals, dissertations, publications on CD ROM, DVD. It offers: Lending of library materials; Electronic Document Delivery; Online access to the library catalogues since 1980; Interlibrary loan. Searching in electronic catalogues and databases; INTERNATIONAL ACTIVITY Represents the Republic of Bulgaria in international organizations on the subject of its activities. Joint actions and projects with related national information and documentation centers in the EU. 4 ○○○○○ National Scientific Programmes with European Dimensions ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ NATIONAL SCIENTIFIC PROGRAMMES WITH EUROPEAN DIMENSIONS PROGNOSTIC MODELS FOR ASSESSMENT OF RISK OF CENTRAL SLEEP APNOEA IN PATIENTS WITH CHRONIC HEART FAILURE. EFFECTS FROM THE NON-INVASIVE VENTILATION Kiril Terziyski1, Zdravko Z. Taralov1, Anna Hristova1, Ilcho Ilchev2, Okan Aliman2, Stefan Kostianev1 1Pathophysiology Dept., Medical University of Plovdiv 2Cardiology Dept., Medical University of Plovdiv 15-A, Vasil Aprilov Blvd., 4002 Plovdiv, Bulgaria Abstract rate; chronotropic incompetence and heart rate Central sleep apnoea - Cheyne-Stokes respi- variability analysis. ration (CSA-CSR) is among the most important Basic parameters from the mentioned inves- factors responsible for the high morbidity and tigations and their derivatives will be juxtaposed preterm mortality of patients with chronic heart to chemodynamics condition (ejection fraction, failure (CHF). It is present in 30-50% of CHF pa- functional capacity); sleep architecture (non- tients. Despite its significant contribution to the REM and REM), apnoea-hypopnoea index and prognosis of CHF and its high frequency, few desaturation characteristics (amplitude, duration, large scale investigations on its prediction and specific characteristics), quality of life, etc. early diagnosis are present. The main reason for Grounded on the acquired results, an integrative its underdiagnosing is the fact that its diagnosis system (panel of parameters) for CSA risk pre- needs expensive and labour-consuming poly- diction in CHF will be proposed. This panel will be somnographic investigation. The aim of the proj- followed-up after therapy with positive airway ect is to further investigate some recently repor- pressure and oxygen therapy, if needed. The ex- ted parameters, informative of CSA risk in CHF, as pected results would contribute to the early di- well as to look for new parameters with predic- agnostics and purposeful treatment of CSA-CSR tive capabilities, based on the up-to-date knowl- in CHF. edge on CSA pathogenesis. The following parameters of the cardiorespi- INTRODUCTION ratory system will be investigated following scru- The problem with the early functional diag- tinized analysis of its functional profile: nostics of central sleep apnea (CSA) in patients Characteristics of tidal volume dynamics with chronic heart failure (CHF) has been a mat- (cyclic pattern), exhaled CO , ventilatory equiva- ter of extreme interest worldwide since the turn 2 lents at rest, during exercise and sleep. of the century. The bulk of scientific publications Gas exchange response - oxygen uptake, on this problem has been published in the last 5 exhaled CO2, ventilation and ventilatory equiva- years. A considerable part of the authors lents on different stages of exercise testing (on- pointed out the significance of the problem and set, anaerobic threshold, recovery). the necessity for additional research on the topic Changes in heart rate and the equilibrium and particularly on the construction of predictive sympathetic-parasympathetic regulation of heart models for CSA. Currently, leading teams have ○○○○○ 5 Advances in Bulgarian Science ○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○○ been involved with achieving this goal. No such Its clinical significance is determined by its fre- research has been done in Bulgaria so far, which quency, the lack of routine screening and/or eas- puts the scientific community