Personal Report Prepared for: Jane Smith GxRenew Personal Report 1 REPORT SUMMARY This quick overview shows which genes we tested and the rating assigned to the results from your analysis. Make sure to review the detailed results carefully to best interpret your rating for each trait. LOOK RATING GENES IRF4, LOC105374875, NTM, TYR, HERC2, MC1R, Sun Sensitivity FAVORABLE CPNE7, MC1R, RPS2P1, ASIP Skin Aging NORMAL IRF4, SPATA33, RALY/ASIP, BNC2 Facial Aging IMPROVED STXBP5L Stretch Marks NORMAL ELN, SRPX, HMCN1, LOC105373353 Skin Glycation BELOW AVERAGE AGER, GLO1 Fat Loss Response to Cardio LOW ADRB2, LPL NRXN3, GNPDA2, LRRN6C, PRKD1, GPRC5B, Body Composition Response to SLC39A8, FTO, FLJ35779, MAP2K5, QPCTL-GIPR, ENHANCED Strength Training NEGR1, LRP1B, MTCH2, MTIF3, RPL27A, SEC16B, FAIM2, FANCL, ETV5, TFAP2B FEEL RATING GENES Intrinsic Motivation to Exercise MORE LIKELY BDNF Addictive Behavior / LESS LIKELY DRD2 Stimulus Control Impulse Control & Taste Preference BELOW AVERAGE FTO with Aging Sleep Duration ABOVE AVERAGE ABCC9, LOC101927400, DRD2 Sugar Intake NORMAL SLC2A2, GLUT2 FUNCTION RATING GENES SLIGHTLY ABOVE Cognitive Decline with Aging APOE, BDNF AVERAGE Age Related Hearing Loss INCREASED GRM7 Kidney Function with Aging ABOVE AVERAGE UMOD, GALNTL5, GALNT11 Longevity NORMAL FOXO3, APOC1 (APOE-CI-CII) GxRenew Personal Report 4 FUNCTION RATING GENES Fitness Response to Cardio LOW AMPD1, APOE Systemic Inflammation ABOVE AVERAGE CRP, APOC1 (APOE-CI-CII), HNF1A SLIGHTLY ABOVE Polyunsaturated Fatty Acid Levels FADS1-2 AVERAGE Cholesterol Response to Dietary Fat NORMAL LIPC Insulin Response to Dietary Fat SENSITIVE FTO Triglyceride Response to Cardio NORMAL CYYR1, GLT8D2, RBFOX1, ZNF385D Lactose Intolerance UNLIKELY MCM6 CASR, DGKD, GCKR, LINC00709, CARS, Calcium Levels BELOW AVERAGE LOC105370176, CYP24A1 Copper Levels BELOW AVERAGE SMIM1, SELENBP1 Magnesium Levels NORMAL MUC1, SHROOM3, TRPM6, DCDC5, ATP2B1, MECOM Dietary Choline Levels NORMAL PEMT Selenium Levels NORMAL DMGDH Zinc Levels BELOW AVERAGE CA1, PPCDC, LINC01420 GxRenew Personal Report 5 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 BELOW HTLY ABO SLIGHTLY ABOVE HTLY ABOV NORMAL SLIG VE ENSITIVE ENSITIVE CREASED SLIG E NORMAL AVERAGE AVERAGE S S INCREASED IN AVERAGE AVERAGE M U AB IM S L O E E NO N L AV O D NO L P NO S Y I R V G Y L A E V E A R W E E L K E O A R L I E R S R E O R L E E A A N B M N S H E K N IN H V N A M A E A M N M V O G M K L V R A L E E K E D A R G E A R L A A I Y W E B O A E E E O Y O L IG I L E O L C IG O E O L V B R W E H E E R L E O V L L V N L Y R E O O E LOOK L O D L G V G I A S A B G A G A B E O R R A W H R S H R E H R R N C O N L A V W M O A IT M M A M M A A M M V L A N V A G IT L A L A N E R E O B R E I S R Y E R Y L R R E I E R C A G A A A S A G E L E R I R L E E B L A H N L O V L O E L O B E V E V C E V E V E E D D A A N N A N A S N LESS ABOVE ABOVE HIGHLY I W WELL ABOVE BELOW BELOW BELOW LOW NORMAL LIKELY INCREASED NORMAL NORMAL NORMAL INCREASED NORMAL A LIKELY AVERAGE AVERAGE AVERAGE SENSITIVE AVERAGE AVERAGE AVERAGE FACIAL AGING WHAT YOUR GENES SAY ABOUT YOU: BELOW HTLY ABO SLIGHTLY ABOVE HTLY ABOV NORMAL SLIG VE ENSITIVE ENSITIVE CREASED SLIG E NORMAL AVERAGE AVERAGE S S INCREASED IN AVERAGE AVERAGE Our analysis indicates that your genetic profile exhibits characteristics that give you M E N U AB N IM N S L O V E O N L AV O ED O L P O S Y IK R G R LY L A E S R A RO W E R E L E E O A M IK I E M R V A M E M O G M L E L A A N B R N S H E E D N N H V N A A R A E an IMPROVED level of visible skin aging. That means that while most people willN see R V L A IK Y E V B A E A E E L Y E E I IK C I O E V B E A E H E E A W O L O L V O L N G L E O L G O L O G R L W O D R L L G E O V V G I A L Y S A R B G A E O E G A B E O R R A W H R S H R E H R R N C O N L A V W M O A IT M M A M M A A M M V L A N V A G IT L A L A N E R E O B R E I S R Y E R Y L R R E I E R C A G A A A S A G E L E R I R L E E B L A H N L O V L O E L O wrinkles as early as their late twenties, you’re not likelyB to notice lines, wrinkles andE skin V E V C E V E V E E D D A A N N A N A SLIGHTLY S N SLIGHTLY I W MORE BELOW ABOVE SLIGHTLY ABOVE ABOVE ABOVE LIKELY NORMAL AVERAGE NORMAL SENSITIVE SENSITIVE UNLIKELY INCREASED INCREASED AVERAGE AVERAGE thinning and saggingNORMAL until later. As with all physical conditions, however,NORMAL genes are only IMPROVED NORMAL B AVERAGE AVERAGE part of the story. A certain amount of skin aging is, of course, inevitable. Also, since skin aging is ultimately caused by skin damage, your lifestyle and dietary habits can accelerate the process no matter what your genetic makeup. BELOW HTLY ABO HTLY ABO SLIGHTLY ABOVE HTLY ABOV HTLY BELO NORMAL NORMAL NORMAL SLIG VE ENSITIVE ENSITIVE SLIG VE CREASED SLIG E CREASED NORMAL SLIG W CREASED AVERAGE AVERAGE S S AVERAGE INCREASED IN AVERAGE AVERAGE IN AVERAGE IN E F I E E L A A A N A B N S H N D N N H V N A A N N N N B V E V B O E E E L Y E O L E I E O O L C I O E O L V B Y D O E H E O Y D O W E E E V O L V N G W E G L E W W L E A O G O R V G E L V G I R A G R S R A R B G R A E O S R G A G R S R R O R O W H S H O E H R H O O H R L A V W M A R O A IT M M L A M A M M A A M M V A M L A N L A M A M A O W G IT L A L A G G O A E R E O R A B R E I S R Y R E R Y L R R E I E E R C R I E G A B A E A A S A G A E A A V B E L E G E R I E R L E R E E R B L A A H N L O V B L L O E L O H L B E B L H L V E V V V E V RELATED GENESV / SNPs A L V E E C E C D C E N N D N F E A A A A A A A S N N N I W N ABOVE BELOW HIGHLY HIGHLY ABOVE I Your genetic profile indicates BELOW I U FAVORABLE NORMAL LOWER NORMAL NORMAL NORMAL NORMAL NORMAL ENHANCED INCREASED C AVERAGE AVERAGE SENSITIVE INCREASED AVERAGE AVERAGE that you are likely to have an STXBP5L IMPROVED level of skin aging. HTLY BELO INCREASED INCREASED NORMAL NORMAL TLY A TLY A A A GHTLY BELO SLIG W NORMAL NORMAL LIGH BOVE LIGH BOVE INCRE SED INCRE SED SLI W AVERAGE S AVERAGE S AVERAGE AVERAGE The gene and its associated SNP included N N N N E F E F E O E O Y D Y D L A L A E R V E R N in this category haveL E been shown in O L E O B V B V V M G M N N You can maximize your fortunate genetic predilection S R S R O O A B A B N N O G O Y D Y D N W E O H H A A E V E E V E A A B A A L E O L E O E O G A M A M R R R R E L E L E O E O B R R W O R G E G E E E W W L A L H S R H S R G R A M I A I A A A V G O V G O G R G R A E E O L O O R R O O A M A M A M R H R H R O A O A A M A M V V G G L E A L L V B V B A W A W L L I E A I E A R E studies to have significantC associations C B R B R R R A A E A B A L A L E A E A R R by takingE steps to protect your skin from undue L E G E G H L H L B V N N F F A A E E L I I E E B L B L C C V V E V E V V A HIGHLY N N A A N N A A A I I SLIGHTLY NORMAL D U U NORMAL UNFAVORABLE ABOVE SLIGHTLY BELOW HIGHLY with a person’s susceptibilityINCREASED to visible NORMAL ABOVE NORMAL INCREASED NORMAL BELOW AVERAGE AVERAGE ABOVE AVERAGE AVERAGE AVERAGE INCREASED damage and help it maintain its elasticity over time.