Federal State Scientific-Industrial Company for Immunobiological Medicines of the Ministry of Health of the Russian Federation MICROGEN is a first-rate company in Russian medical industry with leading role in development and production of immunobiological preparations, diagnosticums and drugs. Priority in company’s work is given to production of vaccines for dangerous infectious diseases, including those for the National Vaccination Schedule of Russia and influenza vaccines. Microgen is actively collaborating with leading Russian research centers in order to develop and manufacture unique products of biotechnology and immunobiology. Highly skilled staff, rigid manufacturing standards and strict control of every production stage guaranty the best quality of the company’s products. Consortium MICROGEN was founded in May, 2003 under the aegis of Public Health Ministry of the Russian Federation in order to preserve and develop the domestic production of medical immunolobiological preparations. The newly established company was to become an advanced enterprise of medical immunobiology that could ensure the realization of national programs of biological security and preservation of epidemiologic and sanitary welfare, switching to international standards of drug production and practical application of new preparations developed by Russian scientists. The staff of the 14 subsidiaries of MICROGEN comprises more than 7500 persons, including 7 professors, 21 doctors of science and 177 candidates of science. MICROGEN subsidiaries are located in 13 cities of the Russian Federation: Moscow, Ekaterinburg, Irkutsk, Makhachkala, Nizhny Novgorod, Omsk, Perm, Stavropol, Tomsk, Tumen, Ufa, Khabarovsk and Belorechensk. MICROGEN manufactures more than 70 percent of all the domestic immunobiological products: vaccines, allergens, therapeutic and diagnostic serums, eubiotics, bacteriophages, donor blood products, human immunoglobulins and drug preparations. The total nomenclature of immunobiological products of MICROGEN exceeds 300 items. In collaboration with leading Russian scientists the company is striving to develop and manufacture new high-quality and moderately priced preparations. At present more than 15 novel preparations are being prepared for commercial production, e.g. new influenza and smallpox vaccines, diphtheria and tetanus toxoids and pertussis vaccine, hepatitis B vaccine, avian influenza vaccine, etc. By taking part in WHO international programs for eradication of smallpox, measles, rubella, tuberculosis, whooping cough, diphtheria, tetanus allows the company specialists to keep abreast of the modern developments in immunobiology. Production facilities of the MICROGEN company allow it to manufacture the whole range of vital immunobiological preparations in the necessary quantities. The main aims of the company are: • complete provision of immunobiological preparations for the maintenance of Russia epidemiologic and sanitary welfare, primarily vaccines for the National Vaccination Schedule of Russia and vaccines for socially important infectious diseases; • maintenance and development of efficient supply of immunobiological preparations to Russian Federation subjects; • development of a unified program of development, funding and modernization of production and research; • improving the international image of the Russian science and producers of immunobiological preparations. • gradual transfer of all enterprises of the consortium to the GMP international quality standard. CONTENTS I.MEDICAL IMMUNOBIOLOGICAL PREPARATIONS 11 Vaccines and toxoids (anatoxins) 11 Diphtheria and tetanus anatoxin (toxoid), purified, adsorbed, liquid 13 Diphtheria and tetanus anatoxin (toxoid), purified, adsorbed, with the reduced antigen content, liquid 13 Diphtheria anatoxin (toxoid), purified, adsorbed, with the reduced antigen content, liquid 14 Tetanus anatoxin (toxoid), purified, adsorbed, liquid 14 “COCAV”: antirabic tissue culture vaccine, concentrated, purified, inactivated 15 “RABIVAC-VNUKOVO-32”: rabies tissue culture vaccine, concentrated, purified, inactivated, for human immunization 15 Brucellosis vaccine, live, dry 15 Gonococcal vaccine, inactivated, liquid (gonovaccine) 16 Influenza virus vaccine, egg-derived, intranasal, live, dry 16 Influenza virus vaccine, inactivated, eluate-centrifuged, liquid 17 “GRIPPOL”®(influenza virus vaccine, trivalent, polymer-subunit, liquid) 17 Typhoid vaccine E, combined, live 18 Diphtheria and tetanus toxoids and pertussis vaccine, adsorbed, liquid (DTP-vaccine) 18 Measles virus vaccine, tissne cultured, live 18 Meningococcal vaccine of A group, polysaccharidal, dry 19 Smallpox vaccine, live, dry 19 Mumps vaccine, tissue cultured, live, dry (parotitis vaccine) 20 Mumps and measles virus vaccine, tissue cultured, live, dry (measles-mumps vaccine) 20 Hepatitis B virus vaccine, recombinant-DNA, yeast (hepatitis B vaccine) 21 Tuberculosis vaccine for sparing immunization (vaccine of Calmette and Guerin-M, BCG-M vaccine) 22 Tuberculosis vaccine (vaccine of Calmette and Guerin, BCG vaccine) 22 Tularemia vaccine, live, dry 23 Tetratoxoid, purified, adsorbed, liquid 23 Tritoxiod, purified, adsorbed, liquid 24 ENCEVIR® (tick-borne encephalitis vaccine, tissue cultured, purified, concentrated, inactivated, sorbed, liquid) 24 Human immunoglobulins 25 Normal human immunoglobulins 26 Immune globulin intravenous (human) 26 IMMUNOVENIN (immune globulin intravenous, human) 26 Immune globulin intramuscular (human) 27 IMBIOGAM® (immune globulin intramuscular, human) 27 Immunoglobulin complex preparation for enteral administration (KIP) 27 Specific human immunoglobulins 28 Antistaphylococcsus human immunoglobulin 28 Antitetanus human globulin 28 ANTIHEP (antihepatitis B human globulin) 29 Immunoglobulin human against encephalitis ixodicum 29 Antiallergic human immunoglobulins 30 Histaglobulin 30 Antiallergic human globulin, liquid 30 Heterogenous serums 31 Antibotulinic serum of A, D, E types, purified, concentrated, liquid 31 Antigangrene serum, polyvalent, purified, concentrated, horse, liquid 31 Antidiphtheric serum, horse, purified, concentrated, liquid 32 Antitetanic serum, horse, purified, concentrated, liquid 32 Anti-viper (anti-adder) venom serum, horse, purified, concentrated, liquid 32 Cytokines (interferons and interleukins) 33 AFFINOLEUKIN ® 33 SVEFERON ® (human leukocyte interferon, suppositories) 33 Human leukocyte interferon 34 Bacteriophages 35 Pseudomonas aeruginosa bacteriophage 36 Coliproteic bacteriophage 36 Staphylococcal bacteriophage 37 Dysenteric bacteriophage, polyvalent 37 Klebsiella bacteriophage, polyvalent, purified 38 Klebsiella pneumoniae bacteriophage, purified 38 Klebsiphage (Klebsiella pneumoniae bacteriophage) 38 Coli bacteriophage 39 Proteus bacteriophage 39 Salmonellosis of ABCDE groups bacteriophage 40 Streptococcal bacteriophage 40 Intesti-bacteriophage 41 Pyopolyphage (pyobacteriophage combined, liquid) 41 Pyobacteriophage polyvalent, purified® 42 SEXTAPHAGE ® (pyobacteriophage polyvalent) 42 Probiotics (Eubiotics) 43 Bifidumbacterin, dry 44 Bifidumbacterin, suppositories 45 Bificol, dry 45 Colibacterin, dry 46 Lactobacterin (Lactobacteria acidophilic, vaginal suppositories) 46 Lactobacterin, dry 47 II. BLOOD PRODUCTS 49 Plasma substitutes 50 Albumin solution, 10% 50 Protein 51 Preparations for parenteral nutrition 51 Infusamin 51 Fibrinolytic preparations 52 Fibrinolysin 52 Eye film with fibrinolysin 52 Antioxidants 53 Ceruloplasmin 53 Nonspecific biostimulators 54 Glunat 54 Plasmol 54 III. DRUGS OF OTHER PHARMACOLOGICAL GROUPS 57 Alpha-adrenomimetics 58 Naphthisin (naphazoline) solution 58 m-Cholinoblockers 58 Platiphylline hydrotartrate 58 Anticoagulants 59 Heparin 59 Fibrinolysis inhibitors 60 INHITRIL® 60 Hemopoiesis stimulants 61 ERYTHROSTIM ® 61 Adenosinergetics 62 Pentoxifyllin 62 Euphyllin 62 H1 antihistamine agents 63 Dimedrol 63 Anabolics 63 Riboxin 63 Vitamins and vitamin-like preparations 64 Ascorbic acid 64 Thiamin chloride 65 Cyanocobalamin 65 Cocarboxylase hydrochloride 66 Nicotinic acid 67 Detoxifying agents 68 Glucose 68 Cartilage and bone tissue metabolism correctors 68 CHONDROLON ® 68 Minerals and trace elements 69 Potassium chloride 69 Calcium chloride 69 Magnesium sulphate 70 Sodium chloride 70 Enzymes and antienzymes 71 Lydase 71 LYRASE ® 71 Trypsin crystalline 72 Chemotrypsin 72 Metabolics 73 Sodium adenosinetriphosphate 73 Anxiolytics 73 Sibason 73 Local anesthetics 74 Lydocaine hydrochloride 74 Novocaine 74 Nootropic agents 75 Piracetam 75 Cerebrolysate 75 Non-narcotic analgesics, nonsteroid anti-inflammatory agents 76 Analgin 76 Ortophen 76 Gastrointestinal agents 77 Dalargin 77 “EQUINE”, natural gastric juice 77 Dental agents 78 Propolis tincture 78 Cardiovascular agents 78 Dibasol 78 Papaverine hydrochloride 79 Nitroglycerin 79 Agents affecting prostate metabolism 80 Prostacor ® 80 Uterotonics 80 Oxytocin 80 Antibiotics 81 Gentamycin sulphate 81 Lincomycin 81 Aids (adjuncts) 82 Water for injection 82 IV. DIAGNOSTIC IMMUNOBIOLOGICAL AGENTS 85 Allergens and allergiods 86 Allergens from tree pollens: birch, oak, maple, alder, hazel and ash for diagnosis and therapy 86 Allergens from pollens of wild and cultivated grasses: orchard grass, sheave, maize, foxtail, fowl-grass, fescue, bent, couch-grass, ryegrass, rye, timothy-grass and dandelion 86 Allergens from weed pollens: ambrosia (ragweed), wormwood, goose-foot, hemp, cyclahen, dandelion and sunflower 86 Mixt-allergen from tree pollens (birch, oak, maple, alder, hazel and ash) for diagnosis and therapy