ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 35, Number 8, Αugust 2015 Proceedings of the 18 th Annual Meeting of the Society of Biotherapeutic Approaches, 13 December 2014, Takamatsu, Japan. Special Issue Edited by M. Kuroki and G.-I. Soma Contents Preface ........................................................................................................................................... 4381 Reviews Functional Alteration of Tumor-infiltrating Myeloid Cells in RNA Adjuvant Therapy. T. SEYA, H. SHIME, M. MATSUMOTO (Sapporo, Japan) ................................................................................................ 4385 Methods to Prevent or Treat Refractory Diseases by Focusing on Intestinal Microbes Using LPS and Macrophages. G.-I. SOMA, H. INAGAWA (Kagawa; Niigata, Japan) .................................................. 4393 Transcriptional Regulation of the p16 Tumor Suppressor Gene. Y. KOTAKE, M. NAEMURA, C. MURASAKI, Y. INOUE, H. OKAMOTO (Fukuoka, Japan) ................................................................. 4397 Experimental Studies Analysis of Wnt and β- catenin Expression in Advanced Colorectal Cancer. N. YOSHIDA, T. KINUGASA, K. OHSHIMA, K. YUGE, T. OHCHI, S. FUJINO, S. SHIRAIWA, M. KATAGIRI, Y. AKAGI (Fukuoka, Japan) ... 4403 Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems. A. TABATA, Y. OHKUBO, N. ANYOJI, K. HOJO, T. TOMOYASU, Y. TATEMATSU, K. OHKURA, H. NAGAMUNE (Tokushima; Kobe; Suzuka, Mie, Japan) ........................................................................ 4411 Contents continued on the back cover Contents continued Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat -deficient Peripheral T-Cells. Y. IWAIHARA, S. ISHIKURA, K. DOI, T. TSUNODA, T. FUJIMOTO, T. OKAMURA, S. SHIRASAWA (Fukuoka; Tokyo, Japan) ............................................................................................. 4419 Early-phase Treatment by Low-dose 5-Fluorouracil or Primary Tumor Resection Inhibits MDSC-mediated Lung Metastasis Formation. D. OTSUBO, K. YAMASHITA, M. FUJITA, M. NISHI, Y. KIMURA, H. HASEGAWA, S. SUZUKI, Y. KAKEJI (Kobe; Osaka, Japan) .............................................................. 4425 Validity of HB-EGF as Target for Human Neuroblastoma Therapy. S.O. NAM, F. YOTSUMOTO, K. MIYATA, R. SOUZAKI, T. TAGUCHI, M. KUROKI, S. MIYAMOTO (Fukuoka, Japan) ....................... 4433 Establishment of a Macrophage-activating Factor Assay System Using the Human Monocytic Cell Line THP-1. T. INOUE, M. ISHIKAWA, Y. SUMIYA, H. KOHDA, T. INUI, D. KUCHIIKE, K. KUBO, Y. UTO, T. NISHIKATA (Kobe; Tokushima; Osaka, Japan) ..................................................................... 4441 Macrophage Activation Mechanisms in Human Monocytic Cell Line-derived Macrophages. Y. SUMIYA, M. ISHIKAWA, T. INOUE, T. INUI, D. KUCHIIKE, K. KUBO, Y. UTO, T. NISHIKATA (Kobe; Tokushima; Osaka, Japan) ................................................................................................................................ 4447 Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS- mediated Signaling Molecules. T. TSUNODA, S. ISHIKURA, K. DOI, Y. IWAIHARA, H. HIDESIMA, H. LUO, Y. HIROSE, S. SHIRASAWA (Fukuoka, Japan) ........................................................................ 4453 Innate Immunity Activated by Oral Administration of LPSp Is Phylogenetically Preserved and Developed in Broiler Chickens. T. KOMORI, K. SAITO, N. SAWA, Y. SHIBASAKI, C. KOHCHI, G.-I. SOMA, H. INAGAWA (Osaka; Tokushima; Kanagawa; Kagawa, Japan) ............................................................... 4461 Effects of the Subaleurone Layer of Rice on Macrophage Activation and Protection of Pollen Allergy in a Murine Model. Y. TAMURA, H. INAGAWA, Y. NAKATA, C. KOHCHI, G.-I. SOMA (Kagawa; Niigata, Japan) ...... 4467 Molecular Response of Human Monocytes Following Interaction with Colon Cancer Cells by Pre-treatment with Low-dose Lipopolysaccharide. T. HONDA, H. INAGAWA (Kanagawa, Japan) ............................... 4473 Aloe vera Extract Suppresses Proliferation of Neuroblastoma Cells In Vitro. A. YONEHARA, Y. TANAKA, K. KULKEAW, T. ERA, Y. NAKANISHI, D. SUGIYAMA (Fukuoka; Kumamoto, Japan) ....................... 4479 Degalactosylated/Desialylated Bovine Colostrum Induces Macrophage Phagocytic Activity Independently of Inflammatory Cytokine Production. Y. UTO, T. KAWAI, T. SASAKI, K. HAMADA, H. YAMADA, D. KUCHIIKE, K. KUBO, T. INUI, M. METTE, K. TOKUNAGA, A. HAYAKAWA, A. GO, T. OOSAKI (Tokushima; Osaka; Kobe; Tokyo; Tottori, Japan) ............................................................................... 4487 Apoptosis-inducing Factor, Mitochondrion-associated 2, Regulates Klf1 in a Mouse Erythroleukemia Cell Line. N. KOJIMA, Y. TANAKA, K. KULKEAW, Y. NAKANISHI, S. SHIRASAWA, D. SUGIYAMA (Fukuoka, Japan) ............................................................................................................................ 4493 Immunopotentiator from Pantoea agglomerans Prevents Atopic Dermatitis Induced by Dermatophagoides farinae Extract in NC/Nga Mouse. K. WAKAME, K.-I. KOMATSU, H. INAGAWA, T. NISHIZAWA (Hokkaido; Kagawa, Japan) ............................................................................................................. 4501 Oral Administration of Lipopolysaccharide of Acetic Acid Bacteria Protects Pollen Allergy in a Murine Model. S. AMANO, H. INAGAWA, Y. NAKATA, M. OHMORI, C. KOHCHI, G.-I. SOMA (Kagawa; Aichi; Niigata, Japan) ..................................................................................................................... 4509 Cytolytic Activity and Molecular Feature of Cardiotoxin and Cardiotoxin-like Basic Protein: The Electrostatic Potential Field Is an Important Factor for Cell Lytic Activity. Y. KAWAGUCHI, Y. TATEMATSU, A. TABATA, H. NAGAMUNE, K. OHKURA (Chiba; Mie; Tokushima, Japan) ................ 4515 Contents continued on the preceding page Contents continued Clinical Studies The Safety of Pegylated Liposomal Doxorubicin Plus Irinotecan in Recurrent Ovarian Cancer Patients: A Phase I Trial. D. MIYAHARA, T. UEDA, T. KATSUDA, M. MAEHARA, S. FUKAGAWA, K. MIYATA, S.O. NAM, H. KONDO, S. MIYAMOTO (Fukuoka; Kitakyushu, Japan) .............................................. 4521 Clinical Efficacy of Aprepitant in Patients with Gynecological Cancer after Chemotherapy Using Paclitaxel and Carboplatin. M. MAEHARA, T. UEDA, D. MIYAHARA, Y. TAKAHASHI, K. MIYATA, S.O. NAM, T. KATSUDA, H. KONDO, S. MIYAMOTO (Fukuoka; Kitakyushu, Japan) .......................................... 4527 Improvement of Impaired Immunological Status of Patients with Various Types of Advanced Cancers by Autologous Immune Cell Therapy. T. KAMIGAKI, H. IBE, S. OKADA, E. MATSUDA, M. TANAKA, E. OGUMA, Y. KINOSHITA, S. OGASAWARA, A. ONO, K. MAKITA, K. NAITOH, S. GOTO (Tokyo, Japan) ........................................................................................................................................... 4535 Oral Colostrum Macrophage-activating Factor for Serious Infection and Chronic Fatigue Syndrome: Three Case Reports. T. INUI, K. KUBO, D. KUCHIIKE, Y. UTO, T. NISHIKATA, N. SAKAMOTO, M. METTE (Tokushima; Osaka; Kobe, Japan) ..................................................................................................... 4545 A Clinical Investigation of Oral Sarcomas at Multi-institutions Over the Past 30 Years. T. SUMIDA, N. OTAWA, Y. KAMATA, T. YAMADA, K. UCHIDA, H. NAKANO, H. HAMAKAWA, T. YAMAMOTO, Y. UEYAMA, Y. MORI (Fukuoka; Kochi; Yamaguchi; Ehime, Japan) ....................................................... 4551.