Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Atlas Journal Atlas Journal versus Atlas Database: the accumulation of the issues of the Journal constitutes the body of the Database/Text-Book. TABLE OF CONTENTS Volume 11, Number 3, Jul-Sep 2007 Previous Issue / Next Issue Genes MSH6 (mutS homolog 6 (E. Coli)) (2p16). Sreeparna Banerjee. Atlas Genet Cytogenet Oncol Haematol 2006; 9 11 (3): 289-297. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/MSH6ID344ch2p16.html LDB1 (10q24). Takeshi Setogawa, Testu Akiyama. Atlas Genet Cytogenet Oncol Haematol 2006; 11 (3): 298-301.[Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/LDB1ID41135ch10q24.html INTS6 (integrator complex subunit 6) (13q14.3). Ilse Wieland. Atlas Genet Cytogenet Oncol Haematol 2006; 11 (3): 302-306.[Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/INTS6ID40287ch13q14.html EPHA7 (EPH receptor A7) (6q16.1). Haruhiko Sugimura, Hiroki Mori, Tomoyasu Bunai, Masaya Suzuki. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 307-312. [Full Text] [PDF] Atlas Genet Cytogenet Oncol Haematol 2007;3 -I URL : http://atlasgeneticsoncology.org/Genes/EPHA7ID40466ch6q16.html RNASET2 (ribonuclease T2) (6q27). Francesco Acquati, Paola Campomenosi. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 313-317. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/RNASET2ID518ch6q27.html RHOB (ras homolog gene family, member B) (2p24.1). Minzhou Huang, Lisa D Laury-Kleintop, George Prendergast. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 318-323. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/RHOBID42108ch2p24.html RBM5 (RNA binding motif protein 5) (3p21.3). Mirna Mourtada-Maarabouni. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 324-331. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/RBM5ID42069ch3p21.html RAC3 (ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)) (17q25.3). Nora C. Heisterkamp. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 332-338. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/RAC3ID42022ch17q25.html NUT (nuclear protein in testis) (15q14). Anna Collin. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 339-342. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/NUTID41595ch15q14.html MUC4 (mucin 4, cell surface associated) (3q29). Nicolas Moniaux, Pallavi Chaturvedi, Isabelle Van Seuningen, Nicole Porchet, Ajay P. Singh, Surinder K. Batra. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 343-354. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/MUC4ID41459ch3q29.html JAG2 (Human Jagged2) (14q32). Atlas Genet Cytogenet Oncol Haematol 2007;3 -II Pushpankur Ghoshal, Lionel J Coignet. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 355-359. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/JAG2ID41030ch14q32.html HSPH1 (heat shock 105kDa/110kDa protein 1) (13q12.3). Takumi Hatayama, Nobuyuki Yamagishi. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 360-364. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/HSPH1ID40891ch13q12.html HSPD1 (Heat Shock 60kDa Protein 1) (2q33.1). Ahmad Faried, Leri S Faried. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 365-371. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/HSPD1ID40888ch2q33.html HIC1 (Hypermethylated in Cancer 1) (17p13.3). Dominique Leprince. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 372-377. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/HIC1ID40819ch17p13.html FLCN (folliculin gene) (17p11.2). Laura S Schmidt. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 378-385. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/FLCNID789ch17p11.html ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2) (8q24.12). Mary L. Stracke, Timothy Clair. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 386-395. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/ENPP2ID40455ch8q24.html BRD4 (bromodomain containing 4) (19p13). Anna Collin. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 396-400. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/BRD4ID837ch19p13.html Atlas Genet Cytogenet Oncol Haematol 2007;3 -III BCL6 (B-Cell Lymphoma 6) (3q27) - updated. Stevan Knezevich. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 401-407. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/BCL6ID20.html BARD1 (BRCA1 associated RING domain 1) (2q35). Irmgard Irminger-Finger. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 408-418. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/BARD1ID756ch2q35.html RAF1 (v-raf-1 murine leukemia viral oncogene homolog 1) (3p25). Max Cayo, David Yu Greentblatt, Muthusamy Kunnimalaiyaan, Herbert Chen. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 419-434. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/RAF1ID42032ch3p25.html PSIP1 (PC4 and SFRS1 interacting protein 1) (9p22.3). Cristina Morerio, Claudio Panarello. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 435-439. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/PSIP1ID405ch9q22.html MIRN21 (microRNA 21) (17q23.1). Sadan Duygu Selcuklu, Mustafa Cengiz Yakicier, Ayse Elif Erson. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 440-447. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/MIRN21ID44019ch17q23.html KLF6 (Krüppel like factor 6) (10p15.1). Scott L. Friedman, Goutham Narla, John A. Martignetti. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 448-455. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/KLF6ID44002ch10p15.html IL6 (interleukin 6 (interferon beta 2)) (7p15.3). Stefan Nagel, Roderick A F MacLeod. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 456-464. [Full Text] [PDF] Atlas Genet Cytogenet Oncol Haematol 2007;3 -IV URL : http://atlasgeneticsoncology.org/Genes/IL6ID519ch7p15.html ALOX12 (Arachidonate 12-Lipoxygenase) Homo sapiens (17p13.1). Sreeparna Banerjee, Asli Erdog. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 465-473. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Genes/ALOX12ID620ch17p13.html Leukaemias t(5;12)(q31;p13) in MDS, AML and AEL. Maria D. Odero. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 474-476. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/t0512q31p13ID1344.html i(8)(q10) in acute myeloid leukaemia. David Betts. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 477-478. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Anomalies/i8q10ID1334.html Solid Tumours Vulva and Vagina tumors: an overview. Roberta Vanni, Giuseppina Parodo. Atlas Genet Cytogenet Oncol Haematol 2007;11 (3): 479-484. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/VulVaginaCarcID5274.html Carcinoma with t(15;19) translocation. Anna Collin. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 485-488. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Tumors/Carcinot1519q14p13ID5474.html Cancer Prone Diseases Diamond-Blackfan anemia (DBA) - updated. Hanna T. Gazda. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 489-492. [Full Text] [PDF] Atlas Genet Cytogenet Oncol Haematol 2007;3 -V URL : http://atlasgeneticsoncology.org/Kprones/DiamondBlackfanID10040.html Deep Insights Case Reports t(16;21)(q24;q22) in therapy-related acute myelogenous leukemia arising from myelodysplastic syndrome . Paola Dal Cin, Karim Ouahchi. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 493-495. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Reports/1621DalCinID100022.html A de novo AML with a t(1;21)(p36;q22) in an elderly patient. Paola Dal Cin, Andrew J Yee, Bimalangshu Dey. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (3): 496-498. [Full Text] [PDF] URL : http://atlasgeneticsoncology.org/Reports/0121DalCinID100021.html Educational Items © Atlas of Genetics and Cytogenetics in Oncology and Haematology X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching For comments and suggestions or contributions, please contact us [email protected]. Atlas Genet Cytogenet Oncol Haematol 2007;3 -VI Atlas of Genetics and Cytogenetics in Oncology and Haematology MSH6 (mutS homolog 6 (E. Coli)) Identity Other names GTBP HSAP HNPCC5 Hugo MSH6 Location 2p16 Genes flanking MSH6 in centromere to telomere direction on 2p16 are: HTLF (2p22-p16) (human T-cell leukemia virus enhancer factor) FBXO11 (2p16.3) (F-box protein 11) Local_order MSH6 (2p16) (mutS homolog 6 (E. coli)) LOC285053 (2p16.3) (similar to ribosomal protein L18a). KCNK12 (2p22-p21) (potassium channel, subfamily K, member 12). MSH2 (2p22-p21) (mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)). DNA/RNA Note The genes for MSH2 and MSH6 which form the major mismatch recognition MutSalpha complex functional in the mismatch repair (MMR) pathway are located within 1 Mb of each other. MSH2 and MSH6 may have been produced by duplication of a primordial mutS repair gene. Exons are represented by gray boxes (in scale) with exon numbers on the bottom. The arrows show the ATG and the stop codons respectively. Description MSH6 gene maps to NC_000002.10 and spans a region of 23.8 kilo bases. MSH6 has 10 exons, the sizes being 347, 197, 170, 2545, 266, 119, 89, 155, 200 and 176 bps. Transcription