International Journal of Molecular Sciences Books Zinc Signaling in Physiology and Pathogenesis Edited by Toshiyuki Fukada and Taiho Kambe Printed Edition of the Special Issue Published in IJMS www.mdpi.com/journal/ijms MDPI Zinc Signaling in Physiology and Pathogenesis Special Issue Editors Toshiyuki Fukada Books Taiho Kambe MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade MDPI Special Issue Editors ToshiyukiFukada TokushimaBunri University Japan TaihoKambe Kyoto University Japan Editorial Office MDPI St. Alban-Anlage 66 Basel, Switzerland This edition is a reprint of the Special Issue published online in the open access journal IJMS (ISSN 1422-0067) from 2017-2018(available at: http:/ /www.mdpi.com/journal/ijms/special...issues/ zinc...signaling). Books For citation purposes, cite each article independently as indicated on the article page online and as indicated below: Lastname, F.M.; Lastname, F.M. Article title. Journal Name Year,A rticle number, page range. First Edition 2018 ISBN 978-3-03842-821-3 (Pbk) ISBN 978-3-03842-822-0 (PDF) Cover photo courtesy ofKoh-ei Toyoshimaand TakashiTsuji. It depicts mouse epidermal hair follicles which express zinc transporter ZIPlO (Bum-Ho Bin et al. PNAS 114, 12243-12248, 2017) Articles in this volume are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book taken as a whole is©2018 MDPI, Basel, Switzerland, distributed under the terms and conditions of the Creative Commons license CC BY-NC-ND(http://creativecommons.org/licenses/by-nc-nd/ 4.0/). MDPI Table of Contents About the Special Issue Editors ..................................... v Preface to “Zinc Signaling in Physiology and Pathogenesis” .................... vii Nicola M. Lowe and Victoria Hall Moran Report of the International Society for Zinc Biology 5th Meeting, in Collaboration with Zinc- Net (COST Action TD1304)—UCLan Campus, Pyla, Cyprus doi:10.3390/ijms18122518 ....................................... 1 Wolfgang Maret Zinc in Cellular Regulation: The Nature and Significance of Zinc Signals doi:10.3390/ijms18112285 ....................................... 6 Taiho Kambe, Mayu Matsunaga and Taka-aki Takeda Understanding the Contribution of Zinc Transporters in the Function of the Early Secretory Pathway doi:10.3390/ijms18102179 ....................................... 18 Teruhisa Takagishi, Takafumi Hara and Toshiyuki Fukada Recent Advances in the Role of SLC39A/ZIP Zinc Transporters In Vivo doi:10.3390/ijms18122708 ....................................... 36 Books Michal Hershfinkel The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease doi:10.3390/ijms19020439 ....................................... 57 Kavitha Subramanian Vignesh and George S. Deepe Jr. Metallothioneins: Emerging Modulators in Immunity and Infection doi:10.3390/ijms18102197 ....................................... 76 Atsushi Takeda and Hanuna Tamano The Impact of Synaptic Zn2+ Dynamics on Cognition and Its Decline doi:10.3390/ijms18112411 .......................................101 Stuart D. Portbury and Paul A. Adlard Zinc Signal in Brain Diseases doi:10.3390/ijms18122506 .......................................112 Ayako Fukunaka and Yoshio Fujitani Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity doi:10.3390/ijms19020476 .......................................125 Martina Maywald, Inga Wessels and Lothar Rink Zinc Signals and Immunity doi:10.3390/ijms18102222 .......................................139 Charlie J. Pyle, Abul K. Azad, Audrey C. Papp, Wolfgang Sadee, Daren L. Knoell and Larry S. Schlesinger Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis doi:10.3390/ijms18112375 .......................................173 iii MDPI Belma Turan and Erkan Tuncay Impact of Labile Zinc on Heart Function: From Physiology to Pathophysiology doi:10.3390/ijms18112395 .......................................189 Yoan Cherasse and Yoshihiro Urade Dietary Zinc Acts as a Sleep Modulator doi:10.3390/ijms18112334 .......................................210 Bo Young Choi, Dae Ki Hong and Sang Won Suh ZnT3 Gene Deletion Reduces Colchicine-Induced Dentate Granule Cell Degeneration doi:10.3390/ijms18102189 .......................................222 Sławomir Gonkowski, Maciej Rowniak and Joanna Wojtkiewicz Zinc Transporter 3 (ZnT3) in the Enteric Nervous System of the Porcine Ileum in Physiological Conditions and during Experimental Inflammation doi:10.3390/ijms18020338 .......................................235 Yen-Hua Chen, Jhe-Ruei Shiu, Chia-Ling Ho and Sen-Shyong Jeng Zinc as a Signal to Stimulate Red Blood Cell Formation in Fish doi:10.3390/ijms18010138 .......................................251 Gyuyoup Kim, Ki-Hyuk Shin and Eung-Kwon Pae Zinc Up-Regulates Insulin Secretion from β Cell-Like Cells Derived from Stem Cells from Human Exfoliated Deciduous Tooth (SHED) doi:10.3390/ijms17122092 .......................................263 Books Laura E. Lehtovirta-Morley, Mohammad Alsarraf and Duncan Wilson Pan-Domain Analysis of ZIP Zinc Transporters doi:10.3390/ijms18122631 .......................................272 iv MDPI About the Special Issue Editors Toshiyuki Fukada, Professor. I received my BS and MS from Hiroshima University in 1990 and 1992, respectively. After working for Mochida Pharmaceutical Co., Ltd. for two years, I entered Osaka University Graduate School of Medicine and received my Ph.D. in 1998. After postdoctoral training at the Cold Spring Harbor Laboratory, New York, from 1999 to 2003, I joined the Research Center for Allergy and Immunology at Riken Yokohama Institute as a senior investigator, until 2014. Then, I moved to Showa University School of Dentistry as an Assistant Professor, and joined Tokushima Bunri University as a full Professor from April 2015. My research goal is to understand the physiological and pathophysiological role of zinc signaling in vivo. Zinc signaling is a novel platform in the life sciences, and I would thus like to explore zinc signaling at the molecular level. In particular, I am interested in the mechanisms regarding how each transporter-mediated zinc signals and controls its downstream target molecules specifically, which may eventually affect the health and disease status in mammals. To address these questions, I mainly employ molecular and physiological methodologies using genetically modified mice to study zinc transporters and human genetics. Taiho Kambe, Associate Professor. I received my BS in Agriculture from Kyoto University in 1995, and my Ph.D. in Agriculture from Kyoto University in 2001. I served as an Assistant Professor at Kyoto University from 1998. After postdoctoral training at the University of Missouri, Columbia, from 2006 to 2007 and at the University of Kansas Medical Center from 2007 to 2008, I rejoined the Books faculty at Kyoto University. My research interests focus on elucidating the cellular and physiological functions of ZIP and ZNT zinc transporters. In particular, I am very interested in when, where, and how ZIPs and ZNTs monitor zinc concentrations and regulate the influx and efflux of zinc across biological membranes. Moreover, I am investigating when, where, and how zinc-containing proteins capture and dissociate zinc mediated by ZIPs and ZNTs. I am also trying to establish a new strategy to improve zinc nutrition in humans. v MDPI Books MDPI Preface to “Zinc Signaling in Physiology and Pathogenesis” Zinc, an essential trace element, plays indispensable roles in multiple cellular processes. It regulates a great number of protein functions, including transcription factors, enzymes, adapters, and growth factors, as a structural and/or catalytic factor. Recent studies have highlighted another function of zinc as an intra- and intercellular signaling mediator, which is now recognized as the zinc signal. Indeed, zinc regulates cellular signaling pathways, which enables the conversion of extracellular stimuli into intracellular signals, and controls various intracellular and extracellular events. Thus, zinc mediates communication between cells. The zinc signal is essential for physiology, and its dysregulation causes a variety of diseases such as diabetes, cancer, osteoarthritis, dermatitis, and dementia. This indicates that the zinc signal is an emerging topic that will assist in our understanding of the nature of physiology and pathophysiology. This special issue, “Zinc Signaling in Physiology and Pathogenesis” has two main goals. The first is to update the current information available about the crucial role of zinc signaling in biological processes on both a molecular and a physiological level. This will assist in addressing the questions underlying this unique phenomenon and discerning its future direction through the publishing of review articles by experts, as well as original papers. The second aim is to feature the 5th Meeting of the International Society for Zinc Biology 2017 (ISZB-2017) in collaboration with Zinc-Net (COST Books Action TD1304), held in Cyprus. As Lowe and Moran reported, ISZB-2017 was held in conjunction with the final dissemination meeting of the Network for the Biology of Zinc (Zinc-Net) at the University of Central Lancashires Cyprus campus in June 2017, with over 160 participants, 17 scientific symposia, four plenary