Differential urinary proteins between AHSP and healthy children using the DDA method Ratio of Uniprot ID Protein description Gene name Average of AHSP Average of HC AHSP/HC or P value HC/AHSP Tumor necrosis factor receptor superfamily member 13C (B-cell- Q96RJ3 activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) TNFRSF13C 0.000 1.0 Infinity 0.004 (CD antigen CD268) Soluble scavenger receptor cysteine-rich domain-containing protein A1L4H1 SSC5D 0.000 0.8 Infinity 0.008 SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D) Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) P12955 PEPD 1.333 0.0 Infinity 0.012 (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid P09417 dihydropteridine reductase) (Short chain dehydrogenase/reductase family QDPR 2.133 0.0 Infinity 0.014 33C member 1) Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) O75891 ALDH1L1 1.800 0.0 Infinity 0.018 (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) P21281 (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton ATP6V1B2 1.533 0.0 Infinity 0.028 pump subunit B 2) Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase P34913 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) EPHX2 0.933 0.0 Infinity 0.032 (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)] Sodium/potassium-transporting ATPase subunit beta-1 P05026 ATP1B1 0.933 0.0 Infinity 0.032 (Sodium/potassium-dependent ATPase subunit beta-1) P25774 Cathepsin S (EC 3.4.22.27) CTSS 2.600 0.0 Infinity 0.033 P07741 Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) APRT 0.867 0.0 Infinity 0.035 Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha- hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of P61457 hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of PCBD1 1.067 0.0 Infinity 0.036 HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD) Q5R3I4 Tetratricopeptide repeat protein 38 (TPR repeat protein 38) TTC38 0.933 0.0 Infinity 0.047 Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A O00754 MAN2B1 6.800 0.0 Infinity 0.049 peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha- mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis- Q5D862 FLG2 0.067 2.0 30.000 0.001 susceptibility protein) (Ifapsoriasin) Glycerol-3-phosphate dehydrogenase [NAD (+)], cytoplasmic (GPD-C) P21695 GPD1 5.600 0.2 28.000 0.017 (GPDH-C) (EC 1.1.1.8) Q16610 Extracellular matrix protein 1 (Secretory component p85) ECM1 0.067 1.6 24.000 0.029 Q9NZT1 Calmodulin-like protein 5 (Calmodulin-like skin protein) CALML5 0.133 2.8 21.000 0.011 Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) Q15274 (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) QPRT 4.133 0.2 20.667 0.014 (QPRTase) Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) P14784 IL2RB 0.133 2.6 19.500 0.002 (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122) Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2- A8K2U0 A2ML1 0.333 6.0 18.000 0.016 macroglobulin domain-containing protein 9) Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) P34896 SHMT1 3.333 0.2 16.667 0.019 (Glycine hydroxymethyltransferase) (Serine methylase) P20930 Filaggrin FLG 0.600 10.0 16.667 0.021 D-dopachrome decarboxylase (EC 4.1.1.84) (D-dopachrome P30046 DDT 3.133 0.2 15.667 0.004 tautomerase) (Phenylpyruvate tautomerase II) Matrilysin (EC 3.4.24.23) (Matrin) (Matrix metalloproteinase-7) (MMP- P09237 MMP7 3.067 0.2 15.333 0.039 7) (Pump-1 protease) (Uterine metalloproteinase) P31151 Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7) S100A7 0.467 7.0 15.000 0.002 Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) Q9Y2S2 CRYL1 2.733 0.2 13.667 0.021 (Gul3DH) CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein Q01151 CD83 0.133 1.8 13.500 0.001 HB15) (CD antigen CD83) Q8TAB3 Protocadherin-19 PCDH19 0.067 0.8 12.000 0.022 Complement component C8 beta chain (Complement component 8 P07358 C8B 0.133 1.6 12.000 0.038 subunit beta) P18206 Vinculin (Metavinculin) (MV) VCL 0.067 0.8 12.000 0.044 Q86Y78 Ly6/PLAUR domain-containing protein 6 LYPD6 0.067 0.8 12.000 0.044 Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) Q6P4A8 PLBD1 0.067 0.8 12.000 0.044 [Cleaved into: Phospholipase B-like 1 chain A; Phospholipase B-like 1 chain B; Phospholipase B-like 1 chain C] N (G),N (G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) O94760 (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) DDAH1 3.933 0.4 9.833 0.026 (Dimethylargininase-1) Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding P20160 AZU1 0.400 3.8 9.500 0.044 protein) (HBP) (hHBP) Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like O75369 protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid FLNB 0.333 3.0 9.000 0.002 autoantigen) (Truncated actin-binding protein) (Truncated ABP) Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; P05164 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase MPO 1.667 14.8 8.880 0.036 light chain; Myeloperoxidase heavy chain] Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl- P50897 PPT1 3.333 0.4 8.333 0.040 protein hydrolase 1) Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta- P04062 glucocerebrosidase) (Beta-GC) (Cholesterol glucosyltransferase) GBA 1.600 0.2 8.000 0.045 (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.104) (D- glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase) Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic Q9UNE0 ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) EDAR 0.267 2.0 7.500 0.031 (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) P46940 Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 0.333 2.2 6.600 0.001 Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) P04083 (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) ANXA1 1.133 7.4 6.529 0.035 (p35) Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored P78423 chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: CX3CL1 0.333 2.0 6.000 0.004 Processed fractalkine] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) Q9NPH3 IL1RAP 2.400 0.4 6.000 0.003 (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3) Q969H8 Myeloid-derived growth factor (MYDGF) MYDGF 3.533 0.6 5.889 0.003 Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH) Q9BYF1 ACE2 3.400 0.6 5.667 0.033 (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin- converting enzyme 2] Gamma-glutamylaminecyclotransferase (GGACT) (EC 4.3.2.8) (AIG2- Q9BVM4 like domain-containing protein 1) (Gamma-glutamylamine GGACT 2.267 0.4 5.667 0.040 cyclotransferase) Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) Q96KP4 (Carnosine dipeptidase II) (Epididymis secretory protein Li 13) CNDP2 7.667 1.4 5.476 0.014 (Glutamate carboxypeptidase-like protein 1) (Peptidase A) C-type lectin domain family 5 member A (C-type lectin superfamily Q9NY25 CLEC5A 0.267 1.4 5.250 0.004 member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) P17050 Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA 10.333 2.0 5.167 0.009 Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing O75223 GGCT 0.467 2.4 5.143 0.004 factor 21) Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) P08246 (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN ELANE 0.467 2.4 5.143 0.046 elastase) N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine P51688 SGSH 15.067 3.0 5.022 0.031 sulfamidase) (Sulphamidase) Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) P02743 APCS 0.400 2.0 5.000 0.036 [Cleaved into: Serum amyloid P-component (1-203)] Protein/nucleic acid deglycase DJ-1 (EC 3.1.2.-) (EC 3.5.1.-) (EC Q99497 3.5.1.124) (Maillard deglycase) (Oncogene DJ1) (Parkinson disease PARK7 6.733 1.4 4.810 0.001 protein 7) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) Q8NCC3 (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) PLA2G15 5.733 1.2 4.778 0.013 (Lysosomal phospholipase A2) (LPLA2) Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) P16930 FAH 2.867 0.6 4.778 0.028 (Fumarylacetoacetate hydrolase) Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase class chi chain) (Alcohol dehydrogenase class- P11766 III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) ADH5 2.867 0.6 4.778 0.031 (FDH) (GSH-FDH) (EC 1.1.1.-) (S- (hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) 5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase