Supplement, Table 8. Genes affected by Celecoxib in "immune response" Gene Ontology category Geometri UniGene HUGO Parametric Gene c mean of Cluster ID Symbol p-value ratios P/F Hs.25647 FOS v-fos FBJ murine osteosarcoma viral oncogene homolog 0.621 0.0407 Hs.423 PAP pancreatitis-associated protein 0.683 0.0040 Hs.407546 TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.736 0.0053 Hs.308680 C1R complement component 1, r subcomponent 0.751 0.0179 Hs.789 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.762 0.0579 Hs.110675 APOE apolipoprotein E 0.762 0.0253 Hs.407506 INHA inhibin, alpha 0.764 0.0185 Hs.78065 C7 complement component 7 0.765 0.0081 Hs.134231 VPS45A vacuolar protein sorting 45A (yeast) 0.78 0.0000 Hs.436042 CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 0.788 0.0189 Hs.172674 NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.793 0.0019 Hs.421342 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.799 0.0314 Hs.1735 INHBB inhibin, beta B (activin AB beta polypeptide) 0.801 0.0311 Hs.458355 C1S complement component 1, s subcomponent 0.815 0.0238 Hs.77546 ANKRD15 ankyrin repeat domain 15 0.818 0.0017 GALNAC4S- Hs.523379 6ST B cell RAG associated protein 0.829 0.0522 Hs.421194 TPST1 tyrosylprotein sulfotransferase 1 0.831 0.0206 Hs.7957 ADAR adenosine deaminase, RNA-specific 0.834 0.0210 Hs.374357 NFRKB nuclear factor related to kappa B binding protein 0.849 0.0104 Hs.1281 C5 complement component 5 0.859 0.0397 Hs.383913 BLM Bloom syndrome 0.866 0.0079 Hs.79107 MAPK14 mitogen-activated protein kinase 14 0.868 0.0032 Hs.2161 C5R1 complement component 5 receptor 1 (C5a ligand) 1.135 0.1185 Hs.155421 AFP alpha-fetoprotein 1.169 0.1460 Hs.180533 MAP2K3 mitogen-activated protein kinase kinase 3 1.169 0.0097 Hs.1721 IL11 interleukin 11 1.184 0.0337 Hs.88974 CYBB cytochrome b-245, beta polypeptide (chronic granulomatous disease) 1.192 0.0139 Hs.38069 C8B complement component 8, beta polypeptide 1.202 0.0228 Hs.446684 ASE-1 CD3-epsilon-associated protein; antisense to ERCC-1 1.21 0.0379 Hs.461934 SPN sialophorin (gpL115, leukosialin, CD43) 1.213 0.0112 Hs.86131 FADD Fas (TNFRSF6)-associated via death domain 1.223 0.0046 Hs.355307 TNFRSF7 tumor necrosis factor receptor superfamily, member 7 1.225 0.0194 Hs.132781 WSX1 class I cytokine receptor 1.232 0.0590 Hs.2007 TNFSF6 tumor necrosis factor (ligand) superfamily, member 6 1.234 0.0567 Hs.652 TNFSF5 tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) 1.236 0.0091 Hs.193418 TNFRSF9 tumor necrosis factor receptor superfamily, member 9 1.24 0.0668 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 Hs.436836 MX1 (mouse) 1.248 0.0455 Hs.36972 CD7 CD7 antigen (p41) 1.249 0.0344 Hs.73917 IL4 interleukin 4 1.256 0.0551 Hs.54460 CCL11 chemokine (C-C motif) ligand 11 1.258 0.0105 Hs.82542 AOAH acyloxyacyl hydrolase (neutrophil) 1.259 0.0400 Hs.458485 G1P2 interferon, alpha-inducible protein (clone IFI-15K) 1.261 0.0061 Hs.442787 ZNF148 zinc finger protein 148 (pHZ-52) 1.267 0.0101 Hs.1570 HRH1 histamine receptor H1 1.267 0.0097 Hs.87205 LY64 lymphocyte antigen 64 homolog, radioprotective 105kDa (mouse) 1.268 0.0167 Hs.1162 HLA-DMB major histocompatibility complex, class II, DM beta 1.28 0.0174 Hs.81564 PF4 platelet factor 4 (chemokine (C-X-C motif) ligand 4) 1.282 0.0071 Hs.1285 C8G complement component 8, gamma polypeptide 1.282 0.0041 Hs.251526 CCL7 chemokine (C-C motif) ligand 7 1.285 0.0589 Hs.193400 IL6R interleukin 6 receptor 1.292 0.0015 Hs.174312 TLR4 toll-like receptor 4 1.293 0.0161 Hs.387871 TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.293 0.0300 Hs.66742 CCL17 chemokine (C-C motif) ligand 17 1.296 0.0402 Hs.159553 CMKLR1 chemokine-like receptor 1 1.296 0.0140 Hs.72933 PF4V1 platelet factor 4 variant 1 1.297 0.0227 Hs.89499 ALOX5 arachidonate 5-lipoxygenase 1.298 0.0263 Hs.76364 AIF1 allograft inflammatory factor 1 1.298 0.0082 Hs.1416 FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23A) 1.299 0.0138 Hs.85258 CD8A CD8 antigen, alpha polypeptide (p32) 1.302 0.0844 Hs.90708 GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.307 0.0129 Hs.103527 SH2D2A SH2 domain protein 2A 1.308 0.0396 Hs.442936 OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa 1.318 0.0128 Hs.54517 FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 1.319 0.0959 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM Hs.67846 LILRB4 domains), member 4 1.324 0.0446 Hs.440898 FCN1 ficolin (collagen/fibrinogen domain containing) 1 1.325 0.0202 Hs.266175 PAG phosphoprotein associated with glycosphingolipid-enriched microdomains 1.327 0.0028 Hs.2605 CMRF35 CMRF35 leukocyte immunoglobulin-like receptor 1.327 0.0389 Hs.512682 CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 1.34 0.0095 Hs.99886 C4BPB complement component 4 binding protein, beta 1.34 0.0019 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional Hs.381081 PSMB9 protease 2) 1.35 0.0004 Hs.153563 LY75 lymphocyte antigen 75 1.354 0.0228 Hs.105806 GNLY granulysin 1.365 0.0001 Hs.14453 ICSBP1 interferon consensus sequence binding protein 1 1.376 0.0088 immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu Hs.381568 IGJ polypeptides 1.38 0.0239 Hs.234569 ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.386 0.0009 Hs.417628 CRHR1 corticotropin releasing hormone receptor 1 1.389 0.0129 Hs.1310 CD1B CD1B antigen, b polypeptide 1.392 0.0101 Hs.334846 PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) 1.394 0.0033 Hs.76415 ITIH4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) 1.399 0.0165 Hs.518546 CCRL2 chemokine (C-C motif) receptor-like 2 1.4 0.0181 Hs.93210 C8A complement component 8, alpha polypeptide 1.405 0.0174 Hs.116481 CD72 CD72 antigen 1.418 0.0226 Hs.194778 IL8RA interleukin 8 receptor, alpha 1.419 0.0030 Hs.515605 KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 1.422 0.0082 Hs.14155 ICOSL inducible T-cell co-stimulator ligand 1.447 0.0003 Hs.501452 EBI3 Epstein-Barr virus induced gene 3 1.464 0.0270 Hs.2259 CD3G CD3G antigen, gamma polypeptide (TiT3 complex) 1.466 0.0053 Hs.405667 CD8B1 CD8 antigen, beta polypeptide 1 (p37) 1.466 0.0060 Hs.423190 CRIP1 cysteine-rich protein 1 (intestinal) 1.472 0.0121 Hs.3003 CD3E CD3E antigen, epsilon polypeptide (TiT3 complex) 1.474 0.0057 Hs.89679 IL2 interleukin 2 1.49 0.0292 Hs.211575 IFNA2 interferon, alpha 2 1.498 0.0023 Hs.93177 IFNB1 interferon, beta 1, fibroblast 1.513 0.0224 Hs.32949 DEFB1 defensin, beta 1 1.523 0.0022 Hs.1311 CD1C CD1C antigen, c polypeptide 1.527 0.0264 Hs.840 INDO indoleamine-pyrrole 2,3 dioxygenase 1.613 0.0172 Hs.151544 SH2D1A SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) 1.683 0.0260 Hs.376208 LTB lymphotoxin beta (TNF superfamily, member 3) 1.719 0.0043 Hs.95327 CD3D CD3D antigen, delta polypeptide (TiT3 complex) 1.743 0.0038 Hs.164021 CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 1.769 0.0000 Hs.502 TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.812 0.0062 Hs.438040 MS4A1 membrane-spanning 4-domains, subfamily A, member 1 1.814 0.0313 Hs.135194 IGSF6 immunoglobulin superfamily, member 6 1.964 0.0000.