Selenium dioxide sc-258150 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Selenium dioxide STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY0 HEALTH3 HAZARD INSTABILITY0 SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS O2-Se, SeO2, "selenious anhydride", "selenium oxide", "selenium (IV) dioxide (12)" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability 0 Toxicity 3 Min/Nil=0 Body Contact 2 Low=1 Reactivity 0 Moderate=2 High=3 Chronic 2 Extreme=4 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Danger of cumulative effects. Toxic by inhalation and if swallowed. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ■ Toxic effects may result from the accidental ingestion of the material; animal experiments indicate that ingestion of less than 40 gram may be fatal or may produce serious damage to the health of the individual. ■ Acute effects of selenium poisoning include nervousness, convulsions, drowsiness, frontal headaches, and in extreme cases, death from respiratory depression. There may also be skin eruptions, tiredness, stomach upset, discolouration of teeth, an odorous garlic breath and loss of hair and nails. EYE ■ Although the material is not thought to be an irritant (as classified by EC Directives), direct contact with the eye may cause transient discomfort characterised by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result. SKIN ■ The material is not thought to be a skin irritant (as classified by EC Directives using animal models). Abrasive damage however, may result from prolonged exposures. ■ Skin contact with the material may damage the health of the individual; systemic effects may result following absorption. ■ Open cuts, abraded or irritated skin should not be exposed to this material. ■ Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ■ Inhalation of dusts, generated by the material, during the course of normal handling, may produce toxic effects. ■ The material is not thought to produce respiratory irritation (as classified by EC Directives using animal models). Nevertheless inhalation of dusts, or fumes, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. ■ Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. If prior damage to the circulatory or nervous systems has occurred or if kidney damage has been sustained, proper screenings should be conducted on individuals who may be exposed to further risk if handling and use of the material result in excessive exposures. ■ The inhalation of small particles of metal oxide results in sudden thirst, a sweet, metallic foul taste, throat irritation, cough, dry mucous membranes, tiredness and general unwellness. Headache, nausea and vomiting, fever or chills, restlessness, sweating, diarrhoea, excessive urination and prostration may also occur. CHRONIC HEALTH EFFECTS ■ Substance accumulation, in the human body, is likely and may cause some concern following repeated or long-term occupational exposure. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Chronic exposure to selenium and its compounds irritate the bronchi, cause gastrointestinal problems, irritation of the nasopharynx and a persistent foul garlic breath. There is often a metallic taste, pallor, irritability, extreme tiredness after years of exposure. Occasionally kidney and liver damage can occur. Selenium can cause tooth decay. Repeated or prolonged exposure to selenium oxide may result in a metallic taste in the mouth followed by a garlic odour of the breath and sweat. Other symptoms may include pallor, coated tongue, gastrointestinal disturbances including nausea, vomiting, abdominal pain, diarrhoea, weight loss, lumbar pain, depression, lassitude, fatigue, giddiness and emotional instability. Liver and spleen effects and albuminuria, porphyrinuria, and urobilinuria have also been reported. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS NAME CAS RN % selenium dioxide 7446-08-4 >99.5 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. For advice, contact a Poisons Information Centre or a doctor. Urgent hospital treatment is likely to be needed. In the mean time, qualified first-aid personnel should treat the patient following observation and employing supportive measures as indicated by the patient's condition. EYE If this product comes in contact with the eyes Immediately hold eyelids apart and flush the eye continuously with running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. Continue flushing until advised to stop by the Poisons Information Centre or a doctor, or for at least 15 minutes. Transport to hospital or doctor without delay. SKIN If skin contact occurs Immediately remove all contaminated clothing, including footwear. Flush skin and hair with running water (and soap if available). Seek medical attention in event of irritation. INHALED If fumes or combustion products are inhaled remove from contaminated area. Lay patient down. Keep warm and rested. Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating first aid procedures. Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device, or pocket mask as trained. Perform CPR if necessary. NOTES TO PHYSICIAN ■ Selenium dusts produce respiratory tract irritation, manifested by nasal discharge, loss of smell, epistaxis, and cough. Consumption of selenites and to a lesser degree, selenates causes nausea, vomiting, abdominal pain and tremor which resolves in 24 hrs. Muscle tenderness, tremor, light-headedness and facial flushing are observed in selenite poisoning. Both the acid and elemental form are well absorbed through the lungs and gastro-intestinal tract. Elimination (mostly in the urine) results in a biological half-life of around 1.2 days. Chronic selenium poisoning resembles arsenic poisoning. Management of chronic intoxication is supportive with elimination of the selenium source. BAL and CaNa2EDTA may enhance toxicity. High dose vitamin C (several grams daily) has produced equivocal results. This is probably reasonable as in-vitro results indicate selenium salts are then reduced to poorly absorbed elemental selenium. Management of chronic selenium intoxication is supportive with elimination of the selenium source. BAL (dimercaprol, 2,3-dimercaptopropanol) and CaNa2EDTA may enhance toxicity. There are no antidotes to selenious acid toxicity; treatment is expectant (cardiopulmonary monitoring in an intensive care setting) and supportive (intravenous infusion, supplemental oxygen and ventilation as needed). For inhalation, consider oxygen. Avoid gastric lavage or emesis. Avoid calcium sodium edetate, dimercaprol as antidotes. [MDL OHS] Section 5 - FIRE FIGHTING MEASURES Vapor Pressure (mmHg) 12.451 @ 70C Upper Explosive Limit (%) Not applicable Specific Gravity (water=1) 3.95 Lower Explosive Limit (%) Not applicable EXTINGUISHING MEDIA Water spray or fog. Foam. Dry chemical powder. BCF (where regulations permit). FIRE FIGHTING Alert Fire Brigade and tell them location and nature of hazard. Wear full body protective clothing with breathing apparatus. Prevent, by any means available, spillage from entering drains or water course. Use fire fighting procedures suitable for surrounding area. When any large container (including road and rail tankers) is involved in a fire, consider evacuation by 800 metres in all directions. GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS Non combustible. Not considered a significant fire risk, however containers may burn. Decomposition may produce toxic fumes of metal oxides. May emit clouds of acrid smoke. May emit poisonous fumes. FIRE INCOMPATIBILITY None known. Section 6 - ACCIDENTAL RELEASE MEASURES MINOR SPILLS Clean up waste regularly and abnormal spills immediately. Avoid breathing dust and contact with skin and eyes. Wear protective clothing, gloves, safety glasses and dust respirator. Use dry clean up procedures and avoid generating dust. MAJOR SPILLS Clear area of personnel and move upwind. Alert Fire Brigade and tell them location and nature of hazard. Wear full body protective clothing with breathing apparatus. Prevent, by any means available, spillage from entering drains or water course. Section 7 - HANDLING AND STORAGE PROCEDURE FOR HANDLING Avoid all personal contact, including inhalation.