L-Arginine L-Pyroglutamate Cambridge Commodities Chemwatch Hazard Alert Code: 0 Part Number: P0153 Issue Date: 15/02/2021 Version No: 1.1 Print Date: 05/10/2021 Safety data sheet according to REACH Regulation (EC) No 1907/2006, as amended by UK REACH Regulations SI 2019/758 S.REACH.GB.EN SECTION 1 Identification of the substance / mixture and of the company / undertaking 1.1. Product Identifier Product name L-Arginine L-Pyroglutamate Chemical Name L-arginine-L-pyroglutamate Synonyms Not Available Chemical formula Not Applicable Other means of P0153 identification 1.2. Relevant identified uses of the substance or mixture and uses advised against Pyroglutamic acid or its derivatives or its mimetics. Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid) is a natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue. The sodium salt of pyroglutamic acid -known either as sodium pyroglutamate, sodium PCA (sodium pyrrolidone carboxylate), or sodium pidolate is used for dry skin and hair products, as it is a humectant. Relevant identified uses PCA-increases moisturisation, activates autophagy, reduces Trans Epidermal Water Loss (TEWL) and improves the skin barrier function. PCA is a natural moisturizing factor (NMF) in the stratum corneum has a high moisture retaining efficacy, and plays a major role in the skin barrier function. Autophagy is the natural destructive mechanism that allows the orderly degradation and recycling of cellular components. Increased autophagy delays aging and extends longevity. PCA is thought to activate sirtuin 1 ( SIRT1) by direct interaction. Through this interaction the substance increases a deacetylation of SIRT1 target protein FoxO1, resulting in the cell protective autophagy. (SIRT1 is a nicotinamide adenine dinucleotide (NAD+)- dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. Active SIRT1 regulates the autophagy during cell stress, including calorie restriction, endoplasmic reticulum (ER) stress and oxidative stress L-pyroglutamic acid is a nootropic dietary supplement. Magnesium pidolate, the magnesium salt of pyroglutamic acid, is found in some mineral supplements. Uses advised against Not Applicable Product code: P0153 Version No: 1.1 Page 1 of 18 S.REACH.GB.EN Lancaster Way Business Park Safety Data Sheet (Conforms to Regulation (EU) No 2020/878) Ely, Cambridgeshire, CB6 3NX, UK. Chemwatch: 9-807439 +44 (0) 1353 667258 Issue Date: 15/02/2021 [email protected] Print Date: 05/10/2021 www.c-c-l.com 1.3. Details of the supplier of the safety data sheet Registered company name Cambridge Commodities Address Lancaster Way Business Park, Ely, Cambridgeshire Cambridgeshire CB6 3NX United Kingdom Telephone +44 1353 667258 Fax Not Available Website Not Available Email [email protected] 1.4. Emergency telephone number Association / Organisation Not Available Emergency telephone Not Available numbers Other emergency Not Available telephone numbers SECTION 2 Hazards identification 2.1. Classification of the substance or mixture Classified according to GB-CLP Regulation, UK SI Not Applicable 2019/720 and UK SI 2020/1567 [1] 2.2. Label elements Hazard pictogram(s) Not Applicable Signal word Not Applicable Hazard statement(s) Not Applicable Supplementary statement(s) Not Applicable Precautionary statement(s) Prevention Not Applicable Precautionary statement(s) Response Not Applicable Precautionary statement(s) Storage Not Applicable Precautionary statement(s) Disposal Product code: P0153 Version No: 1.1 Page 2 of 18 S.REACH.GB.EN Lancaster Way Business Park Safety Data Sheet (Conforms to Regulation (EU) No 2020/878) Ely, Cambridgeshire, CB6 3NX, UK. Chemwatch: 9-807439 +44 (0) 1353 667258 Issue Date: 15/02/2021 [email protected] Print Date: 05/10/2021 www.c-c-l.com Not Applicable 2.3. Other hazards REACh - Art.57-59: The mixture does not contain Substances of Very High Concern (SVHC) at the SDS print date. SECTION 3 Composition / information on ingredients 3.1.Substances See 'Composition on ingredients' in Section 3.2 3.2.Mixtures 1.CAS No 2.EC No Classified according to GB-CLP Regulation, UK SI Nanoform Particle %[weight] Name 3.Index No 2019/720 and UK SI 2020/1567 Characteristics 4.REACH No 1.56265-06-6 2.260-081-5 L-arginine- 100 Not Applicable Not Available 3.Not Available L-pyroglutamate 4.Not Available Legend: 1. Classified by Chemwatch; 2. Classification drawn from GB-CLP Regulation, UK SI 2019/720 and UK SI 2020/1567; 3. Classification drawn from C&L; * EU IOELVs available; [e] Substance identified as having endocrine disrupting properties SECTION 4 First aid measures 4.1. Description of first aid measures If this product comes in contact with eyes: Wash out immediately with water. Eye Contact If irritation continues, seek medical attention. Removal of contact lenses after an eye injury should only be undertaken by skilled personnel. If skin or hair contact occurs: Skin Contact Flush skin and hair with running water (and soap if available). Seek medical attention in event of irritation. If fumes, aerosols or combustion products are inhaled remove from contaminated area. Inhalation Other measures are usually unnecessary. Immediately give a glass of water. Ingestion First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor. 4.2 Most important symptoms and effects, both acute and delayed See Section 11 4.3. Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5 Firefighting measures 5.1. Extinguishing media Foam. Product code: P0153 Version No: 1.1 Page 3 of 18 S.REACH.GB.EN Lancaster Way Business Park Safety Data Sheet (Conforms to Regulation (EU) No 2020/878) Ely, Cambridgeshire, CB6 3NX, UK. Chemwatch: 9-807439 +44 (0) 1353 667258 Issue Date: 15/02/2021 [email protected] Print Date: 05/10/2021 www.c-c-l.com Dry chemical powder. BCF (where regulations permit). Carbon dioxide. Water spray or fog - Large fires only. 5.2. Special hazards arising from the substrate or mixture Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may Fire Incompatibility result 5.3. Advice for firefighters Alert Fire Brigade and tell them location and nature of hazard. Wear breathing apparatus plus protective gloves. Prevent, by any means available, spillage from entering drains or water courses. Use water delivered as a fine spray to control fire and cool adjacent area. Fire Fighting DO NOT approach containers suspected to be hot. Cool fire exposed containers with water spray from a protected location. If safe to do so, remove containers from path of fire. Equipment should be thoroughly decontaminated after use. Combustible solid which burns but propagates flame with difficulty; it is estimated that most organic dusts are combustible (circa 70%) - according to the circumstances under which the combustion process occurs, such materials may cause fires and / or dust explosions. Organic powders when finely divided over a range of concentrations regardless of particulate size or shape and suspended in air or some other oxidizing medium may form explosive dust-air mixtures and result in a fire or dust explosion (including secondary explosions). Avoid generating dust, particularly clouds of dust in a confined or unventilated space as dusts may form an explosive mixture with air, and any source of ignition, i.e. flame or spark, will cause fire or explosion. Dust clouds generated by the fine grinding of the solid are a particular hazard; accumulations of fine dust (420 micron or less) may burn rapidly and fiercely if ignited - particles exceeding this limit will generally not form flammable dust clouds; once initiated, however, larger particles up to 1400 microns diameter will contribute to the propagation of an explosion. In the same way as gases and vapours, dusts in the form of a cloud are only ignitable over a range of concentrations; in principle, the concepts of lower explosive limit (LEL) and upper explosive limit (UEL) are applicable to dust clouds but only the LEL is of practical use; - this is because of the inherent difficulty of achieving homogeneous dust clouds at high temperatures (for dusts the LEL is often called the "Minimum Explosible Concentration", MEC). When processed with flammable liquids/vapors/mists,ignitable (hybrid) mixtures may be formed with combustible dusts. Ignitable mixtures will increase the rate of explosion pressure rise and the Minimum Ignition Energy (the minimum amount of energy required to ignite dust clouds - MIE) will be lower than the pure dust in air mixture. The Lower Explosive Limit (LEL) of Fire/Explosion Hazard the vapour/dust mixture will be lower than the individual LELs for the vapors/mists or dusts. A dust explosion may release of large quantities of gaseous products; this in turn creates a subsequent pressure rise of explosive force capable of damaging plant and buildings and injuring people. Usually the initial or primary explosion takes place in a confined space such as plant or machinery, and can be of sufficient force to damage or rupture the plant. If the shock wave from the primary explosion enters the surrounding area, it will disturb any settled dust layers, forming a second dust cloud, and often initiate a much larger secondary explosion.