TheJournalof VOLUME275 PHARMACOLOGY OCTOBER 1995 NUMBER 1 AND EXPERIMENTAL THERAPEUTICS Contents ANALGESIA AND DRUGS OF ABUSE Tiapride Attenuates Pain Transmission Through an Indirect Nobuaki Takeshita, Yoshitaka Ohkubo and 23 Activation of Central Serotonergic Mechanism Isamu Yamaguchi Characterization of the Spinal Antinociceptive Activity of Tony L. Yaksh, Annika B. Malmberg, 63 Constrained Peptidomimetic Oploids Seonggu Ro, Peter Schiller and Murray Goodman Spinal Opioid Receptors and Adenosine Release: Catherine M. Cahill, Thomas D. White and 84 Downloaded from Neurochemical and Behavioral Characterization of Opioid Jana Sawynok Subtypes Felbamate Relieves Several Abnormal Pain Sensations in Rats Yoshiki Imamura and Gary J. Bennett 177 with an Experimental Peripheral Neuropathy Intrathecal Baclofen and Muscimol, But Not Midazolam, are David M. Ding and Tony L. Yaksh 219 Antinociceptive Using the Rat-Fonnalin Model jpet.aspetjournals.org Opioid Modulation of Fetal Glucose Homeostasis: Role of Hazel H. Szeto, Yi Soong, Dun-li Wu and 334 Receptor Subtypes Peter Y. Cheng Microinfusion of Mu but Not Delta or Kappa Opioid Agonists Fred J. Helmstetter, 381 into the Basolateral Amygdala Results in Inhibition of the Tail Patrick S. F. Beilgowan and Flick Reflex in Pentobarbital-Anesthetized Rats Laura H. Poore Distribution of Morphine 6-Glucuronide and Morphine Across Tor A. Aasmundstad, J#{248}rgM#{248}rlandand 435 at ASPET Journals on September 25, 2021 the Blood-Brain Barrier in Awake, Freely Moving Rats Ragnhild E. Paulsen Investigated by in Vivo Microdialysis Sampling Distribution of the g.t and 8 Opioid Binding Sites in the Brain Jean-Pascal de Wade, Kalervo Kiianmaa 518 of the Alcohol-Preferring AA and Alcohol.Avoiding ANA and Christina Gianoulakis Lines of Rats AUTONOMIC PHARMACOLOGY 5-Hydroxytryptamine-Induced Synovial Plasma Extravasation Pamela A. Pierce, Guo-Xi Xie, 502 Is Mediated via 5-Hydroxytryptamine2A Receptors on Stephen J. Peroutka, Paul G. Green and Sympathetic Eflerent Terminals Jon D. Levine BEHAVIORAL PHARMACOLOGY Antagonism of the Discriminative Stimulus Effects of t- Jenny L. Wiley, John A. Lowe, 1 Tetrahydrocannabinol in Rats and Rhesus Monkeys Robert L. Baister and Billy R. Martin Effects of Single and Multiple Intravenous Cocaine Injections Richard W. Foltin, Ingrid Chnstiansen, 38 in Humans Maintained on Methadone Frances R. Levin and Marian W. Fischman Noradrenergic Involvement in the Discriminative Stimulus Roger D. Spealman 53 Effects of Cocaine in Squirrel Monkeys Development of Behavioral Sensitization to Cocaine: Influence Christian A. Heidbreder, 150 of Kappa Opioid Receptor Agonists Dusica Babovic-Vuksanovic, Mohammed Shoaib and Toni S. Shippenberg Schedule-Controlled Behavioral Effects of the Selective 2- Mark J. Benvenga, Paul L. Ornstein and 164 Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid J. David Leander Antagonist LY293558 in Pigeons Drug Discrimination Analysis of Midazolam under a Three- Chrisne A. Sannerud and Nancy A. Ator 183 Lever Procedure II: Differential Effects of Benzodiazepine Receptor Agonists Cocaine Sensitization in Periadolescent and Adult Rats Giovanni Laviola, Robin D. Wood, 345 Cynthia Kuhn, Reynolds Francis and Linda P. Spear Contents continued on ii Contents continued from i Agonist and Antagonist Effects of Dynorphin A-(1-13) in a Eduardo R. Butelman, Charles P. France 374 Thermal Anlinociception Assay in Rhesus Monkeys and James H. Woods Comparison of Benzodiazepine Receptor LigandS with Partial J. R. Martin, F. Jenck and J.-L. Moreau 405 Agonistic, Antagonistic or Partial Inverse Agonistic Properties in Precipitating Withdrawal in Squirrel Monkeys CARDIOVASCULAR PHARMACOLOGY Interactions between Hydroxocobalamin and Nitric Oxide Lori G. Rochelle, Salvatore J. Morana, 48 (NO): Evidence for a Redox Reaction between NO and Harriet Kruszyna, Michael A. Russell, Reduced Cobalainin and Reversible NO Binding to Oxidized Dean E. Wilcox and Roger P. Smith Cobalamin Zatebradine, a Specific Bradycardic Agent, Alters the Paul S. Pagel, Christopher P. Harkin, 127 Hemodynamic and Left Ventricular Mechanical Actions of Douglas A. Hettrick and David C. Warltier Levosimendan, a New Myofflament aIcium Sensitizer, in Conscious Dogs Pharmacological Characterization of the Selective Nonpeptide Henri N. Doods, Wolfgang Wienen, 136 Neuropeptide Y Yl Receptor Antagonist BIBP 3226 Michael Entzeroth, Klaus Rudolf, Downloaded from Wolfgang Eberlein, Wolfhard Engel and Heike A. Wieland Subtype Selectivity and Antagonistic Profile of the Nonpeptide Heike A. Wieland, Klaus D. Willim, 143 Yl Receptor Antagonist BIBP 3226 Michael Entzeroth, Wolfgang Wienen, Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel and Henri N. Doods jpet.aspetjournals.org Quantification of the In Vivo Potency of the Adenosine A2 Ron A. A. Math#{244}t, 245 Receptor Antagonist S-(3..Chlorostyryl)Caffeine Josy M. Gubbens-Stibbe, Willem Soudijn, Kenneth A. Jacobson, Adriaan P. IJzerman and Meindert Danhof Changes in Sympathetic Neurotransmission and Adrenergic Annalisa Rubino and Geoffrey Burnstock 422 Control of Cardiac Contractility During 1,3-Dipropyl-8- Sulfophenyixanthine-Induced Hypertension at ASPET Journals on September 25, 2021 CELLULAR AND MOLECULAR PHARMACOLOGY Modulation by o Ligands of Intracellular Free Ca Teruo Hayashi, Ariyuki Kagaya, 207 Mobilization by N#{149}Methyl..D.aspartate In Primary Culture of Minoru Takebayashi, Masami Shimizu, Rat Frontal Cortical Neurons Yosuke Uchitomi, Nobutaka Motohashi and Shigeto Yamawaki The Endothelin Receptor Profile in L6 Myotubes Zoltan Fekete, Xiao Yan Yang, 215 Masayuki Kimura and Abraham Aviv Acute Amiodarone Terminates Ventricular Fibrillation by Shoji Kojima, Shao T. Wu, 254 Modifying Cellular Ca9 Homeostasis in Isolated Perfused Joan Wikman-Coffelt and Rat Hearts William W. Parmley Actions of the Benzopyran Compound Terikalant on James G. McLarnon and Rending Xu 389 Macroscopic Currents In Rat Ventricular Myocytes Prevention and Reduction of Neural Damage in Ischemic George C. Y. Chiou and Show-Jen Hong 474 Strokes by w4N,N’-Diethylamlno)-n-alkyl-3,4,5- Trimethoxybenzoate Compounds CHEMOTHERAPY/GENE THERAPY Cepharanthin, a Multidrug Resistant Modifier, is a Substrate Midori Hirai, Kumiko Tanaka, 73 for P-Glycoprotein Takako Shimizu, Yusuke Tanigawara, Masato Yasuhara, Ryohei Hori, Yoshiyuki Kakehi, Osamu Yoshida, Kazumitsu Ueda, Tohru Komano and Ken-Ichi Inui Induction of Apoptosis in Murine and Human Neuroblastoma Theresa L. Hartsell, Jack C. Yalowich, 479 Cell Lines by the Enedlyne Natuii4 Product Neocarzinostatin Mary K. Ritke, A. J. Martinez and Nina Felice Schor DRUG METABOLISM AND DISPQITION Phenethyl Isothiocyanate, a Ne Dietary Liver Aldehyde Kai 0. Lindros, Thomas Badger, 79 Dehydrogenase Inhibitor Martin Ronis, Magnus Ingelman-Sundberg and Martti Koivusalo Contents continued on iii Contents continued from ii Hepatic Transport of Rose Bengal by Perfused Rabbit Liver: B. A. Luxon and P. D. King 296 The Effect of Albumin Binding on the Unidirectional Rate Constants In Vitro Pharmacokinetics of Phosphorothioate Antisense Rosanne M. Crooke, Mark J. Graham, 462 Margaret E. Cooke and Stanley T. Crooke Oligonucleotides ENDOCRINE PHARMACOLOGY Prophylaxis of Genetically Determined Diabetes by Diazoxide: Toni Aizawa, Nahoko Taguchi, 194 A Study In a Rat Model of Naturally Occurring Obese Yoshihiko Sato, Tetsuo Nakabayashi, Diabetes Hideko Kobuchi, Hiroya Hidaka, Takeshi Nagasawa, Fujiki Ishihara, Nobuo Itoh and Kiyoshi Hashizume GASTROINTESTINAL PHARMACOLOGY Role of Na in the Asymmetric Paracellular Transport of 4- Wan-Ching Yen and Vincent H. L. Lee 114 Phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly.L-Pro-D-Arg Across Rabbit Colonic Segments and Caco-2 Cell Monolayers Downloaded from Characterization of Endothelln Receptors Mediating Graham H. Allcock, Bruno Battistini, 120 Mechanical Responses to the Endothelins In the IsOlated Alain Fournier, Timothy D. Warner and Stomach Strip of the Rat John R. Vane Peptide Structural Requirements for Antagonism Differ Jaw-Town Un, David H. Coy, 285 between the Two Mammalian Bombesin Receptor Subtypes Samuel A. Mantey and Robert T. Jensen Arachidonic Acid Cascade and Stimulation of Acetylchollne Shun-ichi Mameya, TakafUmi Sawa and 319 jpet.aspetjournals.org Release by Human Recombinant Interleukln-1 in Guinea Pig Kohtaro Taniyama ileum Preventive Effect of Rebainipide on Gastric Lesions Induced Chi Dae Kim and Ki Whan Hong 340 by Ischemla-Reperfusion In the Rat Necessity of Newly Synthesized AlP by Creatine Kinase for Tadayoshi Takeuchi, Akikazu Fujita, 429 Contraction of Permeabilized LOngitUdInal Muscle Toshiaki Ishii, Hideaki Nishio and Preparations of Rat Proximal Colon Fumiaki Hata at ASPET Journals on September 25, 2021 Reversal of Cyclosporine A-Induced Alterations In Bifiary Emilio Fern#{225}ndez,Ma I. Gal#{225}n, 442 Secretion by S.Adenosyl-L-Methionine in Rats Dominica Moran, Jos#{233}M.Gonz#{225}lez-Buitrago, Maria E. Mufloz and Rafael Jim#{233}nez Different Molecular Forms of Basic Fibroblast Growth Factor Stefano Kusstatscher, Zsuzsa Sandor, 456 (bFGF) Accelerate Duodenal Ulcer Healing In Rats Sandor Szabo, Andrew Seddon and Peter BOhien Peripheral and Central Cholecystokinin Receptors Regulate A. Rodrlguez-Membrilla, V. Martinez and 486 Postprandlal Intestinal Motility In the Rat P. Vergara Roles of Prostaglandins, Nitric Oxide and the Capsalcin- Mine Kinoshita, Eisuke Kume and 494 Sensitive Sensory Nerves In Gastroprotection Produced by Hajime Tamaki Ecabet Sodium IMMUNOPHARMACOLOGY New Antlinflammatory