springer.com Steven Kanner (Ed.) Tumor Metabolome Targeting and Drug Development Series: Cancer Drug Discovery and Development Provides expert reviews of multiple metabolic targets covering the glycolytic pathway, Krebs cycle, tumor microenvironment, hypoxia, and therapeutic strategies Explores experimental models for evaluating the tumor metabolome to provide knowledge and access to the field Bridges the fields of cancer cell metabolism, tumor/stroma microenvironments, autophagy, drug discovery and development, and translational application of novel cancer therapies 2014, VIII, 198 p. 22 illus., 12 illus. in color. In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development Printed book in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of Hardcover both energy and biomass needed for them to grow, divide and differentiate. However, the 159,99 € | £139.99 | $199.99 metabolism of malignant cells generally varies from that of normal cells. These differences [1]171,19 € (D) | 175,99 € (A) | CHF provide a platform for the discovery of new approaches to targeting potential vulnerabilities in 189,00 cancer cells for therapeutic options Some of the significant changes that occur involve ATP Softcover production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and 140,17 € | £99.99 | $159.99 [1]149,98 € (D) | 154,19 € (A) | CHF suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics 165,50 and more are discussed in this volume. eBook 117,69 € | £79.50 | $119.00 [2]117,69 € (D) | 117,69 € (A) | CHF 132,00 Available from your library or springer.com/shop MyCopy [3] Printed eBook for just € | $ 24.99 springer.com/mycopy Order online at springer.com / or for the Americas call (toll free) 1-800-SPRINGER / or email us at: [email protected]. / For outside the Americas call +49 (0) 6221-345-4301 / or email us at: [email protected]. The first € price and the £ and $ price are net prices, subject to local VAT. Prices indicated with [1] include VAT for books; the €(D) includes 7% for Germany, the €(A) includes 10% for Austria. Prices indicated with [2] include VAT for electronic products; 19% for Germany, 20% for Austria. All prices exclusive of carriage charges. Prices and other details are subject to change without notice. All errors and omissions excepted. [3] No discount for MyCopy. Part of .