ViraX Professional Formulation Purpose of Product • Support the immune system • Support the body’s antiviral processes • Promote Th1 activity Use of product ViraX is a unique blend of botanicals and compounds designed to help nutritionally support antiviral activity and overall immune function. The ingredients in ViraX may help support the body’s antiviral processes as well as may help support T-helper 1 activity. 90 capsules and proliferation of neutrophils and natural killer cells, and proliferation and phagocytosis of macrophages30, as well Ingredients as increasing the cytokines IL-1, IL-6, IL-10, TNFa, and interferon30,31,32. Astragalus (Astragalus membranaceus) has been used for centuries in Traditional Chinese Medicine (TCM) for Licorice (glycyrrhiza galabra) is largely native to the its antioxidant, anti-inflammatory, and immunomodulatory Mediterranean region and contains a number of active supporting activities. Astralagus may also possess some constituents including triterpene saponins (i.e. glycyrrhizin), hepatoprotective and hypotensive properties. As an antiviral flavonoids, isoflavones and polysaccharides. Certain agent, astragalus has demonstrated the ability to reduce compounds in licorice appear to have antiviral properties, viral load and replication, or improve immunological function and have demonstrated to inhibit growth and cytopathology in HSV, HBV, CMV, and viral myocarditis.1-6 Numerous of numerous RNA and DNA viruses such as hepatitis A33,34, mechanisms for its antiviral effects have been suggested B35,36, and C37,38, coronavirus (SARS) 39, herpes40 and varicella including increased interferon production and potentiation7-9, zoster41, HIV42,43, CMV44, Epstein-Barr45, influenza46, entero increase NK cell activity10,11, activate macrophages12,13, and coxackie virus47, and others48. There are numerous increase the number or activity of T helper cells14-17, increase proposed mechanisms for the antiviral activities of licorice, lymphokine-activated killer cell activity18, and modulate and while it appears to be virus-dependent, they include cytokines towards a stronger Th1 profile19-23. immunomodulation, inhibition of virus replication, reduction of cell membrane fluidity and binding to cell, activate T Echinacea species is a perennial group of native lymphocyte proliferation, and induction of interferon 48,49. American wildflowers, indigenous to areas east of the Rocky Mountains, and is from the daisy family (Asteracea/ Maitake (Grifola frondosa) is the Japanese name for Compositae). It has a long history as an “immunostimulant” an edible mushroom used for culinary and medicinal due to the many effects it appears to have on the immune purposes, the latter largely due to its polysaccharides, system. As an antiviral agent, Echinacea has been shown perhaps most notably, the beta-glucans. Antiviral effects to be effective against herpes24,25 and infIuenza26, 27 as well of maitake may be due to multiple mechanisms including as other viruses28. Echinacea may possess mild direct direct effects, such as inhibition of viral enzymes, as well antiviral activates, by blocking cellular virus receptors26 and as indirect effects, which include immunomodulatory inhibiting hyaluronidases29, but the majority of its antiviral effects50. Such mechanisms include increased production effects appear to be indirect, by way of increasing activation of TNFa by macrophages51,52,53, increased lymphocyte *These statements have not been evaluated by the Food and Drug Administration.This www.biogenetix.com product is not intended to diagnose, treat, cure, or prevent any disease. 54, 55, activity activation of the alternative complement pathway ViraX Supplement Facts 56,57, increasing phagocytosis and NK cell activity enhanced Serving size: 1 Capsule 58, neutrophil and monocyte function as well as increase Amount Per Serving %DV interferon-gamma, IL-12 and IL-18, while suppressing IL-4 Calories 2 and B cell activation59,60,61. Total Fat 0 Total Carbohydrate 0.5g ** Lemon Balm (Melissa officinalis) is a perennial herb Dietary Fiber 0.5g ** from the mint (Lamiacea) family, and is native to the Sugars 0g Mediterranean and southern Europe. Constituents of lemon Astragalus Extract 170mg ** balm include rosmarinic acid, caffeic acids, chlorogenic Echinacea Purpurea Extract 85mg ** acids, tannins, flavonoids, and sesquiterpenes. Compounds Licorice Extract 65mg ** from lemon balm have demonstrated activity against HIV- Ginseng Root Extract (PANAX) 25mg ** 162, herpes simplex63, as well as Newcastle disease virus, Maitake Mushroom Fruit Body 85mg ** vaccinia virus, and Semliki Forest virus64. Lemon balm Lemon Balm Extract (leaf) 85mg ** also appears to have immunomodulating effects of both the Quercetin 85mg ** cellular and humoral components of the immune system 65. † Daily Values are based on a 2,000 calorie diet. **Daily Value (DV) not established. Lemon balm’s antiviral effects are attributed to tannins66,67 Other ingredients: Gelatin Capsule (Gelatin, Purified Water), Magnesium Stearate, Silica. and polyphenols68,69,70 DOES NOT CONTAIN: Sugar, wheat, casein, gluten, soy, milk, egg, preservatives, yeast, artificial flavorings, colorings, peanuts, corn, tree nuts or fish. Quercitin is a flavonoid found in many foods including onions, berries, apples, and the Brassica family of Directions: Take 1 capsule 3 times per day, or as directed by your healthcare professional. vegetables. Quercetin is well known for its antioxidant Storage: Store in a cool, dry place away from direct sunlight. Product from unopened and anti-inflammatory properties, but has also shown to containers that have been stored under recommended conditions (55-85° F / 13-29°C) may be used for up to 24 months. have antiviral and immunomodulating abilities as well. Quercetin has been shown to be effective in reducing Warning: Consult your healthcare professional before use if pregnant, nursing, taking medications, or for any use by minors. Do not use if safety seal is broken or missing. infectivity or replication against rhinovirus71, poliovirus72,73, Keep out of reach of children. influenza74, respiratory syncytial virus75, herpes simplex and adenoviruses76, H1N177, hepatitis C78,79, and offers possible prophylaxis against Ebola infections80. Quercetin has also been shown to influence cytokine production. Specifically, quercetin appears to influence (suppress) interferon-gamma, IL-2, IL-4, IL-12 and TNF-alpha81,82,83,84,85. The preceding information has not been evaluated by the FDA, and was compiled from the scientific literature. The Ginseng (Panax ginseng) has a long history, and is well information should not be construed as a product claim to known for its adaptogenic activities and as a general tonic. diagnose, treat, reverse, cure, or prevent any particular It also has a number of immunomodulatory activities, disease, or provide any specific effect. Biogenetix, LLC. including antiviral properties. Ginseng has been shown asserts its products are solely intended to support the to be effective against multiple viruses, via numerous human body in its attempt to maintain health and balance. mechanisms, including respiratory syncytial virus86,87,88, Biogenetix, LLC’s. products are not intended to replace or rhinovirus89, influenza90,91,92,93, HIV94,95,96,97,98, herpes virus99,100, delay prescription medication. For nutritional use only. hepatitis virus101,102, and others103,104. The immunomodulatory effects of ginseng include increasing NK cell activity and antibody production105,106,107, as well as stimulating macrophages and lymphocytes108,109,110. *These statements have not been evaluated by the Food and Drug Administration.This www.biogenetix.com product is not intended to diagnose, treat, cure, or prevent any disease. References 1. Liu, Zhao Lan, Zhi Jun Liu, Jian Ping Liu, Min Yang, and Joey 12. Jin, R., L. L. Wan, T. Mitsuishi, K. Kodama, and S. Kurashige. Kwong. 2010. “Herbal Medicines for Viral Myocarditis.” The 1994. “[Immunomodulative effects of Chinese herbs in mice treated Cochrane Database of Systematic Reviews, no. 7 (July): with anti-tumor agent cyclophosphamide].” Yakugaku Zasshi: CD003711. doi:10.1002/14651858.CD003711.pub3. Journal of the Pharmaceutical Society of Japan 114 (7): 533–38. 2. Kobayashi, H., N. Mizuno, H. Teramae, H. Kutsuna, S. Ueoku, 13. Zhang, Li-feng, Wei-dong Cheng, Man-man Gui, Xue-yan Li, and J. Onoyama, K. Yamanaka, N. Fujita, and M. Ishii. 2004. “Diet Dong-feng Wei. 2012. “[Comparative study of Radix Hedyseri and Japanese Herbal Medicine for Recalcitrant Atopic Dermatitis: as sulstitute for Radix Astragali of yupingfeng oral liquid on Efficacy and Safety.” Drugs Under Experimental and Clinical cellular immunity in immunosuppressed mice].” Zhong Yao Cai Research 30 (5–6): 197–202. = Zhongyaocai = Journal of Chinese Medicinal Materials 35 (2): 3. Wang, Shuguang, Jiyang Li, Hai Huang, Wen Gao, Changlong 269–73. Zhuang, Bo Li, Pei Zhou, and Deyun Kong. 2009. “Anti-Hepatitis B 14. Brush, Julie, Elissa Mendenhall, Alena Guggenheim, Tracy Chan, Virus Activities of Astragaloside IV Isolated from Radix Astragali.” Erin Connelly, Amala Soumyanath, Randal Buresh, Richard Barrett, Biological & Pharmaceutical Bulletin 32 (1): 132–35. and Heather Zwickey. 2006. “The Effect of Echinacea Purpurea, 4. McCulloch, Michael, Michael Broffman, Jin Gao, and John M. Astragalus Membranaceus and Glycyrrhiza Glabra on CD69 Colford. 2002. “Chinese Herbal Medicine and Interferon in the Expression and Immune Cell Activation in Humans.” Phytotherapy Treatment