Screening of Specific Inhibitors for Human Carboxylesterases or Arylacetamide Deacetylase Mai Shimizu, Tatsuki Fukami, Miki Nakajima, and Tsuyoshi Yokoi Drug Metab Dispos Supplemental Table 1. Chemicals used in this study. Alfa Aesar (Tokyo, Japan) 3-(4-Fluorobenzoyl) propiponic Acid, 3-Methylflavone-8-carboxylic acid BD Gentest (Woburn, MA) a25-Hydroxycholesterol, b4'-Hydroxydiclofenac, b5-Hydroxydiclofenac Biomol international (Plymouth Meeting, PA) Pizotifen malate Merk (Darmstadt, Germany) Mevastatin, Resveratrol Carbosynthe (Berkshire, UK) N-Acetyl-l-cysteine, Adefovir, 5,6-Dichlorobenzimidazole 1-β-d-Riboburanoside, Indiplon, Milnacipran hydrochloride, Pyridoxal 5'-phosphate Cayman Chemical (Ann Arbor, MI) N-(4-Hydroxyphenyl)-arachidonoyl amide, JW480 Dojindo Laboratories (Kumamoto, Japan) N-Cyclohexyl-3-aminopropanesulfonic acid, 3,3'-Diaminobenzidine tetrahydrochloride, Ethylene glycol-bis (β-aminoethylether)-N,N,N',N'-tetraacetic acid Enzo Life Science (Farmingdale, NY) Castanospermine, Pregnenolone-16α-carbonitrate Fujicco (Kobe, Japan) Daidzein Funakoshi (Tokyo, Japan) Blasticidin S hydrochloride, Chloroquine, Coumarin, Diethyldithiocarbamate, 7-Ethoxy-4-(trifluoromethyl) coumarin, Furafylline, G-418 sulfate, Ketoconazole, MelQ, l-α-Phosphatidyl choline dilauroyl, Potassium ferricyanide, SKF-525A, Tetrabutylammonium hydrogen sulfate, WST-1 Life Technologies (Catlsbad, CA) Cadmium Chloride LKT Laboratories (St. Paul, MN) Bestatin hydrochloride, Capecitabine, Clotrimazole, Doxifluridine, Enalaprilat, Ezetimibe, Ftorafur, Indole-3-carbinol, Montelukast, Rebamipide, Rosiglitazone, Tegafur, bTelmisartan, Temocapril hydrochloride, Terazosin hydrochloride, Tolmetin sodium, Toremifene base MP Biochemicals (Tokyo, Japan) Arachidonic acid Nacalai Tesque (Kyoto, Japan) Sodium laurylsulfate Research Organics (Cleveland, OH) N-Acetyl procainamide hydrochloride Santa Cruz Biotechnology (Santa Cruz, CA) Benzyl-2-acetamido-2-deoxy-α-d-galactopyranoside, Camostat mesylate, (+)-Clopidogrel hydrogen sulfate, Dicloxacillin sodium salt monohydrate, d-Mannose-6-phosphate disodium salt, Metyrapon, 1-Naphthyl acetate, α-Naphthoflavone, Ondansetron hydrochloride, Perphenazine, Sparteine, Sulfaphenazole, Thiouric acid sodium salt dehydrate, Tryptamine hydrochloride, WY-14643 Sigma-Aldrich Acebutolol hydrochloride, Acemetacin, p-Acetamidobenzoic acid, 9-Acetylanthracene, Acetyl-dl-carnitine hydrochloride, Amantadine hydrochloride, p-Aminobenzoic acid, 2-Aminobenzylalcohol, 6-Aminochrysene, 2-Aminofluorene, Amiodarone hydrochloride, Ammonium pyrrolidinedithiocarbamate, 5α-Androstane-3α,17β-diol, 2-Anthramine, Astaxanthin, 5-Azacytidine, Barbital, Bezafibrate, Benzbromarone, 6-Benzyl-2-thiouracil, 5-Bromouracil, Bupropion, Busulfan, l-Buthionine-[S,R]-sulfoximine, Caffeine, Cefamandole, Cefoperazone, 2-Chloro-3',4'-dimethoxybenzil, 5-Chlorouracil, Chlorpropamide, Chlorzoxazone, Chrysin, Clofibric acid, Cloxacillin sodium salt monohydrate, (-)-Cotinine, Cyclobenzaprine hydrochloride, Dapson, Deferoxamine mesylate salt, Dehydroisoandrosterone-3-sulfate, Deoxycorticosterone, Diazepam, Diclofenac sodium salt, (-)-3-(3,4-Dihydroxyphenyl)-2-methyl-l-alanine sesquihydrate, 2,6-Dihydroxypyridine hydrochloride, Dimethyl pimelimidate dihydrochloride, Diosmin, Doxepin hydrochloride, 17-Epiestriol, (-)-Epinephrine (+)-bitartratee, β-Estradiol, Estriol, Estrone, Estrone 3-sulfate potassium salt, dl-Ethionine, 7-Ethoxycoumarin, Ethoxyresorufin, 5-Ethyl-5-p-tolybarbituric acid, Fenbendazole, Fenofibrate, Ficoll 400, Flunitrazepam, 5-Fluoro-2'-deoxyuridine, 5-Fluorouridine, Fluoxetine, Flurbiprofen, Gadolinium (III) chloride hexahydrate, Hecogenin acetate, Hexobarbital, Hydralazine hydrochloride, 3-Hydroxybenzylhydrazine dihydrochloride, 7-Hydroxycoumarin, 12-Hydroxydodecanoic acid, 11β-Hydroxytestosterone, 3-Hydroxybenzylhydrazine dihydrochloride 2-Hydroxy-1,4-naphthoquinone, 5-(3-Hydroxyphenyl)-5-phenylhydantoin, 5-(4-Hydroxyphenyl)-5-phenylhydantoin, 17α-Hydroxyprogesterone, 7-(β-Hydroxypropyl) theophylline, dl-Isocitric acid, Isoniazid, Kaempferol, Labetalol hydrochloride, Lauric acid sodium salt, Z-Leu-Leu-Leu-al, Leupeptin, Levofloxacin, Loxapine succinate salt, Maprotiline hydrochloride, Methapyrilene hydrochloride, Methimazole, (S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, 3-Methylindole, 4-Methylumbelliferone, 5-(4-Methylphenyl)-5-phenyl-hydantoin, 1-Methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine hydrochloride, Nalidixic acid, Naloxone hydrochloride, β-Naphthoflavone, 1,2-Naphthoquinone, Nialamide, (-)-Nicotine, Nicotinic acid N-oxide, Nimesulide, Nimodipine, Nordihydroguaiaretic acid, l-(-)-Norepinephrine, Norfloxacin, Nortriptyline hydrochloride, Omeprazole, Oxibendazole, Oxybutiynin chloride, Paclitaxel, Pepstatin A, 1,7-Phenanthroline, Phenazine ethosulfate, p-Phenetidine, (R)-1-Phenyl-1,2-ethanediol, (S)-1-Phenyl-1,2-ethanediol, Pilocarpine hydrochloride, Polymyxin B sulfate salt, Praziquantel, Prednisolone, 5α-Pregnan-3,20-dione, 5-Pregnen-3β-ol-20-one-16α-carbonitrile, Prilocaine hydrochloride, Procainamide hydrochloride, Procaine hydrochloride, Prochlorperazine dimaleate salt, Progesterone, Proglumide, Promazine hydrochloride, (R)-(+) Propranolol hydrochloride, 6-Propyl-2-thiouracil, Protriptyline hydrochloride, Pyrazole, Quercetin, d-Saccharic acid 1,4-lactone, Sodium orthovanadate, Sulfamethazine, Tetrabutylammonium hydroxide, Thiobenzamide, l-Thyroxine, (±)-α-Tocopherol nicotinate, Triacetyloleandomycin, Trichostatin A, Trimipramine maleate, l-Tryptophan, Uracil, Uridine, Uridine 5'-diphosphate sodium salt, R,S-Warfarin, Zolpidem, Zomepirac sodium salt Steraloids (Newport, RI) 5β-Pregnan-3,20-dione Tokyo Chemical Industry (Tokyo, Japan) 1-Aminobenzotriazole, 2-Amino-m-cresol, 4-Amino-3,5-xylenol, Benzo[a]anthracene, Captopril, Dehydroepiandrosterone, Delapril hydrochloride, 2,2'-Dihydroxy-4-methoxybenzophenone, Dimethyl pimelimidate dihydrochrolide, 4-Hydroxybenzoic acid n-hexyl ester, Methotrexate, Methylviologen, Mifepristone, 1-(1-Naphthyl)-2-thiourea, Oxymetholine, Spironolactone, 1,2,3,6-Tetrahydro-4-phenylpyridine hydrochloride Toronto Research Chemicals N-Acetyl dapsone, Albendazole sulfoxide, Azasetron, Bufuralol hydrochloride, Butenafin hydrochloride, Candesartan, Cefmetazole, 5-Chloro-2,4-dihydroxypyridine, Digoxin, Docetaxel, Eprosartan, Fenofibric acid, GW4064, 6-Hydroxychlorzoxazone, 3-Hydroxy desloratadine, (+/-)-4'-Hydroxy mephenytoin, Imidapril hydrochloride, Irbesartan, Irinotecan, Isocarboxazid, Losartan carboxaldehyde, Losartan carboxylic acid, Mephenytoin, Nateglinide, Olmesartan, Oxonic acid potassium salt, Pitavastatin lactone, Prasugrel hydrochloride, Quetiapine hemifumarate, Raloxifene hydrochloride, Sertraline hydrochloride, Simvastatin, SN-38, Tolcapone, 3,3',5-Triiodo-l-thyronine, Valsartan, Vanillylamine hydrochloride Ultrafine Chemicals and Minerals (Tamilnadu, India) Debrisoquine sulphate, Dextromethorphan hydrobromide, Oxydized nifedipine, Terfenadine Wako Pure Chemical Industries Acarbose, Aceclofenac, Acetanilide, Acetoaminophen, Acetohexamide, 7-Acetoxy-4-methylcoumarin, Acetylsalicylic acid, Albiflorin, Allopurinol, (p-Amidinophenyl) methanesulfonyl fluoride hydrochloride, dl-2-Aminobutyric acid, Aminoguanidine hydrochloride, 6-Aminohexanoic acid, 5-Aminolevulinic acid hydrochloride, 1-Amino-2-methylindoline, 2-Amino-5-nitrobenzophenone, 5-Amino-2-nitrobenztrifluoride, 3-Aminophenol, 3-Amino-1H-1,2,4-triazole, 4-Amino-1,2,4-triazole, 4-Amino-2-(trifluoromethyl)benzonitrile, Amitriptyline hydrochloride, Amoxapine, Ampicillin sodium, (+)-4-Androstene-3,17-dione, l(+)-Arabinose, 5-Aza-2'-deoxycitidine, 3'-Azido-3'-deoxythymidine, Baicalein, Baicalin, Barium hydroxide octahydrate, p-Benzoyl phenol, Benzhydrol, Benzophenone, Benzylhydrazine dihydrochloride, Bicalutamide, Bilirubin, Borneol, Buformine hydrochloride, t-Butylhydroquinone, S-Butyrylthiocholine iodide, Calcitriol, Camptothecin, Capsaicin, Carbamazepine, Carbomethoxymethylene, Carvedilol, Cefazolin sodium salt, Chenodeoxycholic acid, 3-[(3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate, Chloramphenicol, p-Chlorobenzoic acid, 4-Chloro-1-naphthol, Chlorpromazine hydrochloride, Ciclosporine, Ciprofloxacin hydrochloride monohydrate, Clarithromycin, Clomipramine hydrochloride, Clopidogrel carboxylic acid, Clozapine, Colchicine, Corticosterone, Coumarin-3-carboxylic acid, o-Cresol, p-Cresol, Cyclizine hydrochrolide, Cycloheximide, 2-Cyclohexyl-2-phenylglycolic Acid, Cyclophosphamide monohydrate, l-Cysteine, Cytidine, Cytosine-1-β-d(+)-arabinofuranoside, Dantrolene sodium, 1-Decanesulfonic acid, Desipramine hydrochloride, Dexamethasone, cis-Diammine dichloroplatinum (II), Dibucaine hydrochloride, 2,6-Di-tert-butyl-4-methylphenol, N6,2'-O-Dibutyryladenosine 3',5'-(cyclic)monophosphate sodium salt, 2,6-Dichloro-4-nitrophenol, 3,4-Dichloroaniline, 3,4-Dichloronitrobenzene, 2,6-Dichlorophenol, Digitonin, 1,2-Dihydroxy-4-nitrobenzene, dl-β-(3,4-Dihydroxyphenyl) alanine, Diltiazem hydrochloride, (±)-Dithiothreitol, p-Dimethylaminobenzaldehyde, 1,3-Dimethyluric acid, Diphenhydramine hydrochloride, Disodium molybdate (VI) dehydrate, Disulfiram, Dopamine hydrochloride, Enalapril maleate, Erythromycin, Ethacrynic acid, Ethylcarbamate, 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-Ethylmaleimide, Ethynylestradiol, Etizolam, Etodolac, Etoposide, Famotidine, Felbamate, Flavoxate hydrochloride, Fluconazole, Fluoranthene, p-Fluorophenyl acetic acid, 5-Fluorouracil, Flutamide, Fluvastatin sodium, o-Formylbenzoic acid, Fulvestrant, 2-Furancarboxylic,