View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Springer - Publisher Connector Oncol Ther DOI 10.1007/s40487-017-0040-8 CASE SERIES Switching from an LHRH Antagonist to an LHRH Agonist: A Case Report of 10 Finnish Patients with Advanced Prostate Cancer Harri Visapa¨a¨ Received: December 14, 2016 Ó The Author(s) 2017. This article is published with open access at Springerlink.com ABSTRACT injections were switched to the 3-monthly leuprorelin acetate implant (Leuprorelin Ò Introduction: Luteinizing hormone-releasing Sandoz ) subcutaneous injections. hormone (LHRH) analogues are widely used Results: Mean patient age was 75 years (SD 8.3; for the treatment of advanced range 59–85) and Gleason scores ranged from 7 hormone-dependent prostate cancer. However, to 9. The mean [±standard deviation (SD)] there are currently no clinical guidelines for duration of degarelix treatment was switching between LHRH analogues. It has been 5 ± 3.7 months (range 2–13). After switching, reported that there may be clinical benefits for prostate serum antigen levels were comparable patients switching between different or reduced from those measured prior to formulations of LHRH agonists, as well as from switching, showing that efficacy was not an LHRH agonist to LHRH antagonist, but there compromised. Throughout the course of are no published data on switching from an treatment, no patients reported injection site LHRH antagonist to an LHRH agonist. In this reactions. Patients reported increased paper, we summarize the clinical notes of 10 satisfaction with the leuprorelin acetate patients with hormone-sensitive advanced implant versus degarelix, mainly because of a prostate cancer who switched from an LHRH lack of injection site reactions and reduced antagonist to an LHRH agonist. frequency of injection. Methods: Patients with T3N0M0–T4N1M1 Conclusion: This is the first report of the prostate cancer experiencing injection site clinical experience and potential cost reactions, such as pain and swelling, with implications of switching from an LHRH monthly degarelix (FirmagonÒ) subcutaneous antagonist to an LHRH agonist. These data are consistent with other experiences of switching between LHRH analogues in terms of efficacy, safety, and potential cost savings, and provide preliminary evidence that the switch from an LHRH antagonist to an agonist is safe and Enhanced content To view enhanced content for this article go to http://www.medengine.com/Redeem/ equally efficacious. E787F0607539A79D. Keywords: Case report summary; Degarelix; H. Visapa¨a¨ (&) Leuprorelin acetate; LHRH analogues; Prostate Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland cancer; Switching e-mail: Harri.Visapaa@hus.fi Oncol Ther INTRODUCTION however, been no published data reported for switching from an LHRH antagonist to an Androgen deprivation therapy (ADT) is still the LHRH agonist. Here we summarize the clinical mainstay of treatment for advanced notes of 10 patients with hormone-sensitive hormone-dependent prostate cancer, with the advanced prostate cancer who switched from an main form being luteinizing hormone-releasing LHRH antagonist to an LHRH agonist. hormone (LHRH) agonists, such as goserelin acetate and leuprorelin acetate [1]. If permanent castration is required, orchiectomy is the most CASE PRESENTATION cost-effective and effective treatment option, but is very seldom used in clinical practice in Ten patients with T3N0M0–T4N1M1 prostate Western countries. cancer experiencing injection site reactions, Luteinizing hormone-releasing hormone such as pain and swelling, with monthly (LHRH) agonists bind to the LHRH receptor degarelix (FirmagonÒ) subcutaneous injections and stimulate luteinizing hormone (LH) and were included within this collection of 10 case follicle-stimulating hormone (FSH) secretion. studies (Fig. 1). Mean patient age was 75 years Chronic exposure leads to downregulation of [standard deviation (SD) 8.3; range 59–85] and LHRH receptors, thereby suppressing LH and Gleason scores ranged from 7 to 9 (Table 1). All FSH secretion, and ultimately inhibiting patients provided informed consent and the testosterone production. Castration levels of study was carried out in accordance with ethical testosterone with LHRH agonists are typically standards and Good Clinical Practice. achieved within 2–4 weeks [2]. LHRH Primary treatment for prostate cancer was antagonists, such as degarelix, are an external beam radiation therapy (n = 9) or alternative form of ADT. They inhibit LHRH chemical castration (n = 1). The mean (± SD) receptors, leading to a rapid decrease in LH, duration of degarelix treatment was FSH, and testosterone levels, without the 5 ± 3.7 months (range 2–13). The first patient testosterone flare associated with LHRH was switched to the leuprorelin acetate implant agonists [2]. (Leuprorelin SandozÒ), with no antiandrogen Clinical trials have compared the effects of therapy, in December 2015 and the mean LHRH agonists and LHRH antagonists on duration of treatment is currently 7 months prostate-specific antigen (PSA) and (range 4–10). Of the 10 patients who switched testosterone levels, but large comparative trials from degarelix, three received the are needed to provide overall survival and/or leuprorelin acetate implant before radiotherapy progression-free survival data [3]. Previous as neoadjuvant therapy and the seven men who studies have also reported LHRH agonists and received it as adjuvant therapy are still receiving LHRH antagonists to be generally well tolerated the implant (Fig. 1). PSA levels were measured (with most adverse events being consistent with before and after switching treatments [time to androgen suppression or the underlying post-switch PSA measurement, 1–6 months, condition), with the exception of reactions at mean 2.2 ± 1.6 (SD)]. PSA levels were the injection site with LHRH antagonists [4–8]. comparable or reduced from those measured Switching between hormonal therapies has prior to switching, showing that efficacy was been reported to have clinical benefits [6, 8–10]. not compromised (Fig. 2). Mean PSA level There are currently no clinical guidelines for before switching was 6.1 ± 9.1 versus switching between LHRH analogues [2, 11, 12], 4.4 ± 6.7 ng/mL after switching. but it has been reported that there could Throughout the course of treatment, no potentially be clinical benefits for patients if patients reported injection site reactions, such they switch between the different formulations as pain or swelling, with the leuprorelin acetate of LHRH agonists [8] as well as from an LHRH implant. Patients reported increased satisfaction agonist to LHRH antagonist [6, 10]. There have, with the leuprorelin acetate implant than with Oncol Ther Fig. 1 Patient flow diagram Table 1 Baseline characteristics and time to the first PSA test after switching to the leuprorelin acetate implant Patient Gleason score Gleason sum cTNM Time to first PSA test after the switch (months) 14? 5 9 T3N0M0 2 24? 3 7 T3N0M0 1 35? 4 9 T4N1M1 4 44? 4 8 T3N0M0 2 54? 5 9 T3N0M0 6 64? 4 8 T3N0M0 2 74? 4 8 T3N0M0 2 84? 5 9 T3N0M0 1 94? 5 9 T3N1M1 1 10 4 ? 3 7 T3N1M1 1 PSA prostate-specific antigen degarelix, mainly because of a lack of injection In Finland, continuous treatment with the site reactions and reduced frequency of leuprorelin acetate implant also appeared to be injection. Moreover, the 3-month injection more cost-effective due to reduced costs interval with the leuprorelin acetate implant (decreased from €517 for 3 months treatment was reported by the patients to be preferable to with degarelix to €316 for the leuprorelin the monthly interval of degarelix. Following the acetate implant). In addition, costs associated switch to the leuprorelin acetate implant in the with nurse involvement were reduced to adjuvant setting, all seven patients stated that one-third of the original cost due to less they preferred to continue with this therapy. frequent administration of injections. Oncol Ther Fig. 2 PSA levels of 10 patients measured before and after switching from an LHRH antagonist to an LHRH agonist SUMMARY AND CONCLUSIONS progression-free survival of LHRH agonists and LHRH antagonists [3]. This is the first report of the clinical experience and the potential for associated cost savings when switching men with advanced prostate ACKNOWLEDGEMENTS cancer from an LHRH antagonist to an LHRH agonist. The recurrent injection site reactions No funding or sponsorship was received for the experienced by all 10 Finnish patients who study. Article processing charges were funded initially received degarelix could be attributed by Sandoz International GmbH. The author to the associated histamine release from mast collated the data in this study and takes cells, which has been associated with all LHRH complete responsibility for the integrity of the antagonists [13]. The data reported here for men data and accuracy of the data analysis. switching from degarelix to the leuprorelin Medical writing support was provided by acetate implant are consistent with other Sarah Stutfield, Spirit Medical Communications switching experiences between LHRH analogues Ltd., supported by Sandoz International GmbH. in terms of efficacy and safety [6, 8, 10]aswellas All named authors meet the International the potential for associated for cost savings [1]. Committee of Medical Journal Editors (ICMJE) The case report presented here, therefore, criteria for authorship for this manuscript, take provides preliminary evidence that