Supplemental Table 1. List of known genes affected by radiation as detected by microarray analysis of polysome-bound RNA and total cellular RNA. U87 cell were irradiated with 7 Gy and collected for microarray analyses 6h later. Polysome-bound RNA UniGene # Gene Description Fold Change (log 2) Hs.429294 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.5829 Hs.471277 ACADL Acyl-Coenzyme A dehydrogenase, long chain 1.2587 Hs.471461 ACSL3 Acyl-CoA synthetase long-chain family member 3 1.2404 Hs.268785 ACSL4 Acyl-CoA synthetase long-chain family member 4 1.5611 Hs.14945 ACSL6 Acyl-CoA synthetase long-chain family member 6 1.5067 Hs.393201 ACTR2 ARP2 actin-related protein 2 homolog (yeast) 1.4219 Hs.433512 ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.2404 Hs.150402 ACVR1 activin A receptor, type I=Ser/Thr protein kinase receptor R1 1.2864 Hs.438918 ACVR1B Activin A receptor, type IB 1.0827 Hs.127930 ADAM18 A disintegrin and metalloproteinase domain 18 1.0261 Hs.370287 ADAM23 A disintegrin and metalloproteinase domain 23 1.226 Hs.2442 ADAM9 A disintegrin and metalloproteinase domain 9 (meltrin gamma) 1.6771 Hs.151435 ADAMTS3 A disintegrin-like and metalloprotease (reprolysin type) with 1.3683 thrombospondin type 1 motif, 3 Hs.498313 ADSS Adenylosuccinate synthase 1.1344 Hs.515053 AES Amino-terminal enhancer of split 1.518 Hs.75823 AF1Q ALL1-fused gene from chromosome 1q 1.879 Hs.904 AGL Amylo-1, 6-glucosidase, 4-alpha-glucanotransferase (glycogen 1.2491 debranching enzyme, glycogen storage disease type III) Hs.530009 AGR2 Anterior gradient 2 homolog (Xenopus laevis) 1.0291 Hs.488945 AIP1 Atrophin-1 interacting protein 1 2.309 Hs.105105 AKAP11 A kinase (PRKA) anchor protein 11 1.2621 Hs.459211 AKAP13 A kinase (PRKA) anchor protein 13 1.1679 Hs.98397 AKAP3 A kinase (PRKA) anchor protein 3 1.1621 Hs.515406 AKT2 V-akt murine thymoma viral oncogene homolog 2 1.3025 Hs.499886 ALDH3A2 Aldehyde dehydrogenase 3 family, member A2 1.4854 Hs.159118 AMD1 Adenosylmethionine decarboxylase 1 1.2007 Hs.514463 AMY2A Amylase, alpha 2A; pancreatic 1.0363 Hs.480876 ANAPC10 Anaphase promoting complex subunit 10 1.6952 Hs.369675 ANGPT1 Angiopoietin 1 1.6068 Hs.448589 ANKRD1 Cytokine inducible nuclear protein=cardiac ankyrin repeat protein 1.0246 Hs.494173 ANXA1 Annexin A1 1.5475 Hs.181107 ANXA13 Annexin A13 1.1382 Hs.406191 AP3S1 Adaptor-related protein complex 3, sigma 1 subunit 2.169 Hs.486063 APG5L APG5 autophagy 5-like (S. cerevisiae) 1.2181 Hs.560 APOBEC1 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 1.4838 Hs.227457 APOBEC2 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 1.5868 Hs.130730 AQP2 Aquaporin 2 (collecting duct) 1.1132 Hs.234642 AQP3 Aquaporin 3 1.2715 Hs.496240 AR Androgen receptor (dihydrotestosterone receptor; testicular 1.3776 feminization; spinal and bulbar muscular atrophy; Kennedy disease) Hs.62578 ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 1.6478 (brefeldin A-inhibited) Hs.416089 ARFIP1 ADP-ribosylation factor interacting protein 1 (arfaptin 1) 1.7266 Hs.440934 ARG1 Arginase, liver 1.1512 Hs.6838 ARHE Rho family GTPase 3 1.7539 Hs.435291 ARHGAP6 Rho GTPase activating protein 6 1.5181 Hs.161000 ARID4A AT rich interactive domain 4A (RBP1-like) 1.5365 Hs.372616 ARL1 ADP-ribosylation factor-like 1 1.0695 Hs.518060 ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 1.2676 Hs.486031 ASCC3 DJ467N11.1 protein 1.289 Hs.446684 ASE-1 CD3-epsilon-associated protein; antisense to ERCC-1 1.5855 Hs.489037 ASK Activator of S phase kinase 1.1802 Hs.546238 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon 2.1574 1 subunit Hs.514870 ATP5F1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, 1.3954 isoform 1 Hs.429 ATP5G3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c 1.1623 (subunit 9) isoform 3 Hs.85539 ATP5I ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e 1.1542 Hs.246310 ATP5J ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 1.5751 Hs.216623 ATP8B1 ATPase, Class I, type 8B, member 1 2.747 Hs.465475 ATP9B ATPase, Class II, type 9B 1.2243 Hs.533526 ATRX Alpha thalassemia/mental retardation syndrome X-linked (RAD54 1.2137 homolog, S. cerevisiae) Hs.55220 BAG2 BCL2-associated athanogene 2 1.2472 Hs.13261 BAI3 Brain-specific angiogenesis inhibitor 3 1.6211 Hs.169441 BAIAP1 BAI1-associated protein 1 1.2942 Hs.470369 BAZ2B Bromodomain adjacent to zinc finger domain, 2B 1.3289 Hs.22960 BCAS2 Breast carcinoma amplified sequence 2 1.0667 Hs.513520 BCKDK Branched chain ketoacid dehydrogenase kinase 1.227 Hs.489132 BET1 BET1 homolog (S. cerevisiae) 1.0591 Hs.27372 BMX BMX non-receptor tyrosine kinase 1.8336 Hs.10136 BPHL Biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin- 1.1572 associated antigen) Hs.127950 BRD1 Bromodomain containing 1 1.6437 Hs.500526 BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 1.1791 170kDa (Mot1 homolog, S. cerevisiae) Hs.499833 C10orf74 Chromosome 10 open reading frame 74 1.5968 Hs.72925 C11orf13 Chromosome 11 open reading frame 13 1.2252 Hs.277517 C11orf2 Chromosome 11 open reading frame2 1.3659 Hs.441926 C13orf24 Chromosome 13 open reading frame 24 1.0308 Hs.464697 C18orf1 Chromosome 18 open reading frame 1 1.3068 Hs.525462 C1orf41 Chromosome 1 open reading frame 41 1.6556 Hs.110196 C1orf42 Chromosome 1 open reading frame 42 1.0806 Hs.204559 C1orf9 Chromosome 1 open reading frame 9 1.1792 Hs.369284 C20orf6 Chromosome 20 open reading frame 6 1.5443 Hs.303808 C2orf3 Chromosome 2 open reading frame 3 1.1054 Hs.303808 C2orf3 Chromosome 2 open reading frame 3 1.2779 Hs.485588 C6orf142 Chromosome 6 open reading frame 142 1.0082 Hs.436445 C8orf1 Chromosome 8 open reading frame 1 2.1074 Hs.23118 CA1 Carbonic anhydrase I 1.2829 Hs.23118 CA1 Carbonic anhydrase I 1.4759 Hs.82129 CA3 Carbonic anhydrase III, muscle specific 1.4363 Hs.100322 CA6 Carbonic anhydrase VI 1.0999 Hs.408449 CACNA1A Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.2464 Hs.508524 CACYBP Calcyclin binding protein 1.1441 Hs.489127 CALCR Calcitonin receptor 1.1172 Hs.468442 CALM2 Calmodulin 2 (phosphorylase kinase, delta) 1.0372 Hs.495984 CASK Calcium/calmodulin-dependent serine protein kinase (MAGUK family) 1.6077 Hs.9216 CASP7 CASPASE-7=mch3=Ice-lap3 1.0862 Hs.430124 CASP8 CASPASE-8=Mch5=FLICE=MACH-alpha-1 1.2974 Hs.546332 CASP8AP2 CASP8 associated protein 2 1.1608 Hs.435615 CASR Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe 1.4537 neonatal hyperparathyroidism) Hs.440961 CAST Calpastatin 1.21 Hs.502302 CAT Catalase 1.4323 Hs.504096 CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.1503 Hs.436242 CCDC7 Coiled-coil domain containing 7 1.0148 Hs.303649 CCL2 MCP-1=MCAF=small inducible cytokine A2=JE=chemokine 1.4226 Hs.85137 CCNA2 cyclin A2 1.5948 Hs.430646 CCNC Cyclin C 1.2999 Hs.13291 CCNG2 Cyclin G2 1.9074 Hs.279906 CCNT1 cyclin T 1.0107 Hs.292754 CCNT2 Cyclin T2 1.2751 Hs.491494 CCT3 Chaperonin containing TCP1, subunit 3 (gamma) 1.0939 Hs.369661 CD226 adhesion molecule DNAM-1 1.2611 2 Hs.485518 CD2AP CD2-associated protein 1.4568 Hs.75626 CD58 CD58=LFA-3 1.2493 Hs.334562 CDC2 Cell division cycle 2, G1 to S and G2 to M 1.8611 Hs.428147 CDC40 Cell division cycle 40 homolog (yeast) 1.1995 Hs.116471 CDH11 Cadherin 11, type 2, OB-cadherin (osteoblast) 1.8221 Hs.436040 CDH13 Cadherin 13, H-cadherin (heart) 1.0814 Hs.433201 CDK2AP1 CDK2-associated protein 1=putative oral tumor suppressor protein 1.8285 (doc-1) Hs.397734 CDK8 Cdk8=Cyclin-dependent kinase 8 1.0491 Hs.238990 CDKN1B Cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.5503 Hs.444430 CDS1 CDP-diacylglycerol synthetase 1.2014 Hs.499222 CES1 Carboxylesterase 1 (monocyte/macrophage serine esterase 1) 1.6478 Hs.128342 CESK1 T-complex protein 1 1.6808 Hs.528302 CETN3 Centrin, EF-hand protein, 3 (CDC31 homolog, yeast) 1.5159 Hs.161220 CG018 Hypothetical gene CG018 1.1702 Hs.119689 CGA Glycoprotein hormones, alpha polypeptide 1.0744 Hs.444818 CGGBP1 CGG triplet repeat binding protein 1 1.3908 Hs.170129 CHML Choroideremia-like (Rab escort protein 2) 1.2895 Hs.283725 CHODL Chondrolectin 1.328 Hs.293077 CHPT1 Choline phosphotransferase 1 1.1348 Hs.15159 CKLF Chemokine-like factor 1.2894 Hs.889 CLC Charcot-Leyden crystal protein 1.0372 Hs.535985 CLCN5 Chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease) 1.096 Hs.504657 CLECSF6 C-type lectin domain family 4, member A 1.2502 Hs.86368 CLGN Calmegin=putative testis-specific chaperon 1.1779 Hs.54570 CLIC2 Chloride intracellular channel 2 1.1084 Hs.433732 CLK1 CLK-1=CDC-like kinase 1=PITSLRE alpha 1=galactosyltransferase 1.3448 associated protein kinase P58/GTA Hs.311346 CMAS Cytidine monophosphate N-acetylneuraminic acid synthetase 1.1612 Hs.1323 CNGA1 Cyclic nucleotide gated channel alpha 1 1.335 Hs.294603 CNIH Cornichon homolog (Drosophila) 1.4668 Hs.377466 COCH Coch-5B2=similar to chicken collagen XIV=coagulation factor C 1.5431 (Limulus polyphemus homolog); cochlin Hs.520339 COL10A1 Collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) 1.0571 Hs.211933 COL13A1 Collagen, type XIII, alpha 1 1.1546 Hs.149809 COL9A1 Collagen, type IX, alpha 1 1.1108 Hs.534383 COX17 COX17 homolog, cytochrome c oxidase assembly protein (yeast) 1.1375 Hs.351875 COX6C Cytochrome c oxidase subunit VIc 1.6452 Hs.430075 COX7C cytochrome c oxidase subunit VIIc 1.6898 Hs.646 CPA3 Carboxypeptidase A3 (mast cell) 1.1095 Hs.191219 CPNE3 Copine III 1.2686 Hs.435675 CPSF2 Cleavage and polyadenylation specific factor
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