SCIENTIFIC and EXECUTIVE COMMITTEE Jesús BALSINDE: Instituto de Biología y Genética Molecular; Spanish National Research Council (CSIC); Valladolid, Spain; E-mail: [email protected] Gerard BANNENBERG Centro Nacional de Biotecnología; Spanish National Research Council (CSIC); Madrid, Spain; Email: [email protected] Francis BERENBAUM : Pierre & Marie Curie University (UR-4) ; Department of Rheumatology AP-HP Saint-Antoine hospital ; 184 rue du faubourg Saint-Antoine ; 75012 Paris ; France ; Email : [email protected] Joan CLÀRIA Department of Biochemistry and Molecular Genetics; Hospital Clínic/IDIBAPS; Villarroel 170; 08036 Barcelona, Spain; Email: [email protected] Xavier NOREL INSERM U698, Bichat Hospital; Hemostasis, Bio-engineering and Cardiovascular Remodeling; 46, rue Henri Huchard; 75018 Paris, France; Email: [email protected] Lhousseine TOUQUI INSERM U874 ; Défense Innée & Inflammation ; Institut Pasteur ; 25, rue du Dr Roux ; 75015 Paris, France ; Email : [email protected] 1 LOCAL ORGANIZING COMMITTEE Under the auspices of Laurent Baud, INSERM U702, Tenon Hospital, Paris. Claude P.Bertrand, IPSEN, Boulogne-Billancourt. Charles Brink, GREMI, Pasteur Institute, Paris. Michel Chignard, INSERM U874, Pasteur Institute, Paris. Sylvie Chollet-Martin, Bichat Hospital; INSERM U756, Faculté de Pharmacie de Paris XI. Maïté Corvol, UMR-S 530 INSERM, Paris 5 University. Lise Halbwachs-Mecarelli, INSERM U845, Necker Hospital, Paris. Vincent Lagente, INSERM U620, Rennes 1 University. Françoise Pons, EA 3771, Louis Pasteur University, Illkirch. Jean-Francois Savouret, UMR-747-INSERM; Paris 5 University. Mustapha Si-Tahar, INSERM U874, Pasteur Institute, Paris. Christiane Taligault, Pasteur Institute, Paris. Nathalie Vergnolle, INSERM U563, Toulouse. Véronique Witko-Sarsat, INSERM U845, Necker Hospital, Paris. 2 Scientific Program - June 3, 2010 SCIENTIFIC PROGRAM JUNE 3 8:30-10:00 Registration, coffee and poster set-up 10:00-10:05 Welcome by the Organizers Opening lecture 10:05-10:45 Charles N. Serhan (Brigham & Women’s Hospital, HMS, Boston, USA) Resolution of inflammation; A novel genus of anti-inflammatory and pro-resolving lipid mediators. Session 1. The Pharmacology of Lipid Mediators Part 1: "Targets and Bullets in cardiovascular and respiratory diseases" Chairpersons: Joan Clària & Xavier Norel 10:45-11:10 Jane A. Mitchell (Imperial College, London, UK) Prostanoids in respiratory and vascular inflammation. 11:10 -11:35 Ingrid Fleming (Goethe University, Frankfurt, Germany) Epoxyeicosatrienoic acids & vascular function. 11:35-11:55 Ignacio Garcia-Verdugo* (Pasteur Institute, Paris, France) A role for 12R-lipoxygenase in mucus production by respiratory epithelial cells. 11:55-12:15 Gokce Topal* (Istanbul University, Turkey) Involvement of prostaglandin F2alpha in preeclamptic human umbilical vein vasospasm: a role of FP and TP receptors. 12:15-12:35 Angelo Sala* (University of Milan, Italy) Transcellular biosynthesis of leukotrienes in vivo. 12:35-14:35 Lunch Part 2: "Targets and Bullets in inflammation, cancer, musculoskeletal and neuronal diseases" Chairperson: Francis Berenbaum & Joan Clària 14:35-15:00 Sylvain Doré (Johns Hopkins University, Baltimore, USA) Prostaglandins receptors in stroke. 15:00-15:25 Oliver Werz (University of Frankfurt, Tübingen, Germany) 5-Lipoxygenase in health and disease. 3 Scientific Program - June 3, 2010 15:25-15:50 Leslie J. Crofford (University of Kentucky, Lexington, USA) mPGES-1 as a novel target for inflammation in musculoskeletal diseases. 15:50-16:10 Marjolaine Gosset* (Paris VI University, France) Inhibition of MMP-3 and MMP-13 synthesis induced by IL-1beta; in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. 16:10-16:30 Saul Yedgar* (Hebrew University - Hadassah Medical School, Israel) Inclusive control of lipid mediator production: a multi-factorial approach to treatment of inflammatory/allergic diseases. 16:30-17:00 Coffee Break: Poster session and Exhibition visit Session 2. Non-mammalian Lipid Mediators Chairperson: Gerard Bannenberg & Francis Berenbaum 17:00-17:25 Ernst Oliw (Uppsala University, Uppsala, Sweden) Fungal fatty acid dioxygenases. 17:25-17:50 Ivo Feussner (Georg-August University, Göttingen, Germany) Oxylipins & host-pathogen interactions in plants. 17:50-18:10 Kjetil Berge* (Haukeland University Hospital, Bergen, Norway) Krill and fish oil: differences in composition and anti-inflammatory properties. 18:10-18:30 Ivan Chechetkin* (Kazan Institute of Biochemistry and Biophysics, Russia) Linolipin biosynthesis as a new kind of plant defense strategy. 18:30-18:50 Maite Sanmartin* (Centro Nacional de Biotecnología CSIC, Madrid, Spain) Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. Closing Remarks for Day 1 Gerard Bannenberg Cheese and Wine Session and Poster session 4 Scientific Program - June 4, 2010 JUNE 4 9:00-9:05 Morning address by Francis Berenbaum Session 3. Young Investigator Session Part 1: 9:05 – 10:40 Chairperson: Charles Brink & Lhousseine Touqui 8 Junior speakers, 8+4 min. selected from abstract submissions Erika Villanueva (Irving K. Barber School of Arts and Sciences, Univ. British Columbia, Kelowna, Canada): Characterizing the role of secretory phospholipase A2 group IIA in glial cell- mediated neurotoxicity. David Balgoma (Instituto de Biología y Genética Molecular/CSIC, Valladolid, Spain): Markers of monocyte activation revealed by lipidomic profiling of arachidonic acid-containing phospholipids. Sophie Ayciriex (Membrane Biogenesis laboratory, CNRS UMR5200, Bordeaux, France): Lipid species profiling of yeast mutants defective for putative glycerolipid acyltransferases by mass spectrometry. Michela Rigoni (Dept. of Biomedical Sciences, University of Padova, Italy): Inverted cone- shaped lipids cause blockade and degeneration of nerve terminals. Jeremy Bellien (Dept. Pharmacology, Rouen University Hospital & INSERM / University of Rouen, France): Cytochrome-derived eicosanoids and nitric oxide regulate arterial wall viscosity in vivo in humans. Nicolas Cenac (INSERM U563, CHU Purpan, Toulouse, France): TRPV4 expression and activation in animal model of colitis. Beatriz Díez-Dacal (Centro de Investigaciones Biológicas, CSIC, Madrid, Spain): Electrophilic prostaglandin 15d-PGJ2 induces irreversible GSTP1-1 oligomerization and apoptosis in Jurkat T cells. Olivier Beaslas (Minerva Foundation Institute for Medical Research. Helsinki, Finland): Decrypting Oxysterol Binding-protein Related Protein 8 (ORP8) functions. 10:40 – 11.05 Coffee Break: Poster session and Exhibition visit 5 Scientific Program - June 4, 2010 Part 2: 11:05 – 12.30 Chairperson: Charles Brink & Xavier Norel 7 Junior speakers, 8+4 min. selected from abstract submissions Manuela Oraldi (Dipartimento Medicina ed Oncologia Sperimentale, Univ. Torino, Italy): Effect of n-3 polyunsaturated fatty acids on cachexia in advanced lung cancer: study “in vivo” and “in vitro”. Esther Titos (Dept. Biochemistry and Molecular Genetics, Hospital Cliníc, Barcelona, Spain): Omega-3 fatty acids promote the resolution of adipose tissue inflammation by inducing M2 (alternative) macrophage polarization. Valia Verriere (Departments of Molecular Medicine & Respiratory Medicine, Beaumont Hospital Dublin, Ireland): Lipoxin A4 increases airway surface liquid height in cystic fibrosis and non-CF human bronchial epithelia. Éva Ruisanchez. (Semmelweis University, Faculty of Medicine, Budapest, Hungary): Vascular effects of sphingomyelinase and sphingosine-1-phosphate. Andy Liedtke (A.B. Hancock Jr. Memorial Laboratory for Cancer Research, and Vanderbilt University School of Medicine, Nashville, TN, USA): Development of cyclooxygenase (COX)-1- selective inhibitors derived from 2’-des-methyl sulindac sulfide. Ingrid Gomez (Eicosanoids and Vascular Pharmacology, INSERM U698, CHU X. Bichat, Paris 13 University, Paris, France): Metabolism of PGE2 in human varicose veins. Sven-Christian Pawelzik (Department of Medicine, Karolinska University Hospital, Stockholm, Sweden): Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase 1. 12:30-14:15 Lunch Session 4. Lipid Mediators in Innate Immunity Chairperson: Lhousseine Touqui & Lisardo Boscá, CSIC, Madrid 14:15-14:40 María A. Balboa (Spanish Research Council, Valladolid, Spain) Innate immune signaling & phospholipases. 14:40-15:05 Jesper Z. Haeggström (Karolinska Institutet, Stockholm, Sweden) Leukotrienes & innate immunity. 15:05-15:30 Martin Thurnher (University of Innsbrück, Austria) Dendritic cells and innate immunity. 6 Scientific Program - June 4, 2010 15:30-15:50 Janos Filep* (University of Montreal, Canada) Aspirin-triggered lipoxins facilitate resolution of inflammation by promoting neutrophil apoptosis. 15:50-16:10 Jonas Bystrom* (William Harvey Research Institute, London, UK) Epoxygenases in control of macrophage phenotype. 16:10-16:30 Pierre Borgeat* (Centre de recherche du CHUQ, (CHUL), Quebec, Canada) The extra domain A of fibronectin primes leukotriene biosynthesis through Toll-like receptor-4 and stimulates human neutrophil migration. 16:30-17:00 Coffee Break : Poster session and Exhibition visit Session 5. Lipidomics Chairperson: Jesús Balsinde & Gerard Bannenberg 17:00-17:25 Anthony Postle (University of Southampton, UK) The specificty of hepatic phosphatidylcholine synthesis in vivo by the CRP: Choline and PEMT pathways. 17:25-17:50 Michel Lagarde (INSERM, Lyon, France)