nutrients Nutrigenetics Edited by Dolores Corella Printed Edition of the Special Issue Published in Nutrients www.mdpi.com/journal/nutrients Nutrigenetics Nutrigenetics Special Issue Editor Dolores Corella MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Special Issue Editor Dolores Corella University of Valencia Spain Editorial Office MDPI St. Alban-Anlage 66 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Nutrients (ISSN 2072-6643) from 2016 to 2017 (available at: http://www.mdpi.com/journal/nutrients/special issues/nutrigenetics) For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03842-995-1 (Pbk) ISBN 978-3-03842-996-8 (PDF) Articles in this volume are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book taken as a whole is c 2018 MDPI, Basel, Switzerland, distributed under the terms and conditions of the Creative Commons license CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/). Contents About the Special Issue Editor ...................................... vii Preface to ”Nutrigenetics” ......................................... ix Dolores Corella, Oscar Coltell, Jose V. Sorl´ı, Ram´on Estruch, Laura Quiles, Miguel Angel´ Mart´ınez-Gonz´alez, Jordi Salas-Salvad´o, Olga Casta ˜ner, Fernando Ar´os, Manuel Ortega-Calvo, Llu´ıs Serra-Majem, Enrique G´omez-Gracia, Olga Portol´es, Miquel Fiol, Javier D´ıez Espino, Josep Basora, Montserrat Fit´o, Emilio Ros and Jos´eM. Ordov´as Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores Reprinted from: Nutrients 2016, 8, 793, doi: 10.3390/nu8120793 ................... 1 Nikul K. Soni, Alastair B. Ross, Nathalie Scheers, Otto I. Savolainen, Intawat Nookaew, Britt G. Gabrielsson and Ann-Sofie Sandberg Splenic Immune Response Is Down-Regulated in C57BL/6J Mice Fed Eicosapentaenoic Acid and Docosahexaenoic Acid Enriched High Fat Diet Reprinted from: Nutrients 2017, 9, 50, doi: 10.3390/nu9010050 .................... 19 Abraham Wall-Medrano, Laura A. de la Rosa, Alma A. V´azquez-Flores, Gilberto Mercado-Mercado, Rogelio Gonz´alez-Arellanes,Jos´eA.L´opez-D´ıaz, Aar´onF. Gonz´alez-C´ordova, Gustavo A. Gonz´alez-Aguilar, Belinda Vallejo-Cordoba and Francisco J. Molina-Corral Lipidomic and Antioxidant Response to Grape Seed, Corn and Coconut Oils in Healthy Wistar Rats Reprinted from: Nutrients 2017, 9, 82, doi: 10.3390/nu9010082 .................... 36 Kaitlin J. Day, Melissa M. Adamski, Aimee L. Dordevic and Chiara Murgia Genetic Variations as Modifying Factors to Dietary Zinc Requirements—A Systematic Review Reprinted from: Nutrients 2017, 9, 148, doi: 10.3390/nu9020148 ................... 53 Kaitlin Roke, Kathryn Walton, Shannon L. Klingel, Amber Harnett, Sanjeena Subedi, Jess Haines and David M. Mutch Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention Reprinted from: Nutrients 2017, 9, 240, doi: 10.3390/nu9030240 ................... 69 Patrick Borel and Charles Desmarchelier Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability Reprinted from: Nutrients 2017, 9, 246, doi: 10.3390/nu9030246 ................... 83 Juan J. Salinero, Beatriz Lara, Diana Ruiz-Vicente, Francisco Areces, Carlos Puente-Torres, C´esar Gallo-Salazar, Teodoro Pascual and Juan Del Coso CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study Reprinted from: Nutrients 2017, 9, 269, doi: 10.3390/nu9030269 ...................100 v You-Lin Tain, Yu-Ju Lin, Jiunn-Ming Sheen, Hong-Ren Yu, Mao-Meng Tiao, Chih-Cheng Chen, Ching-Chou Tsai, Li-Tung Huang and Chien-Ning Hsu High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring Reprinted from: Nutrients 2017, 9, 357, doi: 10.3390/nu9040357 ...................112 Chiara Murgia and Melissa M. Adamski Translation of Nutritional Genomics into Nutrition Practice: The Next Step Reprinted from: Nutrients 2017, 9, 366, doi: 10.3390/nu9040366 ...................131 Min Yang, Min Xiong, Huan Chen, Lanlan Geng, Peiyu Chen, Jing Xie, Shui Qing Ye, Ding-You Li and Sitang Gong Novel Genetic Variants Associated with Child Refractory Esophageal Stricture with Food Allergy by Exome Sequencing Reprinted from: Nutrients 2017, 9, 390, doi: 10.3390/nu9040390 ...................135 Josiane Steluti, Aline M. Carvalho, Antonio A. F. Carioca, Andreia Miranda, Gilka J. F. Gatt´as, Regina M. Fisberg and Dirce M. Marchioni Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era Reprinted from: Nutrients 2017, 9, 539, doi: 10.3390/nu9060539 ...................142 Brinda K. Rana, Shirley W. Flatt, Dennis D. Health, Bilge Pakiz, Elizabeth L. Quintana, Loki Natarajan and Cheryl L. Rock The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention Reprinted from: Nutrients 2017, 9, 552, doi: 10.3390/nu9060552 ...................154 Fr´ed´eric Gu´enard, Annie Bouchard-Mercier, Iwona Rudkowska, Simone Lemieux, Patrick Couture and Marie-Claude Vohl Genome-Wide Association Study of Dietary Pattern Scores Reprinted from: Nutrients 2017, 9, 649, doi: 10.3390/nu9070649 ...................159 Xingxing Song, Zongyao Li, Xinqiang Ji and Dongfeng Zhang Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis Reprinted from: Nutrients 2017, 9, 679, doi: 10.3390/nu9070679 ...................176 Kevin B. Comerford and Gonca Pasin Gene–Dairy Food Interactions and Health Outcomes: A Review of Nutrigenetic Studies Reprinted from: Nutrients 2017, 9, 710, doi: 10.3390/nu9070710 ...................191 Janaina L. S. Donadio, Marcelo M. Rogero, Simon Cockell, John Hesketh and Silvia M. F. Cozzolino Influence of Genetic Variations in Selenoprotein Genes on the Pattern of Gene Expression after Supplementation with Brazil Nuts Reprinted from: Nutrients 2017, 9, 739, doi: 10.3390/nu9070739 ...................208 vi About the Special Issue Editor Dolores Corella, is Full Professor of Preventive Medicine and Public Health at the University of Valencia, Valencia, Spain. She has a background in Nutrition, Omics and Epidemiology. Since 1998, she has been the Director of the Genetic and Molecular Epidemiology Rresearch Unit. She focuses on the study of genetic determinants of disease and has developed research methodology for analyzing gene—environment interactions. Within In the a gene—environment interaction study, gene—diet interactions have constituted an important research line giving rise to the development of Nutritional Genomics, Nutrigenetics and Nutrigenomics. She has also been a principal investigator (PI) in the CIBER of Physiopathology of Obesity and Nutrition, a center of excellence for networking research in Spain. She has directed more than 23 PhD dissertations and has been the PI for more than 30 research projects. Currently, she is focused on omics (genomics, epigenomics, transcriptomics, metabolomics, proteomics, phenomics, etc.) integration into the field of diet, obesity, and cardiovascular-related diseases. vii viii Preface to ”Nutrigenetics” In the new era of Precision Nutrition, it is crucial to provide scientific evidence of gene–diet interactions that can result in a practical application. Although enormous progress has been made in the development of omic technologies (genomics, epigenomics, transcriptomis, metabolomics, etc.), the integration of these technologies in the nutrition field is still scarce. Therefore, more studies are needed in Nutritional Genomics to provide the evidence required for Precision Nutrition. Moreover, Nutritional Genomics is a multidisciplinary field and both studies in humans and in animal models are required. In human studies, mainly epidemiological findings related to the associations between genetic variants and disease phenotypes have been published. Large cohorts have been analyzed and genome-wide association studies (GWAs) published. However, the dietary modulation of the reported genetic associations in the GWAs studies is largely unknown. Thus, both observational and experimental gene-diet interaction studies analyzing dietary modulations in determining the genetic risk of disease are needed. In this book, relevant epidemiological studies in the nutrigenetic field are included. These chapters analyze a wide range of study designs and clinical phenotypes, as well as dietary exposures and include, among others, a general overview of the translation of nutritional genomics into nutrition practice; a review of the nutrigenetic studies on gene–dairy food interactions and health outcomes; an analysis of the role of genetic variations associated with vitamin A status and bioavailability; the study of genetic variants involved in one-carbon metabolism and their effects; a meta-analysis