SUPPLEMENTARY TABLE S4 B Cmap results- drug list of Set B CML PRIOR TREATMENT BONE MARROW VS CML POST TREATMENT BONE MARROW -Set B CMap rank batch cmap name dose cell score up down instance_id 1 664 alprostadil 11 µM HL60 1 0.27 -0.189 2938 2 618 mebendazole 14 µM HL60 0.916 0.272 -0.148 2338 3 634 puromycin 7 µM HL60 0.907 0.277 -0.14 2448 4 623 colchicine 10 µM HL60 0.905 0.261 -0.154 1598 5 665 quinpirole 16 µM HL60 0.904 0.287 -0.128 2977 6 749 (-)-isoprenaline 16 µM HL60 0.882 0.256 -0.149 6149 7 645 gossypol 8 µM HL60 0.861 0.228 -0.168 2202 8 602 tanespimycin 1 µM HL60 0.861 0.296 -0.099 1167 9 602 monorden 100 nM HL60 0.851 0.273 -0.117 1160 10 602 tretinoin 1 µM HL60 0.85 0.242 -0.149 1152 11 645 lycorine 12 µM HL60 0.846 0.251 -0.137 2195 12 630 anisomycin 15 µM HL60 0.83 0.262 -0.119 1304 13 623 methylergometrine 9 µM HL60 0.828 0.232 -0.149 1607 14 634 menadione 23 µM HL60 0.813 0.215 -0.158 2439 15 644 co-dergocrine mesilate 6 µM HL60 0.81 0.195 -0.177 2136 16 640 dihydroergocristine 6 µM HL60 0.785 0.229 -0.132 1745 17 602 thioridazine 10 µM HL60 0.781 0.242 -0.116 1171 18 650 thioridazine 10 µM HL60 0.779 0.216 -0.142 2690 19 623 etoposide 7 µM HL60 0.776 0.207 -0.149 1626 20 635 orciprenaline 8 µM HL60 0.771 0.194 -0.16 2485 21 644 emetine 7 µM HL60 0.77 0.211 -0.143 2145 22 602 LY-294002 10 µM HL60 0.761 0.206 -0.144 1177 23 634 cephaeline 6 µM HL60 0.758 0.209 -0.139 2429 24 641 (+)-chelidonine 11 µM HL60 0.75 0.264 -0.081 1786 25 602 tanespimycin 1 µM HL60 0.745 0.237 -0.105 1166 26 750 tanespimycin 1 µM HL60 0.735 0.235 -0.103 6185 27 613 bromocriptine 5 µM HL60 0.732 0.205 -0.131 2007 28 645 helveticoside 7 µM HL60 0.732 0.211 -0.125 2192 29 619 pergolide 10 µM HL60 0.727 0.199 -0.135 2403 30 634 dinoprost 8 µM HL60 0.723 0.241 -0.091 2446 31 651 isoetarine 12 µM HL60 0.718 0.21 -0.12 2711 32 612 niclosamide 12 µM HL60 0.715 0.164 -0.164 1998 33 602 sirolimus 100 nM HL60 0.712 0.186 -0.141 1162 34 750 15-delta prostaglandin J2 10 µM HL60 0.692 0.175 -0.143 6190 35 629 betazole 27 µM HL60 0.692 0.168 -0.15 1854 36 657 parthenolide 16 µM MCF7 0.692 0.146 -0.172 2885 37 614 dihydroergotamine 3 µM HL60 0.689 0.165 -0.151 1398 38 603 prochlorperazine 10 µM PC3 0.687 0.147 -0.168 1215 39 650 geldanamycin 1 µM HL60 0.686 0.221 -0.094 2688 40 661 Prestwick-983 17 µM HL60 0.686 0.225 -0.09 3141 41 612 thioridazine 10 µM HL60 0.686 0.222 -0.093 1986 42 623 clenbuterol 13 µM HL60 0.677 0.205 -0.106 1613 43 614 terfenadine 8 µM HL60 0.677 0.199 -0.112 1381 44 602 geldanamycin 1 µM HL60 0.674 0.167 -0.142 1169 45 622 etacrynic acid 13 µM HL60 0.673 0.18 -0.128 1565 46 650 tretinoin 1 µM HL60 0.67 0.151 -0.156 2671 47 750 thioridazine 10 µM HL60 0.669 0.193 -0.115 6189 48 640 prenylamine 10 µM HL60 0.668 0.194 -0.112 1737 49 733 strophanthidin 10 µM PC3 0.667 0.208 -0.098 5826 50 651 corbadrine 22 µM HL60 0.664 0.211 -0.094 2710 51 617 chlorphenesin 16 µM PC3 0.663 0.136 -0.169 2115 52 602 sirolimus 100 nM HL60 0.661 0.147 -0.157 1148 53 651 cicloheximide 14 µM HL60 0.66 0.212 -0.091 2723 54 619 perhexiline 10 µM HL60 0.659 0.184 -0.119 2410 55 650 tanespimycin 1 µM HL60 0.658 0.208 -0.094 2666 56 630 suloctidil 12 µM HL60 0.657 0.162 -0.14 1297 57 645 lanatoside C 4 µM HL60 0.656 0.19 -0.111 2193 58 602 tanespimycin 1 µM HL60 0.648 0.162 -0.136 1159 59 750 LY-294002 10 µM HL60 0.647 0.176 -0.121 6195 60 650 tanespimycin 1 µM HL60 0.647 0.182 -0.115 2678 61 650 prochlorperazine 10 µM HL60 0.646 0.17 -0.127 2675 62 603 thioridazine 10 µM PC3 0.645 0.121 -0.175 1230 63 610 thioridazine 10 µM PC3 0.643 0.13 -0.166 1905 64 506 15-delta prostaglandin J2 10 µM MCF7 0.641 0.156 -0.139 1011 65 750 tanespimycin 1 µM HL60 0.64 0.189 -0.104 6184 66 603 trifluoperazine 10 µM PC3 0.639 0.096 -0.197 1224 67 622 tretinoin 13 µM HL60 0.639 0.174 -0.119 1548 68 602 15-delta prostaglandin J2 10 µM HL60 0.634 0.171 -0.12 1172 69 619 isotretinoin 13 µM HL60 0.633 0.195 -0.095 2407 70 630 bepridil 10 µM HL60 0.633 0.134 -0.157 1274 71 749 oxedrine 24 µM HL60 0.632 0.202 -0.088 6156 72 702 methylbenzethonium 9 µM PC3 0.628 0.194 -0.094 4325 chloride 73 623 cefoperazone 6 µM HL60 0.628 0.184 -0.104 1627 74 626 15-delta prostaglandin J2 10 µM MCF7 0.627 0.119 -0.169 1656 75 623 metitepine 8 µM HL60 0.625 0.129 -0.158 1616 76 602 LY-294002 10 µM HL60 0.624 0.136 -0.151 1168 77 634 ciclopirox 15 µM HL60 0.622 0.187 -0.098 2456 78 1069 MG-262 100 nM PC3 0.621 0.145 -0.141 7068 79 660 tonzonium bromide 7 µM HL60 0.618 0.177 -0.107 3080 80 628 chlorpromazine 11 µM PC3 0.617 0.169 -0.114 1822 81 618 salbutamol 17 µM HL60 0.616 0.153 -0.13 2344 82 623 adenosine phosphate 11 µM HL60 0.613 0.187 -0.094 1622 83 686 helveticoside 7 µM MCF7 0.612 0.158 -0.123 3851 84 634 amphotericin B 4 µM HL60 0.609 0.184 -0.095 2441 85 75 1,5-isoquinolinediol 100 µM HL60 0.608 0.193 -0.086 543 86 650 tanespimycin 1 µM HL60 0.608 0.208 -0.071 2686 87 648 strophanthidin 10 µM HL60 0.606 0.194 -0.084 2525 88 602 fluphenazine 10 µM HL60 0.605 0.187 -0.091 1178 89 1073 MG-262 100 nM PC3 0.605 0.135 -0.142 7079 90 753 azacyclonol 15 µM PC3 0.604 0.064 -0.213 6298 91 686 citiolone 25 µM MCF7 0.603 0.157 -0.12 3836 92 619 minocycline 8 µM HL60 0.602 0.118 -0.158 2405 93 623 dobutamine 12 µM HL60 0.601 0.17 -0.106 1589 94 734 alimemazine 5 µM PC3 0.601 0.092 -0.184 5881 95 659 (+)-isoprenaline 11 µM HL60 0.601 0.139 -0.137 3046 96 514 MG-132 21 µM MCF7 0.601 0.148 -0.128 1140 97 614 dexamethasone 9 µM HL60 0.599 0.113 -0.162 1396 98 729 puromycin 7 µM MCF7 0.599 0.121 -0.154 5310 99 623 ketanserin 7 µM HL60 0.599 0.166 -0.109 1593 100 664 meptazinol 15 µM HL60 0.597 0.114 -0.16 2906 101 649 mephentermine 9 µM HL60 0.597 0.191 -0.083 2563 102 686 lanatoside C 4 µM MCF7 0.596 0.172 -0.102 3852 103 75 gefitinib 10 µM HL60 0.595 0.15 -0.123 541 104 664 trichostatin A 100 nM HL60 0.595 0.161 -0.112 2904 105 677 pyrvinium 3 µM MCF7 0.591 0.158 -0.113 3518 106 754 pyrvinium 3 µM PC3 0.59 0.115 -0.156 6339 107 701 foliosidine 13 µM PC3 0.589 0.127 -0.144 4295 108 602 LY-294002 10 µM HL60 0.589 0.178 -0.093 1180 109 631 digitoxigenin 11 µM HL60 0.589 0.169 -0.102 1339 110 718 chlorpromazine 11 µM PC3 0.589 0.146 -0.125 5074 111 750 tanespimycin 1 µM HL60 0.587 0.156 -0.113 6166 112 623 trichostatin A 100 nM HL60 0.587 0.117 -0.152 1612 113 650 15-delta prostaglandin J2 10 µM HL60 0.584 0.179 -0.089 2691 114 603 tanespimycin 1 µM PC3 0.582 0.087 -0.18 1225 115 631 bacampicillin 8 µM HL60 0.581 0.159 -0.108 1337 116 630 ouabain 5 µM HL60 0.58 0.172 -0.095 1302 117 622 albendazole 15 µM HL60 0.58 0.161 -0.105 1547 118 640 lobelanidine 11 µM HL60 0.58 0.184 -0.082 1747 119 686 flecainide 8 µM MCF7 0.578 0.155 -0.111 3843 120 502 pyrvinium 1 µM MCF7 0.578 0.069 -0.197 978 121 686 pempidine 13 µM MCF7 0.576 0.136 -0.128 3832 122 714 desipramine 13 µM PC3 0.574 0.129 -0.134 6693 123 765 15-delta prostaglandin J2 10 µM MCF7 0.573 0.146 -0.117 6990 124 648 terazosin 9 µM HL60 0.573 0.181 -0.081 2530 125 714 profenamine 11 µM PC3 0.572 0.121 -0.142 6697 126 707 ouabain 5 µM MCF7 0.572 0.132 -0.13 5026 127 640 ceftazidime 6 µM HL60 0.571 0.128 -0.134 1721 128 1052 trichostatin A 1 µM PC3 0.568 0.124 -0.137 6886 129 617 etofylline 18 µM PC3 0.568 0.092 -0.168 2093 130 657 prenylamine 10 µM MCF7 0.567 0.109 -0.151 2886 131 648 tetryzoline 17 µM HL60 0.567 0.123 -0.137 2507 132 718 pizotifen 9 µM PC3 0.566 0.151 -0.109 5072 133 706 lasalocid 7 µM MCF7 0.566 0.135 -0.125 4985 134 502 5252917 14 µM MCF7 0.566 0.092 -0.168 944 135 727 thioridazine 10 µM PC3 0.566 0.175 -0.084 4454 136 626 thioridazine 10 µM MCF7 0.565 0.148 -0.111 1655 137 513 geldanamycin 1 µM MCF7 0.564 0.114 -0.145 1066 138 612 trichostatin A 100 nM HL60 0.564 0.162 -0.097 1971 139 626 trifluoperazine 10 µM MCF7 0.563 0.118 -0.141 1649 140 725 alvespimycin 100 nM MCF7 0.562 0.176 -0.082 5210 141 710 ouabain 5 µM PC3 0.562 0.196 -0.062 6680 142 603 fluphenazine 10 µM PC3 0.559 0.098 -0.159 1237 143 728 clomipramine 11 µM PC3 0.559 0.08 -0.177 4487 144 657 mometasone 8 µM MCF7 0.558 0.09 -0.166 2896 145 502 rottlerin 10 µM MCF7 0.556 0.114 -0.142 941 146 730 digoxin 5 µM MCF7 0.556 0.135 -0.12 5324 147 714 loxapine 9 µM PC3 0.556 0.163 -0.093 6694 148 731 cicloheximide 14 µM PC3 0.555 0.138 -0.117 5743 149 732 spiperone 10 µM PC3 0.554 0.138 -0.116 5777 150 506 tanespimycin 1 µM MCF7 0.554 0.121 -0.133 998 151 618 kawain 17 µM HL60 0.552 0.141 -0.113 2337 152 712 bepridil 10 µM PC3 0.552 0.079 -0.174 4613 153 603 LY-294002 10 µM PC3 0.552 0.065 -0.189 1227 154 641 vinburnine 14 µM HL60 0.552 0.168 -0.085 1788 155 650 trifluoperazine 10 µM HL60 0.552 0.174 -0.079 2684 156 750 sirolimus 100 nM HL60 0.552 0.133 -0.121 6180 157 1032 5155877 10 µM PC3 0.551 0.088 -0.165 6544 158 623 probucol 8 µM HL60 0.55 0.145 -0.107 1608 159 714 chlorprothixene 11 µM PC3 0.55 0.083 -0.169 6692 160 727 sirolimus 100 nM PC3 0.55 0.149 -0.103 4445 161 698 0175029-0000 1 µM PC3 0.55 0.095 -0.158 7392 162 665 S-propranolol 14 µM HL60 0.549 0.124 -0.128 2961 163 732 mianserin 13 µM PC3 0.549 0.133 -0.119 5786 164 727 alvespimycin 100 nM PC3 0.548 0.126 -0.125 4437 165 656 thiostrepton 2 µM MCF7 0.548 0.095 -0.156 2823 166 686 ethoxyquin 18 µM MCF7 0.547 0.179 -0.073 3846 167 622 clonidine 15 µM HL60 0.547 0.141 -0.11 1555 168 651 securinine 18 µM HL60 0.547 0.113 -0.138 2729 169 626 tanespimycin 1 µM MCF7 0.546 0.14 -0.111 1643 170 502 wortmannin 1 µM MCF7 0.545 0.102 -0.148 977 171 664 harpagoside 8 µM HL60 0.545 0.135 -0.115 2935 172 703 withaferin A 1 µM PC3 0.545 0.094 -0.157 4554 173 502 monorden 100 nM MCF7 0.545 0.113 -0.137 953 174 762 homochlorcyclizine