PROGRAM MNS MEETING 2015 SANTA MARGHERITA DI PULA, 12-15 JUNE 2015 Santa Margherita di Pula, 12-15 June 2015 ORGANIZED UNDER THE AUSPICES OF Università degli Studi di Cagliari Santa Margherita di Pula, 12-15 June 2015 SPONSORS Santa Margherita di Pula, 12-15 June 2015 EXHIBITORS Santa Margherita di Pula, 12-15 June 2015 LOCAL ORGANIZING COMMITTEE Liana Fattore (Cagliari) Cristina Cadoni (Cagliari) Anna Carta (Cagliari) Marco Diana (Sassari) Miriam Melis (Cagliari) Annalisa Pinna (Cagliari) Valentina Valentini (Cagliari) Patrizia Campolongo (Roma) Carla Cannizzaro (Palermo) Paola Fadda (Cagliari) Patrizia Fattori (Bologna) Walter Fratta (Cagliari) Micaela Morelli (Cagliari) SCIENTIFIC COMMITTEE Marie Moftah President Egypt Marc Landry President Elect France Nora Abrous General Secretary France Hagai Bergman Vice Secretary Israel Abdelhamid Benazzouz Treasurer France Yasin Temel Vice Treasurer Netherlands Hedayat Abdel Ghaffar Council Member Egypt Latifa Dorbani-Mamine Council Member Algeria Mohammed Errami Council Member Morocco Liana Fattore Council Member Italy Patrizia Fattori Council Member Italy Suleyman Kaplan Council Member Turkey Mohammed Najimi Council Member Morocco Maria-Paz Viveros Council Member Spain Secretariat of the 5th MNS Meeting 2015 Monica Valentini PROGRAM 7 Santa Margherita di Pula, 12-15 June 2015 Friday, June 12th 2015 13.00 - 19.00 Registration Room: NAUTILUS 13.45 - 14.00 MNS Presentation & Introduction to the Meeting Marie Moftah, MNS President, Liana Fattore, President of the 2015 MNS Meeting 14.00 - 14.30 Presentation of COST ACTIONS Graziano Fiorito & Laura Della Corte 14.30-15.30 PLENARY LECTURE GAETANO DI CHIARA (Italy): Drugs of abuse as unconditioned homologs of conditioned rewards: the role of accumbens shell dopamine Host: Carla Cannizzaro 15.30 - 17.15 SYMPOSIA Room: NAUTILUS Neurocognitive function and emotion processing in psychopathology Chairs: Adrianna Mendrek (Canada) & Walter Fratta (Italy) FLORINE DOLCOS (USA): “Neural mechanisms of emotion-cognition interactions in healthy functioning and disease: Evidence from brain imaging investigations”. ANDRIANNA MENDREK (Canada): “Functional cerebral connectivity in schizophrenia women during visuo-spatial processing”. ANGELA SIRIGU (France): “How oxytocin modulates the human brain and behavior”. HELENE POISSANT (Canada): “Transmission of fronto-parietal dysfunction during forethought in families with attention deficit/hyperactivity disorder”. 8 Friday, June 12th 2015 Santa Margherita di Pula, 12-15 June 2015 Room CYPREA Emerging concepts in dopaminergic system development and regulation Chairs: Stefano Espinoza (Italy) & Małgorzata Filip (Poland) ELIA DI SCHIAVI (Italy): “Genetic characterization of the dopamine system in the animal model C. elegans” GIUSEPPE RONZITTI (France): “HDAC inhibition reduces dopamine-dependent neurodegeneration in a mouse model of DAT-deficiency syndrome” DAMIANA LEO (Italy): “Pronounced dopaminergic dysregulation in dopamine transporter knock out rats” DAVID MORENO (France): “Targeting dopamine D1-histamine H3 receptor heteromers reverts learning and long-term memory deficits in a mouse model of Huntington’s disease”. MASSIMILIANO CAIAZZO (Italy): “Direct reprogramming of fibroblasts into functional dopaminergic neurons”. Room ASTREA Glia in the nervous system: From housekeeping to processing functions Chairs: Stéphane Oliet (France) & Anna R. Carta (Italy) STEPHANE OLIET (France): “Surface dynamics of GLT-1 on astrocytes shapes excitatory transmission”. STEPHEN D. SKAPER (Italy): “Co-ultramicronized palmitoylethanolamide/luteolin promotes maturation of rat cortical oligodendrocytes in vitro”. NATHALIE ROUACH (France): “Connexin 30: unconventional determinant of astroglial synapse coverage and memory”. ESTEE KURANT (Israel): “Keeping the CNS clear: Glial phagocytosis of neuronal debris”. ARNAU BUSQUETS-GARCIA (France): “Involvement of astrocytic CB1 receptors in synaptic plasticity and hippocampal-based memory”. 9 th Santa Margherita di Pula, 12-15 June 2015 Friday, June 12 2015 Room ALVANIA Neurobiology of food intake regulation Chairs: Carole Rovere (France) & Mohamed Najimi (Morocco) SERGE LUQUET (France): “Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding”. ETIENNE CHALLET (France): “Timed feeding: impact on circadian clocks and metabolism”. MOHAMMED ERRAMI (Morocco): “Molecular mechanisms underlying cannabinoids action on hypothalamic neuropeptide neurons”. CAROLE ROVERE (France): Role of chemokines in neuroinflammation and feeding behavior”. NICOLAS CHARTREL (France): “26RFa, a novel neuropeptide regulating feeding behavior and glucose homeostasis”. 17.15 - 17.45 Coffee break 17.45 - 19.30 SYMPOSIA Room NAUTILUS Depression, anxiety and addiction: is it all converge to impaired dopaminergic function? Chairs: Rami Yaka (Israel) & Barry J. Everitt (UK) CHRISTINA DALLA (Greece) : “Sex differences in models of depression: is it all about serotonin?” MIRIAM MELIS (Italy): “Effects of in utero exposure to cannabinoids on postnatal synaptic maturation of glutamatergic transmission in the VTA “. FRANCOIS GEORGES (France): “In vivo homeostatic plasticity at the single-cell level in the BNST triggers persistent anxiolytic effect”. RAMI YAKA (Israel): “Targeting drug-cue associations to prevent drug relapse”. MARK UNGLESS (UK): “Functional diversity of midbrain dopamine neurons”. 10 th Santa Margherita di Pula, 12-15 June 2015 Friday, June 12 2015 Room CYPREA Parkinson’s disease - from neuroprotection to the treatment of motor and non- motor symptoms Chairs: Gilberto Fisone (Sweden) & Moussa Youdim (Israel) ANNA CARTA (Italy): “Microgliosis in Parkinson’s disease: can we harness it for good?” NEVILLE VASSALLO (Malta): “Amyloid-lipid membrane interaction: a novel target for neurodegeneration“. RICCARDO BRAMBILLA (Italy): “Intracellular signalling mechanisms controlling L-DOPA induced Dyskinesia: a translational neuroscience perspective”. GILBERTO FISONE (Sweden): “Cognitive and affective dysfunctions in experimental Parkinsonism: modeling and mechanisms”. ROSARIO MORATALLA (Spain): “Activation of DREAM, a calcium-binding protein, reduces L- DOPA- induced dyskinesias in mice”. Room ASTREA Neuronal plasticity in health and disease: cognitive and clinical perspectives Chairs: Said Boujraf (Morocco) & Driss Boussaoud (France) JULIEN DOYON (Canada): “Neural and physiological correlates of motor learning and consolidation”. HABIB BENALI (France): “Longitudinal functional network analysis for motor skill learning in humans”. MOHAMMED BENZAGMOUT (Morocco): “Brain plasticity induced by hemodialysis: neuroanatomical and BOLD-fMRI study”. DRISS BOUSSAOUD (France): “Social learning: from behavior to neurons“. YVES JOANETTE (Canada): “Brain, communication and aging: a life-long adaptive process sustaining quality of life”. 11 th Santa Margherita di Pula, 12-15 June 2015 Friday, June 12 2015 Room ALVANIA Genes do matter: insights in the genetic vulnerability to nicotine addiction Chairs: Cristina Cadoni (Italy) & Nataliè Thiriet (France) LAURIANE HARRINGTON (France): “The role of nicotinic acetylcholine receptor subunits in nicotine addiction”. CRISTINA CADONI (Italy): “Strain differences in the long lasting effect of adolescent nicotine exposure on mesolimbic dopamine transmission of Lewis and Fischer 344 rats”. JENNIFER J. WARE (UK): “Using biomarkers of tobacco exposure in genome-wide association studies”. MORGANE BESSON (France): “The rs16969968 polymorphism predisposing to smoking confers midbrain- and hippocampus-dependent affective impairments that are alleviated by nicotine”. 19.30 - 20.30 WELCOME COCKTAIL 12 Santa Margherita di Pula, 12-15 June 2015 Saturday, June 13th 2015 Room NAUTILUS 8.30 - 9.30 PLENARY LECTURE IDAN SEGEV – “The Human Brain Project: from Mouse to Man” Host: Marco Diana 9.30 - 11.15 SYMPOSIA Room NAUTILUS Interaction between dopaminergic and non-dopaminergic neurotransmission on Parkinson’s disease: implication in therapy, dyskinesia and neuroprotection Chairs: Marie-Therese Armentero (Italia) & Rosario Moratalla (Spain) ANNALISA PINNA (Italy): “Novel therapeutic strategy for the control of dyskinesia in the therapy of Parkinson’s disease: acute and chronic studies”. MARIANNE AMALRIC (France): “Bee venom and apamin, a small conductance calcium- activated potassium channel blocker, are potential new therapeutic targets for Parkinson's disease”. RODRIGO A. CUNHA (Portugal): “ATP and adenosine modulation of striatal plasticity and Parkinson's disease”. MARIE-THERESE ARMENTERO (Italy): “Neuroprotective and symptomatic potential of combined non- dopaminergic therapy in Parkinson’s disease”. KRYSTYNA GOLEMBIOWSKA (Poland): “The antioxidative and anti-inflammatory effects of adenosine A2A receptor antagonist as a new therapy of PD”. 13 Saturday, June 13th 2015 Santa Margherita di Pula, 12-15 June 2015 Room CYPREA Serotonin interaction with other neurotransmitters Chairs: Giuseppe Di Giovanni (Malta) & Philippe De Deurwaerdère (France) PHILIPPE DE DEURWAERDERE (France): “A closer look at the pivotal role of serotonergic neurons in the mechanism of action of L-DOPA”. GIUSEPPE DI GIOVANNI (Malta): “5-HT2C receptor control of generalized and focal seizures”. MASSIMO PIERUCCI (Malta): “Role of the lateral habenula in nicotine addiction“. NELA PIVAC (Croatia): “Serotonin and dopamine in sleep disturbances in PTSD”. Room ASTREA The GABA-B receptor: from molecular to behavioral regulation! Chairs: Maria Paola Castelli (Italy) & Bernhard Bettler (Switzerland)