Supplementary Table S2. List of the genes up-regulated 1-2 days following CTX treatment Gene Parametric Description EntrezID symbol p-value* PHPT1 phosphohistidine phosphatase 1 29085 1.20E-06 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1026 1.20E-06 BBC3 BCL2 binding component 3 27113 4.00E-06 TRIAP1 hypothetical protein HSPC132 51499 6.80E-06 OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 4938 1.80E-05 RXRA retinoid X receptor, alpha 6256 2.16E-05 FCGR1A FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2209 2.26E-05 RPS27L ribosomal protein S27-like 51065 2.73E-05 MKNK2 MAP kinase interacting serine/threonine kinase 2 2872 3.32E-05 AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 10327 3.33E-05 RPS27L ribosomal protein S27-like 51065 4.90E-05 D15Wsu75e DNA segment, Chr 15, Wayne State University 75, expressed 27351 5.85E-05 IFI30 interferon, gamma-inducible protein 30 10437 8.34E-05 DMD dystrophin (muscular dystrophy, Duchenne and Becker types) 1756 1.07E-04 SAC3D1 Sac3 homology domain 1 (S. cerevisiae) 29901 1.12E-04 ZDHHC3 zinc finger, DHHC domain containing 3 51304 1.21E-04 CALML4 calmodulin-like 4 91860 1.29E-04 NAPRT1 similar to CG3714 gene product 93100 1.56E-04 UBE2L6 ubiquitin-conjugating enzyme E2L 6 9246 1.65E-04 PTPN7 Protein tyrosine phosphatase, non-receptor type 7 5778 1.68E-04 SULT1A3 Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 6818 1.69E-04 PLXNB1 plexin B1 5364 1.88E-04 PLAC8 placenta-specific 8 51316 1.99E-04 CD163L1 scavenger receptor cysteine-rich type 1 protein M160 283316 2.05E-04 BAX BCL2-associated X protein 581 2.07E-04 CLN2 tripeptidyl peptidase I 1200 2.07E-04 RPL14 ribosomal protein L14 9045 2.18E-04 FTLP3 ferritin, light polypeptide pseudogene 3 284764 2.25E-04 RGS19 regulator of G-protein signalling 19 10287 2.40E-04 Q9Y4D0 KIAA0674 23307 2.58E-04 FTL ferritin, light polypeptide 2512 2.60E-04 RNASET2 ribonuclease T2 8635 2.66E-04 ISG20L1 hypothetical protein FLJ12484 64782 2.88E-04 VNN2 vanin 2 8875 2.93E-04 DAPK3 death-associated protein kinase 3 1613 2.94E-04 LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM 10288 3.05E-04 domains), member 2 TMEM134 hypothetical protein FLJ21749 80194 3.12E-04 COMT Catechol-O-methyltransferase 1312 3.13E-04 TTYH2 tweety homolog 2 (Drosophila) 94015 3.23E-04 PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 5321 3.39E-04 PNKD myofibrillogenesis regulator 1 25953 3.57E-04 PPM1F protein phosphatase 1F (PP2C domain containing) 9647 3.61E-04 NEU1 sialidase 1 (lysosomal sialidase) 4758 3.71E-04 SYK spleen tyrosine kinase 6850 3.79E-04 FDXR Ferredoxin reductase 2232 3.81E-04 GALK1 galactokinase 1 2584 4.15E-04 GSTP1 glutathione S-transferase pi 2950 4.20E-04 UNC93B1 unc-93 homolog B1 (C. elegans) 81622 4.35E-04 BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) 604 4.39E-04 MSRB methionine sulfoxide reductase B2 22921 4.63E-04 IBA2 DNA segment on chromosome X (unique) 9879 expressed sequence 8270 4.72E-04 PYCARD PYD and CARD domain containing 29108 4.76E-04 NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells 4792 5.51E-04 inhibitor, alpha SERPINF2 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, 5345 6.12E-04 pigment epithelium derived factor), member 2 IRF5 interferon regulatory factor 5 3663 6.22E-04 IFITM2 interferon induced transmembrane protein 2 (1-8D) 10581 6.27E-04 CD68 CD68 antigen 968 6.32E-04 MGST2 microsomal glutathione S-transferase 2 4258 6.63E-04 SLC39A1 solute carrier family 39 (zinc transporter), member 1 27173 6.65E-04 C9orf69 chromosome 9 open reading frame 69 90120 6.89E-04 PX19 px19-like protein 27166 6.98E-04 MARCO macrophage receptor with collagenous structure 8685 7.20E-04 MS4A7 membrane-spanning 4-domains, subfamily A, member 7 58475 7.23E-04 GATAD2B transcription repressor p66 beta component of the MeCP1 complex 57459 7.45E-04 GRHPR glyoxylate reductase/hydroxypyruvate reductase 9380 7.83E-04 HN1 hematological and neurological expressed 1 51155 7.94E-04 RRAS related RAS viral (r-ras) oncogene homolog 6237 8.20E-04 ORAI3 hypothetical protein MGC13024 93129 8.22E-04 GLRX glutaredoxin (thioltransferase) 2745 8.28E-04 SCO2 SCO cytochrome oxidase deficient homolog 2 9997 8.39E-04 NPNT NPNT nephronectin 255743 8.53E-04 NICAL NEDD9 interacting protein with calponin homology and LIM domains 64780 8.56E-04 SESN2 sestrin 2 83667 8.67E-04 IFI27 interferon, alpha-inducible protein 27 3429 8.77E-04 DRAM hypothetical protein FLJ11259 55332 8.79E-04 RBMY2EP RNA binding motif protein, Y-linked, family 2, member E pseudogene 159125 8.85E-04 DOCR tumor suppressor deleted in oral cancer-related 1 10263 8.88E-04 POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 5439 8.89E-04 SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), 6556 9.02E-04 member 1 C19orf39 hypothetical protein FLJ35119 126074 9.20E-04 STX10 syntaxin 10 8677 9.33E-04 ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 10094 9.33E-04 PHLDA3 pleckstrin homology-like domain, family A, member 3 23612 9.36E-04 H163 HSPC163 protein 29097 9.42E-04 SCARB2 scavenger receptor class B, member 2 950 9.63E-04 LAMP2 lysosomal-associated membrane protein 2 3920 9.78E-04 BATF3 Jun dimerization protein p21SNFT 55509 1.03E-03 FLJ21511 hypothetical protein FLJ21511 80157 1.04E-03 TFEC transcription factor EC 22797 1.06E-03 MAML3 mastermind-like 3 (Drosophila) 55534 1.08E-03 HES4 hairy and enhancer of split 4 (Drosophila) 57801 1.08E-03 GLA galactosidase, alpha 2717 1.16E-03 PGD Phosphogluconate dehydrogenase 5226 1.19E-03 BLVRA biliverdin reductase A 644 1.20E-03 BAX BCL2-associated X protein 581 1.24E-03 RNF31 ring finger protein 31 55072 1.25E-03 PYCARD PYD and CARD domain containing 29108 1.28E-03 IGFBP7 insulin-like growth factor binding protein 7 3490 1.31E-03 SLC17A2 solute carrier family 17 (sodium phosphate), member 2 10246 1.31E-03 NAGK N-acetylglucosamine kinase 55577 1.33E-03 RAB24 RAB24, member RAS oncogene family 53917 1.35E-03 TINF2 TERF1 (TRF1)-interacting nuclear factor 2 26277 1.37E-03 PLCG2 Phospholipase C, gamma 2 (phosphatidylinositol-specific) 5336 1.40E-03 UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1 29128 1.43E-03 CDK11 cell division cycle 2-like 6 (CDK8-like) 23097 1.45E-03 GNA15 Guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2769 1.46E-03 CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 10645 1.46E-03 PTCD3 FLJ20758 protein 55037 1.48E-03 SF3B2 splicing factor 3b, subunit 2, 145kDa 10992 1.48E-03 FAM21C KIAA0592 protein 253725 1.49E-03 KYNU kynureninase (L-kynurenine hydrolase) 8942 1.50E-03 C3orf60 nuclear protein E3-3 25915 1.53E-03 G10 maternal G10 transcript 8896 1.54E-03 DDB2 damage-specific DNA binding protein 2, 48kDa 1643 1.55E-03 LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM 11026 1.55E-03 domain), member 3 SIDT2 SID1 transmembrane family, member 2 51092 1.59E-03 ITPRIPL2 hypothetical protein LOC162073 162073 1.59E-03 ROGDI leucine zipper domain protein 79641 1.59E-03 RHOC ras homolog family member C 389 1.61E-03 UBE2R2 ubiquitin-conjugating enzyme E2R 2 54926 1.66E-03 IRF7 interferon regulatory factor 7 3665 1.68E-03 LOC388955 PRELI domain-containing protein 1, mitochondrial pseudogene 388955 1.69E-03 CTSC cathepsin C 1075 1.71E-03 CNKSR1 connector enhancer of kinase suppressor of Ras 1 10256 1.72E-03 NUP43 nucleoporin 43kDa 348995 1.74E-03 HES4 hairy and enhancer of split 4 (Drosophila) 57801 1.81E-03 OSIL sequestosome 1 8878 1.84E-03 GABBR1 Gamma-aminobutyric acid (GABA) B receptor, 1 2550 1.85E-03 ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 6484 1.86E-03 LOC440525 proline rich 13 pseudogene 440525 1.86E-03 TST thiosulfate sulfurtransferase (rhodanese) 7263 1.91E-03 ASB5 ankyrin repeat and SOCS box-containing 5 140458 1.91E-03 PPARGC1B peroxisome proliferative activated receptor, gamma, coactivator 1, beta 133522 1.96E-03 CISD3 hypothetical protein LOC284106 284106 1.96E-03 JTB jumping translocation breakpoint 10899 2.01E-03 MHC2TA MHC class II transactivator 4261 2.02E-03 MLN motilin 4295 2.02E-03 BZRP benzodiazapine receptor (peripheral) 706 2.07E-03 GPS2 G protein pathway suppressor 2 2874 2.07E-03 Q9P2L8 KIAA1328 57536 2.07E-03 C8orf70 CGI-62 protein 51101 2.10E-03 CCND3 cyclin D3 896 2.12E-03 APG3L APG3 autophagy 3-like (S. cerevisiae) 64422 2.12E-03 LOC400236 Hypothetical LOC400236 400236 2.15E-03 SNRPA small nuclear ribonucleoprotein polypeptide A 6626 2.17E-03 SCYL1 SCY1-like 1 (S. cerevisiae) 57410 2.21E-03 GAA glucosidase, alpha; acid 2548 2.22E-03 C19orf45 FLJ35784 protein 374877 2.22E-03 CD97 CD97 antigen 976 2.23E-03 TYK2 tyrosine kinase 2 7297 2.26E-03 NQO2 NAD(P)H dehydrogenase, quinone 2 4835 2.31E-03 TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 7132 2.31E-03 HDAC5 histone deacetylase 5 10014 2.31E-03 G1P2 interferon, alpha-inducible protein (clone IFI-15K) 9636 2.33E-03 O2B3 olfactory receptor, family 2, subfamily B, member 3 442184 2.39E-03 EMR2 Egf-like module containing, mucin-like, hormone receptor-like 2 30817 2.39E-03 XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 7515 2.40E-03 ACK1 tyrosine kinase, non-receptor, 2 10188 2.41E-03 LST1 leukocyte specific transcript 1 7940 2.41E-03 DDB2 damage-specific DNA binding protein 2, 48kDa 1643 2.42E-03 CG96 CGI-96 protein 27341 2.42E-03 LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM 10859 2.50E-03 domains), member 1 C1orf54 hypothetical