CLAHRC West Midlands Current Projects Collaboration for Leadership in Applied Health Research and Care West Midlands January 2014 – December 2018 Join our Conversation: News Blog: http://clahrcwmblog.wordpress.com/ Twitter: @CLAHRC_WM Version 5.02 (February 2016) 1.Maternity and child health The start of the human journey, through childhood to adolescence, is a critical period for future physical and mental health. Parents are partners in their children’s health and the NHS is committed to high quality, safe and accessible maternity and children’s services, as well as addressing unhealthy family lifestyles. Theme Lead: Prof. Christine MacArthur, Professor of Maternal and Child Epidemiology, University of Birmingham [email protected] Partner Study Title Study Lead Organisations Birmingham Women’s Exploratory review of the home birth service at Dr Sara Kenyon, Hospital NHS Birmingham Women’s NHS Foundation Trust. Foundation Trust University Hospital of North Staffordshire Feasibility study for implementation in other maternity trusts of a NHS Trust; The Royal Dr Sara Kenyon maternity triage system developed during the CLAHRC pilot. Wolverhampton NHS Trust; Shrewsbury & Telford NHS Trust Birmingham Women’s Place of birth discussion in maternity services. Dr Sara Kenyon Hospital NHS Foundation Trust Examine effects of very early hospital discharge on women, babies (Project development Dr Sara Kenyon and health professionals. phase) Establish feasibility of long-term follow-up of women and children in a (Project development trial of pregnancy outreach worker support conducted in the CLAHRC Dr Sara Kenyon phase) pilot with a view to making an application for external funding. Investigate views of children, adolescents and parents on health Dr Chris Chiswell, Birmingham Children’s and behaviour change advice delivered in the hospital to inform Dr Carole Hospital NHS theoretically and empirically-based interventions. Cummins Foundation Trust Ms Fiona Evaluate the rollout of electronic prescribing with bespoke paediatric Renyolds, Birmingham Children’s decision support suitable to the UK setting across secondary and Dr Carole Hospital NHS tertiary services in a children’s hospital. Cummins, Dr Foundation Trust Jamie Coleman Carry out a cross-sectional evaluation of implementation of Advance Birmingham Children’s Dr Carole Care Plans for children with life-limiting conditions across two NHS Hospital NHS Cummins regions. Foundation Trust Home birth exploratory review: Comparing framework qualitative Dr Sara Kenyon (Methodological study) analysis with a rapid analysis approach. Effectiveness of regular weighing and feedback by community mid- Primary care settings wives in preventing excessive gestational weight gain: randomised Dr Amanda Daley in West Midlands & controlled trial (POPS 2). Oxford A systematic review to examine the evidence regarding discussions Dr Sara Kenyon (Systematic review) by midwives, with women, around their options for where to give birth. Heart of England NHS Feasibility study for implementation in other maternity trusts of a Foundation Trust; maternity triage system developed during the CLAHRC pilot Dr Sara Kenyon University Hospital of [Birmingham Symptom specific Obstetric Triage System]: North Staffordshire Protocol for implementation. NHS Trust Miss Ellie Jones, University of Neonatal hospitalisation in the first 28 days after birth: An exploratory Prof Christine Birmingham; cross-sectional study of preventable neonatal admissions in England MacArthur, Dr Birmingham Children’s 2008-2014. Beck Taylor, Dr Hospital NHS Carole Cummins Foundation Trust University of Birmingham, Magnolia House: New building, new service? A project to evaluate Dr Karen Shaw Birmingham Children’s the early implementation and impact of Magnolia. Hospital NHS Foundation Trust 2. Prevention and early intervention in youth mental health There is overwhelming evidence that many lifelong mental health problems begin in childhood and adolescence. However, despite being the leading cause of disability and burden in young people, failure to seek help and delays within mental health services can often leave them vulnerable and untreated. Theme Lead: Prof. Max Birchwood, Professor of Youth Mental Health, University of Warwick [email protected] Health & Social Care Study Title Study Lead Partner Organisations Don’t turn your back on the symptoms of psychosis: Birmingham & Solihull a proof-of-principle, quasi-experimental public Prof Max Birchwood, Mental Health NHS health trial to reduce the duration of untreated University of Warwick Foundation Trusts psychosis in Birmingham, UK. Prof Max Birchwood, Depression in adolescents and young adults: University of Warwick; Primary care settings in A matched case control study. Prof Tom Marshall, Birmingham University of Birmingham A systematic review and meta-analysis of cognitive- Prof Max Birchwood, behavioural therapy for social anxiety disorder (Systematic review) University of Warwick in psychosis. Dr Charlotte Connor, Understanding Risk Factors for the Development Birmingham & Solihull Mental Secondary schools in of Eating Disorders: A Qualitative Study. Health NHS Foundation Birmingham Trusts Women’s lived experiences of a First Episode of Psychosis (FEP): A qualitative analysis of the Dr Anna Lavis, influence of gender on day-to-day experiences of University of Birmingham FEP and related healthcare needs. Dr Charlotte Connor, Birmingham City Council; Prospective study of young people at risk of Birmingham & Solihull Mental Birmingham & Solihull developing eating disorders: The ‘SchoolSpace’ Health NHS Foundation Mental Health NHS project. Trusts Foundation Trusts Prof Max Birchwood, Birmingham Community Prof Swaran Singh, Healthcare NHS Trust; Bir- How can health services effectively improve the University of Warwick; mingham City Council; Bir- mental health and wellbeing of young people Prof Doug Simkiss, mingham & Solihull Mental leaving public care? The LYNC Study. Birmingham Community Health NHS Foundation Healthcare NHS Trust Trusts Sustaining Positive Engagement and Recovery (SUPEREDEN) – the next step after Early Intervention for Psychosis. Study 3: Improving social Prof Max Birchwood, Multisite recovery in young people with emerging severe University of Warwick social disability: A proof of principle randomised controlled trial. A pilot study to assess the feasibility and impact Birmingham & Solihull of a brief motivational intervention on problem Prof Alex Copello, Mental Health NHS drug and alcohol use in adult mental health University of Birmingham Foundation Trust. inpatient units. PARTNERS2: development and pilot trial of primary Prof Max Birchwood, Primary care settings in care based collaborative care for people with University of Warwick Birmingham serious mental illness. THE MILESTONE PROJECT: Managing the link Prof Swaran Singh, and strengthening transition from child to adult Multisite University of Warwick mental health care. Linear and non-linear brain changes over the Prof Stephen Wood, transition to psychosis. University of Birmingham 3. Prevention and detection of diseases There is an increasingly strong financial incentive to improve prevention and detection of disease amongst younger and middle-aged adults. To ensure the UK ages healthily, the promotion of healthy lifestyles must run alongside screening programmes for a population empowered by increased awareness of symptoms, diagnosis, and treatment options. Theme Leader: Prof. Aileen Clarke, Professor of Public Health and Health Services Research, University of Warwick [email protected] Health & Social Care Study Title Study Lead Partner Organisations The Royal Orthopaedic Mr Edward Davis, Does total joint arthroplasty of the hip and knee Hospital NHS Foundation Prof Tom Marshall, reduce the risk for serious cardiovascular events in Trust; Dudley Group of University of patients with moderate-severe osteoarthritis? Hospitals NHS Foundation Birmingham Trust University Hospitals A retrospective cohort study to determine the impact Prof Tom Marshall, Birmingham NHS of infection in CKD on all-cause mortality, University of Foundation Trust; Primary cardiovascular disease and kidney function. Birmingham Care Settings in Birmingham Changing case Order to Optimise patterns of Dr Sian Taylor-Philips, UK wide – Breast Screening Performance in mammography Screening (CO-OPS): University of Warwick Centres study protocol for a randomized controlled trial. Fluorouracil plasma monitoring: the My5-FU assay Dr Paul Sutcliffe, for guiding dose adjustment in patients receiving University of Warwick fluorouracil chemotherapy by continuous infusion. Accurate diagnosis of latent Tuberculosis in children, in people who are immunocompromised or at risk Dr Paul Sutcliffe, from immunosuppression, and recent arrivals from University of Warwick countries with a high incidence of Tuberculosis: systematic review and economic evaluation. Prof Tom Marshall, Estimation of undiagnosed and untreated atrial University of UK wide primary care settings fibrillation in UK primary care. Birmingham A randomised controlled trial evaluating the effective- Coventry City Council, Dr Wendy Robertson, ness and cost-effectiveness of ‘Families for Health’, a Warwickshire City Council, University of Warwick family-based childhood obesity treatment intervention. Wolverhampton City Council UK National Screening Non-Invasive prenatal testing (NIPT) for T21, 18 and Dr Sian Taylor-Philips, Committee; University 13, an Evidence Review for