SAFETY DATA SHEET Creation Date 21-Feb-2012 Revision Date 07-May-2021 Revision Number 3 SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1. Product identifier Product Description: Sulfolane Cat No. : A13466 Synonyms Sulfolane; Tetrahydrothiophene 1,1-dioxide CAS-No 126-33-0 EC-No. 204-783-1 Molecular Formula C4 H8 O2 S Reach Registration Number - 1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals. Sector of use SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites Product category PC21 - Laboratory chemicals Process categories PROC15 - Use as a laboratory reagent Environmental release category ERC6a - Industrial use resulting in manufacture of another substance (use of intermediates) Uses advised against No Information available 1.3. Details of the supplier of the safety data sheet Company Alfa Aesar . Avocado Research Chemicals, Ltd. Shore Road Port of Heysham Industrial Park Heysham, Lancashire LA3 2XY United Kingdom Office Tel: +44 (0) 1524 850506 Office Fax: +44 (0) 1524 850608 E-mail address [email protected] www.alfa.com Product Safety Department 1.4. Emergency telephone number Call Carechem 24 at +44 (0) 1865 407333 (English only); +44 (0) 1235 239670 (Multi-language) SECTION 2: HAZARDS IDENTIFICATION 2.1. Classification of the substance or mixture CLP Classification - Regulation (EC) No 1272/2008 Physical hazards ______________________________________________________________________________________________ ALFAAA13466 Page 1 / 11 SAFETY DATA SHEET Sulfolane Revision Date 07-May-2021 ______________________________________________________________________________________________ Based on available data, the classification criteria are not met Health hazards Acute oral toxicity Category 4 (H302) Reproductive Toxicity Category 1B (H360) Environmental hazards Based on available data, the classification criteria are not met Full text of Hazard Statements: see section 16 2.2. Label elements Signal Word Danger Hazard Statements H302 - Harmful if swallowed H360 - May damage fertility or the unborn child Precautionary Statements P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting P312 - Call a POISON CENTER or doctor/physician if you feel unwell P264 - Wash face, hands and any exposed skin thoroughly after handling P201 - Obtain special instructions before use P280 - Wear protective gloves/protective clothing/eye protection/face protection Additional EU labelling Restricted to professional users 2.3. Other hazards Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent and very bioaccumulative (vPvB) SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS 3.1. Substances Component CAS-No EC-No. Weight % CLP Classification - Regulation (EC) No 1272/2008 Tetramethylene sulfone 126-33-0 EEC No. 204-783-1 <=100 Acute Tox. 4 (H302) Repr. 1B (H360) ______________________________________________________________________________________________ ALFAAA13466 Page 2 / 11 SAFETY DATA SHEET Sulfolane Revision Date 07-May-2021 ______________________________________________________________________________________________ Reach Registration Number - Full text of Hazard Statements: see section 16 SECTION 4: FIRST AID MEASURES 4.1. Description of first aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention if symptoms occur. Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately. Inhalation Remove to fresh air. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Get medical attention. If not breathing, give artificial respiration. Self-Protection of the First Aider Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination. 4.2. Most important symptoms and effects, both acute and delayed No information available. 4.3. Indication of any immediate medical attention and special treatment needed Notes to Physician Treat symptomatically. SECTION 5: FIREFIGHTING MEASURES 5.1. Extinguishing media Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Extinguishing media which must not be used for safety reasons No information available. 5.2. Special hazards arising from the substance or mixture Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition. Hazardous Combustion Products Carbon monoxide (CO), Carbon dioxide (CO2), Sulfur oxides. 5.3. Advice for firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. SECTION 6: ACCIDENTAL RELEASE MEASURES ______________________________________________________________________________________________ ALFAAA13466 Page 3 / 11 SAFETY DATA SHEET Sulfolane Revision Date 07-May-2021 ______________________________________________________________________________________________ 6.1. Personal precautions, protective equipment and emergency procedures Use personal protective equipment as required. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. 6.2. Environmental precautions Should not be released into the environment. See Section 12 for additional Ecological Information. Do not flush into surface water or sanitary sewer system. 6.3. Methods and material for containment and cleaning up Sweep up and shovel into suitable containers for disposal. 6.4. Reference to other sections Refer to protective measures listed in Sections 8 and 13. SECTION 7: HANDLING AND STORAGE 7.1. Precautions for safe handling Wear personal protective equipment/face protection. Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Avoid ingestion and inhalation. Hygiene Measures Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do not eat, drink or smoke when using this product. Remove and wash contaminated clothing and gloves, including the inside, before re-use. Wash hands before breaks and after work. 7.2. Conditions for safe storage, including any incompatibilities Keep containers tightly closed in a dry, cool and well-ventilated place. Technical Rules for Hazardous Substances (TRGS) 510 Storage Class (LGK) Class 6.1C (Germany) 7.3. Specific end use(s) Use in laboratories SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1. Control parameters Exposure limits List source(s): Biological limit values This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific regulatory bodies Derived No Effect Level (DNEL) / Derived Minimum Effect Level (DMEL) See table for values Component Acute effects local Acute effects Chronic effects local Chronic effects ______________________________________________________________________________________________ ALFAAA13466 Page 4 / 11 SAFETY DATA SHEET Sulfolane Revision Date 07-May-2021 ______________________________________________________________________________________________ (Dermal) systemic (Dermal) (Dermal) systemic (Dermal) Tetramethylene sulfone DNEL = 0.04mg/kg 126-33-0 ( <=100 ) bw/day Component Acute effects local Acute effects Chronic effects local Chronic effects (Inhalation) systemic (Inhalation) (Inhalation) systemic (Inhalation) Tetramethylene sulfone DNEL = 2.16mg/m3 126-33-0 ( <=100 ) Predicted No Effect Concentration (PNEC) See values below. Component Fresh water Fresh water Water Intermittent Microorganisms in Soil (Agriculture) sediment sewage treatment Tetramethylene sulfone PNEC = 0.1mg/L PNEC = 0.39mg/kg PNEC = 1mg/L PNEC = 100mg/L PNEC = 0.02mg/kg 126-33-0 ( <=100 ) sediment dw soil dw Component Marine water Marine water Marine water Food chain Air sediment intermittent Tetramethylene sulfone PNEC = 0.01mg/L PNEC = 126-33-0 ( <=100 ) 0.039mg/kg sediment dw 8.2. Exposure controls Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source Personal protective equipment Eye Protection Goggles (European standard - EN 166) Hand Protection Protective gloves Glove material Breakthrough time Glove thickness EU standard Glove comments Natural rubber See manufacturers - EN 374 (minimum requirement) Nitrile rubber recommendations Neoprene PVC Skin and body protection Long sleeved clothing. Inspect gloves before use. Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. (Refer to manufacturer/supplier for information) Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g. sensitisation effects, also take into consideration the specific