The world’s premier stem cell 9th Annual Meeting research event Final Program June 15 – 18, 2011 Metro Toronto Convention Centre Toronto, Ontario Canada www.isscr.org Co-sponsored by Scan to access the online itinerary builder. Mouse neural crest stem cells image ©Deepak Srivastava ISSCR 9th Annual Meeting www.isscr.org ISSCR Supporters Thank You to the Following ISSCR 9th Annual Meeting Supporters: Diamond Platinum Gold 4 www.isscr.org Final Program ISSCR Supporters Thank You to the Following ISSCR 9th Annual Meeting Supporters: Silver ® Bronze General 5 ISSCR 9th Annual Meeting www.isscr.org Letter from ISSCR Dear Colleagues: On behalf of the International Society for Stem Cell Research, welcome to the ISSCR 9th Annual Meeting at the Metro Toronto Convention Centre. The ISSCR Annual Meeting is the preeminent international forum for stem cell science. From Wednesday afternoon through Saturday evening, this meeting is packed with the best and brightest the stem cell field has to offer. One hundred eleven speakers from academia and industry around the world will present their latest and most exciting research. Additionally, all posters will be on display for the duration of the meeting, giving you more time than ever to explore the great science in the poster hall. As usual, there are also a number of social and educational activities for junior investigators, students and postdocs, and there are many opportunities for networking at all levels. This year, the morning prior to the start of the meeting on Wednesday will also be special. In addition to industry- oriented programs and focus sessions highlighting important topics in bioethics and basic science, there will be a satellite symposium honoring the late Ernest McCulloch, one of the true pioneers of stem cell biology. Admission to the satellite sessions is free to all meeting attendees and we encourage you to participate. ISSCR is very pleased to be able to honor the memory of one of the giants of our field by introducing the Ernest McCulloch Memorial Lecture here in Toronto. ISSCR will also be introducing two new awards at this meeting, the ISSCR Public Service Award and the McEwen Centre Award for Innovation. You can read about the recipients of these two awards and the ISSCR Outstanding Young Investigator Award in this program. Judging from advanced registration and abstract submissions, this meeting is on track to be one of the largest and most successful ever for ISSCR. We think you are going to find it as exciting and stimulating as we expect it to be, and are happy to have you here. Haifan Lin Elaine Fuchs ISSCR Program Chair ISSCR President 6 www.isscr.org Final Program Table of Contents ISSCR 9th Annual Meeting Co-Sponsor 3 ISSCR Media Partners 36 ISSCR 9th Annual Meeting Supporters 4 – 5 Exhibits and Exhibitor Floor Plan 37 Letters of Welcome 3, 6, 20, 34 Exhibitor List 38 – 39 ISSCR Keynote Speaker 8 Exhibitor/Supporter Directory 41 – 57 Fourth Annual Anne McLaren Memorial Lecture 9 Detailed Program and Abstracts 59 – 93 Inaugural Ernest McCulloch Memorial Lecture 9 Wednesday, June 15 59 – 60 ISSCR Public Service Award 10 Thursday, June 16 61 – 71 ISSCR Outstanding Young Investigator Award 10 Friday, June 17 71 – 82 McEwen Centre Award for Innovation 11 Saturday, June 18 82 – 93 ISSCR Leadership and Staff 13, 24, 28, 32 Innovation Showcases 94 – 97 Detailed Schedule at a Glance 15 – 35 Poster Floor Plan 98 – 99 ISSCR Future Annual Meetings 16, 104 Author Index 101 – 103 Travel Award Winners 18, 22, 26, 30 What’s New for 2011 Meeting Orientation Area Need a quick overview of the ISSCR Annual Meeting? First time to the meeting or to the Metro Toronto Convention Centre? Stop by the ISSCR Orientation Area located on the 600 level near registration for a five-minute virtual tour, what’s new and what not to miss. Attend and be entered to win: • Two tickets to visit the CN Tower • Dinner for two at the Hard Rock Café “Private Philanthropy and the Future of Stem Cell Research” luncheon panel Robert Klein, Susan Solomon, Gordon Keller and Cheryl McEwen will demystify the process of finding and securing private funding. Friday, June 17, 11:30 – 1:30 p.m. See page 14 for details. Two New ISSCR Awards Honoring Contributions to the Stem Cell Field Join us for the inaugural presentations of the ISSCR Public Service Award and the ISSCR McEwen Centre Award for Innovation, in addition to the third annual ISSCR Outstanding Young Investigator Award. See pages 11 for details about the recipients and presentation days and times. Ernest McCulloch Memorial Lecture The ISSCR Board of Directors is pleased to establish the Ernest McCulloch Memorial Lecture to honor and celebrate his pioneering work. This inaugural lecture will be presented by John E. Dick during Plenary IV on Thursday. See page 9 for more information. Lunch in the Exhibit Hall Now you don’t have to leave the convention center to grab something to eat and continue networking with your colleagues. Lunch is available for purchase in the Exhibit Hall (Concessions) on Thursday, Friday and Saturday. 7 ISSCR 9th Annual Meeting www.isscr.org Don’t Miss these Featured Presentations ISSCR Keynote Speaker Presidential Symposium: Stem Cell Biology and the Prospects for Regenerative Medicine: Past, Present and Future Wednesday, 1:00 p.m. Robert S. Langer is the David H. Koch Institute Professor, the highest faculty member honor at the Massachusetts Institute of Technology. Dr. Langer has written more than 1,100 articles, with approximately 760 issued and pending patents worldwide. Dr. Langer’s patents have been licensed or sublicensed to more than 220 pharmaceutical, chemical, biotechnology and medical device companies. He is the most cited engineer in history. He served as a member of the United States Food and Drug Administration’s SCIENCE Board, the FDA’s highest advisory board, from 1995 – 2002 and as its Chairman from 1999 – 2002. Dr. Langer has received more than 180 major awards including the 2006 United States National Medal of Science; the Charles Stark Draper Prize, considered the equivalent of the Nobel Prize for engineers and the 2008 Millennium Prize, the world’s largest technology prize. He is the also the only engineer to receive the Gairdner Foundation International Award; 72 recipients of this award have subsequently received a Nobel Prize. In 1989 Dr. Langer was elected to the Institute of Medicine of the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is one of few people ever elected to all three United States National Academies and, at age 43, the youngest in history to ever receive this distinction. Forbes Magazine (1999) and Bio World (1990) named Dr. Langer as one of the 25 most important individuals in biotechnology in the world. Discover Magazine (2002) named him as one of the 20 most important people in this area. Forbes Magazine (2002) selected Dr. Langer as one of the 15 innovators worldwide who will reinvent our future. Time Magazine and CNN (2001) named Dr. Langer as one of the 100 most important people in America and one of the 18 top people in science or medicine in America (America’s Best). Parade Magazine (2004) selected Dr. Langer as one of six “Heroes Whose Research May Save Your Life.” He received his bachelor’s degree from Cornell University in 1970 and his Sc.D. from the Massachusetts Institute of Technology in 1974, both in Chemical Engineering. 8 www.isscr.org Final Program Anne McLaren Memorial Lecturer Plenary VIII: Regulatory Networks of Stem Cells Saturday, 4:00 p.m. Nicole M. Le Douarin is Honorary Professor at the College de France and Permanent Secretary at the Academie des Sciences in Paris. Her research career started under the sponsorship of Pr. Etienne Wolff who was the Director of the Institut d’Embryologie et de Tératologie expérimentales du Centre National de la Recherche Scientifique et du Collège de France in Paris. Her Doctorate in Sciences was an experimental study on digestive tract and liver development in the chick embryo. After her Do. Sci., Dr. Le Douarin was appointed as Assistant Professor at the University of Nantes where she devised a cell marking technique based on the construction of embryonic chimeras between two species of birds, the chick and the Japanese quail. This technique met with great success among embryologists because, in contrast to methods used to label cells in the embryo, it had two major advantages, stability and specificity. By combining this cell labelling technique with molecular tools, Dr. Le Douarin applied it to several embryonic systems in which she brought about a profound renewal of the state of the art. Her main contributions concern the development of the neural primordium and the hemopoietic and immune system. In 1975, she was invited to take over the Directorship of the Institut d’Embryologie du Collège de France et du CNRS. She was appointed as Professor at the Collège de France in the Chair of “Embryologie cellulaire et moléculaire” in 1988. She has been elected in 2001 as the “Secrétaire Perpétuelle” of the Académie des Sciences de l’Institut de France of which she was a member since 1982 She is a member of several academics and has received numerous awards including: the Edwin Conklin Award of The American Society for Developmental Biology (San Francisco) in 2005, the Ralph W. Gerard Prize of Neuroscience, Society of Neuroscience, USA in 2007 and the Prix d’Honneur de l’INSERM Paris in 2009. She is Grand Croix de l’Ordre National du Mérite and Grand Officier de la Légion d’Honneur.