Catalog Update01 - EU_Update 31/01/2013 08:12 Page 1 Catalog update High purity biochemical tools for life scientists •Receptor agonists and antagonists •Ion channel modulators •Enzyme modulators •Signaling tools € - March 2013 Discover more at www.abcam.com/biochemicals Catalog Update01 - EU_Update 31/01/2013 08:12 Page 2 Contents Receptors & Transporters Page Receptors & Transporters (continued) Page Adenosine & Purinergics Peptide Receptors 17 P1 5 Prostanoid 18 P2 5 Serotonin Adrenoceptors 5 5-HT1 18 Cannabinoid 6 5-HT2 19 Catalytic Receptors 7 5-HT3 19 Chemokine 7 5-HT4 19 Dopamine 7 5-HT5 19 Enzyme-Linked Receptors 9 5-HT6 20 G protein-coupled estrogen 10 5-HT7 20 GABA Non-selective 20 GABAA 10 Transporters 20 GABAB 10 Sigma 20 Non-selective 10 Smoothened 20 Other 11 Sphingosine 1-Phosphate Receptors 21 Transporters 11 TGR5 21 Glutamate Toll-Like Receptors 21 AMPA & Kainate 11 Transporters 21 Broad spectrum / non-selective 11 mGlu: General 12 Ion Channels Page mGlu: Group I 12 Calcium 22 mGlu: Group I & II 12 Chloride 22 mGlu: Group II 12 Cyclic nucleotide-gated 22 mGlu: Group III 13 Ionophores, indicators & chelators 22 NMDA: AP-2 binding site 13 Other 22 NMDA: Glutamate Site 13 Potassium 22 NMDA: Glycine Site 13 Sodium 23 NMDA: Ion Channel Site 13 TRP 23 NMDA: Polyamine Site 14 Transporters 14 Enzymes Page Glycine 14 ATPase & GTPase 23 Histamine 14 Caspase 24 Imidazoline 15 Cholinesterase 24 Melatonin 15 Coenzymes 24 Muscarinic 15 Cyclase 24 Nicotinic 15 Cyclooxygenase 24 Nuclear Receptors 16 Cytochrome P450 25 Opioids 16 Deacetylase 25 Orphan 7-TM Receptors 17 Dehydrogenase 25 2 Discover more at www.abcam.com/biochemicals Catalog Update01 - EU_Update 31/01/2013 08:12 Page 3 Contents Enzymes (continued) Page Signaling (continued) Page Demethylase 25 Ca2+ Signaling 34 Hydrolase 25 Cytoskeleton & motor proteins 34 Isomerase 26 DNA, RNA & protein synthesis 34 Kinase 26 Endocytosis & exocytosis 35 Oxidases 29 Epigenetics 36 Oxygenase 29 Extracellular matrix & cell adhesion 36 Phosphatase 29 Heat shock proteins 36 Phosphodiesterase 29 Immunomodulators 37 Phospholipase & Lipase 29 Lipid signaling 37 Polymerase 29 Stem Cells 38 Protease 30 Reductase 30 Signal transduction Page Secretase 30 Cytokines, NF-κB & IκB 39 Synthetase & synthase 30 G-Protein related 39 Telomerase 30 Hedgehog signaling 39 Transaminase 30 Inositol & cAMP signaling 39 Transferase 31 JAK/STAT 39 MAPK 40 Signaling Page Nitric oxide & oxidative stress 40 Amyloidogenesis 31 PI3K/Akt 41 Angiogenesis 31 Wnt signaling 41 Apoptosis & cell cycle 32 Symbol key Ç Products added since publication of 2012 catalog. É Just-Add-Water: typically water-soluble to at least 10 mM or above. Ë Country restrictions and/or license requirements may apply. Please contact customer services for further details. fi Not currently for sale in the US fi Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Iminodyn-22™, Iminodyn-17™, Dynole-34-2™, Dynole-31-2™, RTIL-13™, MiTMAB™, OcTMAB™, Pitstop 1™, Pitstop 2™, Dyngo-4a™, Rhodadyn B10™, Rhodadyn C10™, are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd. fi Sold under exclusive license from Columbia University; Patent Pending fi Sold under license from Columbia University; Patent Pending fi Sold under license from Eli Lilly and company fi Sold under license from Hugin Neurochemicals fi Sold under license from Virginia Commonwealth University. fi Sold under license granted by the University of Pennsylvania. fi Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop-1™ and Pitstop-2™ is a trademark of Freie Universität Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute Discover more at www.abcam.com/biochemicals 3 Catalog Update01 - EU_Update 31/01/2013 08:12 Page 4 Great supporting data for your research Tried and tested Apoptotic stimuli biological information Every product has a detailed description including Bcl-2 Family members potency (Ki, IC50 etc.), cell permeability and solubility data. Mitochondria Apoptosome Useful references for HtrA2 SMAC cyt-c formation IAP ARTS every product antagonists Every Abcam Biochemicals product is listed with a range of useful references and citations to help you Inhibitors of XIAP Apaf-1 figure out the best conditions for your experiment - apoptosis from in vitro to in vivo; western blotting to (IAPs) immunofluorescence. Caspase 9 Initiator caspase Caspase 7 Effector Caspase 3 Find the product caspases you need • You can check chemical names, structures, formula and CAS number online. Apoptosis • Our smiles information now allows you to recreate structures using chemical drawing packages. Guides to signalling Examples include: pathways and pharmacology • Akt signaling • MAPK signaling • Apoptosis • Glutamate Visit: www.abcam.com/at-a-glance for the full range of @ a glance guides Refer to page 3 for symbol key 4 Discover more at www.abcam.com/biochemicals Catalog Update01 - EU_Update 31/01/2013 08:12 Page 5 Receptors & Transporters: Adenosine & Purinergics: P1 Cat No. Product Pack Sizes Purity Description É ab120498 Adenosine 1g: € 15 5g: € 40 25g: € 55 >99% Endogenous P1 receptor agonist É ab120240 Caffeine 1g: € 15 5g: € 30 >99% PDE inhibitor. Adenosine antagonist Ç ab120453 CGS 21680 10mg: € 205 50mg: € 895 >98% Potent, selective A2A agonist 6 ab120434 2-Chloro-N -cyclopentyladenosine (CCPA) 10mg: € 95 50mg: € 380 >98% Highly potent, selective A1 agonist É ab120037 2-Chloroadenosine (CADO) 10mg: € 30 50mg: € 70 250mg: € 305 >98% Adenosine agonist ab120442 8-(3-Chlorostyryl)caffeine 10mg: € 55 50mg: € 250 >98% Selective A2A receptor antagonist. MAO-B inhibitor. 6 ab120472 N -Cyclohexyladenosine 50mg: € 55 250mg: € 220 >98% Selective A1 receptor agonist 6 ab120398 N -Cyclopentyladenosine (CPA) 25mg: € 40 100mg: € 140 >99% Potent, selective A1 agonist ab120396 DPCPX 25mg: € 45 100mg: € 95 >99% Potent A1 antagonist ab120458 HENECA 1mg: € 70 10mg: € 185 >99% Selective A2A receptor agonist ab120438 IB-MECA 5mg: € 140 25mg: € 605 >97% Highly potent and selective A3 agonist Ç É ab120724 Inosine 100mg: € 15 1g: € 30 >99% Purine nucleoside. Adenosine metabolite. ab120452 Iodotubercidin 1mg: € 85 5mg: € 270 >95% Potent, adenosine kinase inhibitor fi ab120397 MRS 1754 10mg: € 130 50mg: € 555 >98% Selective A2B antagonist ab120440 NECA 10mg: € 40 50mg: € 110 >99% Highly potent adenosine agonist Ç ab118162 NECA fluorescent ligand (Red) 50μg: € 250 100μg: € 415 >97% Fluorescent non-selective adenosine agonist Ç ab120921 Reversine 1mg: € 30 5mg: € 135 >98% Potent selective A3 receptor antagonist ab120439 SCH-58261 10mg: € 120 50mg: € 525 >99% Potent, highly selective A2A antagonist Ç ab118163 XAC Fluorescent ligand-1 (Red) 50μg: € 250 100μg: € 415 >97% Fluorescent non-selective adenosine antagonist Ç ab118164 XAC A3 fluorescent ligand (Red) 50μg: € 250 100μg: € 415 >97% Fluorescent A3 antagonist ab120218 ZM 241385 10mg: € 120 50mg: € 515 >99% Potent, selective A2A antagonist Receptors & Transporters: Adenosine & Purinergics: P2 Cat No. Product Pack Sizes Purity Description ab120413 A 438079 10mg: € 110 50mg: € 470 >98% Potent, competitive P2X7 receptor antagonist É ab120385 ATP disodium salt 1g: € 30 5g: € 70 10g: € 130 25g: € 250 >99% P2 receptor agonist. Signalling molecule. É ab120389 Brilliant Blue G 100mg: € 30 1g: € 130 >90% Potent, noncompetitive P2X7 antagonist Ç É ab120444 BzATP triethylammonium salt 1mg: € 45 5mg: € 45 25mg: € 165 >99% Potent, prototypic P2X7 agonist. P2 agonist. ab120387 (±)-Clopidogrel 10mg: € 100 50mg: € 425 >99% Potent, selective P2Y12 antagonist É ab120395 GW791343 10mg: € 120 50mg: € 525 >99% P2X7 allosteric modulator ab120421 KN-62 1mg: € 95 5mg: € 205 >98% CaM kinase II inhibitor. P2X7 antagonist. É ab120414 MRS 2179 10mg: € 165 50mg: € 735 >98% Potent, selective P2Y1 antagonist Ç É ab120445 MRS 2211 10mg: € 65 50mg: € 305 >95% Selective competitive P2Y13 antagonist É ab120454 NF023 10mg: € 85 50mg: € 345 >97% Competitive P2X1 receptor antagonist Ç É ab120415 NF 449 10mg: € 130 50mg: € 555 >95% Highly selective, potent P2X1 receptor antagonist É ab120403 β-Nicotinamide adenine dinucleotide (β-NAD) 25mg: € 30 250mg: € 95 1g: € 260 >96% Coenzyme and enzyme substrate. P2Y11 agonist. É ab120009 PPADS 10mg: € 45 50mg: € 185 250mg: € 740 P2 purinergic receptor antagonist. Ç É ab120422 Suramin hexasodium salt 100mg: € 55 500mg: € 270 >99% Non-selective P2 purinergic antagonist É ab120384 UDP-glucose 100mg: € 55 1g: € 220 >98% Highly potent P2Y14 agonist É ab120383 UDP sodium salt (Uridine 5’-diphosphate) 100mg: € 45 500mg: € 185 >98% P2Y6 agonist. P2Y14 ligand. Receptors & Transporters: Adrenoceptors Cat No. Product Pack Sizes Purity Description Ç ab118167 Alprenolol fluorescent ligand (Red) 50μg: € 250 100μg: € 415 >97% Fluorescent β2 adrenoceptor antagonist Ç ab120576 Asenapine maleate 10mg: € 45 50mg: € 185 >99% Multiple receptor antagonist. Anti-psychotic agent. Ç É ab120752 (R,S)-Atenolol 1g: € 45 >99% β1 adrenoceptor antagonist Ç ab120856 (S)-(-)-Atenolol 10mg: € 70 50mg: € 280 >98% Selective β1 adrenoceptor antagonist Ç ab120785 Atipamezole hydrochloride 10mg: € 120 50mg: € 470 >99% Selective α2 adrenergic receptor antagonist Ç ab120783 (±)-Bisoprolol hemifumarate 10mg: € 110 50mg: € 445 >99% Selective β1 antagonist Ç É ab120520 BMY 7378 dihydrochloride 10mg: € 40 50mg: € 150 >99% 5-HT1A partial agonist. α-adrenoceptor antagonist. Ç ab120806 BRL 44408 maleate 10mg: € 110 50mg: € 445 >99% Selective α2A adrenoceptor antagonist